| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Muaz Belviranlı, Nilsel Okuda. Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. Neuromolecular medicine. vol 20. issue 3. 2019-05-14. PMID:29971668. |
hippocampal bdnf, fndc5, pgc-1α, mtor, arc, cf-os, erk, sirt, and foxo expressions were lower, but nf-κb expressions were higher in the aged control rats than in the young control, young exercised, and aged exercised rats (p < 0.05). |
2019-05-14 |
2023-08-13 |
rat |
| Muaz Belviranlı, Nilsel Okuda. Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. Neuromolecular medicine. vol 20. issue 3. 2019-05-14. PMID:29971668. |
similarly, hippocampal bdnf and fndc5 protein expression were lower in the aged control rats than in the young control, young exercised, and aged exercised rats (p < 0.05). |
2019-05-14 |
2023-08-13 |
rat |
| Muaz Belviranlı, Nilsel Okuda. Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway. Neuromolecular medicine. vol 20. issue 3. 2019-05-14. PMID:29971668. |
these findings show that aging-induced cognitive dysfunction is associated with a decrease in hippocampal expression of pgc-1α, fndc5, and bdnf, and that exercise training might improve cognitive functioning via activation of these genes and proteins. |
2019-05-14 |
2023-08-13 |
rat |
| Danfeng Xu, Di Lian, Zhijie Zhang, Ying Liu, Jiaming Sun, Ling L. Brain-derived neurotrophic factor is regulated via MyD88/NF-κB signaling in experimental Streptococcus pneumoniae meningitis. Scientific reports. vol 7. issue 1. 2019-05-13. PMID:28615695. |
cortical and hippocampal bdnf was assessed using rt-pcr and elisa, respectively. |
2019-05-13 |
2023-08-13 |
mouse |
| Dong Wook Lim, Min Young Um, Taewon Han, Jaekwang Lee, Yun Tai Kim, Suengmok Cho, In-Ho Kim, Daeseok Han, Changho Le. Standardized Citrus unshiu peel extract ameliorates dexamethasone-induced neurotoxicity and depressive-like behaviors in mice. Metabolic brain disease. vol 33. issue 6. 2019-05-13. PMID:30229385. |
additionally, repeated dex injection markedly decreased brain derived neurotrophic factor (bdnf) level, tropomyosin receptor kinase b (trkb), and cyclic amp-response element-binding protein (creb), while scp treatment improved these levels in the cerebral cortex and hippocampus regions. |
2019-05-13 |
2023-08-13 |
mouse |
| Sherin Jacob, Thangarajan Sumath. Extenuation of in utero toxic effects of MeHg in the developing neurons by Fisetin via modulating the expression of synaptic transmission and plasticity regulators in hippocampus of the rat offspring. Chemico-biological interactions. vol 305. 2019-05-10. PMID:30890323. |
fisetin also prevented mehg exposure induced downregulation of brain derived neurotrophic factor (bdnf), glial-cell derived neurotrophic factor (gdnf) protein expressions and hampered reactive astrogliosis in the hippocampus of f |
2019-05-10 |
2023-08-13 |
rat |
| Maria Mele, Sabrina Morelli, Gilda Fazzari, Ennio Avolio, Raffaella Alò, Antonella Piscioneri, Loredana De Bartolo, Rosa Maria Facciolo, Marcello Canonac. Application of the Co-culture Membrane System Pointed to a Protective Role of Catestatin on Hippocampal Plus Hypothalamic Neurons Exposed to Oxygen and Glucose Deprivation. Molecular neurobiology. vol 54. issue 9. 2019-05-08. PMID:27815840. |
similarly, hypothalamic neurons supplied very evident upregulations of glun1, orx1r, and above all of glun2a transcripts along with increased bdnf and orx-a secretion in the presence of hippocampal cells. |
2019-05-08 |
2023-08-13 |
Not clear |
| Meng Zhang, Yating Zhai, Yaping Sun, Wenli Zhang, Qian Li, Darrell Brann, Ruimin Wan. Swimming improves cognitive reserve in ovariectomized rats and enhances neuroprotection after global cerebral ischemia. Brain research. vol 1692. 2019-05-08. PMID:29778778. |
