| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B L Schlaggar, J A De Carlos, D D O'Lear. Acetylcholinesterase as an early marker of the differentiation of dorsal thalamus in embryonic rats. Brain research. Developmental brain research. vol 75. issue 1. 1993-12-10. PMID:8222210. |
the enzyme acetylcholinesterase (ache) is transiently expressed in rats by neurons of the principal sensory thalamic nuclei, although these neurons do not use acetylcholine as a neurotransmitter. |
1993-12-10 |
2023-08-12 |
rat |
| J L Sussman, M Harel, I Silma. Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs. Chemico-biological interactions. vol 87. issue 1-3. 1993-09-03. PMID:8343975. |
based on our recent x-ray crystallographic determination of the structure of acetylcholinesterase (ache) from torpedo californica, we can see for the first time, at atomic resolution, a protein binding pocket for the neurotransmitter, acetylcholine. |
1993-09-03 |
2023-08-12 |
Not clear |
| M Z Wrona, R N Goyal, D J Turk, C L Blank, G Dryhurs. 5,5'-Dihydroxy-4,4'-bitryptamine: a potentially aberrant, neurotoxic metabolite of serotonin. Journal of neurochemistry. vol 59. issue 4. 1992-10-26. PMID:1357095. |
furthermore, an unidentified autoxidation product of this neurotransmitter is an inhibitor of acetylcholinesterase (ache), an enzyme compromised in the alzheimer brain. |
1992-10-26 |
2023-08-11 |
mouse |
| E E Tyrala, S V Mathews, G S Ra. Effect of intrauterine exposure to cocaine on acetylcholinesterase in primary cultures of fetal mouse brain cells. Neurotoxicology and teratology. vol 14. issue 4. 1992-10-15. PMID:1522827. |
the effect of in utero exposure to cocaine on the developmental pattern of acetylcholinesterase (ache), a major regulator of the central nervous system neurotransmitter acetylcholine, was studied in fetal brain cell cultures collected from mice on gestational day 15 after maternal exposure to cocaine from gestational days 6-14. |
1992-10-15 |
2023-08-11 |
mouse |
| S K Dutta, K Das, B Ghosh, C F Blackma. Dose dependence of acetylcholinesterase activity in neuroblastoma cells exposed to modulated radio-frequency electromagnetic radiation. Bioelectromagnetics. vol 13. issue 4. 1992-09-24. PMID:1510740. |
to explore the physiological importance of these findings, we have examined the impact of rfr exposure on a membrane-bound enzyme, acetylcholinesterase (ache), which is intimately involved with the acetylcholine (ach) neurotransmitter system. |
1992-09-24 |
2023-08-11 |
Not clear |
| J M de Gandarias, J Irazusta, E Echevarría, J Gil, L Casí. [Acetylcholinesterase activity during the cortical development of the cat brain]. Archivos de neurobiologia. vol 55. issue 3. 1992-09-08. PMID:1497415. |
acetylcholinesterase (ache) hydrolyses acetylcholine to choline and acetate, thereby inactivating the neurotransmitter. |
1992-09-08 |
2023-08-11 |
cat |
| H Soreq, Y Lapidot-Lifson, H Zaku. A role for cholinesterases in tumorigenesis? Cancer cells (Cold Spring Harbor, N.Y. : 1989). vol 3. issue 12. 1992-08-06. PMID:1820094. |
hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ache) and butyrylcholinesterase (bche) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions. |
1992-08-06 |
2023-08-11 |
human |
| M Stengl, U Homberg, J G Hildebran. Acetylcholinesterase activity in antennal receptor neurons of the sphinx moth Manduca sexta. Cell and tissue research. vol 262. issue 2. 1991-04-22. PMID:2076532. |
since none of the olfactory receptor neurons show a high level of echothiophate-resistant ache activity, and all known mechanoreceptors are ache-positive, apparently "intracellular" ache activity in the antenna correlates well with mechanosensory functions and is consistent with the idea that these cells employ acetylcholine as a neurotransmitter. |
1991-04-22 |
2023-08-11 |
Not clear |
| R W Russell, R A Booth, C A Smith, D J Jenden, M Roch, K M Rice, S D Lauret. Roles of neurotransmitter receptors in behavior: recovery of function following decreases in muscarinic receptor density induced by cholinesterase inhibition. Behavioral neuroscience. vol 103. issue 4. 1989-09-27. PMID:2765189. |
cholinergic neurotransmitter levels were elevated in rat brain by reducing its inactivating enzyme, acetylcholinesterase (ache), with an anti-ache agent. |
1989-09-27 |
2023-08-11 |
rat |
| G L Meerdin. Organophosphorus and carbamate insecticide poisoning in large animals. The Veterinary clinics of North America. Food animal practice. vol 5. issue 2. 1989-09-08. PMID:2667712. |
organophosphorus and carbamate insecticides generate their toxic effects by bonding to and inhibiting che enzymes (most importantly, ache), which are responsible for breaking down the neurotransmitter ach. |
1989-09-08 |
2023-08-11 |
Not clear |
| I López, G Mez. Some properties of frog vestibular choline acetyltransferase and acetylcholinesterase. Neurochemical research. vol 14. issue 2. 1989-07-10. PMID:2786162. |
although the precise localization of chat and ache is not yet certain the efferent neurotransmitter in the vertebrate vestibular sensory periphery is believed to be acetylcholine and thus the enzymes responsible for its synthesis and degradation may participate in regulating inner ear function. |
1989-07-10 |
2023-08-11 |
Not clear |
