| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asha Naidu, Qiang Xu, Rosanne Catalano, Barbara Cordel. Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. Brain research. vol 958. issue 1. 2003-02-25. PMID:12468034. |
we determined that protein prenylation is required for apoe release from a continuous microglial cell line, primary mixed glia, and from organotypic hippocampal cultures. |
2003-02-25 |
2023-08-12 |
Not clear |
| M Czapiga, C A Colto. Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport. Journal of neuroimmunology. vol 134. issue 1-2. 2003-02-25. PMID:12507771. |
to understand apoe's function, we have examined microglia, the cns specific macrophage, in transgenic mice expressing the human apoe3 and apoe4 gene allele. |
2003-02-25 |
2023-08-12 |
mouse |
| S Vogelgesang, E Schroeder, L C Walker, J Pahnke, A Naubereit, R Walther, D Stausske, R W Warzo. Activated microglia do not mediate the early deposition of Abeta in carriers of the apolipoprotein Eepsilon4 allele. Clinical neuropathology. vol 21. issue 3. 2002-11-18. PMID:12049183. |
to determine whether microglia are involved in the initial stages of beta-amyloid pathogenesis and whether apoe genotype influences microglial activation, we quantified hla-dr-immunoreactive microglia in the medial temporal lobe of 229 non-demented humans of various apoe genotypes who had died between 50 and 91 years of age. |
2002-11-18 |
2023-08-12 |
Not clear |
| S Vogelgesang, E Schroeder, L C Walker, J Pahnke, A Naubereit, R Walther, D Stausske, R W Warzo. Activated microglia do not mediate the early deposition of Abeta in carriers of the apolipoprotein Eepsilon4 allele. Clinical neuropathology. vol 21. issue 3. 2002-11-18. PMID:12049183. |
in contrast to amyloid plaques and neurofibrillary tangles, there is no significant correlation between apoe genotype and density of microglia, although apoeepsilon4 homozygotes tended to have more microglia than did other apoe groups. |
2002-11-18 |
2023-08-12 |
Not clear |
| B P Nathan, R Nisar, S Randall, J Short, M Sherrow, G K Wong, R G Strubl. Apolipoprotein E is upregulated in olfactory bulb glia following peripheral receptor lesion in mice. Experimental neurology. vol 172. issue 1. 2001-12-05. PMID:11681846. |
double-labeling immunocytochemical studies confirmed that both reactive astroglia and microglia produced detectable amounts of apoe following the lesion. |
2001-12-05 |
2023-08-12 |
mouse |
| S Hass, A Weidemann, G Utermann, G Baie. Intracellular apolipoprotein E affects Amyloid Precursor Protein processing and amyloid Abeta production in COS-1 cells. Molecular genetics and genomics : MGG. vol 265. issue 5. 2001-09-13. PMID:11523796. |
the findings suggest that in cells that express both apoe and app, such as astrocytes and microglia, a functional apoe:app interaction may occur which modulates app processing and abeta production. |
2001-09-13 |
2023-08-12 |
Not clear |
| G J Harry, C Lefebvre d'Hellencourt, A Bruccoleri, D Schmeche. Age-dependent cytokine responses: trimethyltin hippocampal injury in wild-type, APOE knockout, and APOE4 mice. Brain, behavior, and immunity. vol 14. issue 4. 2001-03-01. PMID:11120597. |
these data suggest an age-dependent effect on both microglia early inflammatory responses to injury associated with the apoe genotype. |
2001-03-01 |
2023-08-12 |
mouse |
| G M Cole, W Beech, S A Frautschy, J Sigel, C Glasgow, M D Ar. Lipoprotein effects on Abeta accumulation and degradation by microglia in vitro. Journal of neuroscience research. vol 57. issue 4. 1999-09-09. PMID:10440900. |
because hdl lipoproteins have been shown to carry the beta-amyloid peptide (abeta) in plasma and csf, we have investigated the influence of plasma high-density lipoprotein (hdl) and lipidated apoe and apoj particles on the interaction of cultured rat microglia with abeta1-42. |
1999-09-09 |
2023-08-12 |
rat |
| M O McCarron, J A Nicoll, J Stewart, J W Ironside, D M Mann, S Love, D I Graham, D Dewa. The apolipoprotein E epsilon2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411341. |
we performed immunohistochemistry for amyloid beta-protein (a beta), apoe, cystatin c, and activated microglia, and examined the morphology of cortical and leptomeningeal vessels in 37 caa-related hemorrhage (caah), 26 alzheimer disease (ad) patients, and 20 controls. |
1999-07-27 |
2023-08-12 |
Not clear |
| M O McCarron, J A Nicoll, J Stewart, J W Ironside, D M Mann, S Love, D I Graham, D Dewa. The apolipoprotein E epsilon2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411341. |
the extent of immunostaining of vessels for a beta, apoe, cystatin c, and perivascular activated microglia increased from controls through ad to a maximum in caah patients. |
1999-07-27 |
2023-08-12 |
Not clear |
| M O McCarron, J A Nicoll, J Stewart, J W Ironside, D M Mann, S Love, D I Graham, D Dewa. The apolipoprotein E epsilon2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411341. |
