| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuai Lian, Bin Xu, Di Wang, Lipeng Wang, Wenjie Li, Ruizhi Yao, Hong Ji, Jianfa Wang, Jingru Guo, Shize Li, Huanmin Yan. Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats. Behavioural brain research. vol 359. 2019-04-19. PMID:30423388. |
the results showed that prenatal cold stress affected offspring hpa axis activity, inhibited the expression of mr, bdnf and igf1r in the hippocampus of male offspring, and lowered the expression of gr in female offspring. |
2019-04-19 |
2023-08-13 |
rat |
| Jian Liu, Han-Xiao Zhu, Wan-Li Fu, Xin-Wei Xu, Jun-Zhe Yang, Dan Dai, Yun L. Downregulated hippocampal expression of brain derived neurotrophic factor and tyrosine kinase B in a rat model of comorbid epilepsy and depression. Neurological research. vol 41. issue 5. 2019-04-18. PMID:30741614. |
to investigate the expression of brain-derived neurotrophic factor(bdnf) and tyrosine kinase b (trkb) protein in the hippocampus of model rats of comorbid epilepsy and depression. |
2019-04-18 |
2023-08-13 |
rat |
| Chan Li, Genghong Tu, Chaohua Luo, Youli Guo, Miao Fang, Chen Zhu, Hancheng Li, Jinying Ou, Yuting Zhou, Wei Liu, Ken Kin Lam Yung, Zhixian M. Effects of rhynchophylline on the hippocampal miRNA expression profile in ketamine-addicted rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 86. 2019-04-15. PMID:29476799. |
interestingly, we found that the downstream protein of nurr1, brain-derived neurotrophic factor (bdnf), showed identical expression trends in the hippocampus as nurr1. |
2019-04-15 |
2023-08-13 |
rat |
| Yong-Ku Kim, Byung-Joo Ham, Kyu-Man Ha. Interactive effects of genetic polymorphisms and childhood adversity on brain morphologic changes in depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 91. 2019-04-15. PMID:29535036. |
individuals with the met allele of bdnf val66met and a history of childhood adversity had reduced volume in the hippocampus and its subfields, amygdala, and pfc and thinner rostral acc in a study of depressed patients and healthy controls. |
2019-04-15 |
2023-08-13 |
Not clear |
| Michelle T Tong, Tae-Young P Kim, Thomas A Clelan. Kinase activity in the olfactory bulb is required for odor memory consolidation. Learning & memory (Cold Spring Harbor, N.Y.). vol 25. issue 5. 2019-04-15. PMID:29661832. |
long-term fear memory formation in the hippocampus and neocortex depends upon brain-derived neurotrophic factor (bdnf) signaling after acquisition. |
2019-04-15 |
2023-08-13 |
mouse |
| Lícia P Pereira, Cristiano A Köhler, Brendon Stubbs, Kamilla W Miskowiak, Gerwyn Morris, Bárbara P de Freitas, Trevor Thompson, Brisa S Fernandes, André R Brunoni, Michael Maes, Diego A Pizzagalli, André F Carvalh. Imaging genetics paradigms in depression research: Systematic review and meta-analysis. Progress in neuro-psychopharmacology & biological psychiatry. vol 86. 2019-04-15. PMID:29778546. |
total hippocampal volumes did not significantly vary in mdd participants or controls carrying either the bdnf val66met 'met' (386 participants with mdd and 376 controls) or the 5-httlpr short 's' (310 participants with mdd and 230 controls) risk alleles compared to non-carriers. |
2019-04-15 |
2023-08-13 |
human |
| Lícia P Pereira, Cristiano A Köhler, Brendon Stubbs, Kamilla W Miskowiak, Gerwyn Morris, Bárbara P de Freitas, Trevor Thompson, Brisa S Fernandes, André R Brunoni, Michael Maes, Diego A Pizzagalli, André F Carvalh. Imaging genetics paradigms in depression research: Systematic review and meta-analysis. Progress in neuro-psychopharmacology & biological psychiatry. vol 86. 2019-04-15. PMID:29778546. |
