| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Zhang, Hu-Qin Zhang, Xiang-Yan Liang, Hai-Feng Zhang, Ting Zhang, Fang-E Li. Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: role of oxidative stress, BDNF and CaMKII. Behavioural brain research. vol 256. 2014-12-18. PMID:23933144. |
the possible mechanism may be attributed to its ability to reduce oxidative stress and increase the levels of camkii and bdnf in cc and hippocampus. |
2014-12-18 |
2023-08-12 |
rat |
| Jianqiang Lu, Yongjun Xu, Weiwu Hu, Yuanwu Gao, Xin Ni, Hui Sheng, Yu Li. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neuroscience letters. vol 573. 2014-12-18. PMID:24813109. |
exercise ameliorates depression-like behavior and increases hippocampal bdnf level in ovariectomized rats. |
2014-12-18 |
2023-08-13 |
rat |
| Jianqiang Lu, Yongjun Xu, Weiwu Hu, Yuanwu Gao, Xin Ni, Hui Sheng, Yu Li. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neuroscience letters. vol 573. 2014-12-18. PMID:24813109. |
given that decreased level of brain-derived neurotrophic factor (bdnf) in many brain areas including hippocampus and prefrontal cortex is associated with estrogen deficiency-induced depression-like behavior, we also determined whether exercise affects the levels of bdnf and its receptor in hippocampus and prefrontal cortex (pfc). |
2014-12-18 |
2023-08-13 |
rat |
| Jianqiang Lu, Yongjun Xu, Weiwu Hu, Yuanwu Gao, Xin Ni, Hui Sheng, Yu Li. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neuroscience letters. vol 573. 2014-12-18. PMID:24813109. |
it was found that ovariectomy (ovx) caused an increase in depression-like behavior in rats and a decrease in bdnf level in hippocampus but not in pfc. |
2014-12-18 |
2023-08-13 |
rat |
| Jianqiang Lu, Yongjun Xu, Weiwu Hu, Yuanwu Gao, Xin Ni, Hui Sheng, Yu Li. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neuroscience letters. vol 573. 2014-12-18. PMID:24813109. |
the expression of trkb, a high affinity bdnf receptor in hippocampus and pfc was not affected by ovx. |
2014-12-18 |
2023-08-13 |
rat |
| Jianqiang Lu, Yongjun Xu, Weiwu Hu, Yuanwu Gao, Xin Ni, Hui Sheng, Yu Li. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neuroscience letters. vol 573. 2014-12-18. PMID:24813109. |
17β-estradiol (e2) treatment ameliorated depression-like behavior and increased bdnf level in hippocampus in ovx rats. |
2014-12-18 |
2023-08-13 |
rat |
| Jianqiang Lu, Yongjun Xu, Weiwu Hu, Yuanwu Gao, Xin Ni, Hui Sheng, Yu Li. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neuroscience letters. vol 573. 2014-12-18. PMID:24813109. |
serum e2 level inversely correlated to depression-like behavior and positively correlated to bdnf level in hippocampus. |
2014-12-18 |
2023-08-13 |
rat |
| Jianqiang Lu, Yongjun Xu, Weiwu Hu, Yuanwu Gao, Xin Ni, Hui Sheng, Yu Li. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neuroscience letters. vol 573. 2014-12-18. PMID:24813109. |
exercise ameliorated depression-like behavior, increased serum e2 level and bdnf level in hippocampus in ovx rats. |
2014-12-18 |
2023-08-13 |
rat |
| Jianqiang Lu, Yongjun Xu, Weiwu Hu, Yuanwu Gao, Xin Ni, Hui Sheng, Yu Li. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neuroscience letters. vol 573. 2014-12-18. PMID:24813109. |
our results suggested that e2 maintains bdnf in hippocampus, thereby ameliorating depression-like behavior. |
2014-12-18 |
2023-08-13 |
rat |
| Catherine J Wei, Elisabete Augusto, Catarina A Gomes, Philipp Singer, Yumei Wang, Detlev Boison, Rodrigo A Cunha, Benjamin K Yee, Jiang-Fan Che. Regulation of fear responses by striatal and extrastriatal adenosine A2A receptors in forebrain. Biological psychiatry. vol 75. issue 11. 2014-12-16. PMID:23820821. |
adenosine a2a receptors (a2ars) are enriched in the striatum but are also present at lower levels in the extrastriatal forebrain (i.e., hippocampus, cortex), integrating dopamine, glutamate, and brain-derived neurotrophic factor (bdnf) signaling, and are thus essential for striatal neuroplasticity and fear and anxiety behavior. |
2014-12-16 |
2023-08-12 |
Not clear |
| Laura L Hurley, Luli Akinfiresoye, Olubukola Kalejaiye, Yousef Tizab. Antidepressant effects of resveratrol in an animal model of depression. Behavioural brain research. vol 268. 2014-12-16. PMID:24717328. |
the major purpose of this study was to investigate whether resveratrol would manifest an antidepressant effect in wistar-kyoto (wky) rats, a putative and non-induced animal model of depression, and whether this effect might be associated with an increase in hippocampal and frontal cortical brain-derived neurotrophic factor (bdnf), a protein implicated in chronic effects of many antidepressants. |
