| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosemary J Jackson, Jonah C Meltzer, Huong Nguyen, Caitlin Commins, Rachel E Bennett, Eloise Hudry, Bradley T Hyma. APOE4 derived from astrocytes leads to blood-brain barrier impairment. Brain : a journal of neurology. 2021-12-27. PMID:34957486. |
apolipoprotein e (apoe) is a multifaceted secreted molecule synthesized in the cns by astrocytes and microglia, and in the periphery largely by the liver. |
2021-12-27 |
2023-08-13 |
mouse |
| Caden M Henningfield, Miguel A Arreola, Neelakshi Soni, Elizabeth E Spangenberg, Kim N Gree. Microglia-specific ApoE knock-out does not alter Alzheimer's disease plaque pathogenesis or gene expression. Glia. vol 70. issue 2. 2021-12-10. PMID:34643971. |
previous studies suggest that microglial-expressed apolipoprotein e (apoe) is necessary to shift microglia into a neurodegenerative transcriptional state in alzheimer's disease (ad) mouse models. |
2021-12-10 |
2023-08-13 |
mouse |
| Caden M Henningfield, Miguel A Arreola, Neelakshi Soni, Elizabeth E Spangenberg, Kim N Gree. Microglia-specific ApoE knock-out does not alter Alzheimer's disease plaque pathogenesis or gene expression. Glia. vol 70. issue 2. 2021-12-10. PMID:34643971. |
on the other hand, elimination of microglia shifts amyloid beta (aβ) accumulation from parenchymal plaques to cerebral amyloid angiopathy (caa), mimicking the effects of global apoe*4 knock-in. |
2021-12-10 |
2023-08-13 |
mouse |
| Caden M Henningfield, Miguel A Arreola, Neelakshi Soni, Elizabeth E Spangenberg, Kim N Gree. Microglia-specific ApoE knock-out does not alter Alzheimer's disease plaque pathogenesis or gene expression. Glia. vol 70. issue 2. 2021-12-10. PMID:34643971. |
immunostaining revealed apoe protein present in plaque-associated microglia in 5xfad mice with microglial-specific apoe knockout, suggesting that microglia can take up apoe from other cellular sources. |
2021-12-10 |
2023-08-13 |
mouse |
| Caden M Henningfield, Miguel A Arreola, Neelakshi Soni, Elizabeth E Spangenberg, Kim N Gree. Microglia-specific ApoE knock-out does not alter Alzheimer's disease plaque pathogenesis or gene expression. Glia. vol 70. issue 2. 2021-12-10. PMID:34643971. |
mice with apoe knocked-out of microglia had lower synaptic protein levels than control mice, indicating that microglial-expressed apoe may have a role in synapse maintenance. |
2021-12-10 |
2023-08-13 |
mouse |
| Caden M Henningfield, Miguel A Arreola, Neelakshi Soni, Elizabeth E Spangenberg, Kim N Gree. Microglia-specific ApoE knock-out does not alter Alzheimer's disease plaque pathogenesis or gene expression. Glia. vol 70. issue 2. 2021-12-10. PMID:34643971. |
altogether, our data indicates that microglial-expressed apoe may not be necessary for plaque formation or for the microglial transcriptional shift into a disease associated microglia state that is associated with reactivity to plaques but may be necessary for plaque homeostasis in disease and synaptic maintenance under normal conditions. |
2021-12-10 |
2023-08-13 |
mouse |
| Amy M Smith, Karen Davey, Stergios Tsartsalis, Combiz Khozoie, Nurun Fancy, See Swee Tang, Eirini Liaptsi, Maria Weinert, Aisling McGarry, Robert C J Muirhead, Steve Gentleman, David R Owen, Paul M Matthew. Diverse human astrocyte and microglial transcriptional responses to Alzheimer's pathology. Acta neuropathologica. 2021-12-08. PMID:34767070. |
significant differences in glial gene expression (including ad risk genes expressed in both the astrocytes [clu, mef2c, iqck] and microglia [apoe, ms4a6a, pilra]) were correlated with tissue amyloid or ptau expression. |
2021-12-08 |
2023-08-13 |
human |
| Whitney Thiel, Emma J Esposito, Anna P Findley, Zachary I Blume, Diana M Mitchel. Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia. Biology open. 2021-12-08. PMID:34878094. |
transcriptome analyses performed in both human and zebrafish indicate strong expression of apoe and apoc1 by microglia. |
2021-12-08 |
2023-08-13 |
human |
| Whitney Thiel, Emma J Esposito, Anna P Findley, Zachary I Blume, Diana M Mitchel. Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia. Biology open. 2021-12-08. PMID:34878094. |
apoe expression by microglia is well appreciated, but apoc1 expression has not been well-examined. |
2021-12-08 |
2023-08-13 |
human |
