| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Gotkiewicz, Janne Capra, Pasi O Miettinen, Teemu Natunen, Heikki Tanil. Three-dimensional view of microglia-amyloid plaque interactions. Glia. 2024-10-22. PMID:39435610. |
further, they support a chemotactic role of apoe for microglia contacts with amyloid plaques. |
2024-10-22 |
2024-10-24 |
mouse |
| Seiji Kaji, Stefan A Berghoff, Lena Spieth, Lennart Schlaphoff, Andrew O Sasmita, Simona Vitale, Luca Büschgens, Shreeya Kedia, Martin Zirngibl, Taisiia Nazarenko, Alkmini Damkou, Leon Hosang, Constanze Depp, Frits Kamp, Patricia Scholz, David Ewers, Martin Giera, Till Ischebeck, Wolfgang Wurst, Benedikt Wefers, Martina Schifferer, Michael Willem, Klaus-Armin Nave, Christian Haass, Thomas Arzberger, Sarah Jäkel, Oliver Wirths, Gesine Saher, Mikael Simon. Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis. Immunity. 2024-10-18. PMID:39419029. |
sporadic ad is linked genetically to apolipoprotein e (apoe) and other genes expressed in microglia related to immune, lipid, and endocytic functions. |
2024-10-18 |
2024-10-20 |
mouse |
| Seiji Kaji, Stefan A Berghoff, Lena Spieth, Lennart Schlaphoff, Andrew O Sasmita, Simona Vitale, Luca Büschgens, Shreeya Kedia, Martin Zirngibl, Taisiia Nazarenko, Alkmini Damkou, Leon Hosang, Constanze Depp, Frits Kamp, Patricia Scholz, David Ewers, Martin Giera, Till Ischebeck, Wolfgang Wurst, Benedikt Wefers, Martina Schifferer, Michael Willem, Klaus-Armin Nave, Christian Haass, Thomas Arzberger, Sarah Jäkel, Oliver Wirths, Gesine Saher, Mikael Simon. Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis. Immunity. 2024-10-18. PMID:39419029. |
these apoe aggregates that stained positive for β sheet-binding dyes triggered aβ amyloidosis within the endo-lysosomal system of microglia, in a process influenced by microglial lipid metabolism and the jak/stat signaling pathway. |
2024-10-18 |
2024-10-20 |
mouse |
| Seiji Kaji, Stefan A Berghoff, Lena Spieth, Lennart Schlaphoff, Andrew O Sasmita, Simona Vitale, Luca Büschgens, Shreeya Kedia, Martin Zirngibl, Taisiia Nazarenko, Alkmini Damkou, Leon Hosang, Constanze Depp, Frits Kamp, Patricia Scholz, David Ewers, Martin Giera, Till Ischebeck, Wolfgang Wurst, Benedikt Wefers, Martina Schifferer, Michael Willem, Klaus-Armin Nave, Christian Haass, Thomas Arzberger, Sarah Jäkel, Oliver Wirths, Gesine Saher, Mikael Simon. Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis. Immunity. 2024-10-18. PMID:39419029. |
taking these observations together, we propose a model for the onset of aβ amyloidosis in ad, suggesting that the endocytic uptake and aggregation of apoe by microglia can initiate aβ plaque formation. |
2024-10-18 |
2024-10-20 |
mouse |
| Ma Wan, Yaojuan Liu, Dongjun Li, Ryan J Snyder, Lillian B Elkin, Christopher R Day, Joseph Rodriguez, Christopher Grunseich, Robert W Mahley, Jason A Watts, Vivian G Cheun. The enhancer RNA, AANCR, regulates APOE expression in astrocytes and microglia. Nucleic acids research. 2024-08-20. PMID:39162226. |
the enhancer rna, aancr, regulates apoe expression in astrocytes and microglia. |
2024-08-20 |
2024-08-22 |
human |
| Ilayda Ozsan McMillan, Li Liang, Guowei Su, Xuehong Song, Kelly Drago, Hua Yang, Claudia Alvarez, Amika Sood, James Gibson, Robert J Woods, Chunyu Wang, Jian Liu, Fuming Zhang, Tom J Brett, Lianchun Wan. TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid. The Journal of biological chemistry. 2024-08-19. PMID:39159814. |