among cases with caa (37 caah, 19 ad, and 6 controls, n = 62) vascular apoe (p < 5 x 10(-4)), cystatin c (p < 10(-4)), activated microglia (p < 10(-4)), vessels with a high ratio of wall thickness to lumen diameter (p < 0.003) as well as dilated/microaneurysmal vessels (p < 0.01) were present more frequently in patients with hemorrhage than without; however, these features were not associated with the apoe epsilon2 allele. |
1999-07-27 |
2023-08-12 |
Not clear |
| M Overmyer, S Helisalmi, H Soininen, M Laakso, P Riekkinen, I Alafuzof. Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue. Acta neuropathologica. vol 97. issue 4. 1999-07-20. PMID:10208278. |
the counts of hla dr-expressing activated microglia were significantly higher in female ad patients compared to males, significantly higher in ad patients with the age at death greater than 75 years compared to those dying younger and higher, although not statistically significantly, in ad patients with the apolipoprotein e (apoe) epsilon4 allele compared to those patients not carrying this allele. |
1999-07-20 |
2023-08-12 |
human |
| M Overmyer, S Helisalmi, H Soininen, M Laakso, P Riekkinen, I Alafuzof. Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue. Acta neuropathologica. vol 97. issue 4. 1999-07-20. PMID:10208278. |
a significant correlation between activated microglia and neurofibrillary tangles was seen in female ad patients compared to males, in ad cases without apoe epsilon4 allele compared to those with this allele, in sporadic cases compared to familial and in cases with senile rather than presenile onset of the disease. |
1999-07-20 |
2023-08-12 |
human |
| M Overmyer, S Helisalmi, H Soininen, M Laakso, P Riekkinen, I Alafuzof. Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue. Acta neuropathologica. vol 97. issue 4. 1999-07-20. PMID:10208278. |
our results indicate that there is an age- and/or sex-related variability in up-regulation of hla dr expression of microglia and that the linkage between this up-regulation and ad lesions is significantly influenced by the apoe epsilon4 allele, gender of subjects, age at onset and familiality of the disease. |
1999-07-20 |
2023-08-12 |
human |
| G M Pasinetti, M Hassler, D Stone, C E Finc. Glial gene expression during aging in rat striatum and in long-term responses to 6-OHDA lesions. Synapse (New York, N.Y.). vol 31. issue 4. 1999-05-07. PMID:10051108. |
the findings extend the established age-related increases in gfap (glial fibrillary acidic protein) to other glial mrnas: two lipoprotein mrnas that are predominantly expressed in striatal astrocytes, apoe (apolipoprotein e) and apoj (apolipoprotein j, clusterin, cli, or sgp-2), and two mrnas expressed in striatal microglia, tgf-beta1 and complement c1qb. |
1999-05-07 |
2023-08-12 |
rat |
| V R Lombardi, M García, R Cacabelo. Microglial activation induced by factor(s) contained in sera from Alzheimer-related ApoE genotypes. Journal of neuroscience research. vol 54. issue 4. 1999-01-19. PMID:9822164. |
in addition, major histocompatibility complex (mhc) class ii antigen expression, as measured by flow cytometric analysis, and interleukin-1beta (il-1beta) release as measured by enzyme linked immunoadsorbent assay (elisa), in comparison with control groups and lipopolysaccharide (lps)-treated cells, clearly demonstrate a direct effect of apoe 3/4 and 4/4 and/or an indirect effect mediated by the release of il-1beta on microglia activation. |
1999-01-19 |
2023-08-12 |
human |
| R Egensperger, S Kösel, U von Eitzen, M B Graebe. Microglial activation in Alzheimer disease: Association with APOE genotype. Brain pathology (Zurich, Switzerland). vol 8. issue 3. 1998-09-09. PMID:9669695. |
the number of activated microglia and the tissue area occupied by these cells increased significantly with apoe epsilon4 gene dose. |
1998-09-09 |
2023-08-12 |
Not clear |
| R Egensperger, S Kösel, U von Eitzen, M B Graebe. Microglial activation in Alzheimer disease: Association with APOE genotype. Brain pathology (Zurich, Switzerland). vol 8. issue 3. 1998-09-09. PMID:9669695. |
since microglial activation by app has been shown to be modulated by apoe in vitro, a direct role of microglia in ad pathogenesis is conceivable. |
1998-09-09 |
2023-08-12 |
Not clear |
| S D Styren, M I Kamboh, S T DeKosk. Expression of differential immune factors in temporal cortex and cerebellum: the role of alpha-1-antichymotrypsin, apolipoprotein E, and reactive glia in the progression of Alzheimer's disease. The Journal of comparative neurology. vol 396. issue 4. 1998-09-08. PMID:9651008. |
in affected regions of ad brain, act and apoe colocalize with abeta deposits and reactive microglia and astrocytes. |
1998-09-08 |
2023-08-12 |
human |
| S D Styren, M I Kamboh, S T DeKosk. Expression of differential immune factors in temporal cortex and cerebellum: the role of alpha-1-antichymotrypsin, apolipoprotein E, and reactive glia in the progression of Alzheimer's disease. The Journal of comparative neurology. vol 396. issue 4. 1998-09-08. PMID:9651008. |
in temporal cortex, act and apoe staining was localized to plaque-like profiles, reactive astrocytes, and blood vessels; human leukocyte antigen-dr (hla-dr) and glial fibrillary acidic protein (gfap) staining revealed focal clusters of reactive microglia and astrocytes. |
1998-09-08 |
2023-08-12 |
human |