| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong Liu, Lili Zhong, Yuwei Zhang, Xuewei Liu, Ji L. Rutin attenuates cerebral ischemia-reperfusion injury in ovariectomized rats via estrogen-receptor-mediated BDNF-TrkB and NGF-TrkA signaling. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 96. issue 5. 2018-11-26. PMID:29420916. |
rutin treatment also increased the levels of erα, erβ, brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), tropomyosin receptor kinase a (trka), trkb, and phospho-camp-responsive element binding protein (p-creb) in rat hippocampus and cerebral cortex. |
2018-11-26 |
2023-08-13 |
rat |
| Wei Han, Xiangjun Dong, Xiaojie Song, Li Cheng, Lingling Xie, Hengsheng Chen, Li Jian. Effects of advanced maternal age on cognitive and emotional development in offspring rats. Behavioural brain research. vol 353. 2018-11-26. PMID:29626499. |
moreover, hematoxylin-eosin (he) staining and nissl staining were conducted to detect differences in the hippocampal morphology of the offspring, and western blot analysis was conducted to detect the protein expression of brain-derived neurotrophic factor (bdnf), camp response element binding protein (creb) and phosphorylated creb (pcreb). |
2018-11-26 |
2023-08-13 |
rat |
| Luanna M P Fernandes, Sabrina C Cartágenes, Mayara A Barros, Taiana C V S Carvalheiro, Nair C F Castro, Marissa G Schamne, Rafael R Lima, Rui D Prediger, Marta C Monteiro, Enéas A Fontes-Júnior, Rodrigo A Cunha, Cristiane S F Mai. Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats. Behavioural brain research. vol 350. 2018-11-26. PMID:29752970. |
to investigate the short-term effects of bei during adolescence, rats underwent 1 or 4 cycles of bei, being evaluated at pnd37 and pnd58, respectively: both groups displayed anxiety-like behavior in the open field and elevated plus-maze tests, as well as short-term memory deficits in the object recognition task; this was associated with transient decreases of bdnf levels and increases of gfap levels in the hippocampus. |
2018-11-26 |
2023-08-13 |
rat |
| Luanna M P Fernandes, Sabrina C Cartágenes, Mayara A Barros, Taiana C V S Carvalheiro, Nair C F Castro, Marissa G Schamne, Rafael R Lima, Rui D Prediger, Marta C Monteiro, Enéas A Fontes-Júnior, Rodrigo A Cunha, Cristiane S F Mai. Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats. Behavioural brain research. vol 350. 2018-11-26. PMID:29752970. |
these findings show that repeated binge-like ethanol episodes from adolescence to adulthood in female rats cause consistent and long-term alterations of anxiety and hippocampal astrogliosis, whereas they trigger a recognition memory deficit paralleled by lower hippocampal bdnf levels, both recovering upon ethanol withdrawal. |
2018-11-26 |
2023-08-13 |
rat |
| Karem H Alzoubi, Enas Mokhemer, Amjad N Abuirmeile. Beneficial effect of etazolate on depression-like behavior and, learning, and memory impairment in a model of Parkinson's disease. Behavioural brain research. vol 350. 2018-11-26. PMID:29758248. |
antioxidant biomarkers and bdnf protein levels were assessed in the hippocampus. |
2018-11-26 |
2023-08-13 |
rat |
| Marissa Giovanna Schamne, Josiel Mileno Mack, Morgana Moretti, Filipe Carvalho Matheus, Roger Walz, Laurence Lanfumey, Rui Daniel Predige. The Gender-Biased Effects of Intranasal MPTP Administration on Anhedonic- and Depressive-Like Behaviors in C57BL/6 Mice: the Role of Neurotrophic Factors. Neurotoxicity research. vol 34. issue 4. 2018-11-26. PMID:29808370. |
we also investigated the immunocontent of neurotrophins (bdnf, gdnf, and vegf) in the hippocampus and prefrontal cortex by western blot. |
2018-11-26 |
2023-08-13 |
mouse |