our results revealed that (1) morris water maze and shuttle box test analysis revealed that swimming improved cognitive function in ovx-rats, (2) the levels of psd95 and synaptophysin, as well as the protein expression of p-erk, p-creb and bdnf were all increased in the hippocampus after swimming with or without gci, and (3) swimming also increased the number of surviving neurons and il4 protein expression, while decreasing the iba1 (a microglia marker) level in the hippocampus. |
2019-05-08 |
2023-08-13 |
rat |
| Jing Du, Rodrigo Machado-Vieira, Rushaniya Khairov. Synaptic plasticity in the pathophysiology and treatment of bipolar disorder. Current topics in behavioral neurosciences. vol 5. 2019-05-07. PMID:25236555. |
we conclude that increased serotonin, norepinephrine, dopamine, brain-derived neurotrophic factor (bdnf), acute corticosterone, and antidepressant treatments lead to enhanced synaptic strength in the hippocampus and also correlate with antidepressant-like behaviors. |
2019-05-07 |
2023-08-13 |
Not clear |
| Yu Zhong, Jing Chen, Li Li, Yi Qin, Yi Wei, Shining Pan, Yage Jiang, Jialin Chen, Yubo Xi. PKA-CREB-BDNF signaling pathway mediates propofol-induced long-term learning and memory impairment in hippocampus of rats. Brain research. vol 1691. 2019-05-06. PMID:29684336. |
moreover, hippocampal neun-positive cell loss, long-lasting ultrastructural abnormalities of the neurons and synapses, and long-term down-regulation of pka, pcreb and bdnf protein expression in adult hippocampus were also found. |
2019-05-06 |
2023-08-13 |
rat |
| Qin Ru, Qi Xiong, Mei Zhou, Lin Chen, Xiang Tian, Huqiao Xiao, Chaoying Li, Yi L. Withdrawal from chronic treatment with methamphetamine induces anxiety and depression-like behavior in mice. Psychiatry research. vol 271. 2019-05-06. PMID:30544074. |
additional experiments showed that expression of brain-derived neurotrophic factor (bdnf), phosphorylated tropomyosin receptor kinase b (p-trkb), phosphorylated extracellular signal-related kinase 1/2 (p-erk1/2) and phosphorylated camp-response element binding protein (p-creb) were decreased in the hippocampus and prefrontal cortex of mice in meth group and the level of mitogen activated protein kinase phosphatase-1 (mkp-1) was increased. |
2019-05-06 |
2023-08-13 |
mouse |
| Francele Valente Piazza, Ethiane Segabinazi, André Luís Ferreira de Meireles, Filipe Mega, Christiano de Figueiredo Spindler, Otávio Américo Augustin, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Maria Sol Kruse, Héctor Coirini, Simone Marcuzz. Severe Uncontrolled Maternal Hyperglycemia Induces Microsomia and Neurodevelopment Delay Accompanied by Apoptosis, Cellular Survival, and Neuroinflammatory Deregulation in Rat Offspring Hippocampus. Cellular and molecular neurobiology. vol 39. issue 3. 2019-05-06. PMID:30739252. |
hippocampal modifications were studied through cellular survival by brdu in the dentate gyrus, expression of apoptosis-regulatory proteins (procaspase 3, caspase 3, and bcl-2), bdnf, and neuroinflammatory modulation by interleukins, mhc-i, mhc-ii, iba-1, and gfap proteins. |
2019-05-06 |
2023-08-13 |
rat |
| Francele Valente Piazza, Ethiane Segabinazi, André Luís Ferreira de Meireles, Filipe Mega, Christiano de Figueiredo Spindler, Otávio Américo Augustin, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Maria Sol Kruse, Héctor Coirini, Simone Marcuzz. Severe Uncontrolled Maternal Hyperglycemia Induces Microsomia and Neurodevelopment Delay Accompanied by Apoptosis, Cellular Survival, and Neuroinflammatory Deregulation in Rat Offspring Hippocampus. Cellular and molecular neurobiology. vol 39. issue 3. 2019-05-06. PMID:30739252. |
moreover, in a later stage of development, it was found an increase of tnf-α and a decrease of procaspase 3, caspase 3, mhc-i, il-1β, and bdnf in the hippocampus, as well as impairment in cellular survival in the dentate gyrus. |
