| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pedro Afonso, Pasqualino De Luca, Rafael S Carvalho, Luísa Cortes, Paulo Pinheiro, Barbara Oliveiros, Ramiro D Almeida, Miranda Mele, Carlos B Duart. BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons. Science signaling. vol 12. issue 586. 2020-07-24. PMID:31213568. |
furthermore, bdnf increased the local synthesis of pyk2 at the synapse, and the observed increase in pyk2 protein abundance along dendrites of cultured hippocampal neurons was mediated by a mechanism dependent on the ribonucleoprotein hnrnp k, which bound to |
2020-07-24 |
2023-08-13 |
rat |
| Keli Yao, Qin Yang, Yajuan Li, Ting Lan, Hong Yu, Yang Y. MicroRNA-9 mediated the protective effect of ferulic acid on hypoxic-ischemic brain damage in neonatal rats. PloS one. vol 15. issue 5. 2020-07-24. PMID:32470970. |
indeed, the silencing of mir-9 by lna-mir-9 or fa similarly attenuated neuronal damage and cerebral atrophy in the rat hippocampus after hibd, which was consistent with the restored expression levels of brain-derived neurotrophic factor (bdnf). |
2020-07-24 |
2023-08-13 |
rat |
| Maryam Zeraati, Mohsen Enayati, Laya Kafami, Seyed Houtan Shahidi, Ali-Akbar Salar. Gut microbiota depletion from early adolescence alters adult immunological and neurobehavioral responses in a mouse model of multiple sclerosis. Neuropharmacology. vol 157. 2020-07-21. PMID:31247271. |
we measured levels of interferon (ifn)-γ, interleukin (il)-17a and il-10 in serum, and bdnf, il-1β and tumor necrosis factor (tnf)-α) in the hippocampus. |
2020-07-21 |
2023-08-13 |
mouse |
| Maryam Zeraati, Mohsen Enayati, Laya Kafami, Seyed Houtan Shahidi, Ali-Akbar Salar. Gut microbiota depletion from early adolescence alters adult immunological and neurobehavioral responses in a mouse model of multiple sclerosis. Neuropharmacology. vol 157. 2020-07-21. PMID:31247271. |
antibiotic treatment significantly decreased hippocampal bdnf and enhanced learning and memory impairments in eae-induced mice. |
2020-07-21 |
2023-08-13 |
mouse |
| Ali Rashidy-Pour, Kowsar Bavarsad, Hossein Miladi-Gorji, Zahra Seraj, Abbas Ali Vafae. Voluntary exercise and estradiol reverse ovariectomy-induced spatial learning and memory deficits and reduction in hippocampal brain-derived neurotrophic factor in rats. Pharmacology, biochemistry, and behavior. vol 187. 2020-07-21. PMID:31697961. |
this study was designed to investigate the effects of voluntary exercise and estrogen replacement on learning and memory deficits and reduction in hippocampal brain derived neurotrophic factor (bdnf) levels induced by ovariectomy. |
2020-07-21 |
2023-08-13 |
rat |
| Ali Rashidy-Pour, Kowsar Bavarsad, Hossein Miladi-Gorji, Zahra Seraj, Abbas Ali Vafae. Voluntary exercise and estradiol reverse ovariectomy-induced spatial learning and memory deficits and reduction in hippocampal brain-derived neurotrophic factor in rats. Pharmacology, biochemistry, and behavior. vol 187. 2020-07-21. PMID:31697961. |
at the end of the behavioral tests, all animals were decapitated and their hippocampal levels of bdnf were measured. |
2020-07-21 |
2023-08-13 |
rat |
| Ali Rashidy-Pour, Kowsar Bavarsad, Hossein Miladi-Gorji, Zahra Seraj, Abbas Ali Vafae. Voluntary exercise and estradiol reverse ovariectomy-induced spatial learning and memory deficits and reduction in hippocampal brain-derived neurotrophic factor in rats. Pharmacology, biochemistry, and behavior. vol 187. 2020-07-21. PMID:31697961. |
ovariectomy impaired spatial learning and memory and reduced hippocampal bdnf levels. |
2020-07-21 |
2023-08-13 |
rat |
| Ali Rashidy-Pour, Kowsar Bavarsad, Hossein Miladi-Gorji, Zahra Seraj, Abbas Ali Vafae. Voluntary exercise and estradiol reverse ovariectomy-induced spatial learning and memory deficits and reduction in hippocampal brain-derived neurotrophic factor in rats. Pharmacology, biochemistry, and behavior. vol 187. 2020-07-21. PMID:31697961. |
exercise significantly improved performance during both training and the retention of the water-maze task and increased hippocampal bdnf. |
2020-07-21 |
2023-08-13 |
rat |
| Jun Yamada, Shozo Jinn. Potential link between antidepressant-like effects of ketamine and promotion of adult neurogenesis in the ventral hippocampus of mice. Neuropharmacology. vol 158. 2020-07-20. PMID:31310776. |
the induction of expression of glun2b subunit of the nmdar, phosphorylated mammalian target of rapamycin (p-mtor), glua1 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampar), and brain derived neurotrophic factor (bdnf), by ketamine was greater in the ventral hippocampus than in the dorsal hippocampus. |
2020-07-20 |
2023-08-13 |
mouse |
| Jun Yamada, Shozo Jinn. Potential link between antidepressant-like effects of ketamine and promotion of adult neurogenesis in the ventral hippocampus of mice. Neuropharmacology. vol 158. 2020-07-20. PMID:31310776. |
furthermore, ventral-dominant induction of the glun2b subunit of nmdar, p-mtor, glua1 subunit of ampar, and bdnf, in the hippocampus may underlie the unique antidepressant-like effects of ketamine. |
