| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
it is not known whether brain‑derived neurotrophic factor (bdnf) protects hippocampal neurons from high glucose‑induced apoptosis and/or synaptic plasticity dysfunction. |
2019-03-05 |
2023-08-13 |
rat |
| Yuan Zhong, Yitong Zhu, Ting He, Wei Li, Qinjie Li, Ya Mia. Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365051. |
the present study aimed to assess whether bdnf exerted a neuroprotective effect in rat hippocampal neurons exposed to high glucose and examine the underlying mechanisms. |
2019-03-05 |
2023-08-13 |
rat |
| Catherine Fleitas, Gerard Piñol-Ripoll, Pau Marfull, Daniel Rocandio, Isidro Ferrer, Claire Rampon, Joaquim Egea, Carme Espine. proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing. Molecular brain. vol 11. issue 1. 2019-03-04. PMID:30428894. |
contrarily to bdnf, the precursor form of bdnf (probdnf) induces apoptosis through the specific interaction with p75 and its co-receptor, sortilin.we used hippocampal tissue and cerebrospinal fluid from ad patients and controls. |
2019-03-04 |
2023-08-13 |
mouse |
| Wei Pan, Guang-Fen Zhang, Hui-Hui Li, Mu-Huo Ji, Zhi-Qiang Zhou, Kuan-Yu Li, Jian-Jun Yan. Ketamine differentially restores diverse alterations of neuroligins in brain regions in a rat model of neuropathic pain-induced depression. Neuroreport. vol 29. issue 10. 2019-02-27. PMID:29742620. |
it is noteworthy that ketamine (10 mg/kg) relieved neuropathic pain-induced depressive behaviors and restored alterations of bdnf and nls in the mpfc and the hippocampus at 24 h and 72 h after the administration of ketamine, but only restored bdnf in the acc. |
2019-02-27 |
2023-08-13 |
rat |
| Dandan Liu, Yilu Ye, Linhao Xu, Wenxia Yuan, Qi Zhan. Icariin and mesenchymal stem cells synergistically promote angiogenesis and neurogenesis after cerebral ischemia via PI3K and ERK1/2 pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-02-27. PMID:30245466. |
the combined therapy increased expression of vegf and bdnf to a maximum through activating pi3k and erk1/2 pathways in the hippocampus and frontal cortex in response to transient mcao. |
2019-02-27 |
2023-08-13 |
rat |
| C R A F Diniz, C Becari, A Lesnikova, C Biojone, M C O Salgado, H C Salgado, L B M Resstel, F S Guimarães, E Castrén, P C Casarotto, S R L Joc. Elastase-2 Knockout Mice Display Anxiogenic- and Antidepressant-Like Phenotype: Putative Role for BDNF Metabolism in Prefrontal Cortex. Molecular neurobiology. vol 55. issue 8. 2019-02-26. PMID:29383685. |
increased levels of bdnf were found in the prefrontal cortex but not in the hippocampus of ela2ko mice compared to wt. |
2019-02-26 |
2023-08-13 |
mouse |
| Miguel Ángel Luján, Adriana Castro-Zavala, Laia Alegre-Zurano, Olga Valverd. Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus. Neuropharmacology. vol 143. 2019-02-25. PMID:30273593. |
in parallel, cbd increased expression of type 1 cannabinoid receptor, mapk-creb phosphorylation, bdnf expression, and neural cell proliferation in the hippocampus, and reduced the glua1/2 ampa subunit receptor ratio in the striatum. |
2019-02-25 |
2023-08-13 |
mouse |
| Stine Normann Hansen, David Højland Ipsen, Anne Marie Schou-Pedersen, Jens Lykkesfeldt, Pernille Tveden-Nybor. Long term Westernized diet leads to region-specific changes in brain signaling mechanisms. Neuroscience letters. vol 676. 2019-02-22. PMID:29655945. |
here we investigate the effects of dyslipidemia induced by two high fat diets with or without high sucrose on hippocampal and frontal cortical oxidative stress, brain-derived neurotrophic factor (bdnf) and down-stream markers of synaptic plasticity, as well as alterations in monoaminergic neurotransmitter levels. |
2019-02-22 |
2023-08-13 |
Not clear |
| Kristen R Maynard, John W Hobbs, Mahima Sukumar, Alisha S Kardian, Dennisse V Jimenez, Robert J Schloesser, Keri Martinowic. Bdnf mRNA splice variants differentially impact CA1 and CA3 dendrite complexity and spine morphology in the hippocampus. Brain structure & function. vol 222. issue 7. 2019-02-21. PMID:28324222. |
bdnf mrna splice variants differentially impact ca1 and ca3 dendrite complexity and spine morphology in the hippocampus. |
2019-02-21 |
2023-08-13 |
mouse |
| Kristen R Maynard, John W Hobbs, Mahima Sukumar, Alisha S Kardian, Dennisse V Jimenez, Robert J Schloesser, Keri Martinowic. Bdnf mRNA splice variants differentially impact CA1 and CA3 dendrite complexity and spine morphology in the hippocampus. Brain structure & function. vol 222. issue 7. 2019-02-21. PMID:28324222. |
brain-derived neurotrophic factor (bdnf) is an activity-dependent neurotrophin critical for neuronal plasticity in the hippocampus. |
2019-02-21 |
2023-08-13 |
mouse |
| Kristen R Maynard, John W Hobbs, Mahima Sukumar, Alisha S Kardian, Dennisse V Jimenez, Robert J Schloesser, Keri Martinowic. Bdnf mRNA splice variants differentially impact CA1 and CA3 dendrite complexity and spine morphology in the hippocampus. Brain structure & function. vol 222. issue 7. 2019-02-21. PMID:28324222. |
