| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mikhail Stepanichev, Anna Manolova, Danil Peregud, Mikhail Onufriev, Sofia Freiman, Viktor Aniol, Yulia Moiseeva, Margarita Novikova, Natalia Lazareva, Natalia Gulyaev. Specific Activity Features in the Forced Swim Test: Brain Neurotrophins and Development of Stress-induced Depressive-like Behavior in Rats. Neuroscience. vol 375. 2019-02-21. PMID:29438801. |
the levels of bdnf exix and exi as well trkb mrnas were higher in the hippocampus of hi rats as compared to li rats. |
2019-02-21 |
2023-08-13 |
rat |
| Elane N Magn. Proliferative hippocampal activity in a group of patients with Rasmussen's encephalitis: Neuronal, glial, and BDNF tissue expression correlations. Epilepsy & behavior : E&B. vol 82. 2019-02-21. PMID:29579552. |
proliferative hippocampal activity in a group of patients with rasmussen's encephalitis: neuronal, glial, and bdnf tissue expression correlations. |
2019-02-21 |
2023-08-13 |
human |
| Maria Domenica Sanna, Alessandro Quattrone, Nicoletta Galeott. Antidepressant-like actions by silencing of neuronal ELAV-like RNA-binding proteins HuB and HuC in a model of depression in male mice. Neuropharmacology. vol 135. 2019-02-20. PMID:29626565. |
the antidepressant-like phenotype of anti-hub and anti-huc mice was not shown concurrently with the promotion of adult hippocampal neurogenesis in the dentate gyrus, and no increase in the bdnf and creb content was detected. |
2019-02-20 |
2023-08-13 |
mouse |
| Tingxu Yan, Bosai He, Shutong Wan, Mengjie Xu, Huilin Yang, Feng Xiao, Kaishun Bi, Ying Ji. Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism. Scientific reports. vol 7. issue 1. 2019-02-19. PMID:28761074. |
additionally, cums exposure significantly decreased brain derived neurotrophic factor (bdnf) levels in hippocampus as indicated by elisa, immunohistochemistry and immunofluorescence assays, accompanied by down-regulated tyrosine kinase receptor b (trkb)/camp-response element binding protein (creb)/extracellular signal-regulated kinase (erk) and phosphatidylinositol 3 kinase (pi3k)/ protein kinase b (akt)/ glycogen synthase kinase-3β (gsk-3β) signaling pathways. |
2019-02-19 |
2023-08-13 |
mouse |
| Tingxu Yan, Bosai He, Shutong Wan, Mengjie Xu, Huilin Yang, Feng Xiao, Kaishun Bi, Ying Ji. Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism. Scientific reports. vol 7. issue 1. 2019-02-19. PMID:28761074. |
it suggested that sce could improve the depression-like emotional status and associated cognitive deficits in cums mice, which might be mediated by regulation of bdnf levels in hippocampus, as well as up-regulating of trkb/creb/erk and pi3k/akt/gsk-3β pathways. |
2019-02-19 |
2023-08-13 |
mouse |
| Gabriel Keine Kuga, Vitor Rosetto Muñoz, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Diego Botezelli, José Alexandre Curiacos de Almeida Leme, Ricardo José Gomes, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Paul. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental gerontology. vol 104. 2019-02-19. PMID:29421605. |
the insulin and brain-derived neurotrophic factor (bdnf) signaling in the hippocampus promotes synaptic plasticity and memory formation. |
2019-02-19 |
2023-08-13 |
rat |
| G A Martínez-Levy, L Rocha, F Rodríguez-Pineda, M A Alonso-Vanegas, A Nani, R M Buentello-García, M Briones-Velasco, D San-Juan, J Cienfuegos, C S Cruz-Fuente. Increased Expression of Brain-Derived Neurotrophic Factor Transcripts I and VI, cAMP Response Element Binding, and Glucocorticoid Receptor in the Cortex of Patients with Temporal Lobe Epilepsy. Molecular neurobiology. vol 55. issue 5. 2019-02-18. PMID:28527108. |
we previously reported an increased expression of bdnf messenger for the exon vi in the hippocampus of temporal lobe epilepsy patients compared to an autopsy control group. |
