| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tongfei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang, Jun Yin, Xiaoguang Li, LuLin Jiang, Andrew P Hodges, Sara Brin Rosenthal, Lisa Zhou, Joel Yancey, Amanda McQuade, Mathew Blurton-Jones, Rudolph E Tanzi, Timothy Y Huang, Huaxi X. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. The Journal of experimental medicine. vol 217. issue 12. 2021-03-11. PMID:32941599. |
multi-omic comparison of alzheimer's variants in human esc-derived microglia reveals convergence at apoe. |
2021-03-11 |
2023-08-13 |
mouse |
| Tongfei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang, Jun Yin, Xiaoguang Li, LuLin Jiang, Andrew P Hodges, Sara Brin Rosenthal, Lisa Zhou, Joel Yancey, Amanda McQuade, Mathew Blurton-Jones, Rudolph E Tanzi, Timothy Y Huang, Huaxi X. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. The Journal of experimental medicine. vol 217. issue 12. 2021-03-11. PMID:32941599. |
using this modeling and analysis platform for human microglia, we provide new insight into epistatic interactions in ad genes and demonstrate convergence of microglial ad genes at the apoe locus. |
2021-03-11 |
2023-08-13 |
mouse |
| Yu Yamazaki, Chia-Chen Liu, Akari Yamazaki, Francis Shue, Yuka A Martens, Yuanxin Chen, Wenhui Qiao, Aishe Kurti, Hiroshi Oue, Yingxue Ren, Ying Li, Tomonori Aikawa, Yesesri Cherukuri, John D Fryer, Yan W Asmann, Betty Y S Kim, Takahisa Kanekiyo, Guojun B. Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function. Neuron. vol 109. issue 3. 2021-02-25. PMID:33321072. |
apoe is abundantly expressed in multiple brain cell types, including astrocytes, microglia, and vascular mural cells (vmcs). |
2021-02-25 |
2023-08-13 |
mouse |
| Alberto Serrano-Pozo, Sudeshna Das, Bradley T Hyma. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. The Lancet. Neurology. vol 20. issue 1. 2021-01-28. PMID:33340485. |
although initial studies causally linked apoe with amyloid-β peptide aggregation and clearance, over the past 5 years our understanding of apoe pathogenesis has expanded beyond amyloid-β peptide-centric mechanisms to tau neurofibrillary degeneration, microglia and astrocyte responses, and blood-brain barrier disruption. |
2021-01-28 |
2023-08-13 |
mouse |
| Zhishen Xie, Jianping Zhao, Hui Wang, Yali Jiang, Qiaoling Yang, Yu Fu, Huahui Zeng, Christian Hölscher, Jiangyan Xu, Zhenqiang Zhan. Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 124. 2020-11-12. PMID:32000045. |
the target gene lxr of ppar-γ is activated by mg, which upregulates apoe and promotes microglia phagocytosis and the degradation of aβ, and these effects were also reversed by gw9662. |
2020-11-12 |
2023-08-13 |
caenorhabditis_elegans |
| Jacob S Friedberg, Nurgul Aytan, Jonathan D Cherry, Weiming Xia, Oliver J Standring, Victor E Alvarez, Raymond Nicks, Sarah Svirsky, Gaoyuan Meng, Gyungah Jun, Hoon Ryu, Rhoda Au, Thor D Stei. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:32076055. |
to test the hypothesis that microglia and ad-implicated cytokines were differentially associated with ad pathology based on the presence of apoe ε4, we examined the dorsolateral frontal cortex from deceased participants within a community-based aging cohort (n = 154). |
2020-11-12 |
2023-08-13 |
human |
| Jacob S Friedberg, Nurgul Aytan, Jonathan D Cherry, Weiming Xia, Oliver J Standring, Victor E Alvarez, Raymond Nicks, Sarah Svirsky, Gaoyuan Meng, Gyungah Jun, Hoon Ryu, Rhoda Au, Thor D Stei. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype. Scientific reports. vol 10. issue 1. 2020-11-12. PMID:32076055. |
cellular density of iba1, a marker of microglia, was positively associated with tau pathology only in apoe ε4 positive participants (p = 0.001). |
2020-11-12 |
2023-08-13 |
human |
| Celia G Fernandez, Mary E Hamby, Morgan L McReynolds, William J Ra. The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer's Disease. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30804776. |
apoe in the brain is primarily expressed by astrocytes and microglia, cell types that are now widely appreciated to play key roles in the pathogenesis of ad; thus, a picture is emerging wherein apoe4 disrupts normal glial cell biology, intersecting with changes that occur during normal aging to ultimately cause neurodegeneration and cognitive dysfunction. |
2020-10-01 |
2023-08-13 |
Not clear |
| Christiane Muth, Alexander Hartmann, Diego Sepulveda-Falla, Markus Glatzel, Susanne Kraseman. Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31130847. |