while individual bdnf 5'utr transcripts influence dendrite morphology in cultured hippocampal neurons, it is unknown whether bdnf splice variants impact dendrite arborization in functional classes of neurons in the intact hippocampus. |
2019-02-21 |
2023-08-13 |
mouse |
| Mikhail Stepanichev, Anna Manolova, Danil Peregud, Mikhail Onufriev, Sofia Freiman, Viktor Aniol, Yulia Moiseeva, Margarita Novikova, Natalia Lazareva, Natalia Gulyaev. Specific Activity Features in the Forced Swim Test: Brain Neurotrophins and Development of Stress-induced Depressive-like Behavior in Rats. Neuroscience. vol 375. 2019-02-21. PMID:29438801. |
the low immobile (li) and high immobile (hi) rats demonstrated elusive differences in expression of bdnf exvi mrna and trka mrna which was higher in the hippocampus and frontal cortex, respectively, of hi rats as compared to li animals. |
2019-02-21 |
2023-08-13 |
rat |
| Mikhail Stepanichev, Anna Manolova, Danil Peregud, Mikhail Onufriev, Sofia Freiman, Viktor Aniol, Yulia Moiseeva, Margarita Novikova, Natalia Lazareva, Natalia Gulyaev. Specific Activity Features in the Forced Swim Test: Brain Neurotrophins and Development of Stress-induced Depressive-like Behavior in Rats. Neuroscience. vol 375. 2019-02-21. PMID:29438801. |
in hippocampus of stressed li rats, the contents of total bdnf mrna decreased. |
2019-02-21 |
2023-08-13 |
rat |
| Mikhail Stepanichev, Anna Manolova, Danil Peregud, Mikhail Onufriev, Sofia Freiman, Viktor Aniol, Yulia Moiseeva, Margarita Novikova, Natalia Lazareva, Natalia Gulyaev. Specific Activity Features in the Forced Swim Test: Brain Neurotrophins and Development of Stress-induced Depressive-like Behavior in Rats. Neuroscience. vol 375. 2019-02-21. PMID:29438801. |
in hippocampus of stressed hi rats, the content of trka mrna increased whereas in frontal cortex, the content of bdnf exon i mrna decreased in both li and hi rats. |
2019-02-21 |
2023-08-13 |
rat |
| Mikhail Stepanichev, Anna Manolova, Danil Peregud, Mikhail Onufriev, Sofia Freiman, Viktor Aniol, Yulia Moiseeva, Margarita Novikova, Natalia Lazareva, Natalia Gulyaev. Specific Activity Features in the Forced Swim Test: Brain Neurotrophins and Development of Stress-induced Depressive-like Behavior in Rats. Neuroscience. vol 375. 2019-02-21. PMID:29438801. |
the levels of bdnf exix and exi as well trkb mrnas were higher in the hippocampus of hi rats as compared to li rats. |
2019-02-21 |
2023-08-13 |
rat |
| Elane N Magn. Proliferative hippocampal activity in a group of patients with Rasmussen's encephalitis: Neuronal, glial, and BDNF tissue expression correlations. Epilepsy & behavior : E&B. vol 82. 2019-02-21. PMID:29579552. |
proliferative hippocampal activity in a group of patients with rasmussen's encephalitis: neuronal, glial, and bdnf tissue expression correlations. |
2019-02-21 |
2023-08-13 |
human |
| Maria Domenica Sanna, Alessandro Quattrone, Nicoletta Galeott. Antidepressant-like actions by silencing of neuronal ELAV-like RNA-binding proteins HuB and HuC in a model of depression in male mice. Neuropharmacology. vol 135. 2019-02-20. PMID:29626565. |
the antidepressant-like phenotype of anti-hub and anti-huc mice was not shown concurrently with the promotion of adult hippocampal neurogenesis in the dentate gyrus, and no increase in the bdnf and creb content was detected. |
2019-02-20 |
2023-08-13 |
mouse |
| Tingxu Yan, Bosai He, Shutong Wan, Mengjie Xu, Huilin Yang, Feng Xiao, Kaishun Bi, Ying Ji. Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism. Scientific reports. vol 7. issue 1. 2019-02-19. PMID:28761074. |
additionally, cums exposure significantly decreased brain derived neurotrophic factor (bdnf) levels in hippocampus as indicated by elisa, immunohistochemistry and immunofluorescence assays, accompanied by down-regulated tyrosine kinase receptor b (trkb)/camp-response element binding protein (creb)/extracellular signal-regulated kinase (erk) and phosphatidylinositol 3 kinase (pi3k)/ protein kinase b (akt)/ glycogen synthase kinase-3β (gsk-3β) signaling pathways. |
2019-02-19 |
2023-08-13 |
mouse |
| Tingxu Yan, Bosai He, Shutong Wan, Mengjie Xu, Huilin Yang, Feng Xiao, Kaishun Bi, Ying Ji. Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism. Scientific reports. vol 7. issue 1. 2019-02-19. PMID:28761074. |
it suggested that sce could improve the depression-like emotional status and associated cognitive deficits in cums mice, which might be mediated by regulation of bdnf levels in hippocampus, as well as up-regulating of trkb/creb/erk and pi3k/akt/gsk-3β pathways. |
2019-02-19 |
2023-08-13 |
mouse |
| Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Diego Botezelli, José Alexandre Curiacos de Almeida Leme, Ricardo José Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology. vol 104. 2019-02-19. PMID:29421605. |
the insulin and brain-derived neurotrophic factor (bdnf) signaling in the hippocampus promotes synaptic plasticity and memory formation. |
2019-02-19 |
2023-08-13 |
rat |