| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yimei Liu, Xiaohua Xu, Hongbo Dou, Ying Hua, Jinwen Xu, Xu Hu. Apolipoprotein E knockout induced inflammatory responses related to microglia in neonatal mice brain via astrocytes. International journal of clinical and experimental medicine. vol 8. issue 1. 2015-03-18. PMID:25785051. |
compared to control group, the microglia cell from apoe(-/-) mice showed more severe inflammation and cell death such as inos and il-1β. |
2015-03-18 |
2023-08-13 |
mouse |
| Yimei Liu, Xiaohua Xu, Hongbo Dou, Ying Hua, Jinwen Xu, Xu Hu. Apolipoprotein E knockout induced inflammatory responses related to microglia in neonatal mice brain via astrocytes. International journal of clinical and experimental medicine. vol 8. issue 1. 2015-03-18. PMID:25785051. |
furthermore, anti-inflammatory such as tgf-β, il-10 from microglia and astrocytes in apoe(-/-) mice were decreased. |
2015-03-18 |
2023-08-13 |
mouse |
| Yimei Liu, Xiaohua Xu, Hongbo Dou, Ying Hua, Jinwen Xu, Xu Hu. Apolipoprotein E knockout induced inflammatory responses related to microglia in neonatal mice brain via astrocytes. International journal of clinical and experimental medicine. vol 8. issue 1. 2015-03-18. PMID:25785051. |
our findings suggested that the anti- inflammation factor such as il-10 mainly from microglia and tgf-β mainly from astrocyte is significant decreased after loss of apoe function in apoe(-/-) mice which induced severe inflammation. |
2015-03-18 |
2023-08-13 |
mouse |
| Wenjuan Zhao, Sonya B Dumanis, Irfan Y Tamboli, Gustavo A Rodriguez, Mary Jo Ladu, Charbel E H Moussa, G William Rebec. Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model. Human molecular genetics. vol 23. issue 5. 2014-10-15. PMID:24154541. |
finally, apoe was present in neurons of the ipsilateral cortex of apoe-tr mice at 2 weeks after lentivirus injection, in addition to astrocytes and microglia in both the ipsilateral and contralateral cerebral cortex. |
2014-10-15 |
2023-08-12 |
mouse |
| Sandra D Mulder, Henrietta M Nielsen, Marinus A Blankenstein, Piet Eikelenboom, Robert Veerhui. Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro. Glia. vol 62. issue 4. 2014-10-06. PMID:24446231. |
astrocytes and microglia are important mediators of aβ clearance and aβ aggregation state and the presence of amyloid associated proteins (aaps), such as apolipoproteins e and j (apoe and apoj), may influence aβ clearance by these cells. |
2014-10-06 |
2023-08-12 |
human |
| Wenjuan Zhao, Jiguo Zhang, Elizabeth G Davis, G William Rebec. Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector. Frontiers in aging neuroscience. vol 6. 2014-09-01. PMID:25177293. |
we conclude that both aging and apoe genotype affect pathways related to aβ metabolism by microglia. |
2014-09-01 |
2023-08-13 |
mouse |
| Jingjing Zhuang, Haikun Zhang, Rong Zhou, Lili Chen, Jing Chen, Xu She. Regulation of prostaglandin F2α against β amyloid clearance and its inflammation induction through LXR/RXR heterodimer antagonism in microglia. Prostaglandins & other lipid mediators. vol 106. 2014-07-10. PMID:24076168. |
cell based assays indicated that pgf2α effectively antagonized the activation of lxr agonist (t0901317) on aβ clearance via inhibiting apolipoprotein e (apoe) expression, and cell apoptosis alleviation by accelerating inflammatory response to aβ or lipopolysaccharide (lps) in microglia. |
2014-07-10 |
2023-08-12 |
Not clear |
| Yue Yang, Eiron Cudaback, Nikolas L Jorstad, Jake F Hemingway, Catherine E Hagan, Erica J Melief, Xianwu Li, Tom Yoo, Shawn B Khademi, Kathleen S Montine, Thomas J Montine, C Dirk Keen. APOE3, but not APOE4, bone marrow transplantation mitigates behavioral and pathological changes in a mouse model of Alzheimer disease. The American journal of pathology. vol 183. issue 3. 2014-03-12. PMID:23831297. |
bmt-derived microglia engraftment was significantly reduced in apoe4/4 recipients, who also had correspondingly less cerebral apoe. |
2014-03-12 |
2023-08-12 |
mouse |
| Sophie Stukas, Sharon May, Anna Wilkinson, Jeniffer Chan, James Donkin, Cheryl L Wellingto. The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1. Biochimica et biophysica acta. vol 1821. issue 3. 2012-11-26. PMID:21889608. |
although apoa-i is not expressed in astrocytes and microglia, which produce cns apoe, apoa-i is reported to be expressed in porcine brain capillary endothelial cells and also crosses the blood-brain barrier (bbb). |
2012-11-26 |
2023-08-12 |
mouse |
| Shweta Mandrekar-Colucci, J Colleen Karlo, Gary E Landret. Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 30. 2012-10-29. PMID:22836247. |
