| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isha Mhatre-Winters, Aseel Eid, Yoonhee Han, Kim Tieu, Jason R Richardso. Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077227. |
sex and apoe genotype alter the basal and induced inflammatory states of primary microglia from apoe targeted replacement mice. |
2022-09-09 |
2023-08-14 |
mouse |
| Emily Sun, Aishat Motolani, Leonardo Campos, Tao L. The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012242. |
some of these cell types and molecules include reactive microglia and astrocytes, β-secretase, apoe, glutamate, mirna, and tau protein, among others. |
2022-08-26 |
2023-08-14 |
mouse |
| Milica A Margeta, Zhuoran Yin, Charlotte Madore, Kristen M Pitts, Sophia M Letcher, Jing Tang, Shuhong Jiang, Christian D Gauthier, Sebastian R Silveira, Caitlin M Schroeder, Eleonora M Lad, Alan D Proia, Rudolph E Tanzi, David M Holtzman, Susanne Krasemann, Dong Feng Chen, Oleg Butovsk. Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. Immunity. 2022-08-17. PMID:35977543. |
here, we found that in two mouse glaucoma models, microglia transitioned to a neurodegenerative phenotype characterized by upregulation of apoe and lgals3 (galectin-3), which were also upregulated in human glaucomatous retinas. |
2022-08-17 |
2023-08-14 |
mouse |
| Milica A Margeta, Zhuoran Yin, Charlotte Madore, Kristen M Pitts, Sophia M Letcher, Jing Tang, Shuhong Jiang, Christian D Gauthier, Sebastian R Silveira, Caitlin M Schroeder, Eleonora M Lad, Alan D Proia, Rudolph E Tanzi, David M Holtzman, Susanne Krasemann, Dong Feng Chen, Oleg Butovsk. Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. Immunity. 2022-08-17. PMID:35977543. |
mice with targeted deletion of apoe in microglia or carrying the human apoe4 allele were protected from retinal ganglion cell (rgc) loss, despite elevated intraocular pressure (iop). |
2022-08-17 |
2023-08-14 |
mouse |
| Bibiana C Mota, Nathan Ashburner, Laura Abelleira-Hervas, Liyueyue Liu, Robertas Aleksynas, Lucio Claudio Rovati, Gianfranco Caselli, Magdalena Sastr. I2-Imidazoline Ligand CR4056 Improves Memory, Increases ApoE Expression and Reduces BBB Leakage in 5xFAD Mice. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806327. |
our results also revealed a change in the profile of microglia by cr4056, resulting in a suppression of pro-inflammatory activated microglia, but increased the density of astrocytes and the expression of apoe, which is mainly produced by these glial cells. |
2022-07-09 |
2023-08-14 |
mouse |
| Yi-Jun Xu, Ngan Pan Bennett Au, Chi Him Eddie M. Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-06-13. PMID:35693341. |
recent in-depth transcriptomic analysis identifies apoe and trem2 from microglia as the major risk factors for ad pathogenesis. |
2022-06-13 |
2023-08-14 |
Not clear |
| Qi Qin, Meng Wang, Yunsi Yin, Yi Tan. The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's Disease. Frontiers in immunology. vol 13. 2022-06-06. PMID:35663962. |
trem2 is involved in the synaptic clearance of microglia, acting alone or with other molecules, such as apolipoprotein e (apoe). |
2022-06-06 |
2023-08-14 |
Not clear |
| Qi Qin, Meng Wang, Yunsi Yin, Yi Tan. The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's Disease. Frontiers in immunology. vol 13. 2022-06-06. PMID:35663962. |
in this review, we systematically summarized the potential mechanisms of microglia involved in synaptic clearance, comprehensively reviewed the role of trem2 in microglia regulating synaptic clearance and proposed our hypothesis that trem2 interacts with apoe and c1q to promote synaptic clearance. |
2022-06-06 |
2023-08-14 |
Not clear |
| Samantha K Baker, Na Wang, Guojun Bu, Chia-Chen Li. Effects of Microglia APOE Expression on Tau Pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557103. |
effects of microglia apoe expression on tau pathology. |
2022-05-13 |
2023-08-13 |
mouse |
| Samantha K Baker, Na Wang, Guojun Bu, Chia-Chen Li. Effects of Microglia APOE Expression on Tau Pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557103. |
thus, apoe expression may be involved in the activation of microglia in alzheimer's disease, eliciting an overactive immune response that accelerates disease progression. |
2022-05-13 |
2023-08-13 |
mouse |
| Yonghe Li, Jesse R Macyczko, Chia-Chen Liu, Guojun B. ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease. Neurobiology of aging. vol 115. 2022-04-22. PMID:35453035. |
apoe expression is greatly up-regulated in disease-associated microglia in mouse models of amyloidosis and in human microglia from ad brains. |
2022-04-22 |
2023-08-13 |
mouse |