2019-02-18 |
2023-08-13 |
Not clear |
| K M J McMurray, M J Ramaker, A M Barkley-Levenson, P S Sidhu, P K Elkin, M K Reddy, M L Guthrie, J M Cook, V H Rawal, L A Arnold, S C Dulawa, A A Palme. Identification of a novel, fast-acting GABAergic antidepressant. Molecular psychiatry. vol 23. issue 2. 2019-02-15. PMID:28322281. |
finally, 5 days of treatment with a glo1 inhibitor (pbbg), but not flx, induced molecular markers of the antidepressant response including brain-derived neurotrophic factor (bdnf) induction and increased phosphorylated cyclic-amp response-binding protein (pcreb) to creb ratio in the hippocampus and medial prefrontal cortex (mpfc). |
2019-02-15 |
2023-08-13 |
Not clear |
| Di Ye, Li Zhang, Weidong Fan, Xianquan Zhang, Erbo Don. Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1. Epigenetics. vol 13. issue 3. 2019-02-15. PMID:29522357. |
in further experiments, we found that the effect of genipin on prs mice occurs through dna demethylation by inhibiting dna methyltransferase 1 (dnmt1), normalizing the expression of reduced brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2019-02-15 |
2023-08-13 |
mouse |
| Chen-Yi-Yu Zhang, Min-Jie Zeng, Li-Ping Zhou, Ya-Qin Li, Fan Zhao, Zhi-Yuan Shang, Xue-Yang Deng, Zhan-Qiang Ma, Qiang Fu, Shi-Ping Ma, Rong Q. Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression. International immunopharmacology. vol 64. 2019-02-15. PMID:30195108. |
results showed that administration of ba improved depressive-like behaviors and significantly increased the levels of doublecortin (dcx), neuron-specific enolase (nse), and brain-derived neurotrophic factor (bdnf) in hippocampus. |
2019-02-15 |
2023-08-13 |
rat |
| Jianan Li, Xueting Li, Haoran Bi, Baixiang L. The MEK/ERK/CREB signaling pathway is involved in atrazine induced hippocampal neurotoxicity in Sprague Dawley rats. Ecotoxicology and environmental safety. vol 170. 2019-02-15. PMID:30580161. |
finally, a downregulation in the mrna and protein expression levels of members of the mek/erk/creb pathway and downstream factors brain-derived neurotrophic factor (bdnf) and zif268 was observed in hippocampal tissue following atr treatment. |
2019-02-15 |
2023-08-13 |
human |
| Or Burstein, Noa Shoshan, Ravid Doron, Irit Akira. Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD. Progress in neuro-psychopharmacology & biological psychiatry. vol 84. issue Pt A. 2019-02-14. PMID:29458190. |
cannabinoids prevented the shock/srs-induced alterations in social recognition memory, locomotion, passive coping, anxiety-like behavior, anhedonia, fear retrieval, fear extinction and startle response as well as the decrease in bdnf levels in the hippocampus and prefrontal cortex (pfc). |
2019-02-14 |
2023-08-13 |
rat |
| Aline Siteneski, Mauricio P Cunha, Vicente Lieberknecht, Francis L Pazini, Karen Gruhn, Patricia S Brocardo, Ana Lúcia S Rodrigue. Central irisin administration affords antidepressant-like effect and modulates neuroplasticity-related genes in the hippocampus and prefrontal cortex of mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 84. issue Pt A. 2019-02-14. PMID:29524513. |
in this study we investigated the effects of the central administration of irisin or bdnf in predictive tests of antidepressant properties paralleled with the gene expression of peroxisome proliferator-activated receptor gamma co-activator 1α (pgc-1α), fibronectin type iii domain-containing protein 5 (fndc5) and brain-derived neurotrophic factor (bdnf) in the hippocampus and prefrontal cortex of mice. |
2019-02-14 |
2023-08-13 |
mouse |