apoe functions to promote the proteolytic clearance of soluble forms of aβ, and we found that the synthetic pparγ agonist, pioglitazone, stimulated aβ degradation by both microglia and astrocytes in an lxr and apoe-dependent manner. |
2012-10-29 |
2023-08-12 |
mouse |
| Xing-Mei Zhang, Xi-Jing Mao, Hong-Liang Zhang, Xiang-Yu Zheng, Therese Pham, Abdu Adem, Bengt Winblad, Eilhard Mix, Jie Zh. Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration. Experimental neurology. vol 233. issue 1. 2012-03-25. PMID:22079154. |
in the present study, we investigated the individual roles of apoe isoforms in the kainic acid (ka)-induced hippocampal neurodegeneration with focus on immune response and microglia functions. |
2012-03-25 |
2023-08-12 |
mouse |
| C Y Daniel Lee, Wayne Tse, Jonathan D Smith, Gary E Landret. Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels. The Journal of biological chemistry. vol 287. issue 3. 2012-03-05. PMID:22130662. |
previously, we demonstrated that intracellular degradation of β-amyloid (aβ) peptides by microglia is dramatically enhanced in the presence of apoe. |
2012-03-05 |
2023-08-12 |
Not clear |
| C Y Daniel Lee, Wayne Tse, Jonathan D Smith, Gary E Landret. Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels. The Journal of biological chemistry. vol 287. issue 3. 2012-03-05. PMID:22130662. |
we demonstrate that promoting intracellular aβ degradation by microglia is a common feature of hdl apolipoproteins, including apoe and apoa-i. |
2012-03-05 |
2023-08-12 |
Not clear |
| Eiron Cudaback, Xianwu Li, Kathleen S Montine, Thomas J Montine, C Dirk Keen. Apolipoprotein E isoform-dependent microglia migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 6. 2011-08-18. PMID:21385991. |
although the c5a-dependent chemotaxis of wild-type microglia was completely blocked by receptor-associated protein (rap), suggesting apoe receptor involvement, atp-stimulated migration was unaffected by rap but was associated with differential erk phosphorylation. |
2011-08-18 |
2023-08-12 |
mouse |
| Eiron Cudaback, Xianwu Li, Kathleen S Montine, Thomas J Montine, C Dirk Keen. Apolipoprotein E isoform-dependent microglia migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 6. 2011-08-18. PMID:21385991. |
studies using primary microglia derived from targeted replacement mice "humanized" for the coding exons (protein isoform) of human ε2 (apoe2), ε3 (apoe3), or ε4 (apoe4) allele of apoe revealed that primary mouse microglia expressing apoe4 or apoe2 exhibited significantly reduced c5a- and atp-stimulated migration compared with microglia expressing human apoe3. |
2011-08-18 |
2023-08-12 |
mouse |
| Dick Terwel, Knut R Steffensen, Philip B Verghese, Markus P Kummer, Jan-Åke Gustafsson, David M Holtzman, Michael T Henek. Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 19. 2011-07-25. PMID:21562267. |
together, these data suggest that astrocytic lxrα activation and subsequent release of apoe by astrocytes is critical for the ability of microglia to remove fibrillar aβ in response to treatment with to901317. |
2011-07-25 |
2023-08-12 |
mouse |
| D Famer, L-O Wahlund, M Crisb. Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD. Biochemical and biophysical research communications. vol 402. issue 2. 2010-12-28. PMID:20946880. |
rosuvastatin reduces microglia in the brain of wild type and apoe knockout mice on a high cholesterol diet; implications for prevention of stroke and ad. |
2010-12-28 |
2023-08-12 |
mouse |
| Nicholas F Fitz, Andrea Cronican, Tam Pham, Allison Fogg, Abdul H Fauq, Robert Chapman, Iliya Lefterov, Radosveta Koldamov. Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 20. 2010-06-04. PMID:20484628. |
in vitro experiments with primary glia demonstrate that abca1 is essential for the proper lipidation of apoe and mediates the effects of t0 on abeta degradation by microglia. |
2010-06-04 |
2023-08-12 |
mouse |
| Ana Pocivavsek, Irina Mikhailenko, Dudley K Strickland, G William Rebec. Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation. Journal of neuroimmunology. vol 214. issue 1-2. 2009-09-28. PMID:19586665. |
we aimed to identify which specific receptor family member mediates the effect of apoe on inflammation in primary cultures of microglia. |
2009-09-28 |
2023-08-12 |
mouse |
| Ana Pocivavsek, Mark P Burns, G William Rebec. Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase. Glia. vol 57. issue 4. 2009-07-01. PMID:18803301. |
to address this hypothesis, we used a small bioactive peptide formed from the receptor-binding domain of apoe, apoe peptide (ep), to study ldl receptor signaling in microglia. |
2009-07-01 |
2023-08-12 |
mouse |