| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steeve Hervé Thany, Hélène Tricoire-Leignel, Bruno Lapie. Identification of cholinergic synaptic transmission in the insect nervous system. Advances in experimental medicine and biology. vol 683. 2010-09-30. PMID:20737784. |
combined application of all these techniques reveals a widespread expression of chat and ache activities in the insect central nervous system and peripheral sensory neurons which implicates ach as a key neurotransmitter. |
2010-09-30 |
2023-08-12 |
Not clear |
| Zaheer-ul-Haq, Sobia Ahsan Halim, Reaz Uddin, Jeffry D Madur. Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 28. issue 8. 2010-08-12. PMID:20447848. |
acetylcholinesterase (ache) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2010-08-12 |
2023-08-12 |
Not clear |
| Cristina López-Galindo, Luis Vargas-Chacoff, Enrique Nebot, José F Casanueva, Daniel Rubio, Montserrat Solé, Juan Miguel Mancer. Sublethal effects of the organic antifoulant Mexel(R)432 on osmoregulation and xenobiotic detoxification in the flatfish Solea senegalensis. Chemosphere. vol 79. issue 1. 2010-06-14. PMID:20110101. |
other parameters tested were the antioxidant enzymes (catalase, cat; glutathione peroxidase, gpx; and glutathione reductase, gr), xenobiotic metabolism defenses involved in detoxification (carboxylesterase, cbe; 7-ethoxyresorufin o-deethylase, erod; and glutathione s-transferase, gst) and the neurotransmitter acetylcholinesterase (ache) activity. |
2010-06-14 |
2023-08-12 |
cat |
| Jana Zdarova Karasova, Jiri Bajgar, Daniel Jun, Ruzena Pavlikova, Kamil Kuc. Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX. Neurotoxicity research. vol 16. issue 4. 2010-01-22. PMID:19728005. |
the toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (ache; ec 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. |
2010-01-22 |
2023-08-12 |
rat |
| Haixia Dang, Lihua Sun, Xinmin Liu, Bo Peng, Qiong Wang, William Jia, Ying Chen, Aihua Pan, Peigen Xia. Preventive action of Kai Xin San aqueous extract on depressive-like symptoms and cognition deficit induced by chronic mild stress. Experimental biology and medicine (Maywood, N.J.). vol 234. issue 7. 2009-08-27. PMID:19429857. |
serum corticosterone and adrenocorticotropic hormone (acth) levels, acetylcholinesterase (ache) protein expression in the hippocampus, and monoamine neurotransmitter concentrations in the prefrontal cortex and hippocampus were also determined to elucidate the neurochemical mechanisms. |
2009-08-27 |
2023-08-12 |
Not clear |
| Haixia Dang, Lihua Sun, Xinmin Liu, Bo Peng, Qiong Wang, William Jia, Ying Chen, Aihua Pan, Peigen Xia. Preventive action of Kai Xin San aqueous extract on depressive-like symptoms and cognition deficit induced by chronic mild stress. Experimental biology and medicine (Maywood, N.J.). vol 234. issue 7. 2009-08-27. PMID:19429857. |
kxs also inhibited the increased ache expression in the hippocampus, up-regulated the decreased monoamine neurotransmitter concentrations of both brain areas and reduced the elevated acth concentrations in the serum induced by cms. |
2009-08-27 |
2023-08-12 |
Not clear |
| Jennifer M Bui, J Andrew McCammo. Intrinsic conformational flexibility of acetylcholinesterase. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18452905. |
to understand the dynamical properties of acetylcholinesterase (ache) in rapid termination of cationic neurotransmitter, acetylcholine at neurosynaptic junctions, multiple molecular dynamics (md) trajectories of ache in the presence and absence of its inhibitors [j.m. |
2008-12-10 |
2023-08-12 |
Not clear |
| Wei Su, Jun Wu, Wei-Yuan Ye, Xue-Jun Zhan. A monoclonal antibody against synaptic AChE: a useful tool for detecting apoptotic cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18538755. |
the classical function of acetylcholinesterase (ache) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ach). |
2008-12-10 |
2023-08-12 |
Not clear |
| Michal Alon, Fishel Alon, Ralf Nauen, Shai Mori. Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associated with a point mutation in an ace1-type acetylcholinesterase and overexpression of carboxylesterase. Insect biochemistry and molecular biology. vol 38. issue 10. 2008-12-10. PMID:18721883. |
organophosphate (op) insecticides are inhibitors of the enzyme acetylcholinesterase (ache), which terminates nerve impulses by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2008-12-10 |
