| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pranay Srivastava, Yogesh K Dhuriya, Vivek Kumar, Akriti Srivastava, Richa Gupta, Rajendra K Shukla, Rajesh S Yadav, Hari N Dwivedi, Aditya B Pant, Vinay K Khann. PI3K/Akt/GSK3β induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin. Neurotoxicology. vol 67. 2019-04-08. PMID:29723552. |
the results provide evidence that curcumin exercises its neuroprotective effect involving pi3k/akt pathway which may affect nmda receptors and downstream signalling through trkβ and bdnf in arsenic induced cognitive deficits in hippocampus. |
2019-04-08 |
2023-08-13 |
rat |
| J D Gray, T G Rubin, J F Kogan, J Marrocco, J Weidmann, S Lindkvist, F S Lee, E F Schmidt, B S McEwe. Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice. Molecular psychiatry. vol 23. issue 4. 2019-04-04. PMID:27956743. |
stress-induced changes in the hippocampus have been implicated in mood disorders, and mutations in several genes have now been associated with increased risk, such as brain-derived neurotrophic factor (bdnf). |
2019-04-04 |
2023-08-13 |
mouse |
| M J Eimerbrink, R J Pendry, S L Hodges, J D Wiles, J L Peterman, J D White, H B Hayes, M J Chumley, G W Boeh. The α5-GABA Behavioural brain research. vol 359. 2019-04-03. PMID:30031883. |
post-training treatment with mrk restored behavioral expression of fear in lps-treated animals, despite elevated hippocampal aβ, an effect that may be attributed to increased bdnf mrna expression. |
2019-04-03 |
2023-08-13 |
mouse |
| M J Eimerbrink, R J Pendry, S L Hodges, J D Wiles, J L Peterman, J D White, H B Hayes, M J Chumley, G W Boeh. The α5-GABA Behavioural brain research. vol 359. 2019-04-03. PMID:30031883. |
therefore, our data indicate that mrk can prevent lps- induced cognitive deficits associated with elevated aβ, and restore hippocampal bdnf expression. |
2019-04-03 |
2023-08-13 |
mouse |
| Sita Sharan Patel, R S Ray, Arun Sharma, Vineet Mehta, Anju Katyal, Malairaman Udayaban. Antidepressant and anxiolytic like effects of Urtica dioica leaves in streptozotocin induced diabetic mice. Metabolic brain disease. vol 33. issue 4. 2019-04-01. PMID:29704081. |
chronic diabetes significantly downregulated bdnf (p < 0.001), trkb (p < 0.001), cyclin d1 (p < 0.001), bcl2 (p < 0.05) and autophagy7 (p < 0.001), while upregulated inos (p < 0.05) mrna expression in the hippocampus as compared to control mice. |
2019-04-01 |
2023-08-13 |
mouse |
| Sita Sharan Patel, R S Ray, Arun Sharma, Vineet Mehta, Anju Katyal, Malairaman Udayaban. Antidepressant and anxiolytic like effects of Urtica dioica leaves in streptozotocin induced diabetic mice. Metabolic brain disease. vol 33. issue 4. 2019-04-01. PMID:29704081. |
further, ud treatment significantly upregulated bdnf (p < 0.01), trkb (p < 0.001), cyclin d1 (p < 0.001), bcl2 (p < 0.01), autophagy5 (p < 0.01) and autophagy7 (p < 0.001), while downregulated inos (p < 0.05) mrna expression in the hippocampus of diabetic mice. |
2019-04-01 |
2023-08-13 |
mouse |
| Alberto Ribes-Navarro, Mariam Atef, Sandra Sánchez-Sarasúa, María Teresa Beltrán-Bretones, Francisco Olucha-Bordonau, Ana María Sánchez-Pére. Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29721854. |
as expected, we observed that a hfd increased hippocampal tumor necrosis factor alpha (tnfα) and amyloid precursor protein (app) levels while reducing brain-derived neurotrophic factor (bdnf) expression and neurogenesis. |
2019-04-01 |
2023-08-13 |
Not clear |
| Alberto Ribes-Navarro, Mariam Atef, Sandra Sánchez-Sarasúa, María Teresa Beltrán-Bretones, Francisco Olucha-Bordonau, Ana María Sánchez-Pére. Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29721854. |
in this study, aba restored hfd-induced hippocampal alterations, including irs1 and irs2 expression, tnfα, app, and bdnf levels and neurogenesis. |
2019-04-01 |
2023-08-13 |
Not clear |
| J Bryce Ortiz, Julia M Anglin, Eshaan J Daas, Pooja R Paode, Kenji Nishimura, Cheryl D Conra. BDNF and TrkB Mediate the Improvement from Chronic Stress-induced Spatial Memory Deficits and CA3 Dendritic Retraction. Neuroscience. vol 388. 2019-03-29. PMID:30076998. |
we previously found that hippocampal brain-derived neurotrophic factor (bdnf) was necessary for spatial ability to improve following a post-stress rest period. |
2019-03-29 |
2023-08-13 |
rat |
| J Bryce Ortiz, Julia M Anglin, Eshaan J Daas, Pooja R Paode, Kenji Nishimura, Cheryl D Conra. BDNF and TrkB Mediate the Improvement from Chronic Stress-induced Spatial Memory Deficits and CA3 Dendritic Retraction. Neuroscience. vol 388. 2019-03-29. PMID:30076998. |
the following studies are the first to investigate the involvement of bdnf and its trkb receptor on the recovery process following the end of chronic stress, as it pertains to hippocampal dendritic retraction and spatial memory deficits. |
2019-03-29 |
2023-08-13 |
rat |
