| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Juan Jin, Lei Pei, Ya-Nan Li, Hui Zheng, Shuai Yang, Yan Wan, Ling Mao, Yuan-Peng Xia, Quan-Wei He, Man Li, Zhen-Yu Yue, Bo H. Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression. Scientific reports. vol 7. issue 1. 2019-07-15. PMID:29097744. |
we found a statistically significant increase in dna methylation at specific cpg sites (loci 2) of bdnf promoter iv in the hippocampus of psd mice. |
2019-07-15 |
2023-08-13 |
mouse |
| Akram Zamani, Junhua Xiao, Ann M Turnley, Simon S Murra. Tropomyosin-Related Kinase B (TrkB) Regulates Neurite Outgrowth via a Novel Interaction with Suppressor of Cytokine Signalling 2 (SOCS2). Molecular neurobiology. vol 56. issue 2. 2019-07-12. PMID:29881947. |
brain-derived neurotrophic factor (bdnf) is highly expressed in the hippocampus, where it can initiate signalling pathways leading to neurite outgrowth, neuron survival, spine maturation and increased synapse strength. |
2019-07-12 |
2023-08-13 |
Not clear |
| Amanda J Sales, Manoela V Fogaça, Ariandra G Sartim, Vitor S Pereira, Gregers Wegener, Francisco S Guimarães, Sâmia R L Joc. Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex. Molecular neurobiology. vol 56. issue 2. 2019-07-11. PMID:29869197. |
the acute antidepressant effects (30 min) were associated with increased expression of synaptophysin and psd95 in the medial prefrontal cortex (mpfc) and elevated bdnf levels in both mpfc and hippocampus (hpc). |
2019-07-11 |
2023-08-13 |
mouse |
| Lu Luo, Congqin Li, Xinxin Du, Qilin Shi, Qiao Huang, Xiangyu Xu, Qiang Wan. Effect of aerobic exercise on BDNF/proBDNF expression in the ischemic hippocampus and depression recovery of rats after stroke. Behavioural brain research. vol 362. 2019-07-11. PMID:30500428. |
bdnf and probdnf play an opposite role in hippocampal neurogenesis. |
2019-07-11 |
2023-08-13 |
rat |
| Lu Luo, Congqin Li, Xinxin Du, Qilin Shi, Qiao Huang, Xiangyu Xu, Qiang Wan. Effect of aerobic exercise on BDNF/proBDNF expression in the ischemic hippocampus and depression recovery of rats after stroke. Behavioural brain research. vol 362. 2019-07-11. PMID:30500428. |
what remains to be known is the effect of balance between bdnf and probdnf in the ischemic hippocampus on pathogenesis of post-stroke depression (psd) and the potential mechanisms of aerobic exercise (ae) on psd. |
2019-07-11 |
2023-08-13 |
rat |
| D Lucia, D Burgess, C L Cullen, E S Dorey, O Rawashdeh, K M Morit. Periconceptional maternal alcohol consumption leads to behavioural changes in adult and aged offspring and alters the expression of hippocampal genes associated with learning and memory and regulators of the epigenome. Behavioural brain research. vol 362. 2019-07-11. PMID:30633938. |
pc:etoh resulted in an upregulation of hippocampal mrna expression of bdnf, grin2a and grin2b at 18 months of age along with increased expression of epigenetic modifiers (dnmt1, dnmt3a and hdac2). |
2019-07-11 |
2023-08-13 |
rat |
| Martina Parrini, Diego Ghezzi, Gabriele Deidda, Lucian Medrihan, Enrico Castroflorio, Micol Alberti, Pietro Baldelli, Laura Cancedda, Andrea Contestabil. Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome. Scientific reports. vol 7. issue 1. 2019-07-05. PMID:29203796. |
additionally, the expression of brain-derived neurotrophic factor (bdnf) was markedly decreased in the hippocampus of patients with ds. |