| Marissa Giovanna Schamne, Josiel Mileno Mack, Morgana Moretti, Filipe Carvalho Matheus, Roger Walz, Laurence Lanfumey, Rui Daniel Predige. The Gender-Biased Effects of Intranasal MPTP Administration on Anhedonic- and Depressive-Like Behaviors in C57BL/6 Mice: the Role of Neurotrophic Factors. Neurotoxicity research. vol 34. issue 4. 2018-11-26. PMID:29808370. |
the observed gender-related effects of mptp on emotional parameters seem to be linked to increased depletion of neurotrophins (particularly bdnf and gdnf) in the hippocampus and prefrontal cortex of female mice. |
2018-11-26 |
2023-08-13 |
mouse |
| Khayelihle B Makhathini, Musa V Mabandla, William M U Daniel. Rosmarinic acid reverses the deleterious effects of repetitive stress and tat protein. Behavioural brain research. vol 353. 2018-11-26. PMID:30029998. |
we also measured plasma corticosterone levels and quantified the expression of mineralocorticoid receptors (mr), glucocorticoid receptors (gr) and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2018-11-26 |
2023-08-13 |
human |
| Khayelihle B Makhathini, Musa V Mabandla, William M U Daniel. Rosmarinic acid reverses the deleterious effects of repetitive stress and tat protein. Behavioural brain research. vol 353. 2018-11-26. PMID:30029998. |
rosmarinic acid attenuated anxiety-like behavior induced by tat and stress, reduced plasma corticosterone levels and increased the expression of hippocampal gr, mr and bdnf when compared to controls. |
2018-11-26 |
2023-08-13 |
human |
| Shu-Qi Dong, Qiu-Ping Zhang, Ji-Xiao Zhu, Min Chen, Cheng-Fu Li, Qing Liu, Di Geng, Li-Tao Y. Gypenosides reverses depressive behavior via inhibiting hippocampal neuroinflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-11-26. PMID:30119182. |
our previous studies have shown that hippocampal glucocorticoid receptor (gr)-brain-derived neurotrophic factor (bdnf)-trkb signaling was involved in the antidepressant-like effects of gypenosides. |
2018-11-26 |
2023-08-13 |
mouse |
| Ze-Mei Zhu, Ji-Hua Yang, Si-Si Yang, Jian-Qin He, Kai-Fang Zhang, Shui-Dong Feng, Hong-Yan Lin. [The effects of dihydromyricetin on cognitive dysfunction in type 2 diabetes mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 33. issue 4. 2018-11-14. PMID:29926637. |
to observe the effects of dihydromyricetin(dhm) on cognitive dysfunction and expression of brain derived neurotrophic factor(bdnf) protein in hippocampus of type 2 diabetic mice(t2dm). |
2018-11-14 |
2023-08-13 |
mouse |
| Hiroshi Maejima, Naohiko Kanemura, Takanori Kokubun, Kenji Murata, Kiyomi Takayanag. Exercise enhances cognitive function and neurotrophin expression in the hippocampus accompanied by changes in epigenetic programming in senescence-accelerated mice. Neuroscience letters. vol 665. 2018-11-13. PMID:29129676. |
aerobic exercise is known to increase expression of neurotrophins, particularly brain-derived neurotrophic factor (bdnf), in the hippocampus and to improve cognitive function. |
2018-11-13 |
2023-08-13 |
mouse |
| Hiroshi Maejima, Naohiko Kanemura, Takanori Kokubun, Kenji Murata, Kiyomi Takayanag. Exercise enhances cognitive function and neurotrophin expression in the hippocampus accompanied by changes in epigenetic programming in senescence-accelerated mice. Neuroscience letters. vol 665. 2018-11-13. PMID:29129676. |
the objective of the present study was to assess the interactive effects of exercise and aging on cognitive function, expression of neurotrophins (bdnf and neurotrophin-4) and their receptors (tyrosine receptor kinase b and p75), and epigenetic regulations, including the activity of hats and hadcs in the hippocampus. |
2018-11-13 |
2023-08-13 |
mouse |
