| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Pocivavsek, Mark P Burns, G William Rebec. Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase. Glia. vol 57. issue 4. 2009-07-01. PMID:18803301. |
to model glial activation, we treated primary mouse microglia and the microglial cell line bv2 with lipopolysaccharide (lps) and studied two inflammatory responses: an increase in nitric oxide production (no) and a decrease in apoe production. |
2009-07-01 |
2023-08-12 |
mouse |
| Ana Pocivavsek, Mark P Burns, G William Rebec. Low-density lipoprotein receptors regulate microglial inflammation through c-Jun N-terminal kinase. Glia. vol 57. issue 4. 2009-07-01. PMID:18803301. |
we found that treatment of primary microglia and bv2 cells with ep attenuated lps-induced no accumulation and apoe reduction in a dose-dependent manner. |
2009-07-01 |
2023-08-12 |
mouse |
| Candice M Brown, Emily Choi, Qing Xu, Michael P Vitek, Carol A Colto. The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17553597. |
since 17beta-estradiol down-regulates inflammation as part of its neuroprotective role, we examined the effect of 17beta-estradiol on the response of microglia to immune activation as a function of apoe genotype. |
2009-01-23 |
2023-08-12 |
mouse |
| Candice M Brown, Emily Choi, Qing Xu, Michael P Vitek, Carol A Colto. The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17553597. |
a significant interaction between apoe genotype and the response to 17beta-estradiol was observed for no and cytokine production by immune activated microglia. |
2009-01-23 |
2023-08-12 |
mouse |
| Yoshinari Uehara, Tatsuo Yamada, Yasuhiko Baba, Shin-ichiro Miura, Satomi Abe, Ken Kitajima, Masa-aki Higuchi, Takahiro Iwamoto, Keijiro Sak. ATP-binding cassette transporter G4 is highly expressed in microglia in Alzheimer's brain. Brain research. vol 1217. 2008-09-09. PMID:18508037. |
these results suggest that upregulated abcg4 in microglia may accelerate the lipidation of apoe and hdl in the ad brain. |
2008-09-09 |
2023-08-12 |
Not clear |
| Qingguang Jiang, C Y Daniel Lee, Shweta Mandrekar, Brandy Wilkinson, Paige Cramer, Noam Zelcer, Karen Mann, Bruce Lamb, Timothy M Willson, Jon L Collins, Jill C Richardson, Jonathan D Smith, Thomas A Comery, David Riddell, David M Holtzman, Peter Tontonoz, Gary E Landret. ApoE promotes the proteolytic degradation of Abeta. Neuron. vol 58. issue 5. 2008-07-10. PMID:18549781. |
the endolytic degradation of abeta peptides within microglia by neprilysin and related enzymes is dramatically enhanced by apoe. |
2008-07-10 |
2023-08-12 |
mouse |
| Izumi Maezawa, Nobuyo Maeda, Thomas J Montine, Kathleen S Montin. Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. Journal of neuroinflammation. vol 3. 2007-07-20. PMID:16603079. |
previously we have shown that primary microglia cultures from targeted replacement (tr) apoe mice have apoe isoform-dependent innate immune activation and paracrine damage to neurons that is greatest with tr by the epsilon4 allele (tr apoe4) and that derives from p38 mitogen-activated protein kinase (p38mapk) activity. |
2007-07-20 |
2023-08-12 |
mouse |
| Guoqing Cao, Kelly R Bales, Ronald B DeMattos, Steven M Pau. Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics. Current Alzheimer research. vol 4. issue 2. 2007-07-10. PMID:17430244. |
in addition, the expression of apolipoprotein e (apoe), synthesized primarily by astrocytes and microglia, is also upregulated by lxr agonists. |
2007-07-10 |
2023-08-12 |
Not clear |
| Rui-Sheng Duan, Zhiguo Chen, Ying-Chun Dou, Hernan Concha Quezada, Inger Nennesmo, Abdu Adem, Bengt Winblad, Jie Zh. Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice. Experimental neurology. vol 202. issue 2. 2007-01-03. PMID:16919271. |
mice lacking apoe demonstrated more hunching and less rearing, more damage to neurons in the ca3 region (mean histopathologic score: 3.7 vs. 1.6, p < 0.05), greater microglial activation confirmed by high levels of cd11b and cd86 expression in hippocampus (cd11b p < 0.01, cd86 p < 0.05), and a greater percentage of activated microglia expressing cc chemokine receptors 3 (ccr3) (p < 0.05). |
2007-01-03 |
2023-08-12 |
mouse |
| Qin Xu, Aubrey Bernardo, David Walker, Tiffany Kanegawa, Robert W Mahley, Yadong Huan. Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 19. 2006-05-31. PMID:16687490. |
egfp was expressed in <10% of microglia after kainic acid treatment, suggesting that microglia are not a major source of brain apoe. |
2006-05-31 |