2019-07-05 |
2023-08-13 |
mouse |
| Katarina Buzgoova, Jan Graban, Lucia Balagova, Natasa Hlavacova, Daniela Jezov. Brain derived neurotrophic factor expression and DNA methylation in response to subchronic valproic acid and/or aldosterone treatment. Croatian medical journal. vol 60. issue 2. 2019-07-05. PMID:31044578. |
to test the hypothesis that valproic acid treatment positively affects brain-derived neurotrophic factor (bdnf) expression and dna methylation in the hippocampus and brain cortex of rats simultaneously treated with aldosterone. |
2019-07-05 |
2023-08-13 |
rat |
| Li Wang, Yilixiati Xiaokaiti, Gang Wang, Xiaoxiao Xu, Ling Chen, Xianfeng Huang, Li Liu, Jianchun Pan, Shuqun Hu, Zhuoyou Chen, Ying X. Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways. Scientific reports. vol 7. issue 1. 2019-06-27. PMID:28935920. |
il-22 and il-17, bax and bcl-2, pka/pkg and the brain derived neurotropic factor (bdnf) levels in hippocampus and cortex were detected with immunoblotting assay. |
2019-06-27 |
2023-08-13 |
Not clear |
| Katja Burk, Binu Ramachandran, Saheeb Ahmed, Joaquin I Hurtado-Zavala, Ankit Awasthi, Eva Benito, Ruth Faram, Hamid Ahmad, Aarti Swaminathan, Jeffrey McIlhinney, Andre Fischer, Pavel Perestenko, Camin Dea. Regulation of Dendritic Spine Morphology in Hippocampal Neurons by Copine-6. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 4. 2019-06-26. PMID:28158493. |
we found that brain-derived neurotrophic factor (bdnf) - a molecule essential for long-term potentiation of synaptic strength - upregulated and recruited copine-6 to dendritic spines in hippocampal neurons. |
2019-06-26 |
2023-08-13 |
Not clear |
| Xing-Ming Wang, Wei Pan, Ning Xu, Zhi-Qiang Zhou, Guang-Fen Zhang, Jin-Chun She. Environmental enrichment improves long-term memory impairment and aberrant synaptic plasticity by BDNF/TrkB signaling in nerve-injured mice. Neuroscience letters. vol 694. 2019-06-21. PMID:30496785. |
the pain threshold, long-term memory, expression of brain-derived neurotrophic factor (bdnf) and synaptic plasticity in hippocampus were determined. |
2019-06-21 |
2023-08-13 |
mouse |
| Xing-Ming Wang, Wei Pan, Ning Xu, Zhi-Qiang Zhou, Guang-Fen Zhang, Jin-Chun She. Environmental enrichment improves long-term memory impairment and aberrant synaptic plasticity by BDNF/TrkB signaling in nerve-injured mice. Neuroscience letters. vol 694. 2019-06-21. PMID:30496785. |
cci also induced the reduction of bdnf expression and synaptic plasticity impairments in the hippocampus, as represented by the dendritic spine density and postsynaptic density protein (psd)-95 reduction, and long-term potential (ltp) dysfunction. |
2019-06-21 |
2023-08-13 |
mouse |
| C Jiang, W-J Lin, M Sadahiro, B Labonté, C Menard, M L Pfau, C A Tamminga, G Turecki, E J Nestler, S J Russo, S R Salto. VGF function in depression and antidepressant efficacy. Molecular psychiatry. vol 23. issue 7. 2019-06-17. PMID:29158577. |
in hippocampus, the antidepressant response to ketamine is associated with rapid vgf translation, is impaired by reduced vgf expression, and as previously reported, requires coincident, rapid bdnf translation and release. |
2019-06-17 |
2023-08-13 |
mouse |
