| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Tong, E R Collantes, Y Chen, W J Wels. A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558505. |
these compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ach) by the enzyme acetylcholinesterase (ache) and hence alleviate memory deficits in patients with alzheimer's disease by potentiating cholinergic transmission. |
1996-02-28 |
2023-08-12 |
human |
| C A Hawkins, S A Greenfiel. Recombinant acetylcholinesterase has behavioural effects in the rat substantia nigra not attributable to its enzymatic activity. Neuroscience letters. vol 197. issue 3. 1996-02-22. PMID:8552299. |
hence ache is not exerting these actions by potentiating the neurotransmitter acetylcholine, but via some cholinergic-independent mechanism. |
1996-02-22 |
2023-08-12 |
human |
| E P Hornstein, D L Sambursky, S C Chamberlai. Histochemical localization of acetylcholinesterase in the lateral eye and brain of Limulus polyphemus: might acetylcholine be a neurotransmitter for lateral inhibition in the lateral eye? Visual neuroscience. vol 11. issue 5. 1994-12-12. PMID:7947410. |
these results along with the histochemical controls eliminate the possibility that some molecule found in histaminergic neurons accounted for the ache staining but support the possibility that acetylcholine might be involved as a neurotransmitter in lateral inhibition in the horseshoe crab retina. |
1994-12-12 |
2023-08-12 |
horseshoe_crab |
| L C Anderson, J R Garret. The effects of streptozotocin-induced diabetes on norepinephrine and cholinergic enzyme activities in rat parotid and submandibular glands. Archives of oral biology. vol 39. issue 2. 1994-06-16. PMID:8185504. |
therefore, glandular levels of the adrenergic neurotransmitter, norepinephrine (ne) and two cholinergic enzymes, choline acetyltransferase (chat) and acetylcholinesterase (ache), were investigated in 6-month streptozotocin-diabetic rats. |
1994-06-16 |
2023-08-12 |
rat |
| B L Schlaggar, J A De Carlos, D D O'Lear. Acetylcholinesterase as an early marker of the differentiation of dorsal thalamus in embryonic rats. Brain research. Developmental brain research. vol 75. issue 1. 1993-12-10. PMID:8222210. |
the enzyme acetylcholinesterase (ache) is transiently expressed in rats by neurons of the principal sensory thalamic nuclei, although these neurons do not use acetylcholine as a neurotransmitter. |
1993-12-10 |
2023-08-12 |
rat |
| J L Sussman, M Harel, I Silma. Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs. Chemico-biological interactions. vol 87. issue 1-3. 1993-09-03. PMID:8343975. |
based on our recent x-ray crystallographic determination of the structure of acetylcholinesterase (ache) from torpedo californica, we can see for the first time, at atomic resolution, a protein binding pocket for the neurotransmitter, acetylcholine. |
1993-09-03 |
2023-08-12 |
Not clear |
| M Z Wrona, R N Goyal, D J Turk, C L Blank, G Dryhurs. 5,5'-Dihydroxy-4,4'-bitryptamine: a potentially aberrant, neurotoxic metabolite of serotonin. Journal of neurochemistry. vol 59. issue 4. 1992-10-26. PMID:1357095. |
furthermore, an unidentified autoxidation product of this neurotransmitter is an inhibitor of acetylcholinesterase (ache), an enzyme compromised in the alzheimer brain. |
1992-10-26 |
2023-08-11 |
mouse |
| E E Tyrala, S V Mathews, G S Ra. Effect of intrauterine exposure to cocaine on acetylcholinesterase in primary cultures of fetal mouse brain cells. Neurotoxicology and teratology. vol 14. issue 4. 1992-10-15. PMID:1522827. |
the effect of in utero exposure to cocaine on the developmental pattern of acetylcholinesterase (ache), a major regulator of the central nervous system neurotransmitter acetylcholine, was studied in fetal brain cell cultures collected from mice on gestational day 15 after maternal exposure to cocaine from gestational days 6-14. |
1992-10-15 |
2023-08-11 |
mouse |
| S K Dutta, K Das, B Ghosh, C F Blackma. Dose dependence of acetylcholinesterase activity in neuroblastoma cells exposed to modulated radio-frequency electromagnetic radiation. Bioelectromagnetics. vol 13. issue 4. 1992-09-24. PMID:1510740. |
to explore the physiological importance of these findings, we have examined the impact of rfr exposure on a membrane-bound enzyme, acetylcholinesterase (ache), which is intimately involved with the acetylcholine (ach) neurotransmitter system. |
1992-09-24 |
2023-08-11 |
Not clear |
| J M de Gandarias, J Irazusta, E Echevarría, J Gil, L Casí. [Acetylcholinesterase activity during the cortical development of the cat brain]. Archivos de neurobiologia. vol 55. issue 3. 1992-09-08. PMID:1497415. |
acetylcholinesterase (ache) hydrolyses acetylcholine to choline and acetate, thereby inactivating the neurotransmitter. |
1992-09-08 |
2023-08-11 |
cat |
| H Soreq, Y Lapidot-Lifson, H Zaku. A role for cholinesterases in tumorigenesis? Cancer cells (Cold Spring Harbor, N.Y. : 1989). vol 3. issue 12. 1992-08-06. PMID:1820094. |
hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ache) and butyrylcholinesterase (bche) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions. |
1992-08-06 |
2023-08-11 |
human |
| M Stengl, U Homberg, J G Hildebran. Acetylcholinesterase activity in antennal receptor neurons of the sphinx moth Manduca sexta. Cell and tissue research. vol 262. issue 2. 1991-04-22. PMID:2076532. |