| J Bryce Ortiz, Julia M Anglin, Eshaan J Daas, Pooja R Paode, Kenji Nishimura, Cheryl D Conra. BDNF and TrkB Mediate the Improvement from Chronic Stress-induced Spatial Memory Deficits and CA3 Dendritic Retraction. Neuroscience. vol 388. 2019-03-29. PMID:30076998. |
in the first study, hippocampal bdnf was downregulated via rna interference and then hippocampal ca3 and ca1 dendritic complexity were evaluated following chronic stress and a post-stress rest period in male sprague-dawley rats. |
2019-03-29 |
2023-08-13 |
rat |
| J Bryce Ortiz, Julia M Anglin, Eshaan J Daas, Pooja R Paode, Kenji Nishimura, Cheryl D Conra. BDNF and TrkB Mediate the Improvement from Chronic Stress-induced Spatial Memory Deficits and CA3 Dendritic Retraction. Neuroscience. vol 388. 2019-03-29. PMID:30076998. |
downregulating hippocampal bdnf prevented the enhancement of ca3 apical dendritic complexity following the rest period. |
2019-03-29 |
2023-08-13 |
rat |
| J Bryce Ortiz, Julia M Anglin, Eshaan J Daas, Pooja R Paode, Kenji Nishimura, Cheryl D Conra. BDNF and TrkB Mediate the Improvement from Chronic Stress-induced Spatial Memory Deficits and CA3 Dendritic Retraction. Neuroscience. vol 388. 2019-03-29. PMID:30076998. |
these data demonstrate that hippocampal bdnf acting via its trkb receptor is necessary during the post-stress rest period in order to improve the impaired hippocampal structural and cognitive outcomes that occur in response to chronic stress. |
2019-03-29 |
2023-08-13 |
rat |
| Tobias Engeroff, Eszter Füzéki, Lutz Vogt, Johannes Fleckenstein, Sina Schwarz, Silke Matura, Ulrich Pilatus, Ralf Deichmann, Rainer Hellweg, Johannes Pantel, Winfried Banze. Is Objectively Assessed Sedentary Behavior, Physical Activity and Cardiorespiratory Fitness Linked to Brain Plasticity Outcomes in Old Age? Neuroscience. vol 388. 2019-03-29. PMID:30077618. |
brain plasticity outcomes included magnetic resonance spectroscopy (mrs)-based markers, quantitative imaging-based hippocampal volume and bdnf serum levels. |
2019-03-29 |
2023-08-13 |
human |
| Jie Gao, Bingrui Xiong, Bo Zhang, Shan Li, Niannian Huang, Gaofeng Zhan, Riyue Jiang, Ling Yang, Yeshun Wu, Liying Miao, Bin Zhu, Chun Yang, Ailin Lu. Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway. Neuroscience. vol 388. 2019-03-29. PMID:30086367. |
the present study aimed to investigate the therapeutic effects of sulforaphane (sfn) on lipopolysaccharide (lps)-induced spatial learning and memory dysfunction, and tried to elucidate its relationship with the role of hippocampal brain-derived neurotrophic factor (bdnf)-mammalian target of rapamycin (mtor) signaling pathway. |
2019-03-29 |
2023-08-13 |
mouse |
| Joel E Soler, Alfred J Robison, Antonio A Núñez, Lily Ya. Light modulates hippocampal function and spatial learning in a diurnal rodent species: A study using male nile grass rat (Arvicanthis niloticus). Hippocampus. vol 28. issue 3. 2019-03-26. PMID:29251803. |
in addition to the behavioral changes, grass rats in the dimld condition exhibited reduced expression of brain-derived neurotrophic factor (bdnf) in the hippocampus, most notably in the ca1 subregion. |
2019-03-26 |
2023-08-13 |
human |
| Joel E Soler, Alfred J Robison, Antonio A Núñez, Lily Ya. Light modulates hippocampal function and spatial learning in a diurnal rodent species: A study using male nile grass rat (Arvicanthis niloticus). Hippocampus. vol 28. issue 3. 2019-03-26. PMID:29251803. |
when dimld animals were transferred to the brld condition for 4 weeks, the hippocampal bdnf and dendritic spine density significantly increased. |
2019-03-26 |
2023-08-13 |
human |
| Luis E Rosas-Vidal, Valeria Lozada-Miranda, Yisel Cantres-Rosario, Alexis Vega-Medina, Loyda Melendez, Gregory J Quir. Alteration of BDNF in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 13. 2019-03-26. PMID:30127343. |
alteration of bdnf in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance. |
2019-03-26 |
2023-08-13 |
Not clear |
| Luis E Rosas-Vidal, Valeria Lozada-Miranda, Yisel Cantres-Rosario, Alexis Vega-Medina, Loyda Melendez, Gregory J Quir. Alteration of BDNF in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 13. 2019-03-26. PMID:30127343. |
by combining retrograde tracers with bdnf immunohistochemistry, we show that extinction of avoidance increases bdnf expression in ventral hippocampal (vhpc) neurons, but not amygdala neurons, projecting to pl and il. |
2019-03-26 |
2023-08-13 |
Not clear |
| Jitao Li, Youhong Li, Yaxin Sun, Han Wang, Xiao Liu, Yingying Zhao, Hongli Wang, Yun'ai Su, Tianmei S. Chronic mild corticosterone exposure during adolescence enhances behaviors and upregulates neuroplasticity-related proteins in rat hippocampus. Progress in neuro-psychopharmacology & biological psychiatry. vol 89. 2019-03-25. PMID:30392783. |
they also showed increased expression of hippocampal neuroplasticity-related proteins, including bdnf, nectin3, and ampa receptor subunits. |
2019-03-25 |
2023-08-13 |
rat |