2020-07-20 |
2023-08-13 |
mouse |
| Henry L Hallock, Henry M Quillian, Yishan Mai, Kristen R Maynard, Julia L Hill, Keri Martinowic. Manipulation of a genetically and spatially defined sub-population of BDNF-expressing neurons potentiates learned fear and decreases hippocampal-prefrontal synchrony in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 13. 2020-07-08. PMID:31170726. |
brain-derived neurotrophic factor (bdnf) signaling regulates synaptic plasticity in the hippocampus (hc) and prefrontal cortex (pfc), and has been extensively linked with fear memory expression in rodents. |
2020-07-08 |
2023-08-13 |
mouse |
| Aanchal Aggarwal, Nishtha Sharma, Rajat Sandhir, Vikas Rish. S-nitrosoglutathione prevents cognitive impairment through epigenetic reprogramming in ovariectomised mice. Biochemical pharmacology. vol 168. 2020-07-06. PMID:31374192. |
reduced h3 acetylation triggers epigenetic repression of brain derived neurotrophic factor (bdnf) in cortex and hippocampus of ovx mice that may be responsible for neuronal damage and cognitive impairment. |
2020-07-06 |
2023-08-13 |
mouse |
| Yalin Zhou, Minjia Zhang, Wei Liu, Yong Li, Yong Qin, Yajun X. Transgenerational transmission of neurodevelopmental disorders induced by maternal exposure to PM2.5. Chemosphere. vol 255. 2020-07-02. PMID:32387734. |
and the hypermethylation of bdnf promoter Ⅳ and downregulated expression of bdnf in hippocampus were stably transmitted across the generations until the third generation. |
2020-07-02 |
2023-08-13 |
Not clear |
| Marta Andreatta, Dorothea Neueder, Hannah Genheimer, Miriam A Schiele, Christoph Schartner, Jürgen Deckert, Katharina Domschke, Andreas Reif, Matthias J Wieser, Paul Paul. Human BDNF rs6265 polymorphism as a mediator for the generalization of contextual anxiety. Journal of neuroscience research. vol 97. issue 3. 2020-07-01. PMID:30402941. |
the met allele of the human brain-derived neurotrophic factor (bdnf) gene might be a risk factor for anxiety disorders and is associated with reduced hippocampal volume. |
2020-07-01 |
2023-08-13 |
human |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
various immunohistochemical techniques and western blot analyses were applied to examine expressions of trem2, microglia, aβ, neuronal migration protein doublecortin (dcx) and bdnf in the hippocampus of mice. |
2020-06-26 |
2023-08-13 |
mouse |
| Zhuang Miao, Jianghong Zhang, Yuanyuan Li, Xianfeng Li, Wei Song, Zhong Sheng Sun, Yan Wan. Presence of the pregnant partner regulates microRNA-30a and BDNF levels and protects male mice from social defeat-induced abnormal behaviors. Neuropharmacology. vol 159. 2020-06-26. PMID:30946846. |
the levels of bdnf, together with its primary transcripts, were down-regulated in the hippocampus of male mice with csds and these decreases were ameliorated by the presence of their pregnant partners. |
2020-06-26 |
2023-08-13 |
mouse |
| Karem H Alzoubi, Zeinab Y Al Subeh, Omar F Khabou. Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones. Behavioural brain research. vol 369. 2020-06-23. PMID:31047921. |
in the current study, the effect of etazolate on oxidative stress parameters, bdnf, and histone acetylation in the hippocampus were evaluated in a rat model of ptsd. |
2020-06-23 |
2023-08-13 |
rat |
| Karem H Alzoubi, Zeinab Y Al Subeh, Omar F Khabou. Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones. Behavioural brain research. vol 369. 2020-06-23. PMID:31047921. |
at the end of the treatment period, the hippocampus was dissected and oxidative stress biomarkers (gsh, gssg, gpx and tbars), bdnf protein level, and histone acetylation were assessed. |
2020-06-23 |
2023-08-13 |
rat |
| Karem H Alzoubi, Zeinab Y Al Subeh, Omar F Khabou. Molecular targets for the interactive effect of etazolate during post-traumatic stress disorder: Role of oxidative stress, BDNF and histones. Behavioural brain research. vol 369. 2020-06-23. PMID:31047921. |
results revealed that ptsd potentiated oxidative stress in the hippocampus and induced significant reductions in bdnf level and histones acetylation (p < 0.05). |
2020-06-23 |
2023-08-13 |
rat |
| Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zh. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 2. 2020-06-23. PMID:32237313. |
they alleviate hippocampal neuronal toxicity mainly by regulating a variety of neurotransmitters, such as acetylcholine, glutamic acid(glu), γ-aminobutyric acid(gaba), serotonin(5-ht), dopamine(da), norepinephrine(ne), 5-indoleacetic acid(5-hiaa), high vanillic acid(hva) and dihydroxyphenylacetic acid(dopac), pro-inflammatory cell growth factors, such as il-1β, il-6 and tnf-α and relevant receptor functions, and exert neuropharmacological effects by effectively increasing mrna expressions of brain neurotrophic factors, such as bdnf and gdnf, and further inhibiting the apoptosis of damaged neurons. |
2020-06-23 |
2023-08-13 |
Not clear |