since none of the olfactory receptor neurons show a high level of echothiophate-resistant ache activity, and all known mechanoreceptors are ache-positive, apparently "intracellular" ache activity in the antenna correlates well with mechanosensory functions and is consistent with the idea that these cells employ acetylcholine as a neurotransmitter. |
1991-04-22 |
2023-08-11 |
Not clear |
| R W Russell, R A Booth, C A Smith, D J Jenden, M Roch, K M Rice, S D Lauret. Roles of neurotransmitter receptors in behavior: recovery of function following decreases in muscarinic receptor density induced by cholinesterase inhibition. Behavioral neuroscience. vol 103. issue 4. 1989-09-27. PMID:2765189. |
cholinergic neurotransmitter levels were elevated in rat brain by reducing its inactivating enzyme, acetylcholinesterase (ache), with an anti-ache agent. |
1989-09-27 |
2023-08-11 |
rat |
| G L Meerdin. Organophosphorus and carbamate insecticide poisoning in large animals. The Veterinary clinics of North America. Food animal practice. vol 5. issue 2. 1989-09-08. PMID:2667712. |
organophosphorus and carbamate insecticides generate their toxic effects by bonding to and inhibiting che enzymes (most importantly, ache), which are responsible for breaking down the neurotransmitter ach. |
1989-09-08 |
2023-08-11 |
Not clear |
| I López, G Mez. Some properties of frog vestibular choline acetyltransferase and acetylcholinesterase. Neurochemical research. vol 14. issue 2. 1989-07-10. PMID:2786162. |
although the precise localization of chat and ache is not yet certain the efferent neurotransmitter in the vertebrate vestibular sensory periphery is believed to be acetylcholine and thus the enzymes responsible for its synthesis and degradation may participate in regulating inner ear function. |
1989-07-10 |
2023-08-11 |
Not clear |
| T Ostholm, P Ekström, A Bruun, T van Vee. Temporal disparity in pineal and retinal ontogeny. Brain research. vol 470. issue 1. 1988-10-11. PMID:3165685. |
the development of photoreceptors and two putative neurotransmitter systems in the pineal organ and retina was studied during embryogenesis in the three-spined stickleback gasterosteus aculeatus l. the investigation was performed by aid of immunocytochemistry using well characterized antisera to the retinal proteins alpha-transducin (td alpha) and s-antigen (sa) (photoreceptor-markers), antisera against l-glutamic acid decarboxylase (gad), gamma-aminobutyric acid (gaba), choline-o-acetyltransferase (chat) and with acetylcholinesterase (ache) histochemistry (neurotransmitter-markers). |
1988-10-11 |
2023-08-11 |
Not clear |
| M Beninato, R F Spence. A cholinergic projection to the rat superior colliculus demonstrated by retrograde transport of horseradish peroxidase and choline acetyltransferase immunohistochemistry. The Journal of comparative neurology. vol 253. issue 4. 1987-02-17. PMID:3540040. |
the localization of ache in these nuclei overlapped the distribution of neurons stained by immunohistochemistry using an antibody to choline acetyltransferase (chat), the synthesizing enzyme of the neurotransmitter acetylcholine. |
1987-02-17 |
2023-08-11 |
rat |
| M M Heitkemper, J F Shave. Pentagastrin on neurotransmitter enzyme activities in the rat gastrointestinal tract. The American journal of physiology. vol 250. issue 4 Pt 1. 1986-05-15. PMID:3963198. |
the effects of three doses (5, 100, and 250 micrograms/kg) of pentagastrin on the activities of choline acetyltransferase (chat) and acetylcholine esterase (ache), the neurotransmitter enzymes that synthesize and degrade acetylcholine, and monoamine oxidase (mao), the degradation enzyme for catecholamines, were investigated. |
1986-05-15 |
2023-08-11 |
rat |
| S P Sivam, B Hoskins, I K H. An assessment of comparative acute toxicity of diisopropyl-fluorophosphate, tabun, sarin, and soman in relation to cholinergic and GABAergic enzyme activities in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 4. issue 4. 1984-11-05. PMID:6479498. |
the results indicate that (a) the acute toxicity of organophosphate acetylcholinesterase inhibitors is directly related to the inhibition of ache though there is a wide difference in their potency; (b) a substantial inhibition of ache activity (over 90% of control) is necessary for lethality to ensue after an acute exposure and the margins between lethal and nonlethal doses are extremely small; and (c) qualitative differences seem to exist among the various organophosphates in affecting noncholinergic neurotransmitter enzymes. |
1984-11-05 |
2023-08-12 |
rat |
| J A Olschowka, V K Vijaya. Postnatal development of cholinergic neurotransmitter enzymes in the mouse cerebellum. Biochemical, light microscopic and electron microscopic cytochemical investigations. The Journal of comparative neurology. vol 191. issue 1. 1980-10-27. PMID:7400393. |
the activity and distribution of the cholinergic neurotransmitter enzymes acetylcholinesterase (ache) and choline acetyltransferase (chac) in the developing cerebellum of the mouse were investigated using biochemical assays and light microscopic histochemistry for ache and chac, and electron microscopic histochemistry for ache. |
1980-10-27 |
2023-08-12 |
mouse |