our data also suggest that the methodological quality of included studies, publication year, and the inclusion of brain volume as a covariate contributed to the heterogeneity of studies that assessed the association of the bdnf val66met 'met' risk allele and hippocampal volumes. |
2019-04-15 |
2023-08-13 |
human |
| Hanjie Yu, Dan Lv, Mengxin Shen, Yanhua Zhang, Dongsheng Zhou, Zhongming Chen, Chuang Wan. BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1. Psychiatry research. vol 271. 2019-04-15. PMID:30529315. |
in addition, the reserpine-induced decreases in serotonin transporter (5-htt), brain-derived neurotrophic factor (bdnf) and tryptophan hydroxylase 1 (tph1) in mouse hippocampus and prefrontal cortex (pfc) were significantly reversed by scopolamine. |
2019-04-15 |
2023-08-13 |
mouse |
| Hanjie Yu, Dan Lv, Mengxin Shen, Yanhua Zhang, Dongsheng Zhou, Zhongming Chen, Chuang Wan. BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1. Psychiatry research. vol 271. 2019-04-15. PMID:30529315. |
our study provides evidence that scopolamine rapidly attenuates reserpine-induced depression in mice partially by regulating 5-htt, bdnf and tph1 in the hippocampus and pfc of mice. |
2019-04-15 |
2023-08-13 |
mouse |
| b' Nata\\xc5\\xa1a Popovi\\xc4\\x87, Vesna Stojiljkovi\\xc4\\x87, Sne\\xc5\\xbeana Peji\\xc4\\x87, Ana Todorovi\\xc4\\x87, Ivan Pavlovi\\xc4\\x87, Ljubica Gavrilovi\\xc4\\x87, Sne\\xc5\\xbeana B Pajovi\\xc4\\x8. Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium. Oxidative medicine and cellular longevity. vol 2019. 2019-04-15. PMID:30911352.' |
in addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (da) and malondialdehyde (mda), protein levels of brain-derived neurotrophic factor (bdnf), tyrosine hydroxylase (th), dopamine transporter (dat), and catechol-o-methyltransferase (comt), as well as activity of monoamine oxidase (mao) in chronically stressed rats. |
2019-04-15 |
2023-08-13 |
rat |
| Esen Gumuslu, Oguz Mutlu, Sibel Kokturk, Guner Ulak, Fatma Ceyla Eraldemir, Ozan Can Tatar, Alisan Burak Yasar, Pelin Tanyeri, Furuzan Akar, Faruk Erde. Effects of Asenapine and Paliperidone on Depression, Anxiety and Analgesy in Mice: Alterations in Brain Neurotrophic Factors, Neurogenesis, and Blood Enzyme Levels. The Chinese journal of physiology. vol 61. issue 5. 2019-04-12. PMID:30384401. |
moreover effectsof drugs, on expression levels of brain neurotrophic factors [brain-derived neurotrophic factor(bdnf), camp response element binding protein (creb),nerve growth factor (ngf), synapsin andfibroblast growth factor 2 (fgf2)] in the hippocampus of mice, neurogenesis and neurodegeneration,and blood enzyme levels were also investigated. |
2019-04-12 |
2023-08-13 |
mouse |
| Su-Su Tang, Yi Ren, Xiao-Qian Ren, Jing-Ran Cao, Hao Hong, Hui Ji, Qing-Hua H. ERα and/or ERβ activation ameliorates cognitive impairment, neurogenesis and apoptosis in type 2 diabetes mellitus mice. Experimental neurology. vol 311. 2019-04-10. PMID:30201537. |
importantly, treatment with the pharmacologic ers agonists caused significant increases in the membrane erα and erβ expression and subsequent pi3k/akt, creb and bdnf activation in the hippocampus of type 2 diabetes mellitus mice. |
2019-04-10 |
2023-08-13 |
mouse |
| Lívea Dornela Godoy, Eduardo H L Umeoka, Deidiane Elisa Ribeiro, Victor Rodrigues Santos, José Antunes-Rodrigues, Samia Regiane Lourenço Joca, Norberto Garcia-Cairasc. Multimodal early-life stress induces biological changes associated to psychopathologies. Hormones and behavior. vol 100. 2019-04-09. PMID:29548783. |
although it has been shown that els-induced changes in hippocampus can be used as biomarkers, multimodal els did not significantly alter bdnf, tyrosine kinase b (trkb) receptor expression or neurogenesis in the hippocampus. |
