| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jazmin Rivera, Bhupender Sharma, Melissa M Torres, Subodh Kuma. Factors affecting the GABAergic synapse function in Alzheimer's Disease: Focus on microRNAs. Ageing research reviews. 2023-11-15. PMID:37967653. |
this study explored the types of gaba receptors associated with neurological dysfunction and various biological and environmental factors that cause gabaergic neuron dysfunction in ad, such as aβ, p-tau, aging, sex, astrocytes, microglia, apoe, mental disorder, diet, physical activity, and sleep. |
2023-11-15 |
2023-11-20 |
human |
| Emile Wogram, Marco Prin. APOE set the microglia free. Nature immunology. 2023-10-23. PMID:37872317. |
apoe set the microglia free. |
2023-10-23 |
2023-11-08 |
Not clear |
| Chia-Chen Liu, Na Wang, Yuanxin Chen, Yasuteru Inoue, Francis Shue, Yingxue Ren, Minghui Wang, Wenhui Qiao, Tadafumi C Ikezu, Zonghua Li, Jing Zhao, Yuka Martens, Sydney V Doss, Cassandra L Rosenberg, Suren Jeevaratnam, Lin Jia, Ana-Caroline Raulin, Fangfang Qi, Yiyang Zhu, Alla Alnobani, Joshua Knight, Yixing Chen, Cynthia Linares, Aishe Kurti, John D Fryer, Bin Zhang, Long-Jun Wu, Betty Y S Kim, Guojun B. Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease. Nature immunology. 2023-10-19. PMID:37857825. |
here, using conditional mouse models expressing apoe isoforms in microglia and central nervous system-associated macrophages (cams), we demonstrate a cell-autonomous effect of apoe3-mediated microglial activation and function, which are negated by apoe4. |
2023-10-19 |
2023-11-08 |
mouse |
| Lisa Kian. ApoE attracts microglia to amyloid-β plaques. Nature reviews. Neurology. 2023-10-09. PMID:37813951. |
apoe attracts microglia to amyloid-β plaques. |
2023-10-09 |
2023-10-15 |
Not clear |
| Zhuoran Yin, Neta Rosenzweig, Kilian L Kleemann, Xiaoming Zhang, Wesley Brandão, Milica A Margeta, Caitlin Schroeder, Kisha N Sivanathan, Sebastian Silveira, Christian Gauthier, Dania Mallah, Kristen M Pitts, Ana Durao, Shawn Herron, Hannah Shorey, Yiran Cheng, Jen-Li Barry, Rajesh K Krishnan, Sam Wakelin, Jared Rhee, Anthony Yung, Michael Aronchik, Chao Wang, Nimansha Jain, Xin Bao, Emma Gerrits, Nieske Brouwer, Amy Deik, Daniel G Tenen, Tsuneya Ikezu, Nicolas G Santander, Gabriel L McKinsey, Caroline Baufeld, Dean Sheppard, Susanne Krasemann, Roni Nowarski, Bart J L Eggen, Clary Clish, Rudolph E Tanzi, Charlotte Madore, Thomas D Arnold, David M Holtzman, Oleg Butovsk. APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints. Nature immunology. 2023-09-25. PMID:37749326. |
the contribution of microglial apoe4 to ad pathogenesis is unknown, although apoe has the most enriched gene expression in neurodegenerative microglia (mgnd). |
2023-09-25 |
2023-10-07 |
mouse |
| Shun-Fat Lau, Wei Wu, Hiu Yi Wong, Li Ouyang, Yi Qiao, Jiahui Xu, Jessica Hiu-Yan Lau, Carlton Wong, Yuanbing Jiang, David M Holtzman, Amy K Y Fu, Nancy Y I. The VCAM1-ApoE pathway directs microglial chemotaxis and alleviates Alzheimer's disease pathology. Nature aging. 2023-09-21. PMID:37735240. |
here, we show that il-33 induces vcam1 in microglia, which promotes microglial chemotaxis toward amyloid-beta (aβ) plaque-associated apoe, and leads to aβ clearance. |
2023-09-21 |
2023-10-07 |
Not clear |
| Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Hong Fan, Dageng Huang, Yuqing He, Xiangwen Tang, Yixiang Ai, Youjun Liu, Hao Yang, Dingjun Ha. Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-09-02. PMID:37658943. |
