| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Styren, M I Kamboh, S T DeKosk. Expression of differential immune factors in temporal cortex and cerebellum: the role of alpha-1-antichymotrypsin, apolipoprotein E, and reactive glia in the progression of Alzheimer's disease. The Journal of comparative neurology. vol 396. issue 4. 1998-09-08. PMID:9651008. |
in cerebellum, act and apoe immunoreactivity was never localized to plaque-like profiles but was weakly localized to unreactive astrocytes; weak hla-dr and gfap immunoreactivity was present on quiescent microglia throughout the cerebellum. |
1998-09-08 |
2023-08-12 |
human |
| D T Laskowitz, W D Matthew, E R Bennett, D Schmechel, M H Herbstreith, S Goel, M K McMillia. Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production. Neuroreport. vol 9. issue 4. 1998-06-02. PMID:9559926. |
addition of human apoe inhibits murine microglial activation in culture, suggesting that microglia might be an important physiological target of apoe. |
1998-06-02 |
2023-08-12 |
mouse |
| D J Stone, I Rozovsky, T E Morgan, C P Anderson, H Hajian, C E Finc. Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro. Experimental neurology. vol 143. issue 2. 1997-04-07. PMID:9056393. |
astrocytes and microglia respond to estrogen with increased apoe mrna in vivo and in vitro. |
1997-04-07 |
2023-08-12 |
rat |
| D J Stone, I Rozovsky, T E Morgan, C P Anderson, H Hajian, C E Finc. Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro. Experimental neurology. vol 143. issue 2. 1997-04-07. PMID:9056393. |
both astrocytes and microglia contributed to this increase in apoe mrna. |
1997-04-07 |
2023-08-12 |
rat |
| D J Stone, I Rozovsky, T E Morgan, C P Anderson, H Hajian, C E Finc. Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro. Experimental neurology. vol 143. issue 2. 1997-04-07. PMID:9056393. |
in vitro, e2 treatment had no effect on apoe mrna levels in monotypic cultures of either astrocytes or microglia. |
1997-04-07 |
2023-08-12 |
rat |
| D J Stone, I Rozovsky, T E Morgan, C P Anderson, H Hajian, C E Finc. Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro. Experimental neurology. vol 143. issue 2. 1997-04-07. PMID:9056393. |
in situ hybridization in combination with cell-specific markers showed that e2 increased apoe mrna levels in both astrocytes and microglia. |
1997-04-07 |
2023-08-12 |
rat |
| D J Stone, I Rozovsky, T E Morgan, C P Anderson, H Hajian, C E Finc. Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro. Experimental neurology. vol 143. issue 2. 1997-04-07. PMID:9056393. |
these results, which are the first evidence of apoe mrna localization to microglia in vivo and the control of apoe expression in brain cells by estrogens, are discussed in terms of the possible protective role of e2 in alzheimer's disease and prior findings that emphasize the expression of apoe mrna in astrocytes within the brain. |
1997-04-07 |
2023-08-12 |
rat |
| T Saitoh, D Kang, M Mallory, R DeTeresa, E Maslia. Glial cells in Alzheimer's disease: preferential effect of APOE risk on scattered microglia. Gerontology. vol 43. issue 1-2. 1997-04-01. PMID:8996833. |
glial cells in alzheimer's disease: preferential effect of apoe risk on scattered microglia. |
1997-04-01 |
2023-08-12 |
Not clear |
| M Nakai, T Kawamata, T Taniguchi, K Maeda, C Tanak. Expression of apolipoprotein E mRNA in rat microglia. Neuroscience letters. vol 211. issue 1. 1996-12-06. PMID:8809843. |
apoe has been postulated to be synthesized by astrocytes and taken up by microglia and neuronal cells. |
1996-12-06 |
2023-08-12 |
rat |
| M Nakai, T Kawamata, T Taniguchi, K Maeda, C Tanak. Expression of apolipoprotein E mRNA in rat microglia. Neuroscience letters. vol 211. issue 1. 1996-12-06. PMID:8809843. |
however, it remains unknown whether apoe is also produced by microglia in the brain. |
1996-12-06 |
2023-08-12 |
rat |
| M Nakai, T Kawamata, T Taniguchi, K Maeda, C Tanak. Expression of apolipoprotein E mRNA in rat microglia. Neuroscience letters. vol 211. issue 1. 1996-12-06. PMID:8809843. |
we analyzed apoe mrna expression of microglia using a rat primary culture system. |
1996-12-06 |
2023-08-12 |
rat |
| M Nakai, T Kawamata, T Taniguchi, K Maeda, C Tanak. Expression of apolipoprotein E mRNA in rat microglia. Neuroscience letters. vol 211. issue 1. 1996-12-06. PMID:8809843. |
reverse transcriptase-polymerase chain reaction (rt-pcr) analysis revealed expression of apoe mrna in cultured rat microglia. |
1996-12-06 |
2023-08-12 |
rat |
| M Nakai, T Kawamata, T Taniguchi, K Maeda, C Tanak. Expression of apolipoprotein E mRNA in rat microglia. Neuroscience letters. vol 211. issue 1. 1996-12-06. PMID:8809843. |
by rt-in situ-pcr, microglia showed positive staining for the pcr product of apoe mrna. |
1996-12-06 |
2023-08-12 |
rat |
| M Nakai, T Kawamata, T Taniguchi, K Maeda, C Tanak. Expression of apolipoprotein E mRNA in rat microglia. Neuroscience letters. vol 211. issue 1. 1996-12-06. PMID:8809843. |
these results indicated that apoe was biosynthesized in rat microglia. |
1996-12-06 |
2023-08-12 |
rat |
| M Nakai, T Kawamata, T Taniguchi, K Maeda, C Tanak. Expression of apolipoprotein E mRNA in rat microglia. Neuroscience letters. vol 211. issue 1. 1996-12-06. PMID:8809843. |
we suggest that microglia might be one of the sources of apoe in the brain, and that apoe synthesized in microglia might be closely related to the pathogenesis of ad. |
1996-12-06 |
2023-08-12 |
rat |