| Tae-Woon Kim, Hye-Sang Par. Physical exercise improves cognitive function by enhancing hippocampal neurogenesis and inhibiting apoptosis in male offspring born to obese mother. Behavioural brain research. vol 347. 2018-11-13. PMID:29551732. |
the result showed that deficits in spatial learning and memory, and short-term memory in male offspring born to obese mothers was associated with decreases in brain-derived neurotrophic factor (bdnf) levels and neurogenesis, and an increase in apoptosis in the hippocampal dentate gyrus. |
2018-11-13 |
2023-08-13 |
rat |
| Tae-Woon Kim, Hye-Sang Par. Physical exercise improves cognitive function by enhancing hippocampal neurogenesis and inhibiting apoptosis in male offspring born to obese mother. Behavioural brain research. vol 347. 2018-11-13. PMID:29551732. |
physical exercise improved spatial learning and memory, and short-term memory by enhancing bdnf levels and neurogenesis, and by inhibiting apoptosis in the hippocampal dentate gyrus of male offspring born to obese mothers. |
2018-11-13 |
2023-08-13 |
rat |
| I-Hua Wei, Kuang-Ti Chen, Mang-Hung Tsai, Ching-Hsiang Wu, Hsien-Yuan Lane, Chih-Chia Huan. Acute Amino Acid d-Serine Administration, Similar to Ketamine, Produces Antidepressant-like Effects through Identical Mechanisms. Journal of agricultural and food chemistry. vol 65. issue 49. 2018-11-12. PMID:29161812. |
the activation of the ampar-mtor signaling pathway, release of brain-derived neurotrophic factor (bdnf), and alteration of ampar and nmdar trafficking in the hippocampus of rats were examined. |
2018-11-12 |
2023-08-13 |
rat |
| Wei Guo, Guhan Nagappan, Bai L. Differential effects of transient and sustained activation of BDNF-TrkB signaling. Developmental neurobiology. vol 78. issue 7. 2018-11-08. PMID:29575722. |
in hippocampal slices, slow delivery of bdnf facilitates ltp, whereas fast application of bdnf enhances basal synaptic transmission in schaffer collateral synapses. |
2018-11-08 |
2023-08-13 |
Not clear |
| Hui Lei, Yu Zhang, Longjian Huang, Shaofeng Xu, Jiang Li, Lichao Yang, Ling Wang, Changhong Xing, Xiaoliang Wang, Ying Pen. L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:29728920. |
in addition, l-nbp significantly increased the expressions of bdnf and ngf, tyrosine phosphorylation of its cognate receptor, and phosphorylation of akt as well as creb at ser133 in the hippocampus of app/ps1 mice. |
2018-11-06 |
2023-08-13 |
mouse |
| Filipe Mega, André Luís Ferreira de Meireles, Francele Valente Piazza, Christiano Spindler, Ethiane Segabinazi, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Simone Marcuzz. Paternal physical exercise demethylates the hippocampal DNA of male pups without modifying the cognitive and physical development. Behavioural brain research. vol 348. 2018-11-05. PMID:29614250. |
the following developmental parameters were examined in male offspring: body growth, physical and cognitive performance, weights of adrenal glands, gonadal fat and hindlimb muscles, bdnf expression and global dna methylation at the hippocampus. |
2018-11-05 |
2023-08-13 |
rat |
| Yan-Jiao Li, Yu-Jiao Li, Liu-Di Yang, Kun Zhang, Kai-Yin Zheng, Xin-Miao Wei, Qi Yang, Wen-Min Niu, Ming-Gao Zhao, Yu-Mei W. Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway. Behavioural brain research. vol 348. 2018-11-05. PMID:29680784. |
slb treatment reversed the decreased expression levels of bdnf and its receptor trkb, and the reduced activation of downstream target proteins including phosphorylated extracellular-regulated protein kinase (p-erk) and phosphorylated camp-response element binding protein (p-creb) in depressived hippocampus. |
2018-11-05 |
2023-08-13 |
mouse |