2019-05-06 |
2023-08-13 |
rat |
| Leyla Sahin, Ozge Selin Cevik, Dilan Deniz Koyuncu, Sayad Kocaha. Caffeine as a potential arousal enhancer: altered NMDA subunit gene expression without improving cognitive performance in REM sleep deprived rats. Cellular and molecular biology (Noisy-le-Grand, France). vol 65. issue 2. 2019-05-06. PMID:30860473. |
fluidigm access array was used for grin2a, grin2b, bdnf, cdk5/cdk5r1, camkiia genes expression in the hippocampus. |
2019-05-06 |
2023-08-13 |
rat |
| Fabiola Vila Dos Santos, Adriano D S Targa, Ivilin Hammerschmidt, Sílvio M Zanata, Flávia G Maia, Jesui V Visentainer, Oscar O Santos Junior, Belmira Andrade da Costa, Cláudia J Lagranha, Anete C Ferra. Fish oil supplementation reverses behavioral and neurochemical alterations induced by swimming exercise in rats. Physiology & behavior. vol 194. 2019-05-03. PMID:29733851. |
to investigate neurochemical parameters such as fatty acids incorporation within the plasma membrane and brain-derived neurotrophic factor (bdnf) levels, the animals were euthanized, and the hippocampus dissected. |
2019-05-03 |
2023-08-13 |
rat |
| Jiucui Tong, Zhiming Zhou, Weiwei Qi, Siyan Jiang, Bin Yang, Zhengling Zhong, Yuanwei Jia, Xuyi Li, Lei Xiong, Liuwang Ni. Antidepressant effect of helicid in chronic unpredictable mild stress model in rats. International immunopharmacology. vol 67. 2019-05-03. PMID:30530165. |
helicid also reversed cums-induced decreases of 5-ht1a receptor expression and promoted brain derived neurotrophic factor (bdnf) expression in the hippocampus the significant reversal of depressive-like behaviors by helicid is similar to that achieved by fluoxetine. |
2019-05-03 |
2023-08-13 |
rat |
| Xiu-Ling Zhu, Jing-Jing Chen, Fei Han, Chuan Pan, Ting-Ting Zhuang, Ya-Fei Cai, Ya-Ping L. Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats. Psychopharmacology. vol 235. issue 7. 2019-05-01. PMID:29752492. |
increasing evidence has suggested that major depressive disorder (mdd) is highly associated with brain-derived neurotrophic factor (bdnf) levels, dendrites atrophy, and loss of dendritic spines, especially in emotion-associated brain regions including the hippocampus. |
2019-05-01 |
2023-08-13 |
rat |
| Razieh Kooshki, Mehdi Abbasnejad, Saeed Esmaeili-Mahani, Maryam Raoo. The effect of CA1 administration of orexin-A on hippocampal expression of COX-2 and BDNF in a rat model of orofacial pain. Arquivos de neuro-psiquiatria. vol 76. issue 9. 2019-05-01. PMID:30365624. |
the effect of ca1 administration of orexin-a on hippocampal expression of cox-2 and bdnf in a rat model of orofacial pain. |
2019-05-01 |
2023-08-13 |
rat |
| Razieh Kooshki, Mehdi Abbasnejad, Saeed Esmaeili-Mahani, Maryam Raoo. The effect of CA1 administration of orexin-A on hippocampal expression of COX-2 and BDNF in a rat model of orofacial pain. Arquivos de neuro-psiquiatria. vol 76. issue 9. 2019-05-01. PMID:30365624. |
involvement of the ca1 orexin 1 receptor (ox1r) on the modulation of orofacial pain and pain-induced changes in hippocampal expression of cyclooxygenase-2 (cox-2) and brain-derived neurotrophic factor (bdnf) was investigated. |
2019-05-01 |
2023-08-13 |
rat |
| Raul Marin de Souza, Letícia de Souza, Adriano Emanuel Machado, Ana Cristina de Bem Alves, Fernanda Silva Rodrigues, Aderbal S Aguiar, Adair Roberto Soares Dos Santos, Andreza Fabro de Bem, Eduardo Luiz Gasnhar Moreir. Behavioural, metabolic and neurochemical effects of environmental enrichment in high-fat cholesterol-enriched diet-fed mice. Behavioural brain research. vol 359. 2019-04-23. PMID:30287273. |
on the other hand, ee was unable to mitigate a decrease in brain-derived neurotrophic factor (bdnf) and il-6 hippocampal levels induced by the hfecd. |
2019-04-23 |
2023-08-13 |
mouse |