| T Ostholm, P Ekström, A Bruun, T van Vee. Temporal disparity in pineal and retinal ontogeny. Brain research. vol 470. issue 1. 1988-10-11. PMID:3165685. |
the development of photoreceptors and two putative neurotransmitter systems in the pineal organ and retina was studied during embryogenesis in the three-spined stickleback gasterosteus aculeatus l. the investigation was performed by aid of immunocytochemistry using well characterized antisera to the retinal proteins alpha-transducin (td alpha) and s-antigen (sa) (photoreceptor-markers), antisera against l-glutamic acid decarboxylase (gad), gamma-aminobutyric acid (gaba), choline-o-acetyltransferase (chat) and with acetylcholinesterase (ache) histochemistry (neurotransmitter-markers). |
1988-10-11 |
2023-08-11 |
Not clear |
| M Beninato, R F Spence. A cholinergic projection to the rat superior colliculus demonstrated by retrograde transport of horseradish peroxidase and choline acetyltransferase immunohistochemistry. The Journal of comparative neurology. vol 253. issue 4. 1987-02-17. PMID:3540040. |
the localization of ache in these nuclei overlapped the distribution of neurons stained by immunohistochemistry using an antibody to choline acetyltransferase (chat), the synthesizing enzyme of the neurotransmitter acetylcholine. |
1987-02-17 |
2023-08-11 |
rat |
| M M Heitkemper, J F Shave. Pentagastrin on neurotransmitter enzyme activities in the rat gastrointestinal tract. The American journal of physiology. vol 250. issue 4 Pt 1. 1986-05-15. PMID:3963198. |
the effects of three doses (5, 100, and 250 micrograms/kg) of pentagastrin on the activities of choline acetyltransferase (chat) and acetylcholine esterase (ache), the neurotransmitter enzymes that synthesize and degrade acetylcholine, and monoamine oxidase (mao), the degradation enzyme for catecholamines, were investigated. |
1986-05-15 |
2023-08-11 |
rat |
| S P Sivam, B Hoskins, I K H. An assessment of comparative acute toxicity of diisopropyl-fluorophosphate, tabun, sarin, and soman in relation to cholinergic and GABAergic enzyme activities in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 4. issue 4. 1984-11-05. PMID:6479498. |
the results indicate that (a) the acute toxicity of organophosphate acetylcholinesterase inhibitors is directly related to the inhibition of ache though there is a wide difference in their potency; (b) a substantial inhibition of ache activity (over 90% of control) is necessary for lethality to ensue after an acute exposure and the margins between lethal and nonlethal doses are extremely small; and (c) qualitative differences seem to exist among the various organophosphates in affecting noncholinergic neurotransmitter enzymes. |
1984-11-05 |
2023-08-12 |
rat |
| J A Olschowka, V K Vijaya. Postnatal development of cholinergic neurotransmitter enzymes in the mouse cerebellum. Biochemical, light microscopic and electron microscopic cytochemical investigations. The Journal of comparative neurology. vol 191. issue 1. 1980-10-27. PMID:7400393. |
the activity and distribution of the cholinergic neurotransmitter enzymes acetylcholinesterase (ache) and choline acetyltransferase (chac) in the developing cerebellum of the mouse were investigated using biochemical assays and light microscopic histochemistry for ache and chac, and electron microscopic histochemistry for ache. |
1980-10-27 |
2023-08-12 |
mouse |
| L Wecker, B Laskowski, W D Dettbar. Neuromuscular dysfunction induced by acetylcholinesterase inhibition. Federation proceedings. vol 37. issue 14. 1979-02-21. PMID:214351. |
electrophysiological studies have shown that paraoxon increases neurotransmitter release and causes spontaneous and impulse-related antidromic nerve activity, both of which can be reduced significantly by reactivation of inhibited acetylcholinesterase (ache) with pyridine-2-aldoxime methiodide. |
1979-02-21 |
2023-08-11 |
rat |
| Y Sarne, B K Schrier, H Gaine. Evidence for the local synthesis of a transmitter enzyme (glutamic acid decarboxylase) in crayfish peripheral nerve. Brain research. vol 110. issue 1. 1976-09-01. PMID:1276952. |
the activities of three enzymes of neurotransmitter metabolism (choline acetyl-transferase, cat; acetylcholinesterase, ache; and glutamic acid decarboxylase, gad) were studied in normal, transected, and organ cultured crayfish nerves. |
1976-09-01 |
2023-08-11 |
cat |
| S J Bird, G K Aghajania. Denervation supersensitivity in the cholinergic septo-hippocampal pathway: a microiontophoretic study. Brain research. vol 100. issue 2. 1976-02-09. PMID:1192181. |
the results suggest that presynaptic ache plays a significant role in modulating the neurotransmitter function of ach in the septo-hippocampal pathway. |
1976-02-09 |
2023-08-11 |
rat |
| J D Minna, J Yavelow, H G Coo. Expression of phenotypes in hybrid somatic cells derived from the nervous system. Genetics. vol 79 Suppl. 1975-11-05. PMID:1150088. |
the ability to synthesize ach and the ability to degrade this neurotransmitter (high levels of acetylcholinesterase activity, ache) appear to segregate independently in nl hybrid progeny.--when a a variety of clonal cell lines replicating in culture are fused to cells freshly derived from the embryonic nervous system, interesting phenotypes result in the hybrid progeny. |
1975-11-05 |
2023-08-11 |
mouse |