| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pu Wang, Bingjin Li, Jie Fan, Kun Zhang, Wei Yang, Bingzhong Ren, Ranji Cu. Additive antidepressant-like effects of fasting with β-estradiol in mice. Journal of cellular and molecular medicine. vol 23. issue 8. 2020-08-13. PMID:31211521. |
activity of the cyclic adenosine monophosphate (camp) response element-binding protein (creb)-brain-derived neurotrophic factor (bdnf) pathway in the prefrontal cortex (pfc) and hippocampus (hp) was increased, as well as neurogenesis in the subgranular zone of the hippocampus. |
2020-08-13 |
2023-08-13 |
mouse |
| Ying Liu, Xing Zhang, Dandan Yan, Yiqi Wang, Na Wang, Yufan Liu, Aijun Tan, Xiaoyi Chen, Hong Ya. Chronic acrylamide exposure induced glia cell activation, NLRP3 infl-ammasome upregulation and cognitive impairment. Toxicology and applied pharmacology. vol 393. 2020-08-13. PMID:32147541. |
chronic exposure to acr caused gait abnormality and cognitive dysfunction, which was associated with neuronal lesions, decrease in synapse associated proteins including synapsin i (syn1), synaptophysin (syp) and postsynaptic density protein 95 (psd95), neurogenesis suppression as shown by reduced brain derived neurotrophic factor (bdnf) and doublecortin (dcx) in the hippocampus and frontal cortex. |
2020-08-13 |
2023-08-13 |
rat |
| Yu-Hui You, Zhi-Qiang Qin, Huan-Li Zhang, Zhao-Hong Yuan, Xin Y. MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Bioscience reports. vol 39. issue 6. 2020-08-07. PMID:30975733. |
therefore, we evaluate the ability of mir-153 to influence brain-derived neurotrophic factor (bdnf) of autism as well as proliferation and apoptosis of hippocampal neuron through the janus kinase-signal transducer and activator of transcription (jak-stat) signaling pathway by targeting leptin receptor (lepr). |
2020-08-07 |
2023-08-13 |
mouse |
| Yu-Hui You, Zhi-Qiang Qin, Huan-Li Zhang, Zhao-Hong Yuan, Xin Y. MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Bioscience reports. vol 39. issue 6. 2020-08-07. PMID:30975733. |
in conclusion, the high expression of mir-153 can inhibit activation of jak-stat signaling pathway by lepr, thus improving bdnf expression and the proliferative ability of hippocampal neurons. |
2020-08-07 |
2023-08-13 |
mouse |
| Mahdiyeh Faatehi, Mohsen Basiri, Akram Nezhadi, Mohammad Shabani, Yaser Masoumi-Ardakani, Zahra Soltani, Masoumeh Nozar. Early enriched environment prevents cognitive impairment in an animal model of schizophrenia induced by MK-801: Role of hippocampal BDNF. Brain research. vol 1711. 2020-08-04. PMID:30677409. |
early enriched environment prevents cognitive impairment in an animal model of schizophrenia induced by mk-801: role of hippocampal bdnf. |
2020-08-04 |
2023-08-13 |
rat |
| Mahdiyeh Faatehi, Mohsen Basiri, Akram Nezhadi, Mohammad Shabani, Yaser Masoumi-Ardakani, Zahra Soltani, Masoumeh Nozar. Early enriched environment prevents cognitive impairment in an animal model of schizophrenia induced by MK-801: Role of hippocampal BDNF. Brain research. vol 1711. 2020-08-04. PMID:30677409. |
this study aims to investigate the long-term effects of enriched environment (ee), which was imposed during the animals' development, on their recognition memory as well as hippocampal levels of brain-derived neurotrophic factor (bdnf), in an animal model of schizophrenia induced by chronic postnatal administration of mk-801. |
2020-08-04 |
2023-08-13 |
rat |
| Mahdiyeh Faatehi, Mohsen Basiri, Akram Nezhadi, Mohammad Shabani, Yaser Masoumi-Ardakani, Zahra Soltani, Masoumeh Nozar. Early enriched environment prevents cognitive impairment in an animal model of schizophrenia induced by MK-801: Role of hippocampal BDNF. Brain research. vol 1711. 2020-08-04. PMID:30677409. |