2014-12-16 |
2023-08-13 |
mouse |
| Laura L Hurley, Luli Akinfiresoye, Olubukola Kalejaiye, Yousef Tizab. Antidepressant effects of resveratrol in an animal model of depression. Behavioural brain research. vol 268. 2014-12-16. PMID:24717328. |
parallel to the observed behavioral effects the level of hippocampal, but not frontal cortical, bdnf was also dose-dependently elevated after chronic resveratrol administration. |
2014-12-16 |
2023-08-13 |
mouse |
| Laura L Hurley, Luli Akinfiresoye, Olubukola Kalejaiye, Yousef Tizab. Antidepressant effects of resveratrol in an animal model of depression. Behavioural brain research. vol 268. 2014-12-16. PMID:24717328. |
these findings indicate an antidepressant-like effect of resveratrol in an animal model of depression possibly via activation of hippocampal bdnf, and suggest therapeutic potential of resveratrol in at least a subpopulation of depressed patients. |
2014-12-16 |
2023-08-13 |
mouse |
| Miriam A Vogt, Dragos Inta, Alessia Luoni, Hasan Elkin, Natascha Pfeiffer, Marco A Riva, Peter Gas. Inducible forebrain-specific ablation of the transcription factor Creb during adulthood induces anxiety but no spatial/contextual learning deficits. Frontiers in behavioral neuroscience. vol 8. 2014-12-16. PMID:25505876. |
bdnf, a postulated creb target gene, was down regulated in the frontal lobe but not in the hippocampus; neurogenesis remained unaltered. |
2014-12-16 |
2023-08-13 |
mouse |
| Puneet Rinwa, Anil Kuma. Panax quinquefolium involves nitric oxide pathway in olfactory bulbectomy rat model. Physiology & behavior. vol 129. 2014-12-15. PMID:24582670. |
these deficits were integrated with increased levels of neuroinflammatory cytokines (tnf-α), apoptotic factor (caspase-3) and a marked reduction in neurogenesis factor (bdnf) in both cerebral cortex and hippocampal regions of bulbectomized rats. |
2014-12-15 |
2023-08-12 |
rat |
| Arum Han, Yu-Bin Sung, Soo-Young Chung, Min-Soo Kwo. Possible additional antidepressant-like mechanism of sodium butyrate: targeting the hippocampus. Neuropharmacology. vol 81. 2014-12-15. PMID:24607816. |
sb prevented and normalized the phosphorylation of camp response element binding protein (pcreb), acetylation of histone h3 (aceh3), hdac2, and brain-derived neurotrophic factor (bdnf) expression level that were decreased by crs in the hippocampus. |
2014-12-15 |
2023-08-12 |
mouse |
| Arum Han, Yu-Bin Sung, Soo-Young Chung, Min-Soo Kwo. Possible additional antidepressant-like mechanism of sodium butyrate: targeting the hippocampus. Neuropharmacology. vol 81. 2014-12-15. PMID:24607816. |
however, it seems to be unsuccessful to prevent depression induction since reduction of pcreb, aceh3 and bdnf were accompanied by crs in the hippocampus. |
2014-12-15 |
2023-08-12 |
mouse |
| Jiaqing Yang, Shilei Song, Jian Li, Tao Lian. Neuroprotective effect of curcumin on hippocampal injury in 6-OHDA-induced Parkinson's disease rat. Pathology, research and practice. vol 210. issue 6. 2014-12-12. PMID:24642369. |
furthermore, curcumin obviously up-regulated hippocampal brain derived neurotrophic factor (bdnf), trkb, phosphatidylinositide 3-kinases (pi3k) protein expressions, respectively as shown in western blot analysis. |
2014-12-12 |
2023-08-12 |
rat |
| V S Tomaz, R C Cordeiro, A M N Costa, D F de Lucena, H V Nobre Júnior, F C F de Sousa, S M M Vasconcelos, M L Vale, J Quevedo, D Macêd. Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice. Neuroscience. vol 268. 2014-12-12. PMID:24662848. |
thus, herein we evaluated the effects of no-pathway-modulating drugs, named aminoguanidine, l-name, sildenafil and l-arginine, on the behavioral (forced swimming test [fst], sucrose preference [spt] and prepulse inhibition [ppi] of the startle) and neurochemical (glutathione [gsh], lipid peroxidation, il-1β) alterations in the prefrontal cortex, hippocampus and striatum as well as in bdnf levels in the hippocampus 24h after lps (0.5mg/kg, i.p.) |
2014-12-12 |
2023-08-12 |
mouse |
| V S Tomaz, R C Cordeiro, A M N Costa, D F de Lucena, H V Nobre Júnior, F C F de Sousa, S M M Vasconcelos, M L Vale, J Quevedo, D Macêd. Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice. Neuroscience. vol 268. 2014-12-12. PMID:24662848. |
twenty-four hours post lps there was an increase in immobility time in the fst, decrease in sucrose preference and ppi levels accompanied by a decrease in gsh levels and an increase in lipid peroxidation, il-1β and hippocampal bdnf levels suggestive of a depressive-like state. |
2014-12-12 |
2023-08-12 |
mouse |