| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Audrey Vautheny, Charlotte Duwat, Gwennaëlle Aurégan, Charlène Joséphine, Anne-Sophie Hérard, Caroline Jan, Julien Mitja, Pauline Gipchtein, Marie-Claude Gaillard, Luc Buée, David Blum, Philippe Hantraye, Gilles Bonvento, Emmanuel Brouillet, Karine Cambon, Alexis-Pierre Bemelman. THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency. Neurobiology of disease. vol 155. 2021-09-03. PMID:34019997. |
among these genes trem2, a cell surface receptor expressed by microglia, arouses strong interest because its r47h variant confers a risk of developing ad comparable to the ε4 allele of the apoe gene. |
2021-09-03 |
2023-08-13 |
mouse |
| Liang He, Jose Davila-Velderrain, Tomokazu S Sumida, David A Hafler, Manolis Kellis, Alexander M Kulminsk. NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data. Communications biology. vol 4. issue 1. 2021-08-16. PMID:34040149. |
using nebula in alzheimer's disease cohort data sets, we found that the cell-level expression of apoe correlated with that of other genetic risk factors (including clu, cst3, trem2, c1q, and itm2b) in a cell-type-specific pattern and an isoform-dependent manner in microglia. |
2021-08-16 |
2023-08-13 |
Not clear |
| Yang Shi, Prabhakar Sairam Andhey, Christina Ising, Kairuo Wang, Lisa L Snipes, Kevin Boyer, Stephanie Lawson, Kaoru Yamada, Wei Qin, Melissa Manis, Javier Remolina Serrano, Bruno A Benitez, Robert E Schmidt, Maxim Artyomov, Jason D Ulrich, David M Holtzma. Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms. Neuron. vol 109. issue 15. 2021-08-13. PMID:34157306. |
ldlr overexpression (ox) in microglia cell-autonomously downregulates microglial apoe expression and is associated with suppressed microglial activation as in apoe-deficient microglia. |
2021-08-13 |
2023-08-13 |
mouse |
| Yang Shi, Prabhakar Sairam Andhey, Christina Ising, Kairuo Wang, Lisa L Snipes, Kevin Boyer, Stephanie Lawson, Kaoru Yamada, Wei Qin, Melissa Manis, Javier Remolina Serrano, Bruno A Benitez, Robert E Schmidt, Maxim Artyomov, Jason D Ulrich, David M Holtzma. Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms. Neuron. vol 109. issue 15. 2021-08-13. PMID:34157306. |
apoe deficiency and ldlr ox strongly drive microglial immunometabolism toward enhanced catabolism over anabolism, whereas ldlr-overexpressing microglia also uniquely upregulate specific ion channels and neurotransmitter receptors upon activation. |
2021-08-13 |
2023-08-13 |
mouse |
| Sonia Sanz Muñoz, Brett Garner, Lezanne Oo. Generation of APOE knock-down SK-N-SH human neuroblastoma cells using CRISPR/Cas9: a novel cellular model relevant to Alzheimer's disease research. Bioscience reports. vol 41. issue 2. 2021-07-21. PMID:33600562. |
apoe is highly expressed in astrocytes and microglia, however its expression can also be induced in neurons under various conditions. |
2021-07-21 |
2023-08-13 |
human |
| Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi, Ilse Dewachte. CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia. Acta neuropathologica communications. vol 9. issue 1. 2021-07-12. PMID:34103079. |
single-cell rna sequencing revealed that atn pathology exacerbated microglial activation towards disease-associated microglia states, with a significant upregulation of apoe as compared to amyloid-only models (a). |
2021-07-12 |
2023-08-13 |
Not clear |
| Chao Wang, Monica Xiong, Maud Gratuze, Xin Bao, Yang Shi, Prabhakar Sairam Andhey, Melissa Manis, Caitlin Schroeder, Zhuoran Yin, Charlotte Madore, Oleg Butovsky, Maxim Artyomov, Jason D Ulrich, David M Holtzma. Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia. Neuron. vol 109. issue 10. 2021-06-21. PMID:33831349. |
in the brain, apoe is produced and secreted primarily by astrocytes and by activated microglia. |
2021-06-21 |
2023-08-13 |
Not clear |
| Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamov. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34099706. |
phospholipids of apoe lipoproteins activate microglia in an isoform-specific manner in preclinical models of alzheimer's disease. |
2021-06-15 |
2023-08-13 |
mouse |
| Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamov. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34099706. |
apoe and trem2 are major genetic risk factors for alzheimer's disease (ad), but how they affect microglia response to aβ remains unclear. |