2023-08-12 |
Not clear |
| Marko Zivin, Peter Pregel. Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system. Psychiatria Danubina. vol 20. issue 2. 2008-09-26. PMID:18587286. |
acetylcholinesterase (ache), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles. |
2008-09-26 |
2023-08-12 |
Not clear |
| J Berger, S Valdez, B Puschner, C M Leutenegger, I A Gardner, J E Madiga. Effects of oral tetrachlorvinphos fly control (Equitrol) administration in horses: physiological and behavioural findings. Veterinary research communications. vol 32. issue 1. 2008-09-17. PMID:17522960. |
tcvp exerts its effect by inhibiting the enzyme cholinesterase (che) leading to the accumulation of the neurotransmitter acetylcholine (ache) in synapses of the central and peripheral nervous systems. |
2008-09-17 |
2023-08-12 |
Not clear |
| J Venkateswara Rao, Ghousia Begum, R Pallela, P K Usman, R Nageswara Ra. Changes in behavior and brain acetylcholinesterase activity in mosquito fish, Gambusia affinis in response to the sub-lethal exposure to chlorpyrifos. International journal of environmental research and public health. vol 2. issue 3-4. 2008-08-29. PMID:16819104. |
the alteration in locomotor behavior of fish may be due to an accumulation of acetylcholine (ach), a neurotransmitter at synaptic junctions, due to the inhibition of ache enzyme activity (40 to 55%) in brain and also bioaccumulation of the toxicant in different parts of fish. |
2008-08-29 |
2023-08-12 |
Not clear |
| Wei Zhao, Si-Xin Sun, Jing-Juan Xu, Hong-Yuan Chen, Xiao-Jian Cao, Xiao-Hong Gua. Electrochemical identification of the property of peripheral nerve fiber based on a biocompatible polymer film via in situ incorporating gold nanoparticles. Analytical chemistry. vol 80. issue 10. 2008-08-11. PMID:18363334. |
we report a simple electrochemical method for the identification of properties of peripheral nerve fibers, based on the detection of a neurotransmitter enzyme, acetylcholinesterase (ache). |
2008-08-11 |
2023-08-12 |
cattle |
| Doaa A Ghareeb, Hend M Husse. Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats. Neuroscience letters. vol 436. issue 1. 2008-07-22. PMID:18378083. |
the alterations of both ache forms observed in diabetic state could be attributed to hyperglycemia and lipid peroxidation that triggered brain dysfunction by disturbing the neurotransmitter acetylcholine level. |
2008-07-22 |
2023-08-12 |
rat |
| Bozica Radić, Ana Lucić Vrdoljak, Davor Zeljezić, Nino Fuchs, Suzana Berend, Nevenka Kopja. Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. Acta biochimica Polonica. vol 54. issue 3. 2008-07-11. PMID:17713603. |
the function of acetylcholinesterase (ache) is the rapid hydrolysis of the neurotransmitter acetylcholine (ach), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. |
2008-07-11 |
2023-08-12 |
human |
| Jere R Virta, Tuula Tolvanen, Kjell Någren, Anna Brück, Anne Roivainen, Juha O Rinn. 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49. issue 3. 2008-05-16. PMID:18287260. |
the neurotransmitter acetylcholine is hydrolyzed in the synaptic clefts by 2 enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2008-05-16 |
2023-08-12 |
human |
| Martina Zimmermann, Sven Grösgen, Martin S Westwell, Susan A Greenfiel. Selective enhancement of the activity of C-terminally truncated, but not intact, acetylcholinesterase. Journal of neurochemistry. vol 104. issue 1. 2008-02-18. PMID:17986217. |
the enzyme is involved in the terminal breakdown of the neurotransmitter acetylcholine, but non-enzymatic roles have also been described for the entire ache molecule and its isolated c-terminal sequences. |
2008-02-18 |
2023-08-12 |
cattle |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboun. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Molecular biology of the cell. vol 18. issue 8. 2007-10-17. PMID:17538015. |
acetylcholinesterase (ache) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses. |
2007-10-17 |
2023-08-12 |
mouse |
| Malathi Srivatsa. An analysis of acetylcholinesterase sequence for predicting mechanisms of its non-catalytic actions. Bioinformation. vol 1. issue 8. 2007-08-01. PMID:17597908. |
the enzyme acetylcholinesterase (ache) which belongs to the family of alpha/beta hydrolases is well known for hydrolyzing the neurotransmitter acetylcholine (ach). |
2007-08-01 |
2023-08-12 |
human |