| Tulsi Patel, Troy P Carnwath, Xue Wang, Mariet Allen, Sarah J Lincoln, Laura J Lewis-Tuffin, Zachary S Quicksall, Shu Lin, Frederick Q Tutor-New, Charlotte C G Ho, Yuhao Min, Kimberly G Malphrus, Thuy T Nguyen, Elizabeth Martin, Cesar A Garcia, Rawan M Alkharboosh, Sanjeet Grewal, Kaisorn Chaichana, Robert Wharen, Hugo Guerrero-Cazares, Alfredo Quinones-Hinojosa, Nilüfer Ertekin-Tane. Transcriptional landscape of human microglia implicates age, sex, and APOE-related immunometabolic pathway perturbations. Aging cell. 2022-04-07. PMID:35388616. |
we applied bulk and single-cell approaches to comprehensively characterize human microglia transcriptomes and their associations with age, sex, and apoe. |
2022-04-07 |
2023-08-13 |
human |
| Shannon Tansley, Sonali Uttam, Alba Ureña Guzmán, Moein Yaqubi, Alain Pacis, Marc Parisien, Haley Deamond, Calvin Wong, Oded Rabau, Nicole Brown, Lisbet Haglund, Jean Ouellet, Carlo Santaguida, Alfredo Ribeiro-da-Silva, Soroush Tahmasebi, Masha Prager-Khoutorsky, Jiannis Ragoussis, Ji Zhang, Michael W Salter, Luda Diatchenko, Luke M Healy, Jeffrey S Mogil, Arkady Khoutorsk. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nature communications. vol 13. issue 1. 2022-02-12. PMID:35149686. |
single-cell rna sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links apoe to chronic pain. |
2022-02-12 |
2023-08-13 |
mouse |
| Shannon Tansley, Sonali Uttam, Alba Ureña Guzmán, Moein Yaqubi, Alain Pacis, Marc Parisien, Haley Deamond, Calvin Wong, Oded Rabau, Nicole Brown, Lisbet Haglund, Jean Ouellet, Carlo Santaguida, Alfredo Ribeiro-da-Silva, Soroush Tahmasebi, Masha Prager-Khoutorsky, Jiannis Ragoussis, Ji Zhang, Michael W Salter, Luda Diatchenko, Luke M Healy, Jeffrey S Mogil, Arkady Khoutorsk. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nature communications. vol 13. issue 1. 2022-02-12. PMID:35149686. |
apolipoprotein e (apoe) is the top upregulated gene in spinal cord microglia at chronic time points after peripheral nerve injury in mice. |
2022-02-12 |
2023-08-13 |
mouse |
| Shannon Tansley, Sonali Uttam, Alba Ureña Guzmán, Moein Yaqubi, Alain Pacis, Marc Parisien, Haley Deamond, Calvin Wong, Oded Rabau, Nicole Brown, Lisbet Haglund, Jean Ouellet, Carlo Santaguida, Alfredo Ribeiro-da-Silva, Soroush Tahmasebi, Masha Prager-Khoutorsky, Jiannis Ragoussis, Ji Zhang, Michael W Salter, Luda Diatchenko, Luke M Healy, Jeffrey S Mogil, Arkady Khoutorsk. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nature communications. vol 13. issue 1. 2022-02-12. PMID:35149686. |
our data provide a detailed analysis of transcriptional states of mouse and human spinal cord microglia, and identify a link between apoe and chronic pain in humans. |
2022-02-12 |
2023-08-13 |
mouse |
| Sabine C Konings, Emma Mc Nyberg, Isak Martinsson, Gunnar K Goura. Neurobiological role of Alzheimer's disease genetic risk factor ApoE on early synaptic changes in Alzheimer-like models. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109139. |
astrocytes are the main source of apoe in the brain, however apoe can also be produced by neurons and microglia. |
2022-02-03 |
2023-08-13 |
mouse |
| Courtney M Kloske, Erica M Weekman, Kevin Xie, Ela Patel, Sonya Anderson, Adam D Bachstetter, Josh M Morganti, David W Fardo, Peter T Nelson, Donna M Wilcoc. APOE-e4 alters the microglial phenotype in the presence of Alzheimer's disease pathology compared to APOE-e3. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109287. |
as microglia are considered to be a primary source of brain inflammation, this study explores how apoe isoforms impact microglial morphology and activation state in human brains. |
2022-02-03 |
2023-08-13 |
human |
| Jolanta Dorszewska, Michal Prendecki, Mikolaj Hurla, Natalia Banaszek, Paulina Szejn, Jolanta Florczak-Wyspianska, Jan Ilkowski, Wojciech Kozubsk. Analysis of genetic variants associated with the removal of the pathological Abeta form in patients with Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109288. |
apoe e4 gene reduces ability to clear aβ by affecting microglia function. |
2022-02-03 |
2023-08-13 |
human |
| Thomas E Mahan, Chao Wang, Xin Bao, Ankit Choudhury, Jason D Ulrich, David M Holtzma. Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis. Molecular neurodegeneration. vol 17. issue 1. 2022-02-03. PMID:35109920. |
apoe can be produced by different cell types in the brain, with astrocytes being the largest producer of apoe, although reactive microglia also express high levels of apoe. |
2022-02-03 |
2023-08-13 |
mouse |
| Saima I Machlovi, Sarah M Neuner, Brittany M Hemmer, Riana Khan, Yiyuan Liu, Min Huang, Jeffrey D Zhu, Joseph M Castellano, Dongming Cai, Edoardo Marcora, Alison M Goat. APOE4 genotype confers transcriptomic and functional alterations to primary mouse microglia. Neurobiology of disease. 2022-01-15. PMID:35031484. |
to address this, we cultured primary microglia from mice in which both alleles of the mouse apoe gene have been humanized to encode either human apoe ε3 or apoe ε4. |
2022-01-15 |
2023-08-13 |
mouse |