| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Yuan Mao, Dan-Feng Cao, Xi Li, Ji-Ye Yin, Zhi-Bin Wang, Ying Zhang, Chen-Xue Mao, Hong-Hao Zhou, Zhao-Qian Li. Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats. International journal of molecular sciences. vol 15. issue 5. 2015-01-06. PMID:24857910. |
after seven weeks, diabetic rats exhibited remarkable reductions in: body weight, percentage of time spent in target quadrant, number of times crossing the platform, chat and bdnf levels, sod, gsh-px and cat accompanied with increases in neuronal damage, plasma glucose levels, escape latency, mean path length, ache, mda level as well as cat, nf-κb p65 unit, tnf-α, il-1β, il-6 and caspase-3 in cerebral cortex and hippocampus. |
2015-01-06 |
2023-08-13 |
rat |
| Amine Bahi, Vijay Chandrasekar, Jean-Luc Dreye. Selective lentiviral-mediated suppression of microRNA124a in the hippocampus evokes antidepressants-like effects in rats. Psychoneuroendocrinology. vol 46. 2015-01-06. PMID:24882160. |
in the current study we aimed to investigate how genetic modulation of bdnf in the hippocampus using microrna124a (mir124a)-expressing lentiviral vectors (lv) might affect depression-like behavior in adult rats. |
2015-01-06 |
2023-08-13 |
rat |
| Amine Bahi, Vijay Chandrasekar, Jean-Luc Dreye. Selective lentiviral-mediated suppression of microRNA124a in the hippocampus evokes antidepressants-like effects in rats. Psychoneuroendocrinology. vol 46. 2015-01-06. PMID:24882160. |
for this purpose, we assessed the expression level of mir124a and its direct target bdnf in the hippocampus and the cortex after 21-days exposure to social defeat stress. |
2015-01-06 |
2023-08-13 |
rat |
| Amine Bahi, Vijay Chandrasekar, Jean-Luc Dreye. Selective lentiviral-mediated suppression of microRNA124a in the hippocampus evokes antidepressants-like effects in rats. Psychoneuroendocrinology. vol 46. 2015-01-06. PMID:24882160. |
however, an anti-depressant like effect was observed when bdnf or mir124a-silencers (sir124a) were injected into the hippocampus. |
2015-01-06 |
2023-08-13 |
rat |
| Amine Bahi, Vijay Chandrasekar, Jean-Luc Dreye. Selective lentiviral-mediated suppression of microRNA124a in the hippocampus evokes antidepressants-like effects in rats. Psychoneuroendocrinology. vol 46. 2015-01-06. PMID:24882160. |
our findings indicate that hippocampal mir124a and its direct target bdnf play an important role in depression-like behavior. |
2015-01-06 |
2023-08-13 |
rat |
| Jianmin Yang, Lauren C Harte-Hargrove, Chia-Jen Siao, Tina Marinic, Roshelle Clarke, Qian Ma, Deqiang Jing, John J Lafrancois, Kevin G Bath, Willie Mark, Douglas Ballon, Francis S Lee, Helen E Scharfman, Barbara L Hempstea. proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell reports. vol 7. issue 3. 2015-01-05. PMID:24746813. |
these results suggest that probdnf acts in vivo as a biologically active factor that regulates hippocampal structure, synaptic transmission, and plasticity, effects that are distinct from those of mature bdnf. |
2015-01-05 |
2023-08-13 |
mouse |
| Dexiang Liu, Qingrui Zhang, Jianhua Gu, Xueer Wang, Kai Xie, Xiuying Xian, Jianmei Wang, Hong Jiang, Zhen Wan. Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 49. 2014-12-31. PMID:24184538. |
additionally, cums exposure significantly elevated serum corticosterone levels and decreased bdnf levels in the prefrontal cortex (pfc) and hippocampus, accompanied by decreased phosphorylation of extracellular signal-regulated kinase (perk) and camp response element-binding protein (pcreb). |
2014-12-31 |
2023-08-12 |
rat |
| Nootchanart Ruksee, Walaiporn Tongjaroenbuangam, Thanutchaporn Mahanam, Piyarat Govitrapon. Melatonin pretreatment prevented the effect of dexamethasone negative alterations on behavior and hippocampal neurogenesis in the mouse brain. The Journal of steroid biochemistry and molecular biology. vol 143. 2014-12-29. PMID:24589478. |
melatonin may protect hippocampal neurons from damage and reverse neurogenesis after chronic dex by activating brain-derived neurotrophic (bdnf) and erk1/2 cascades. |
2014-12-29 |
2023-08-12 |
mouse |
| Yu Song, Taizhen Cui, Na Xie, Xiaoyi Zhang, Zhibin Qian, Juyuan Li. Protocatechuic acid improves cognitive deficits and attenuates amyloid deposits, inflammatory response in aged AβPP/PS1 double transgenic mice. International immunopharmacology. vol 20. issue 1. 2014-12-28. PMID:24667368. |
further, there was a substantial increase of brain derived neurotrophic factor (bdnf) in the hippocampus and cerebral cortex of aβpp/ps1 mice treated with pca (p<0.01). |
2014-12-28 |
2023-08-12 |
mouse |
| Franciele Donato, Marcelo Gomes de Gomes, André Tiago Rossito Goes, Carlos Borges Filho, Lucian Del Fabbro, Michelle S Antunes, Leandro Cattelan Souza, Silvana Peterini Boeira, Cristiano Ricardo Jess. Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NO-cGMP pathway and BDNF levels. Brain research bulletin. vol 104. 2014-12-28. PMID:24709058. |
chronic treatment with hesperidin (0.3 and 1mg/kg) also resulted in an increase in hippocampal brain-derived neurotrophic factor (bdnf) levels. |
2014-12-28 |
2023-08-13 |
mouse |