2023-08-12 |
mouse |
| Si Qin, Catherine Colin, Ina Hinners, Annie Gervais, Cyril Cheret, Michel Malla. System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 12. 2006-04-14. PMID:16554485. |
inhibition of nmda receptors or system xc- prevented the microglia-enhanced neurotoxicity of abeta but also unmasked a neuroprotective effect of microglia mediated by microglial secretion of apolipoprotein e (apoe) in the culture medium. |
2006-04-14 |
2023-08-12 |
mouse |
| Si Qin, Catherine Colin, Ina Hinners, Annie Gervais, Cyril Cheret, Michel Malla. System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 12. 2006-04-14. PMID:16554485. |
immunodepletion of apoe or targeted inactivation of the apoe gene in microglia abrogated neuroprotection by microglial conditioned medium, whereas supplementation by human apoe isoforms restored protection, which was potentiated by the presence of microglia-derived cofactors. |
2006-04-14 |
2023-08-12 |
mouse |
| Davor Sporis, Jadranka Sertic, Neven Henigsberg, Darija Mahovic, Nenad Bogdanovic, Tomislav Babi. Association of refractory complex partial seizures with a polymorphism of ApoE genotype. Journal of cellular and molecular medicine. vol 9. issue 3. 2005-11-08. PMID:16202217. |
apoe is synthesised in astrocytes and microglia and enter to neurons through ldl, lrp and vldl receptors. |
2005-11-08 |
2023-08-12 |
Not clear |
| Shuang Chen, Natale T Averett, Arlene Manelli, Mary Jo Ladu, Warren May, March D Ar. Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia. Journal of Alzheimer's disease : JAD. vol 7. issue 1. 2005-08-02. PMID:15750212. |
two physiologically relevant preparations of apoe displayed an isoform-specific effect on inflammation in primary adult microglia cultured from adult rat brain cortex. |
2005-08-02 |
2023-08-12 |
rat |
| Veronica Hirsch-Reinshagen, Steven Zhou, Braydon L Burgess, Lise Bernier, Sean A McIsaac, Jeniffer Y Chan, Gavin H Tansley, Jeffrey S Cohn, Michael R Hayden, Cheryl L Wellingto. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. The Journal of biological chemistry. vol 279. issue 39. 2004-10-26. PMID:15269218. |
in both astrocytes and microglia, abca1 deficiency reduces lipid efflux to exogenous apoe. |
2004-10-26 |
2023-08-12 |
mouse |
| Veronica Hirsch-Reinshagen, Steven Zhou, Braydon L Burgess, Lise Bernier, Sean A McIsaac, Jeniffer Y Chan, Gavin H Tansley, Jeffrey S Cohn, Michael R Hayden, Cheryl L Wellingto. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. The Journal of biological chemistry. vol 279. issue 39. 2004-10-26. PMID:15269218. |
additionally, apoe secretion is compromised in abca1-/- astrocytes and microglia. |
2004-10-26 |
2023-08-12 |
mouse |
| Ping Zheng, Len A Pennacchio, Wilfried Le Goff, Edward M Rubin, Jonathan D Smit. Identification of a novel enhancer of brain expression near the apoE gene cluster by comparative genomics. Biochimica et biophysica acta. vol 1676. issue 1. 2004-02-27. PMID:14732489. |
in addition, double-label immunofluorescence performed on brain sections and cultures of primary cortical cells localized human apoe protein to cortical neurons and microglia. |
2004-02-27 |
2023-08-12 |
mouse |
| Suzana S Petanceska, Steven DeRosa, Ali Sharma, Nichole Diaz, Karen Duff, Steven G Tint, Lorenzo M Refolo, Miguel Pappoll. Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol. Journal of molecular neuroscience : MN. vol 20. issue 3. 2003-12-23. PMID:14501024. |
we also found that cholesterol loading of primary glial cells increases cellular and secreted apoe levels and that long-term treatment of astrocytes and microglia with statins leads to a decrease in the cellular and/or secreted apoe. |
2003-12-23 |
2023-08-12 |
mouse |
| Josep Saura, Valerie Petegnief, Xin Wu, Yanbin Liang, Steven M Pau. Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide. Journal of neurochemistry. vol 85. issue 6. 2003-07-10. PMID:12787065. |
these data demonstrate that glial apoe and apoj expression are independently regulated by lps in microglia and astroglia, respectively, and that activated microglia are the predominant source of apoe in mixed glial cultures. |
2003-07-10 |
2023-08-12 |
rat |
| Asha Naidu, Qiang Xu, Rosanne Catalano, Barbara Cordel. Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. Brain research. vol 958. issue 1. 2003-02-25. PMID:12468034. |
because astrocytes and microglia represent the major source of extracellular apoe in brain, we investigated apoe secretion by glia. |
2003-02-25 |
2023-08-12 |
Not clear |