| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Shapira, C K Thompson, H Soreq, G E Robinso. Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies. Journal of molecular neuroscience : MN. vol 17. issue 1. 2002-05-10. PMID:11665858. |
because acetylcholinesterase (ache) hydrolyzes acetylcholine, a major neurotransmitter associated with learning in the insect brain, we searched for changes in ache expression in the brain during bee behavioral development. |
2002-05-10 |
2023-08-12 |
bee |
| J El Yazal, S N Rao, A Mehl, W Slikke. Prediction of organophosphorus acetylcholinesterase inhibition using three-dimensional quantitative structure-activity relationship (3D-QSAR) methods. Toxicological sciences : an official journal of the Society of Toxicology. vol 63. issue 2. 2001-12-12. PMID:11568366. |
neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (ache), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. |
2001-12-12 |
2023-08-12 |
Not clear |
| S Olivera, D Rodriguez-Ithurralde, J M Henle. Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain. British journal of pharmacology. vol 133. issue 7. 2001-10-04. PMID:11487516. |
in addition to its role in hydrolyzing the neurotransmitter acetylcholine, the synaptically enriched enzyme acetylcholinesterase (ache) has been reported to play an important role in the development and remodelling of neural processes and synapses. |
2001-10-04 |
2023-08-12 |
rat |
| M U Delmonte Corrado, H Politi, M Ognibene, C Angelini, F Trielli, P Ballarini, C Falug. Synthesis of the signal molecule acetylcholine during the developmental cycle of Paramecium primaurelia (Protista, Ciliophora) and its possible function in conjugation. The Journal of experimental biology. vol 204. issue Pt 11. 2001-09-27. PMID:11441032. |
we recently discovered, in mating-competent paramecium primaurelia, the presence of functionally related molecules of the cholinergic system: the neurotransmitter acetylcholine (ach), both its nicotinic and muscarinic receptors and its lytic enzyme acetylcholinesterase (ache). |
2001-09-27 |
2023-08-12 |
Not clear |
| K V Sharma, C Koenigsberger, S Brimijoin, J W Bigbe. Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth. Journal of neuroscience research. vol 63. issue 2. 2001-04-26. PMID:11169626. |
acetylcholinesterase (ache) can promote neurite outgrowth through a mechanism that is independent of its role in hydrolyzing the neurotransmitter acetylcholine. |
2001-04-26 |
2023-08-12 |
Not clear |
| J W Bigbee, K V Sharma, J J Gupta, J L Dupre. Morphogenic role for acetylcholinesterase in axonal outgrowth during neural development. Environmental health perspectives. vol 107 Suppl 1. 2000-07-27. PMID:10229710. |
acetylcholinesterase (ache) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. |
2000-07-27 |
2023-08-12 |
Not clear |
| P Marcho. [The fasciculin-acetylcholinesterase interaction]. Journal de la Societe de biologie. vol 193. issue 6. 2000-06-19. PMID:10783708. |
acetylcholinesterase (ache) terminates the action of the neurotransmitter acetylcholine at cholinergic synapses in the central and peripheral nervous systems. |
2000-06-19 |
2023-08-12 |
mouse |
| F J Muñoz, R Aldunate, N C Inestros. Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619655. |
acetylcholinesterase (ache) catalyses the hydrolysis of the neurotransmitter acetylcholine and it has been implicated in several non-cholinergic actions, including neurite outgrowth and amyloid formation. |
2000-01-19 |
2023-08-12 |
Not clear |
| J A Love, K Szeben. Morphology and histochemistry of the rabbit pancreatic innervation. Pancreas. vol 18. issue 1. 1999-03-15. PMID:9888661. |
here we report histochemical staining for acetylcholinesterase (ache), nadph-diaphorase (nadph-d), nitric oxide synthase (nos), and several neuropeptides to identify the neurotransmitter content of rabbit pancreatic nerves. |
1999-03-15 |
2023-08-12 |
rabbit |
| F H Calderón, R von Bernhardi, G De Ferrari, S Luza, R Aldunate, N C Inestros. Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro. Molecular psychiatry. vol 3. issue 3. 1998-10-08. PMID:9672900. |
acetylcholinesterase (ache), the enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, has been implicated in non-cholinergic actions which may play a role in neurodegenerative diseases such as alzheimer's disease. |
1998-10-08 |
2023-08-12 |
Not clear |
| C Opazo, N C Inestros. Crosslinking of amyloid-beta peptide to brain acetylcholinesterase. Molecular and chemical neuropathology. vol 33. issue 1. 1998-04-21. PMID:9493175. |