finally, a series of molecular biological experiments including knock-down of triggering receptor expressed on myeloid cells 2 (trem2) and analysis of the level of apolipoprotein e (apoe) expression were performed to investigate the underlying mechanism of involvement of ccm-activated oecs in modulating microglia polarization, leading to neural regeneration and function recovery. |
2023-09-02 |
2023-09-07 |
rat |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. 2023-08-17. PMID:37589745. |
correction: apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2023-08-17 |
2023-09-07 |
Not clear |
| Patrycja Dzianok, Ewa Kubli. Altered granulocyte count and erythrocyte measures in middle-aged, healthy carriers of APOE and PICALM risk genes for Alzheimer's disease. Acta neurobiologiae experimentalis. vol 83. issue 2. 2023-07-26. PMID:37493530. |
apoe has been implicated in many ad pathology mechanisms, like aβ clearance, brain metabolism, changes within microglia and other glial functions and inflammatory processes. |
2023-07-26 |
2023-08-14 |
human |
| Breeanne M Soteros, Haven Tillmon, Mackenna Wollet, Julianne General, Hanna Chin, John Beichen Lee, Flavia R Carreno, David A Morilak, Jun Hee Kim, Gek Ming Si. Layer-specific microglia activation drives chronic stress-induced synapse loss. bioRxiv : the preprint server for biology. 2023-07-10. PMID:37425856. |
here, using single cell rna sequencing of mouse cortical microglia, we identify a stress-associated microglia state marked by high expression of apolipoprotein e (apoe). |
2023-07-10 |
2023-08-14 |
mouse |
| Oscar M Muñoz Herrera, Brian V Hong, Ulises Ruiz Mendiola, Izumi Maezawa, Lee-Way Jin, Carlito B Lebrilla, Danielle J Harvey, Angela M Zivkovi. Cholesterol, Amyloid Beta, Fructose, and LPS Influence ROS and ATP Concentrations and the Phagocytic Capacity of HMC3 Human Microglia Cell Line. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373543. |
microglia treated with combinations containing chol + aβo had lower apolipoprotein e (apoe) secretion, with the combination of chol + aβo + fructose + lps having the strongest effect. |
2023-06-28 |
2023-08-14 |
human |
| Chaojie Li, Peng Lu, Lihan Zhang, Yijing He, Lifang Zhang, Lei Yang, Fan Zhang, Xi Kong, Qianke Tao, Jian Zhou, Jinpeng Wu, Tangming Peng, Bingqing Xie, Yong Jiang, Jianhua Pen. Apolipoprotein E polymorphism impacts white matter injury through microglial phagocytosis after experimental subarachnoid hemorrhage. Neuroscience. 2023-06-08. PMID:37290684. |
in the present study, we investigated the effects of apoe gene polymorphisms, by constructing microglial apoe4 and apoe4-specific overexpression, on wmi and underlying mechanisms of microglia phagocytosis in a mice model of sah. |
2023-06-08 |
2023-08-14 |
mouse |
| Larisa Chernyaeva, Giorgio Ratti, Laura Teirilä, Satoshi Fudo, Uni Rankka, Anssi Pelkonen, Paula Korhonen, Katarzyna Leskinen, Salla Keskitalo, Kari Salokas, Christina Gkolfinopoulou, Katrina E Crompton, Matti Javanainen, Lotta Happonen, Markku Varjosalo, Tarja Malm, Ville Leinonen, Angeliki Chroni, Päivi Saavalainen, Seppo Meri, Tommi Kajander, Adam Jm Wollman, Eija Nissilä, Karita Haapasal. Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation. EMBO reports. 2023-05-08. PMID:37155564. |
flow cytometry and transcriptomic analysis reveal that apoe and fh reduce binding of aβ1-42 to complement receptor 3 (cr3) and subsequent phagocytosis by microglia which alters expression of genes involved in ad. |
