| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Homocysteine thiolactone and human cholinesterases. Cellular and molecular neurobiology. vol 27. issue 1. 2007-05-22. PMID:16955366. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) are serine hydrolase enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine, a key process in the regulation of the cholinergic system. |
2007-05-22 |
2023-08-12 |
human |
| Laura E Paraoanu, Gunnar Steinert, Janine Klaczinski, Michaela Becker-Röck, Afrim Bytyqi, Paul G Laye. On functions of cholinesterases during embryonic development. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192676. |
this means that che functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ach), as a signal, binds to ach receptors and then is degraded by acetylcholinesterase (ache) as the terminating enzyme. |
2007-02-23 |
2023-08-12 |
Not clear |
| Xiu-Ling Ji, Gui-Wen Jin, Li-Ya Qu, Jin-Ping Cheng, Wen-Hua Wan. [Effect of chronic exposure by mercury contaminated rice on neurotransmitter level changes in rat brain]. Huan jing ke xue= Huanjing kexue. vol 27. issue 1. 2007-01-19. PMID:16599137. |
the changes of neurotransmitter acetylcholine (ach) and acetylcholinesterase (ache) in rat brain were examined at different times. |
2007-01-19 |
2023-08-12 |
rat |
| Edson X Albuquerque, Edna F R Pereira, Yasco Aracava, William P Fawcett, Maristela Oliveira, William R Randall, Tracey A Hamilton, Robert K Kan, James A Romano, Michael Adle. Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 35. 2006-09-29. PMID:16914529. |
most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (ache), the enzyme that inactivates the neurotransmitter acetylcholine. |
2006-09-29 |
2023-08-12 |
Not clear |
| T-M Shih, S W Hulet, J H McDonoug. The effects of repeated low-dose sarin exposure. Toxicology and applied pharmacology. vol 215. issue 2. 2006-09-28. PMID:16556454. |
the animals were assessed for changes in body weight, red blood cell (rbc) acetylcholinesterase (ache) levels, neurobehavioral reactions to a functional observational battery (fob), cortical electroencephalographic (eeg) power spectrum, and intrinsic acetylcholine (ach) neurotransmitter (nt) regulation over the 2 weeks of sarin exposure and for up to 12 days postinjection. |
2006-09-28 |
2023-08-12 |
Not clear |
| Dean M Robinson, Greg L Ploske. Galantamine extended release. CNS drugs. vol 20. issue 8. 2006-09-19. PMID:16863272. |
galantamine inhibits acetylcholinesterase (ache) to slow acetylcholine hydrolysis, and may also modulate presynaptic nicotinic receptor activation, thereby increasing neurotransmitter concentrations in the synaptic cleft.black triangle once-daily galantamine extended release (er) 24 mg and twice-daily galantamine immediate release (ir) 12 mg are bioequivalent in terms of the area under the plasma concentration-time curve from time 0 to 24 hours and steady-state minimum plasma concentration.black triangle primary endpoints indicated a significantly greater effect of galantamine er on cognitive performance than placebo, with efficacy similar to galantamine ir, in a randomised, double-blind trial. |
2006-09-19 |
2023-08-12 |
Not clear |
| Jacques-Philippe Colletier, Didier Fournier, Harry M Greenblatt, Jure Stojan, Joel L Sussman, Giuseppe Zaccai, Israel Silman, Martin Wei. Structural insights into substrate traffic and inhibition in acetylcholinesterase. The EMBO journal. vol 25. issue 12. 2006-08-03. PMID:16763558. |
acetylcholinesterase (ache) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. |
2006-08-03 |
2023-08-12 |
Not clear |
| Kamil Kuca, Daniel Juna, Kamil Musile. Structural requirements of acetylcholinesterase reactivators. Mini reviews in medicinal chemistry. vol 6. issue 3. 2006-05-25. PMID:16515465. |
anticholinergic drugs block effects of accumulated neurotransmitter acetylcholine at nicotinic and muscarinic receptor sites, while oximes reactivate ache inhibited by opcs. |
2006-05-25 |
2023-08-12 |
Not clear |
| Maurizio Recanatini, Piero Valent. Acetylcholinesterase inhibitors as a starting point towards improved Alzheimer's disease therapeutics. Current pharmaceutical design. vol 10. issue 25. 2006-04-10. PMID:15544505. |
in this context, in a perspective of drug discovery, the enzyme acetylcholinesterase (ache) holds a key position, as it is a main target for cholinomimetic ad drugs being responsible for the breakdown of the neurotransmitter, and it is also involved in the aggregation of a beta and the formation of the neurotoxic fibrils. |
2006-04-10 |
2023-08-12 |
Not clear |
| Anita Colombo, Federica Orsi, Patrizia Bonfant. Exposure to the organophosphorus pesticide chlorpyrifos inhibits acetylcholinesterase activity and affects muscular integrity in Xenopus laevis larvae. Chemosphere. vol 61. issue 11. 2006-03-02. PMID:15893801. |