mk-801 resulted in decreased levels of bdnf in the hippocampus, and ee exposure restored the decreased level. |
2020-08-04 |
2023-08-13 |
rat |
| Lin-Lin Liu, Jia-Mei Li, Wen-Jun Su, Bo Wang, Chun-Lei Jian. Sex differences in depressive-like behaviour may relate to imbalance of microglia activation in the hippocampus. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31181346. |
afterwards, we observed that the expressions of bdnf and its receptor trkb in hippocampus decreased greater in female compared to male mice when facing stress stimulations. |
2020-08-04 |
2023-08-13 |
mouse |
| Lin-Lin Liu, Jia-Mei Li, Wen-Jun Su, Bo Wang, Chun-Lei Jian. Sex differences in depressive-like behaviour may relate to imbalance of microglia activation in the hippocampus. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31181346. |
furthermore, the depressive-like behaviours were correlated to bdnf mrna quantities in both sex mice, and there was also a sex-specific relationship between bdnf and hippocampal microglia-related inflammatory biomarkers. |
2020-08-04 |
2023-08-13 |
mouse |
| Daniel Silva-Peña, Nuria García-Marchena, Francisco Alén, Pedro Araos, Patricia Rivera, Antonio Vargas, María Inmaculada García-Fernández, Ana Isabel Martín-Velasco, María Ángeles Villanúa, Estela Castilla-Ortega, Luis Santín, Francisco Javier Pavón, Antonia Serrano, Gabriel Rubio, Fernando Rodríguez de Fonseca, Juan Suáre. Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats. Addiction biology. vol 24. issue 5. 2020-08-03. PMID:30277635. |
in the ethanol-exposed rats, the plasma levels of bdnf and nt-3 were also decreased, and a negative correlation between hippocampal bdnf mrna levels and recognition memory was found. |
2020-08-03 |
2023-08-13 |
human |
| Daniel Silva-Peña, Nuria García-Marchena, Francisco Alén, Pedro Araos, Patricia Rivera, Antonio Vargas, María Inmaculada García-Fernández, Ana Isabel Martín-Velasco, María Ángeles Villanúa, Estela Castilla-Ortega, Luis Santín, Francisco Javier Pavón, Antonia Serrano, Gabriel Rubio, Fernando Rodríguez de Fonseca, Juan Suáre. Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats. Addiction biology. vol 24. issue 5. 2020-08-03. PMID:30277635. |
the ethanol-exposed rat hippocampus showed a decrease in the mrna levels of neurotrophic (bdnf and ntf-3) and neurogenic (mki67, sox2, dcx, ncam1 and calb1) factors, associated to a deactivation of the neurogenic regulator mitogen-activated protein kinase extracellular signal-regulated kinase. |
2020-08-03 |
2023-08-13 |
human |
| Michaela Shishmanova-Doseva, Katerina Georgieva, Yvetta Koeva, Dora Terzieva, Lyudmil Peyche. Enhancing effect of aerobic training on learning and memory performance in rats after long-term treatment with Lacosamide via BDNF-TrkB signaling pathway. Behavioural brain research. vol 370. 2020-07-30. PMID:31116960. |
the present study assesses the effect of aerobic training on cognitive functions, hippocampal bdnf/trkb ligand receptor system expression and serum levels of bdnf and corticosterone in intact rats after chronic treatment with lacosamide (lcm). |
2020-07-30 |
2023-08-13 |
rat |
| Michaela Shishmanova-Doseva, Katerina Georgieva, Yvetta Koeva, Dora Terzieva, Lyudmil Peyche. Enhancing effect of aerobic training on learning and memory performance in rats after long-term treatment with Lacosamide via BDNF-TrkB signaling pathway. Behavioural brain research. vol 370. 2020-07-30. PMID:31116960. |
aerobic training increased bdnf and trkb hippocampal immunoreactivity. |
2020-07-30 |
2023-08-13 |
rat |