by delineating the interaction between hs and trem2 on the microglial cell surface and demonstrating its role in facilitating trem2-mediated apoe uptake by microglia, our findings provide valuable insights that can inform targeted interventions for modulating microglial functions in alzheimer's disease. |
2024-08-19 |
2024-08-22 |
Not clear |
| Joseph Giorgio, Caroline Jonson, Yilin Wang, Jennifer Yokoyama, Jingshen Wang, William Jagus. Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions. Research square. 2024-08-16. PMID:39149503. |
these findings offer insights into the function of sex, apoe and microglia in ad progression, and have implications for determining personalised treatment with drugs targeting aβ and tau. |
2024-08-16 |
2024-08-18 |
human |
| Mikhail Melnik, Tina Bilousova, Ricky Ma, Yuriko Matsuo, Swetha Atluri, Achyutha Kodavatikanti, Nina Knitowski, Karen H Gyly. Basic Science and Pathogenesis - Part 2. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 19 Suppl 13. 2024-08-09. PMID:39120864. |
apoe status was also explored as its associated with increased inflammation (suggesting m1 effects) and apoe is highly expressed by amyloid-associated microglia. |
2024-08-09 |
2024-08-12 |
Not clear |
| Neta Rosenzweig, Kilian L Kleemann, Thomas Rust, Madison Carpenter, Madeline Grucci, Michael Aronchik, Nieske Brouwer, Isabel Valenbreder, Joya Cooper-Hohn, Malvika Iyer, Rajesh K Krishnan, Kisha N Sivanathan, Wesley Brandão, Taha Yahya, Ana Durao, Zhuoran Yin, Jean Paul Chadarevian, Michael J Properzi, Roni Nowarski, Hayk Davtyan, Howard L Weiner, Mathew Blurton-Jones, Hyun-Sik Yang, Bart J L Eggen, Reisa A Sperling, Oleg Butovsk. Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease. Nature medicine. 2024-07-03. PMID:38961225. |
leveraging single-cell transcriptomics across apoe variants in both sexes, multiplex flow cytometry and validation in two independent cohorts of apoe4 female carriers with ad, we identify a new subset of neutrophils interacting with microglia associated with cognitive impairment. |
2024-07-03 |
2024-07-10 |
Not clear |
| Neta Rosenzweig, Kilian L Kleemann, Thomas Rust, Madison Carpenter, Madeline Grucci, Michael Aronchik, Nieske Brouwer, Isabel Valenbreder, Joya Cooper-Hohn, Malvika Iyer, Rajesh K Krishnan, Kisha N Sivanathan, Wesley Brandão, Taha Yahya, Ana Durao, Zhuoran Yin, Jean Paul Chadarevian, Michael J Properzi, Roni Nowarski, Hayk Davtyan, Howard L Weiner, Mathew Blurton-Jones, Hyun-Sik Yang, Bart J L Eggen, Reisa A Sperling, Oleg Butovsk. Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease. Nature medicine. 2024-07-03. PMID:38961225. |
this phenotype is defined by increased interleukin (il)-17 and il-1 coexpressed gene modules in blood neutrophils and in microglia of cognitively impaired female apoe ε4 carriers, showing increased infiltration to the ad brain. |
2024-07-03 |
2024-07-10 |
Not clear |
| Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi X. Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity. iScience. vol 27. issue 6. 2024-06-13. PMID:38868202. |
microglia exhibit a substantial upregulation of apoe in ad-associated circumstances, despite astrocytes being the primary source of apoe expression and secretion in the brain. |
2024-06-13 |
2024-06-15 |
human |
| Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi X. Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity. iScience. vol 27. issue 6. 2024-06-13. PMID:38868202. |
although the role of astrocytic apoe in the brain has been extensively investigated, it remains unclear that whether and how apoe particles generated from astrocytes and microglia differ in biological characteristic and function. |
2024-06-13 |
2024-06-15 |