acetylcholinesterase (ache) is the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine in the central nervous system. |
1998-04-21 |
2023-08-12 |
Not clear |
| S Gralewic. [Possible consequences of AChE inhibition in organophosphate poisoning. A new approach to an old problem]. Medycyna pracy. vol 48. issue 4. 1998-02-18. PMID:9471495. |
the known function of ache is hydrolysis of the neurotransmitter, acetylcholine (ach). |
1998-02-18 |
2023-08-12 |
Not clear |
| A Alvarez, C Opazo, R Alarcón, J Garrido, N C Inestros. Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils. Journal of molecular biology. vol 272. issue 3. 1997-10-28. PMID:9325095. |
acetylcholinesterase (ache), an enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, consistently colocalizes with the amyloid deposits characteristic of alzheimer's disease and may contribute to the generation of amyloid proteins and/or physically affect fibril assembly. |
1997-10-28 |
2023-08-12 |
Not clear |
| T Cowen, C Thrasivoulou, S A Shaw, T A Abdel-Rahma. Transplanted sweat glands from mature and aged donors determine cholinergic phenotype and altered density of host sympathetic nerves. Journal of the autonomic nervous system. vol 60. issue 3. 1997-02-20. PMID:8912274. |
markers have been used which indicate changes in nerve fibre morphology (the pan-neuronal marker, pgp9.5) as well as neurotransmitter expression (acetylcholinesterase (ache), vasocative intestinal polypeptide (vip) and tyrosine hydroxylase (th). |
1997-02-20 |
2023-08-12 |
rat |
| V Tõugu, T Kesvater. Role of ionic interactions in cholinesterase catalysis. Biochimica et biophysica acta. vol 1298. issue 1. 1997-01-06. PMID:8948485. |
acetylcholinesterase (ache, ec 3.1.1.7) is an enzyme terminating the transmission of nerve impulse in synapses by rapid and selective hydrolysis of the neurotransmitter acetylcholine. |
1997-01-06 |
2023-08-12 |
Not clear |
| T Cowen, C Thrasivoulou, S A Shaw, T A Abdel-Rahma. Transplanted sweat glands from mature and aged donors determine cholinergic phenotype and altered density of host sympathetic nerves. Journal of the autonomic nervous system. vol 58. issue 3. 1996-11-12. PMID:8738308. |
markers have been used which indicate changes in nerve fibre morphology (the pan-neuronal marker, pgp9.5) as well as neurotransmitter expression (acetylcholinesterase (ache), vasocative intestinal polypeptide (vip) and tyrosine hydroxylase (th)). |
1996-11-12 |
2023-08-12 |
rat |
| W Tong, E R Collantes, Y Chen, W J Wels. A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558505. |
these compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ach) by the enzyme acetylcholinesterase (ache) and hence alleviate memory deficits in patients with alzheimer's disease by potentiating cholinergic transmission. |
1996-02-28 |
2023-08-12 |
human |
| C A Hawkins, S A Greenfiel. Recombinant acetylcholinesterase has behavioural effects in the rat substantia nigra not attributable to its enzymatic activity. Neuroscience letters. vol 197. issue 3. 1996-02-22. PMID:8552299. |
hence ache is not exerting these actions by potentiating the neurotransmitter acetylcholine, but via some cholinergic-independent mechanism. |
1996-02-22 |
2023-08-12 |
human |
| E P Hornstein, D L Sambursky, S C Chamberlai. Histochemical localization of acetylcholinesterase in the lateral eye and brain of Limulus polyphemus: might acetylcholine be a neurotransmitter for lateral inhibition in the lateral eye? Visual neuroscience. vol 11. issue 5. 1994-12-12. PMID:7947410. |
these results along with the histochemical controls eliminate the possibility that some molecule found in histaminergic neurons accounted for the ache staining but support the possibility that acetylcholine might be involved as a neurotransmitter in lateral inhibition in the horseshoe crab retina. |
1994-12-12 |
2023-08-12 |
horseshoe_crab |
| L C Anderson, J R Garret. The effects of streptozotocin-induced diabetes on norepinephrine and cholinergic enzyme activities in rat parotid and submandibular glands. Archives of oral biology. vol 39. issue 2. 1994-06-16. PMID:8185504. |
therefore, glandular levels of the adrenergic neurotransmitter, norepinephrine (ne) and two cholinergic enzymes, choline acetyltransferase (chat) and acetylcholinesterase (ache), were investigated in 6-month streptozotocin-diabetic rats. |
1994-06-16 |
2023-08-12 |
rat |