while apoe expression does not play a relevant role in homeostatic microglia, we and others could recently show that apoe expression is significant upregulated in disease-associated microglia including ad-mouse models and human ad. |
2020-10-01 |
2023-08-13 |
human |
| Christiane Muth, Alexander Hartmann, Diego Sepulveda-Falla, Markus Glatzel, Susanne Kraseman. Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31130847. |
to elucidate the differential roles of the three-major human apoe isoforms on microglia function we each expressed the human apoe isoforms in murine n9 microglia cells. |
2020-10-01 |
2023-08-13 |
human |
| Bailey A Loving, Kimberley D Bruc. Lipid and Lipoprotein Metabolism in Microglia. Frontiers in physiology. vol 11. 2020-09-28. PMID:32411016. |
increased expression of genes such as apolipoprotein e (apoe), triggering receptor expressed on myeloid cells 2 (trem2) and lipoprotein lipase (lpl) in microglia during development, damage, and disease, suggest that increased lipid metabolism is needed to fuel protective cellular functions such as phagocytosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Daria Bortolotti, Valentina Gentili, Antonella Rotola, Elisabetta Caselli, Roberta Rizz. HHV-6A infection induces amyloid-beta expression and activation of microglial cells. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31831060. |
we evaluated the effect of hhv-6a infection on microglial cell expression aβ and the activation status, determined by trem2, apoe, cytokines, and tau expression. |
2020-08-06 |
2023-08-13 |
Not clear |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
furthermore, ad risk genes such as triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) are enriched in the innate immune system and modulate the neuroinflammatory response of microglia to tau pathology. |
2020-07-30 |
2023-08-13 |
Not clear |
| Tien-Phat V Huynh, Chao Wang, Ainsley C Tran, G Travis Tabor, Thomas E Mahan, Caroline M Francis, Mary Beth Finn, Rebecca Spellman, Melissa Manis, Rudolph E Tanzi, Jason D Ulrich, David M Holtzma. Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model. Molecular neurodegeneration. vol 14. issue 1. 2020-06-23. PMID:31623648. |
apoe is produced by both astrocytes and microglia in the brain, whereas hepatocytes produce the majority of apoe found in the periphery. |
2020-06-23 |
2023-08-13 |
mouse |
| Shahrnaz Kemal, Robert Vassa. Death by microglia. The Journal of experimental medicine. vol 216. issue 11. 2020-05-29. PMID:31645368. |
the roles of microglia and apoe in tauopathies, such as alzheimer's disease, remain elusive. |
2020-05-29 |
2023-08-13 |
mouse |
| Dustin Chernick, Stephanie Ortiz-Valle, Angela Jeong, Suresh K Swaminathan, Karunya K Kandimalla, G William Rebeck, Ling L. High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia. Journal of neurochemistry. vol 147. issue 5. 2019-09-27. PMID:30028014. |
we found that 4f significantly increases apoe secretion and lipidation in primary human astrocytes as well as in primary mouse astrocytes and microglia. |
2019-09-27 |
2023-08-13 |
mouse |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
this function of apoe is likely linked to triggering receptor expressed on myeloid cells 2 (trem2), which is expressed by microglia in the cns. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
here, we review the rapidly growing literature on the role of disease-associated microglia, trem2 and apoe in the pathogenesis of alzheimer disease and present an integrated view of innate immune function in alzheimer disease. |
2019-08-15 |
2023-08-13 |
Not clear |
| Melanie Hüttenrauch, Isabella Ogorek, Hans Klafki, Markus Otto, Christine Stadelmann, Sascha Weggen, Jens Wiltfang, Oliver Wirth. Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia. Acta neuropathologica communications. vol 6. issue 1. 2019-06-12. PMID:30340518. |
our data further indicate that gpnmb is part of a microglia activation state that is only present under neurodegenerative conditions and that is characterized by the up-regulation of a subset of genes including trem2, apoe and cst7. |
2019-06-12 |
2023-08-13 |
mouse |
| Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F Lichtenthaler, Stephan A Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Ertürk, Stefan A Grathwohl, Jonas J Neher, David M Holtzman, Melanie Meyer-Luehmann, Christian Haas. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nature neuroscience. vol 22. issue 2. 2019-05-20. PMID:30617257. |
proteomic analyses and microglia depletion experiments revealed microglia as one origin of plaque-associated apoe. |
2019-05-20 |
2023-08-13 |
Not clear |