| Xiaoli Wu, Benqin Tang, Xian Liao, Ziren Su, Simon Ming-Yuen Lee, Yefeng Cai, Chuwen L. Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice. Food & function. vol 10. issue 2. 2019-06-14. PMID:30741293. |
interestingly, further investigations demonstrated that sec inhibited cums-induced activation of the nuclear factor kappa b (nf-κb) and nod-like receptor protein 3 (nlrp3) inflammasomes pathways but upregulated brain-derived neurotrophic factor (bdnf) expression and promoted phosphorylation of extracellular signal-regulated kinase (erk) and camp-response element-binding protein (creb) in hippocampal. |
2019-06-14 |
2023-08-13 |
mouse |
| b' Jelena Petrovi\\xc4\\x87, Du\\xc5\\xa1anka Stani\\xc4\\x87, Zorica Bulat, Nela Pu\\xc5\\xa1ka\\xc5\\xa1, Milica Labudovi\\xc4\\x87-Borovi\\xc4\\x87, Bojan Batini\\xc4\\x87, Du\\xc5\\xa1ko Mirkovi\\xc4\\x87, Svetlana Ignjatovi\\xc4\\x87, Vesna Pe\\xc5\\xa1i\\xc4\\x8. Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration. Hormones and behavior. vol 105. 2019-06-12. PMID:30025718.' |
our results support beneficial behavioral impact of mg in trd model together with increased hippocampal neurogenesis and bdnf expression. |
2019-06-12 |
2023-08-13 |
rat |
| Su-Su Tang, Yi Ren, Li-Jie Xu, Jing-Ran Cao, Hao Hong, Hui Ji, Qing-Hua H. Activation of ERα and/or ERβ ameliorates cognitive impairment and apoptosis in streptozotocin-induced diabetic mice. Hormones and behavior. vol 105. 2019-06-12. PMID:30096284. |
importantly, treatment with the pharmacologic ers agonists caused significant increases in the membrane erα and erβ expression and subsequent pi3k/akt, creb and bdnf activation in the hippocampus of diabetic mice. |
2019-06-12 |
2023-08-13 |
mouse |
| Hong Liu, Jie Yang, Kai Wang, Tengfei Niu, Dongya Huan. Moderate- and Low-Dose of Atorvastatin Alleviate Cognition Impairment Induced by High-Fat Diet via Sirt1 Activation. Neurochemical research. vol 44. issue 5. 2019-06-11. PMID:30820818. |
the level of cognition development was examined by morris water maze (mwm) approach and novel object recognition test (nort); besides, the expression of creb1, gap-43, bdnf, camkii, and erks of frontal cortex and hippocampus was determined by reverse transcription polymerase chain reaction (rt-pcr). |
2019-06-11 |
2023-08-13 |
mouse |
| Abhik Sen, Thomas J Nelson, Daniel L Alkon, Jarin Hongpaisa. Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer's Disease Hippocampus. Journal of Alzheimer's disease : JAD. vol 63. issue 3. 2019-06-10. PMID:29710707. |
loss in pkc epsilon causes downregulation of mnsod and bdnf expression in neurons of alzheimer's disease hippocampus. |
2019-06-10 |
2023-08-13 |
mouse |
| Abhik Sen, Thomas J Nelson, Daniel L Alkon, Jarin Hongpaisa. Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer's Disease Hippocampus. Journal of Alzheimer's disease : JAD. vol 63. issue 3. 2019-06-10. PMID:29710707. |
reduced levels of pkcɛ, mnsod, and bdnf and an increased level of aβ were also found in hippocampal neurons from autopsy-confirmed ad patients. |
2019-06-10 |
2023-08-13 |
mouse |
| Ji-Xiao Zhu, Jia-Ling Shan, Wei-Qiong Hu, Jin-Xiang Zeng, Ji-Cheng Sh. Gallic acid activates hippocampal BDNF-Akt-mTOR signaling in chronic mild stress. Metabolic brain disease. vol 34. issue 1. 2019-06-06. PMID:30280285. |
in addition, gallic acid promoted both the bdnf and p-trkb levels in the hippocampus induced by cms. |
2019-06-06 |
2023-08-13 |
mouse |