since ache is the major neurotransmitter of the neuromuscular system, this initial descriptive study will be an useful starting-point to ongoing and future subcellular/molecular studies that correlate the morphological damage with changes in ache activity. |
2006-03-02 |
2023-08-12 |
xenopus_laevis |
| Bryan F Curtin, Lauren M Tetz, Jaimee R Compton, Bhupendra P Doctor, Richard K Gordon, Madhusoodana P Nambia. Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. Journal of cellular biochemistry. vol 96. issue 4. 2006-02-21. PMID:16149071. |
the biological effects of organophosphorous (op) chemical warfare nerve agents (cwnas) are exerted by inhibition of acetylcholinesterase (ache), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. |
2006-02-21 |
2023-08-12 |
human |
| Isabel Martinez-Pena y Valenzuela, Richard I Hume, Eric Krejci, Mohammed Akaaboun. In vivo regulation of acetylcholinesterase insertion at the neuromuscular junction. The Journal of biological chemistry. vol 280. issue 36. 2005-11-08. PMID:15998641. |
in the absence of muscle postsynaptic activity or evoked nerve presynaptic neurotransmitter release, ache insertion was decreased significantly, whereas direct stimulation of the muscle completely restored ache insertion to control levels. |
2005-11-08 |
2023-08-12 |
mouse |
| Hiroto Tachikawa, Manabu Igarashi, Jun Nishihira, Teruo Ishibash. Ab initio model study on acetylcholinesterase catalysis: potential energy surfaces of the proton transfer reactions. Journal of photochemistry and photobiology. B, Biology. vol 79. issue 1. 2005-07-29. PMID:15792875. |
ab initio molecular orbital (mo) and hybrid density functional theory (dft) calculations have been applied to the initial step of the acylation reaction catalyzed by acetylcholinesterase (ache), which is the nucleophiric addition of ser200 in catalytic triads to a neurotransmitter acetylcholine (ach). |
2005-07-29 |
2023-08-12 |
Not clear |
| Xavier Cousin, Uwe Strähle, Arnaud Chatonne. Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 27. issue 2. 2005-05-16. PMID:15666354. |
acetylcholinesterase (ache) hydrolyses acetylcholine (ach) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. |
2005-05-16 |
2023-08-12 |
Not clear |
| Gerald B Downes, Michael Granat. Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental biology. vol 270. issue 1. 2004-07-02. PMID:15136152. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine. |
2004-07-02 |
2023-08-12 |
zebrafish |
| Fernando Sánchez-Santed, Fernando Cañadas, Pilar Flores, Matilde López-Grancha, Diana Cardon. Long-term functional neurotoxicity of paraoxon and chlorpyrifos: behavioural and pharmacological evidence. Neurotoxicology and teratology. vol 26. issue 2. 2004-05-10. PMID:15019964. |
the major mechanism of acute toxic action is the inhibition of acetylcholinesterase (ache), which is responsible for the degradation of the neurotransmitter acetylcholine. |
2004-05-10 |
2023-08-12 |
Not clear |
| C Ducho, J Balzarini, C Meie. Non-inhibition of acetylcholinesterase by cycloSal nucleotides. Nucleosides, nucleotides & nucleic acids. vol 22. issue 5-8. 2003-12-11. PMID:14565292. |
ache is a physiologically essential enzyme as it catalyzes the hydrolysis of the neurotransmitter acetylcholine. |
2003-12-11 |
2023-08-12 |
human |
| Tirupapuliyur V Damodaran, Katherine H Jones, Anand G Patel, Mohamed B Abou-Doni. Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system. Biochemical pharmacology. vol 65. issue 12. 2003-07-22. PMID:12787884. |
sarin inactivates the enzyme ache which is responsible for the breakdown of the neurotransmitter acetylcholine (ach), leading to its accumulation at ach receptors and overstimulation of the cholinergic system. |
2003-07-22 |
2023-08-12 |
rat |
| Luly A Cabanillas, Anne E Luebk. CGRP- and cholinergic-containing fibers project to guinea pig outer hair cells. Hearing research. vol 172. issue 1-2. 2003-03-24. PMID:12361863. |
results showed that cgrp-containing nerve fiber immunoreactivity mimicked the ache fiber ohc staining pattern across the cochlea suggesting that cgrp can function as both a medial efferent (contacting primarily ohcs) and as a lateral efferent (contacting primarily inner hair cell afferents) neurotransmitter. |
2003-03-24 |
2023-08-12 |
Not clear |
| A De Jaco, G Augusti-Tocco, S Biagion. Alternative acetylcholinesterase molecular forms exhibit similar ability to induce neurite outgrowth. Journal of neuroscience research. vol 70. issue 6. 2003-01-24. PMID:12444597. |
because neurite outgrowth can be modulated by neurotransmitters, we used the n18tg2 neuroblastoma line, which is defective for neurotransmitter production, to evaluate whether ache may modulate neurite sprouting in nonenzymatic ways. |
2003-01-24 |
2023-08-12 |
Not clear |