| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Fosbraey, J R Wetherell, M C Frenc. Effect of acute physostigmine-hyoscine pretreatment on the neurochemical changes produced by soman in the guinea-pig. Neurochemistry international. vol 18. issue 2. 2012-10-02. PMID:20504702. |
both dose levels of pretreatment decreased lethality but only the high dose, which protected a measurable amount of ache and prevented neurotransmitter changes, decreased incapacitation. |
2012-10-02 |
2023-08-12 |
Not clear |
| Miroslav Pohanka, Oto Pavlis, Hana Svobodova, Jiri Pikul. Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice. Interdisciplinary toxicology. vol 5. issue 1. 2012-10-02. PMID:22783145. |
the present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (ache) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ach). |
2012-10-02 |
2023-08-12 |
mouse |
| Guillaume Mercey, Tristan Verdelet, Julien Renou, Maria Kliachyna, Rachid Baati, Florian Nachon, Ludovic Jean, Pierre-Yves Renar. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Accounts of chemical research. vol 45. issue 5. 2012-09-20. PMID:22360473. |
ache breaks down the neurotransmitter acetylcholine at neuronal synapses and neuromuscular junctions. |
2012-09-20 |
2023-08-12 |
Not clear |
| Guillaume Mercey, Tristan Verdelet, Julien Renou, Maria Kliachyna, Rachid Baati, Florian Nachon, Ludovic Jean, Pierre-Yves Renar. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Accounts of chemical research. vol 45. issue 5. 2012-09-20. PMID:22360473. |
the irreversible inhibition of ache causes the neurotransmitter to accumulate in the synaptic cleft, leading to overstimulation of cholinergic receptors, seizures, respiratory arrest, and death. |
2012-09-20 |
2023-08-12 |
Not clear |
| S Anne Boettger, James B McClintoc. Acetyl cholinesterase activity and muscle contraction in the sea urchin Lytechinus variegatus (Lamarck) following chronic phosphate exposure. Environmental toxicology. vol 27. issue 4. 2012-08-14. PMID:20607821. |
nonetheless, chronic exposure to low, medium, and high-sublethal concentrations of organic phosphate inhibits the muscle enzyme acetyl cholinesterase (ache), responsible for the break down of the neurotransmitter acetylcholine, as well as inhibiting contractions in the muscles associated with the aristotle's lantern. |
2012-08-14 |
2023-08-12 |
Not clear |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
other neurotransmitter is a classical neurotransmitter acetylcholine (ach), regulated by enzyme acetylcholinesterase (ache) that hydrolyses the acetylcholine after its releasing. |
2012-06-21 |
2023-08-12 |
rat |
| Amy C Halliday, Susan A Greenfiel. From protein to peptides: a spectrum of non-hydrolytic functions of acetylcholinesterase. Protein and peptide letters. vol 19. issue 2. 2012-06-08. PMID:21933122. |
acetylcholinesterase (ache), a member of the α/β-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ach). |
2012-06-08 |
2023-08-12 |
Not clear |
| Mauricio Valenzuela-Harrington, Irene Castillo, Corín Díaz, Inés Alés, Antonio Rodríguez-Moren. Dimethoate accelerates the extinction of eyeblink conditioning in mice. Neurotoxicology. vol 33. issue 1. 2012-06-04. PMID:22182529. |
these compounds decrease acetylcholine esterase (ache) activity, thereby provoking an accumulation of the neurotransmitter acetylcholine at synapses and resulting in the over-stimulation of acetylcholine receptors. |
2012-06-04 |
2023-08-12 |
mouse |
| Guiling He, Yang Sun, Fei L. RNA interference of two acetylcholinesterase genes in Plutella xylostella reveals their different functions. Archives of insect biochemistry and physiology. vol 79. issue 2. 2012-05-29. PMID:22392769. |
acetylcholinesterase (ache, ec 3.1.1.7) is an important enzyme with a typical function of degrading the neurotransmitter acetylcholine. |
2012-05-29 |
2023-08-12 |
Not clear |
| Manojkumar Valiyaveettil, Yonas Alamneh, Samuel Oguntayo, Yanling Wei, Ying Wang, Peethambaran Arun, Madhusoodana P Nambia. Regional specific alterations in brain acetylcholinesterase activity after repeated blast exposures in mice. Neuroscience letters. vol 506. issue 1. 2012-04-24. PMID:22079491. |
acetylcholinesterase (ache) which catalyzes the hydrolysis of the neurotransmitter acetylcholine has been recognized as one of the major regulators of stress responses after traumatic brain injury (tbi). |
2012-04-24 |
2023-08-12 |
mouse |