2019-04-09 |
2023-08-13 |
rat |
| N V Gulyaev. [Staging of neuroplasticity alterations during epileptogenesis (temporal lobe epileply as an example)]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 117. issue 9. Vyp. 2. 2019-04-08. PMID:29213032. |
during the epileptogenesis, multiple events resulting in forming of epileptic neuronal nets occur: changes in glutamatergic and gabaergic neurons, increase of aberrant neurogenesis, axonal sprouting and dendrite remodeling, particularly, supported by an excessive enhancement of the bdnf system in specific hippocampal regions. |
2019-04-08 |
2023-08-13 |
Not clear |
| Pranay Srivastava, Yogesh K Dhuriya, Vivek Kumar, Akriti Srivastava, Richa Gupta, Rajendra K Shukla, Rajesh S Yadav, Hari N Dwivedi, Aditya B Pant, Vinay K Khann. PI3K/Akt/GSK3β induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin. Neurotoxicology. vol 67. 2019-04-08. PMID:29723552. |
the results provide evidence that curcumin exercises its neuroprotective effect involving pi3k/akt pathway which may affect nmda receptors and downstream signalling through trkβ and bdnf in arsenic induced cognitive deficits in hippocampus. |
2019-04-08 |
2023-08-13 |
rat |
| J D Gray, T G Rubin, J F Kogan, J Marrocco, J Weidmann, S Lindkvist, F S Lee, E F Schmidt, B S McEwe. Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice. Molecular psychiatry. vol 23. issue 4. 2019-04-04. PMID:27956743. |
stress-induced changes in the hippocampus have been implicated in mood disorders, and mutations in several genes have now been associated with increased risk, such as brain-derived neurotrophic factor (bdnf). |
2019-04-04 |
2023-08-13 |
mouse |
| M J Eimerbrink, R J Pendry, S L Hodges, J D Wiles, J L Peterman, J D White, H B Hayes, M J Chumley, G W Boeh. The α5-GABA Behavioural brain research. vol 359. 2019-04-03. PMID:30031883. |
post-training treatment with mrk restored behavioral expression of fear in lps-treated animals, despite elevated hippocampal aβ, an effect that may be attributed to increased bdnf mrna expression. |
2019-04-03 |
2023-08-13 |
mouse |
| M J Eimerbrink, R J Pendry, S L Hodges, J D Wiles, J L Peterman, J D White, H B Hayes, M J Chumley, G W Boeh. The α5-GABA Behavioural brain research. vol 359. 2019-04-03. PMID:30031883. |
therefore, our data indicate that mrk can prevent lps- induced cognitive deficits associated with elevated aβ, and restore hippocampal bdnf expression. |
2019-04-03 |
2023-08-13 |
mouse |
| Sita Sharan Patel, R S Ray, Arun Sharma, Vineet Mehta, Anju Katyal, Malairaman Udayaban. Antidepressant and anxiolytic like effects of Urtica dioica leaves in streptozotocin induced diabetic mice. Metabolic brain disease. vol 33. issue 4. 2019-04-01. PMID:29704081. |
chronic diabetes significantly downregulated bdnf (p < 0.001), trkb (p < 0.001), cyclin d1 (p < 0.001), bcl2 (p < 0.05) and autophagy7 (p < 0.001), while upregulated inos (p < 0.05) mrna expression in the hippocampus as compared to control mice. |
2019-04-01 |
2023-08-13 |
mouse |
| Sita Sharan Patel, R S Ray, Arun Sharma, Vineet Mehta, Anju Katyal, Malairaman Udayaban. Antidepressant and anxiolytic like effects of Urtica dioica leaves in streptozotocin induced diabetic mice. Metabolic brain disease. vol 33. issue 4. 2019-04-01. PMID:29704081. |
further, ud treatment significantly upregulated bdnf (p < 0.01), trkb (p < 0.001), cyclin d1 (p < 0.001), bcl2 (p < 0.01), autophagy5 (p < 0.01) and autophagy7 (p < 0.001), while downregulated inos (p < 0.05) mrna expression in the hippocampus of diabetic mice. |
2019-04-01 |
2023-08-13 |
mouse |