2023-05-08 |
2023-08-14 |
Not clear |
| Jennifer Hua, Elvira Garcia de Paco, Nathalie Linck, Tangui Maurice, Catherine Desrumaux, Bénédicte Manoury, François Rassendren, Lauriane Ulman. Microglial P2X4 receptors promote ApoE degradation and contribute to memory deficits in Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 80. issue 5. 2023-05-05. PMID:37145189. |
we found that p2x4 regulates lysosomal cathepsin b (catb) activity promoting apoe degradation; p2rx4 deletion results in higher amounts of intracellular and secreted apoe in both bone-marrow-derived macrophage (bmdm) and microglia from app |
2023-05-05 |
2023-08-14 |
Not clear |
| Courtney M Kloske, Mary D Gearon, Erica M Weekman, Colin Rogers, Ela Patel, Adam Bachstetter, Peter T Nelson, Donna M Wilcoc. Association between APOE genotype and microglial cell morphology. Journal of neuropathology and experimental neurology. 2023-04-22. PMID:37087107. |
association between apoe genotype and microglial cell morphology. |
2023-04-22 |
2023-08-14 |
human |
| Courtney M Kloske, Mary D Gearon, Erica M Weekman, Colin Rogers, Ela Patel, Adam Bachstetter, Peter T Nelson, Donna M Wilcoc. Association between APOE genotype and microglial cell morphology. Journal of neuropathology and experimental neurology. 2023-04-22. PMID:37087107. |
as microglia are a primary source of neuroinflammation, this study determined whether apoe isoforms have an impact on microglial morphology and activation using immunohistochemistry and digital analyses. |
2023-04-22 |
2023-08-14 |
human |
| Eyiyemisi C Damisah, Anupama Rai, Robert A Hill, Lei Tong, Jaime Grutzendle. TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993245. |
trem2 and apoe are two major risk factors for alzheimer’s disease (ad) that have been proposed to play crucial roles in microglia pathophysiology by affecting their ability to phagocytose cellular debris or aggregated proteins. |
2023-03-30 |
2023-08-14 |
Not clear |
| Eyiyemisi C Damisah, Anupama Rai, Robert A Hill, Lei Tong, Jaime Grutzendle. TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993245. |
our findings showed that the deletion of either trem2 or apoe did not affect the dynamics of microglia engagement with dying neurons or their efficiency in phagocytosing corpses. |
2023-03-30 |
2023-08-14 |
Not clear |
| AnilG Cashikar, DaniraToral Rios, David Timm, Johnathan Romero, Michael Strickland, JustinM Long, Xianlin Han, DavidM Holtzman, StevenM Pau. Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol. Journal of lipid research. 2023-02-27. PMID:36849076. |
since astrocytes synthesize cholesterol in the brain and transport it to other cells via apolipoprotein e (apoe)-containing lipoproteins, we hypothesized that secreted 25hc from microglia may influence lipid metabolism as well as extracellular apoe derived from astrocytes. |
2023-02-27 |
2023-08-14 |
mouse |
| Kristen M Pitts, Cameron E Neeson, Nathan E Hall, Jonathan B Lin, Henisk K Falah, Silas L Wang, Kristine T Lo, Christian E Song, Milica A Margeta, David A Solá-Del Vall. Neurodegeneration Markers Galectin-3 and Apolipoprotein E Are Elevated in the Aqueous Humor of Eyes With Glaucoma. Translational vision science & technology. vol 11. issue 11. 2022-11-01. PMID:36318198. |
galectin-3 (gal-3) and apolipoprotein e (apoe) are markers of activated microglia in neurodegenerative diseases of the central nervous system, whose targeting is protective in mouse models of glaucoma. |
2022-11-01 |
2023-08-14 |
mouse |