| Xinyan Liang, Haijian Wu, Mark Colt, Xinying Guo, Brock Pluimer, Jianxiong Zeng, Shupeng Dong, Zhen Zha. Microglia and its genetics in Alzheimer's Disease. Current Alzheimer research. 2021-12-03. PMID:34749609. |
different microglia subtypes displaying distinct genetic profiles have been identified in ad, and these signatures often link to ad risk genes identified from the genome-wide association studies (gwas), such as apoe and trem2. |
2021-12-03 |
2023-08-13 |
Not clear |
| Yiyi Ma, Lei Yu, Marta Olah, Rebecca Smith, Stephanie R Oatman, Mariet Allen, Ehsan Pishva, Bin Zhang, Vilas Menon, Nilüfer Ertekin-Taner, Katie Lunnon, David A Bennett, Hans-Ulrich Klein, Philip L De Jage. EPIGENOMIC FEATURES RELATED TO MICROGLIA ARE ASSOCIATED WITH ATTENUATED EFFECT OF APOE ε4 ON ALZHEIMER'S DISEASE RISK IN HUMANS. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue Suppl 2. 2021-11-18. PMID:34393677. |
epigenomic features related to microglia are associated with attenuated effect of apoe ε4 on alzheimer's disease risk in humans. |
2021-11-18 |
2023-08-13 |
Not clear |
| Maria Fe Lanfranco, Jordy Sepulveda, Gregory Kopetsky, G William Rebec. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia. vol 69. issue 6. 2021-11-16. PMID:33556209. |
expression and secretion of apoe isoforms in astrocytes and microglia during inflammation. |
2021-11-16 |
2023-08-13 |
mouse |
| Maria Fe Lanfranco, Jordy Sepulveda, Gregory Kopetsky, G William Rebec. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia. vol 69. issue 6. 2021-11-16. PMID:33556209. |
in the brain, apoe protein is synthesized by astrocytes and microglia. |
2021-11-16 |
2023-08-13 |
mouse |
| Maria Fe Lanfranco, Jordy Sepulveda, Gregory Kopetsky, G William Rebec. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia. vol 69. issue 6. 2021-11-16. PMID:33556209. |
we examined primary cultures of astrocytes and microglia from human apoe (e2, e3, and e4) targeted-replacement mice. |
2021-11-16 |
2023-08-13 |
mouse |
| Maria Fe Lanfranco, Jordy Sepulveda, Gregory Kopetsky, G William Rebec. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia. vol 69. issue 6. 2021-11-16. PMID:33556209. |
microglia released only a single species of apoe, while cellular apoe consisted of two forms; the secreted apoe and one of the two forms of cellular apoe were glycosylated. |
2021-11-16 |
2023-08-13 |
mouse |
| Maria Fe Lanfranco, Jordy Sepulveda, Gregory Kopetsky, G William Rebec. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia. vol 69. issue 6. 2021-11-16. PMID:33556209. |
while lps had no effect on astrocytic apoe, apoe2, and apoe3 microglia increased release of apoe; apoe4 microglia showed no effect. |
2021-11-16 |
2023-08-13 |
mouse |
| Maria Fe Lanfranco, Jordy Sepulveda, Gregory Kopetsky, G William Rebec. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia. vol 69. issue 6. 2021-11-16. PMID:33556209. |
the patterns of apoe species produced by astrocytes and microglia were not affected by inflammation. |
2021-11-16 |
2023-08-13 |
mouse |
| Maria Fe Lanfranco, Jordy Sepulveda, Gregory Kopetsky, G William Rebec. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia. vol 69. issue 6. 2021-11-16. PMID:33556209. |
together, our data demonstrate that astrocytes and microglia differentially express and secrete glycosylated forms of apoe and that apoe4 astrocytes and microglia are deficient in immunomodulation compared to apoe2 and apoe3. |
2021-11-16 |
2023-08-13 |
mouse |
| Andrew Folick, Suneil K Koliwad, Martin Valdearco. Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122343. |
such techniques have highlighted specific subsets of microglia notable for their capacity to regulate the expression of lipid metabolic genes, including lipoprotein lipase (lpl), apolipoprotein e (apoe) and triggering receptor expressed on myeloid cells 2 (trem2). |
2021-11-10 |
2023-08-13 |
Not clear |
| Yiyi Ma, Lei Yu, Marta Olah, Rebecca Smith, Stephanie R Oatman, Mariet Allen, Ehsan Pishva, Bin Zhang, Vilas Menon, Nilüfer Ertekin-Taner, Katie Lunnon, David A Bennett, Hans-Ulrich Klein, Philip L De Jage. Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer's disease risk in humans. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-05. PMID:34482628. |
epigenomic features related to microglia are associated with attenuated effect of apoe ε4 on alzheimer's disease risk in humans. |
2021-09-05 |
2023-08-13 |
Not clear |