human |
| Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi X. Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity. iScience. vol 27. issue 6. 2024-06-13. PMID:38868202. |
here, we demonstrate the differences in size between apoe particles generated from microglia and astrocytes. |
2024-06-13 |
2024-06-15 |
human |
| Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi X. Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity. iScience. vol 27. issue 6. 2024-06-13. PMID:38868202. |
for the first time, these results offer concrete evidence that apoe particles produced by microglia are involved in neuronal senescence and toxicity. |
2024-06-13 |
2024-06-15 |
human |
| Hanjie Liu, Hui Yang, Shuqing Liu, Siyu Li, Wen Yang, Anwar Ayesha, Xin Tan, Cen Jiang, Yi Liu, Lushuang Xi. Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles. Journal of visualized experiments : JoVE. issue 207. 2024-06-03. PMID:38829108. |
protein-protein interaction network (ppi) identified mt3, calm2, dlg2, kcnd2, pakacb, camk2d, and nlgn4y in astrocytes, trem2, fos, apoe, app, and nlgn4y in microglia, and grin2a, itpr2, gnas, and nlgn4y in oligodendrocytes as key genes. |
2024-06-03 |
2024-06-05 |
Not clear |
| Masashi Fujita, Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C White, Bernard Ng, Gilad Sahar Green, Orit Rozenblatt-Rosen, Devan Phillips, Liat Amir-Zilberstein, Hyo Lee, Richard V Pearse, Atlas Khan, Badri N Vardarajan, Krzysztof Kiryluk, Chun Jimmie Ye, Hans-Ulrich Klein, Gao Wang, Aviv Regev, Naomi Habib, Julie A Schneider, Yanling Wang, Tracy Young-Pearse, Sara Mostafavi, David A Bennett, Vilas Menon, Philip L De Jage. Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain. Nature genetics. 2024-03-22. PMID:38514782. |
a new variant influences apoe expression only in microglia and is associated with greater cerebral amyloid angiopathy but not alzheimer's disease pathology, after adjusting for apoeε4, providing mechanistic insights into both pathologies. |
2024-03-22 |
2024-03-24 |
Not clear |
| Nicholas R W Cleland, Garrett J Potter, Courtney Buck, Daphne Quang, Dean Oldham, Mikaela Neal, Anthony Saviola, Christy S Niemeyer, Evgenia Dobrinskikh, Kimberley D Bruc. Altered metabolism and DAM-signatures in female brains and microglia with aging. Brain research. 2024-01-20. PMID:38244754. |
transcriptomic analysis revealed increased expression of disease-associated microglia (dam) genes (e.g., apoe, trem2, lpl), and genes involved in glycolysis and oxidative metabolism in microglia from aged females compared to males. |
2024-01-20 |
2024-01-23 |
mouse |
| Qingyun L. TIMely connections: APOE4, aging, and Alzheimer's. Immunity. vol 57. issue 1. 2024-01-10. PMID:38198855. |
examine microglia in ad mice bearing different apoe alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and apoe4 ad brains. |
2024-01-10 |
2024-01-13 |
mouse |
| Ghazaleh Eskandari-Sedighi, Mathew Blurton-Jone. Microglial APOE4: more is less and less is more. Molecular neurodegeneration. vol 18. issue 1. 2023-12-20. PMID:38115077. |
yet, the cell-specific effects of apoe on microglia function have remained unclear. |
2023-12-20 |
2023-12-23 |
Not clear |
| Antara Rao, Nuo Chen, Min Joo Kim, Jessica Blumenfeld, Oscar Yip, Yanxia Hao, Zherui Liang, Maxine R Nelson, Nicole Koutsodendris, Brian Grone, Leo Ding, Seo Yeon Yoon, Patrick Arriola, Yadong Huan. Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014339. |
these findings highlight the concerted roles of neuronal apoe, especially apoe4, and microglia in ad pathogenesis. |
2023-11-28 |
2023-11-29 |
mouse |