| Lotta Berg, C David Andersson, Elisabet Artursson, Andreas Hörnberg, Anna-Karin Tunemalm, Anna Linusson, Fredrik Ekströ. Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140425. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. |
2012-04-09 |
2023-08-12 |
mouse |
| M Sánchez-Guerra, N Pérez-Herrera, B Quintanilla-Veg. Organophosphorous pesticides research in Mexico: epidemiological and experimental approaches. Toxicology mechanisms and methods. vol 21. issue 9. 2012-01-30. PMID:22003926. |
studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (ache) activity (the main acute op toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of mexican farmers. |
2012-01-30 |
2023-08-12 |
human |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
acetylcholinesterase (ache; ec 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. |
2011-11-10 |
2023-08-12 |
mouse |
| Vicky P Chen, Wilson K W Luk, Wallace K B Chan, K Wing Leung, Ava J Y Guo, Gallant K L Chan, Sherry L Xu, Roy C Y Choi, Karl W K Tsi. Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:22046147. |
acetylcholinesterase (ache) is responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system. |
2011-11-10 |
2023-08-12 |
chicken |
| J A Bermúdez-Lugo, M C Rosales-Hernández, O Deeb, J Trujillo-Ferrara, J Correa-Basurt. In silico methods to assist drug developers in acetylcholinesterase inhibitor design. Current medicinal chemistry. vol 18. issue 8. 2011-08-01. PMID:21291371. |
ach is a neurotransmitter hydrolyzed by acetylcholinesterase (ache). |
2011-08-01 |
2023-08-12 |
Not clear |
| Ramón Cacabelo. Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics. Neuropsychiatric disease and treatment. vol 3. issue 3. 2011-05-17. PMID:19300564. |
some potential effects of donepezil on the ad brain, leading to reduced cortico-hippocampal atrophy, include the following: ache inhibition, enhancement of cholinergic neurotransmission and putative modulation of other neurotransmitter systems, protection against glutamate-induced excitotoxicity, activation of neurotrophic mechanisms, promotion of non-amyloidodgenic pathways for app processing, and indirect effects on cerebrovascular function improving brain perfusion. |
2011-05-17 |
2023-08-12 |
Not clear |
| Alvin V Terry, Jerry J Buccafusco, Elizabeth J Herman, Patrick M Callahan, Wayne D Beck, Samantha Warner, Leah Vandenhuerk, Kristy Bouchard, Gary M Schwarz, Jie Gao, James M Chapma. The prototypical ranitidine analog JWS-USC-75-IX improves information processing and cognitive function in animal models. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21106907. |
in the current study, jws was evaluated for binding activity at more than 60 neurotransmitter receptors, transporters, and ion channels, as well as for inhibitory activity at ache and butyrylcholinesterase (bche). |
2011-04-21 |
2023-08-12 |
rat |
| Carles Galdeano, Elisabet Viayna, Pau Arroyo, Axel Bidon-Chanal, J Ramón Blas, Diego Muñoz-Torrero, F Javier Luqu. Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents. Current pharmaceutical design. vol 16. issue 25. 2011-02-08. PMID:20698824. |
some dual binding site ache inhibitors take on added value a significant ability to additionally inhibit the enzymes butyrylcholinesterase and bace-1, involved in the co-regulation of the hydrolysis of the neurotransmitter acetylcholine and in aβ formation, respectively. |
2011-02-08 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, M Reale, Abdulaziz A Al-Jafar. Multiple approaches to analyse the data for rat brain acetylcholinesterase inhibition by cyclophosphamide. Neurochemical research. vol 35. issue 10. 2011-01-18. PMID:20652634. |
acetylcholinesterase (ache) is an externally oriented membrane-bound enzyme and its main physiological role is termination of chemical transmission at cholinergic synapses and secretory organs by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2011-01-18 |
2023-08-12 |
rat |
| Steeve Hervé Thany, Hélène Tricoire-Leignel, Bruno Lapie. Identification of cholinergic synaptic transmission in the insect nervous system. Advances in experimental medicine and biology. vol 683. 2010-09-30. PMID:20737784. |
a major criteria initially used to localize cholinergic neuronal elements in nervous systems tissues that involve acetylcholine (ach) as neurotransmitter is mainly based on immunochemical studies using choline acetyltransferase (chat), an enzyme which catalyzes ach biosynthesis and the ach degradative enzyme named acetylcholinesterase (ache). |
2010-09-30 |
2023-08-12 |
Not clear |