| Aline Siteneski, Mauricio P Cunha, Vicente Lieberknecht, Francis L Pazini, Karen Gruhn, Patricia S Brocardo, Ana Lúcia S Rodrigue. Central irisin administration affords antidepressant-like effect and modulates neuroplasticity-related genes in the hippocampus and prefrontal cortex of mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 84. issue Pt A. 2019-02-14. PMID:29524513. |
bdnf administration reduced pgc-1α mrna in the hippocampus (6 h) and prefrontal cortex (1 and 6 h). |
2019-02-14 |
2023-08-13 |
mouse |
| Aline Siteneski, Mauricio P Cunha, Vicente Lieberknecht, Francis L Pazini, Karen Gruhn, Patricia S Brocardo, Ana Lúcia S Rodrigue. Central irisin administration affords antidepressant-like effect and modulates neuroplasticity-related genes in the hippocampus and prefrontal cortex of mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 84. issue Pt A. 2019-02-14. PMID:29524513. |
it also increased fndc5 mrna expression in the hippocampus (1 and 6 h), but reduced the expression of this gene and also bdnf mrna in the prefrontal cortex (1 and 6 h). |
2019-02-14 |
2023-08-13 |
mouse |
| Jamshid Faraji, Nabiollah Soltanpour, Hamid Lotfi, Reza Moeeini, Ali-Reza Moharreri, Shabnam Roudaki, S Abedin Hosseini, David M Olson, Ali-Akbar Abdollahi, Nasrin Soltanpour, Majid H Mohajerani, Gerlinde A S Met. Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress. Scientific reports. vol 7. issue 1. 2019-02-12. PMID:28706188. |
social isolation also hampered the resilience of the hypothalamic-pituitary-adrenal axis to chronic stress and reduced hippocampal volume and brain-derived neurotrophic factor (bdnf) expression. |
2019-02-12 |
2023-08-13 |
rat |
| Danusa Mar Arcego, Ana Paula Toniazzo, Rachel Krolow, Carine Lampert, Carolina Berlitz, Emily Dos Santos Garcia, Fabrício do Couto Nicola, Juliana Bender Hoppe, Mariana Maier Gaelzer, Caroline Peres Klein, Camilla Lazzaretti, Carla Dalma. Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats. Molecular neurobiology. vol 55. issue 4. 2019-02-11. PMID:28451885. |
on the other hand, stress affected hippocampal brain-derived neurotrophic factor (bdnf) signaling pathways, and increased expression of subunit of the nmda receptor (nr2a). |
2019-02-11 |
2023-08-13 |
rat |
| Danusa Mar Arcego, Ana Paula Toniazzo, Rachel Krolow, Carine Lampert, Carolina Berlitz, Emily Dos Santos Garcia, Fabrício do Couto Nicola, Juliana Bender Hoppe, Mariana Maier Gaelzer, Caroline Peres Klein, Camilla Lazzaretti, Carla Dalma. Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats. Molecular neurobiology. vol 55. issue 4. 2019-02-11. PMID:28451885. |
the mechanisms underlying these behavioral effects may involve changes in the levels of synaptic proteins in hippocampus: hfd consumption appears to affect synaptic markers, while social isolation affected bdnf signaling more significantly. |
2019-02-11 |
2023-08-13 |
rat |
| Judith T Zelikoff, Nancy L Parmalee, Kevin Corbett, Terry Gordon, Catherine B Klein, Michael Aschne. Microglia Activation and Gene Expression Alteration of Neurotrophins in the Hippocampus Following Early-Life Exposure to E-Cigarette Aerosols in a Murine Model. Toxicological sciences : an official journal of the Society of Toxicology. vol 162. issue 1. 2019-02-07. PMID:29161446. |
exposure to e-cigarette aerosols with and without nicotine caused significant reductions in hippocampal gene expression of ngfr and bdnf, as well as in serum levels of cytokines il-1β, il-2, and il-6. |
2019-02-07 |
2023-08-13 |
mouse |
| Nasra Naeim Ayuob, Manal Galal Abd El Wahab, Soad Shaker Ali, Hanem Saad Abdel-Tawa. Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus. Metabolic brain disease. vol 33. issue 3. 2019-02-05. PMID:29356981. |
behavioral tests, serum corticosterone level, hippocampus protein level of the glucocorticoid receptors (grs) and brain-dreived neurotropic factor (bdnf) were determined after exposure to cums. |
2019-02-05 |
2023-08-13 |
mouse |