| Bruk Getachew, Liliana Mendieta, Antonei B Csoka, José Aguilera, Yousef Tizab. Antidepressant effects of C-Terminal domain of the heavy chain of tetanus toxin in a rat model of depression. Behavioural brain research. vol 370. 2020-07-30. PMID:31125623. |
concomitant with the 24 h behavioral effects, the levels of hippocampal and frontal cortical bdnf were significantly increased, whereas the levels of tnf-alpha in both these areas were significantly decreased. |
2020-07-30 |
2023-08-13 |
rat |
| Foad Feizolahi, Mohammad-Ali Azarbayjani, Mohammad Nasehi, Maghsoud Peeri, Mohammad-Reza Zarrindas. The combination of swimming and curcumin consumption may improve spatial memory recovery after binge ethanol drinking. Physiology & behavior. vol 207. 2020-07-27. PMID:31071339. |
furthermore, levels of bdnf were measured in hippocampal tissue by doing real time pcr. |
2020-07-27 |
2023-08-13 |
rat |
| Stephen D Ginsberg, Michael H Malek-Ahmadi, Melissa J Alldred, Yinghua Chen, Kewei Chen, Moses V Chao, Scott E Counts, Elliott J Mufso. Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology. Neurobiology of disease. vol 132. 2020-07-27. PMID:31349032. |
brain-derived neurotrophic factor (bdnf) and trkb hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology. |
2020-07-27 |
2023-08-13 |
Not clear |
| Xiao-Ying Lin, Ying Cui, Lei Wang, Wen Che. Chronic exercise buffers the cognitive dysfunction and decreases the susceptibility to seizures in PTZ-treated rats. Epilepsy & behavior : E&B. vol 98. issue Pt A. 2020-07-27. PMID:31377659. |
the levels of synaptic-related proteins including psd95 (postsynaptic density 95), synapsin, glua1, and bdnf (brain-derived neurotrophic factor) were measured to evaluate the hippocampal synaptic plasticity. |
2020-07-27 |
2023-08-13 |
rat |
| Mingxing Li, Xuejiao Sun, Qian Li, Yong Li, Can Luo, Hailong Huang, Jing Chen, Chenzi Gong, Yajie Li, Yifeng Zheng, Song Zhang, Xiaolin Huang, Hong Che. Fucoidan exerts antidepressant-like effects in mice via regulating the stability of surface AMPARs. Biochemical and biophysical research communications. vol 521. issue 2. 2020-07-27. PMID:31668812. |
interestingly, chronic fucoidan administration not only dose-dependently reduced stress-induced depressive-like behaviors in the tst, fst, sucrose preference test (spt), and novelty-suppressed feeding test (nsft), but also alleviated the downregulation of brain-derived neurotrophic factor (bdnf)-dependent synaptic plasticity via inhibiting caspase-1-mediated inflammation in the hippocampus of mice. |
2020-07-27 |
2023-08-13 |
mouse |
| Pedro Afonso, Pasqualino De Luca, Rafael S Carvalho, Luísa Cortes, Paulo Pinheiro, Barbara Oliveiros, Ramiro D Almeida, Miranda Mele, Carlos B Duart. BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons. Science signaling. vol 12. issue 586. 2020-07-24. PMID:31213568. |
bdnf increases synaptic nmda receptor abundance by enhancing the local translation of pyk2 in cultured hippocampal neurons. |
2020-07-24 |
2023-08-13 |
rat |
| Pedro Afonso, Pasqualino De Luca, Rafael S Carvalho, Luísa Cortes, Paulo Pinheiro, Barbara Oliveiros, Ramiro D Almeida, Miranda Mele, Carlos B Duart. BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons. Science signaling. vol 12. issue 586. 2020-07-24. PMID:31213568. |
bdnf induced the synaptic accumulation of glun2b-containing nmda receptors (nmdars) and increased the amplitude of nmdar-mediated miniature excitatory postsynaptic currents (mepscs) in cultured rat hippocampal neurons by a mechanism requiring activation of the protein tyrosine kinase pyk2 and dependent on cellular protein synthesis. |
2020-07-24 |
2023-08-13 |
rat |