2021-06-15 |
2023-08-13 |
mouse |
| Wenchen Zhao, Jianjia Fan, Iva Kulic, Cheryl Koh, Amanda Clark, Johan Meuller, Ola Engkvist, Samantha Barichievy, Carina Raynoschek, Ryan Hicks, Marcello Maresca, Qi Wang, Dean G Brown, Alvin Lok, Cameron Parro, Jerome Robert, Hsien-Ya Chou, Andrea M Zuhl, Michael W Wood, Nicholas J Brandon, Cheryl L Wellingto. Axl receptor tyrosine kinase is a regulator of apolipoprotein E. Molecular brain. vol 13. issue 1. 2021-06-03. PMID:32366277. |
az7235, a previously discovered axl kinase inhibitor, was identified to have robust apoe activity in brain microglia, astrocytes and pericytes. |
2021-06-03 |
2023-08-13 |
mouse |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2021-05-31 |
2023-08-13 |
human |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
using single-nucleus rna sequencing of postmortem human brain with varied apoe and trem2 genotypes and neuropathology, we identified distinct microglia subpopulations, including a subpopulation of cd163-positive amyloid-responsive microglia (arm) that are depleted in cases with apoe and trem2 risk variants. |
2021-05-31 |
2023-08-13 |
human |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
we validated our single-nucleus rna sequencing findings in an expanded cohort of ad cases, demonstrating that apoe and trem2 risk variants are associated with a significant reduction in cd163-positive amyloid-responsive microglia. |
2021-05-31 |
2023-08-13 |
human |
| Ramsey Najm, Kelly A Zalocusky, Misha Zilberter, Seo Yeon Yoon, Yanxia Hao, Nicole Koutsodendris, Maxine Nelson, Antara Rao, Alice Taubes, Emily A Jones, Yadong Huan. In Vivo Chimeric Alzheimer's Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons. Cell reports. vol 32. issue 4. 2021-05-10. PMID:32726626. |
we also find that aβ from transplanted human neurons forms plaque-like aggregates, with differences in localization and interaction with microglia depending on the transplant and host apoe genotype. |
2021-05-10 |
2023-08-13 |
mouse |
| Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. |
interplay between microglia and alzheimer's disease-focus on the most relevant risks: apoe genotype, sex and age. |
2021-04-28 |
2023-08-13 |
Not clear |
| Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. |
therefore, during the occurrence and development of ad, the key susceptibility factors for ad-apolipoprotein e (apoe) genotype, sex and age-may further interact with microglia to exacerbate neurodegeneration. |
2021-04-28 |
2023-08-13 |
Not clear |
| Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. |
in this review, we discuss the role of microglia in the progression of ad related to the three risk factors for ad: apoe genotype, sex and aging. |
2021-04-28 |
2023-08-13 |
Not clear |
| Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. |
obviously, in the role of microglia in ad, the three main risk factors of apoe, sex, and aging are not independent and have synergistic effects that contribute to the risk of ad. |
2021-04-28 |
2023-08-13 |
Not clear |
| Shima Safaiyan, Simon Besson-Girard, Tuğberk Kaya, Ludovico Cantuti-Castelvetri, Lu Liu, Hao Ji, Martina Schifferer, Garyfallia Gouna, Fumere Usifo, Nirmal Kannaiyan, Dirk Fitzner, Xianyuan Xiang, Moritz J Rossner, Matthias Brendel, Ozgun Gokce, Mikael Simon. White matter aging drives microglial diversity. Neuron. vol 109. issue 7. 2021-04-27. PMID:33606969. |
in the aged brain, wams form independent of apolipoprotein e (apoe), in contrast to mouse models of alzheimer's disease, in which microglia with the wam gene signature are generated prematurely and in an apoe-dependent pathway similar to dams. |
2021-04-27 |
2023-08-13 |
mouse |
| Daniel L Kober, Melissa D Stuchell-Brereton, Colin E Kluender, Hunter B Dean, Michael R Strickland, Deborah F Steinberg, Samantha S Nelson, Berevan Baban, David M Holtzman, Carl Frieden, Jennifer Alexander-Brett, Erik D Roberson, Yuhua Song, Tom J Bret. Functional insights from biophysical study of TREM2 interactions with apoE and Aβ Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-04-10. PMID:33090700. |
functional insights from biophysical study of trem2 interactions with apoe and aβ triggering receptor expressed on myeloid cells-2 (trem2) is an immune receptor expressed on microglia that also can become soluble (strem2). |
2021-04-10 |
2023-08-13 |
Not clear |