| Franciele Donato, Marcelo Gomes de Gomes, André Tiago Rossito Goes, Carlos Borges Filho, Lucian Del Fabbro, Michelle S Antunes, Leandro Cattelan Souza, Silvana Peterini Boeira, Cristiano Ricardo Jess. Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NO-cGMP pathway and BDNF levels. Brain research bulletin. vol 104. 2014-12-28. PMID:24709058. |
these results demonstrated that the antidepressant-like effect of hesperidin is likely mediated by inhibition of l-arginine-no-cgmp pathway and by increased of the bdnf levels in hippocampus. |
2014-12-28 |
2023-08-13 |
mouse |
| Jae-Yeon Woo, Wan Gu, Kyung-Ah Kim, Se-Eun Jang, Myung Joo Han, Dong-Hyun Ki. Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated aging mouse model. Anaerobe. vol 27. 2014-12-23. PMID:24657159. |
excessive intake of d-galactose not only impaired memory, which was indicated by passive avoidance, y-maze, and morris water-maze tasks, but also reduced the expression of brain-derived neurotrophic factor (bdnf) and hippocampal doublecortin (dcx) and the activation of camp response element-binding protein (creb). |
2014-12-23 |
2023-08-12 |
mouse |
| Guyoung Kwon, Hyung Eun Lee, Dong Hwa Lee, Hyun Woo, Se Jin Park, Qingtao Gao, Young Je Ahn, Kun Ho Son, Jong Hoon Ry. Spicatoside A enhances memory consolidation through the brain-derived neurotrophic factor in mice. Neuroscience letters. vol 572. 2014-12-23. PMID:24792393. |
previously, we found that the increased mature bdnf (mbdnf) levels in the hippocampal region at a specific time window after the acquisition trial are required for memory consolidation. |
2014-12-23 |
2023-08-13 |
mouse |
| Jayakumar Preethi, Hemant K Singh, Jois Shreyas Venkataraman, Koilmani Emmanuvel Raja. Standardised extract of Bacopa monniera (CDRI-08) improves contextual fear memory by differentially regulating the activity of histone acetylation and protein phosphatases (PP1α, PP2A) in hippocampus. Cellular and molecular neurobiology. vol 34. issue 4. 2014-12-22. PMID:24610280. |
this would subsequently result in an increased brain-derived neurotrophic factor (bdnf) (exon iv) mrna in hippocampus. |
2014-12-22 |
2023-08-12 |
rat |
| Guillermo S Moreno-Piovano, Jorgelina Varayoud, Enrique H Luque, Jorge G Ramo. Long-term ovariectomy increases BDNF gene methylation status in mouse hippocampus. The Journal of steroid biochemistry and molecular biology. vol 144 Pt B. 2014-12-22. PMID:25102255. |
long-term ovariectomy increases bdnf gene methylation status in mouse hippocampus. |
2014-12-22 |
2023-08-13 |
mouse |
| Guillermo S Moreno-Piovano, Jorgelina Varayoud, Enrique H Luque, Jorge G Ramo. Long-term ovariectomy increases BDNF gene methylation status in mouse hippocampus. The Journal of steroid biochemistry and molecular biology. vol 144 Pt B. 2014-12-22. PMID:25102255. |
in the present study, we determined whether the post-ovariectomy (post-ovx) timeframe elapsed before the initiation of chronic e treatment is critical for the estrogenic induction of neurotrophins (brain-derived neurotrophic factor, bdnf, and synaptophysin, syn) in the rodent hippocampus. |
2014-12-22 |
2023-08-13 |
mouse |
| Guillermo S Moreno-Piovano, Jorgelina Varayoud, Enrique H Luque, Jorge G Ramo. Long-term ovariectomy increases BDNF gene methylation status in mouse hippocampus. The Journal of steroid biochemistry and molecular biology. vol 144 Pt B. 2014-12-22. PMID:25102255. |
transcriptional activity in the hippocampus of individual bdnf promoters was assessed by real-time quantitative rt-pcr, and the methylation levels of regulatory regions were analyzed by methylation-specific pcr and combined bisulfite restriction analysis. |
2014-12-22 |
2023-08-13 |
mouse |
| Bombi Lee, Bongjun Sur, Jaegul Shim, Dae-Hyun Hahm, Hyejung Le. Acupuncture stimulation improves scopolamine-induced cognitive impairment via activation of cholinergic system and regulation of BDNF and CREB expressions in rats. BMC complementary and alternative medicine. vol 14. 2014-12-22. PMID:25231482. |
we also investigated the effects of acupuncture stimulation at gv20 on the cholinergic system as well as the expression of brain-derived neurotrophic factor (bdnf) and camp-response element-binding protein (creb) in the hippocampus. |
2014-12-22 |
2023-08-13 |
rat |
| Hei-Jen Huang, Wei-Lin Chen, Rong-Hong Hsieh, Hsiu Mei Hsieh-L. Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer's Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-12-19. PMID:25525451. |
first, we found that treatment with mp significantly reduced the cell death and increased the brain-derived neurotrophic factor (bdnf) level in an organotypic hippocampal slice culture (ohsc). |
2014-12-19 |
2023-08-13 |
mouse |
| Lei Zhang, Hu-Qin Zhang, Xiang-Yan Liang, Hai-Feng Zhang, Ting Zhang, Fang-E Li. Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: role of oxidative stress, BDNF and CaMKII. Behavioural brain research. vol 256. 2014-12-18. PMID:23933144. |
the expression of brain-derived neurotrophic factor (bdnf) and calcium-calmodulin dependent kinase ii (camkii) proteins in cc and hippocampus was assayed by means of immunohistochemistry. |
2014-12-18 |
2023-08-12 |
rat |