| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Malik Saadullah, Amna Sehar, Zunera Chauhdary, Rida Siddique, Hafsa Tariq, Muhammad Asif, Shazia Anwer Bukhari, Aisha Seth. Anti-neuroinflammatory and neuroprotective potential of Cissus tuberosa ethanol extract in Parkinson's disease model through the modulation of neuroinflammatory markers. PloS one. vol 19. issue 12. 2024-12-06. PMID:39642134. |
neurotransmitter levels were significantly improved in a dose-dependent manner (p<0.001), while acetylcholinesterase (ache) levels were significantly reduced (p<0.001). |
2024-12-06 |
2024-12-09 |
rat |
| Namrita Halder, Sourabh Yadav, Girdhari La. Neuroimmune communication of the cholinergic system in gut inflammation and autoimmunity. Autoimmunity reviews. 2024-11-05. PMID:39500481. |
it includes the neurotransmitter acetylcholine (ach), the enzyme required for the synthesis of ach (choline acetyltransferase, chat), the enzyme required for its degradation (acetylcholinesterase, ache), and cholinergic receptors (nicotinic acetylcholine receptors and muscarinic acetylcholine receptors). |
2024-11-05 |
2024-11-08 |
Not clear |
| Wenhui Xiong, Binbin Liao, Yuanfa Yang, Shanglin Zhong, Jinnan Zhang, Wenxuan Sun, Yang Zou, Hui Ai, Tianrong Xin, Bin Xia, Zhiwen Zo. The deficiency of acetylcholinesterase gene in Aleuroglyphus ovatus increases its susceptibility to phoxim and natural pyrethrins and inhibits its reproduction. Journal of hazardous materials. vol 480. 2024-10-15. PMID:39405704. |
acetylcholinesterase (ache), an essential neurotransmitter hydrolase, is targeted by organophosphorus and carbamate pesticides, and its number varies among species. |
2024-10-15 |
2024-10-18 |
Not clear |
| Priya Gupta, Archisman Mahapatra, Bharat Manna, Anjali Suman, Shubhendu Shekhar Ray, Naresh Singhal, Rahul Kumar Sing. Sorption of PFOS onto polystyrene microplastics potentiates synergistic toxic effects during zebrafish embryogenesis and neurodevelopment. Chemosphere. 2024-10-05. PMID:39368493. |
additionally, co-exposure of zebrafish larvae to ps-mps and pfos resulted in an abrupt behavioral response, which decreased ache activity and altered neurotransmitter levels. |
2024-10-05 |
2024-10-08 |
zebrafish |
| Opeyemi B Ogunsuyi, Olawande C Olagoke, Mayokun E Famutimi, Damilola M Olatunde, Diogo O G Souza, Ganiyu Oboh, Nilda V Barbosa, João B T Roch. Neural acetylcholinesterase and monoamine oxidase deregulation during streptozotocin-induced behavioral, metabolic and redox modification in Nauphoeta cinerea. BMC neuroscience. vol 25. issue 1. 2024-08-30. PMID:39210265. |
the activity of neurotransmitter regulators - ache and mao was exacerbated, with concurrent upregulation of glucose sensing and signaling, and increased mrna levels of redox regulators and inflammation-related genes. |
2024-08-30 |
2024-09-04 |
Not clear |
| Fatima Ezzahra Laghchioua, Carlos F M da Silva, Diana C G A Pinto, José A S Cavaleiro, Ricardo F Mendes, Filipe A Almeida Paz, Maria A F Faustino, El Mostapha Rakib, M Graça P M S Neves, Florbela Pereira, Nuno M M Mour. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS chemical neuroscience. 2024-07-22. PMID:39037949. |
since acetylcholinesterase (ache) is a critical enzyme in the nervous system, responsible for breaking down the neurotransmitter acetylcholine, its inhibition holds a significant interest in the treatment of various neurological disorders. |
2024-07-22 |
2024-07-25 |
Not clear |
| Li Zhang, Xue Li, Qiang Yuan, Sujie Sun, Fasheng Liu, Xinjun Liao, Huiqiang Lu, Jianjun Chen, Zigang Ca. Isavuconazole Induces Neurodevelopment Defects and Motor Behaviour Impairment in Zebrafish Larvae. Molecular neurobiology. 2024-05-24. PMID:38787492. |
at the same time, exposure of zebrafish embryos to isavuconazole downregulated acetylcholinesterase (ache) and adenosine triphosphate (atpase) activities but upregulated oxidative stress, thereby disrupting neural development and gene expression of neurotransmitter pathways. |
2024-05-24 |
2024-05-27 |
zebrafish |
| Changwei Yu, Yalan Xiang, Min Zhang, Jing Wen, Xiaoyu Duan, Lu Wang, Gongying Deng, Pingfei Fan. Glycyrrhizic Acid Alleviates Semen Strychni-Induced Neurotoxicity Through the Inhibition of HMGB1 Phosphorylation and Inflammatory Responses. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-05-21. PMID:38771510. |
inflammatory cytokines (tnf-α and il-1β), neurotransmitter associated enzymes (mao and ache), serum hmgb1, nuclear and cytoplasmic hmgb1/ph-hmgb1, and the interaction between pp2a, pkc, and hmgb1 were evaluated. |
2024-05-21 |
2024-05-27 |
rat |
| Ming Liu, Ping Deng, Guangyu Li, Haoling Liu, Junli Zuo, Wenwen Cui, Huixian Zhang, Xin Chen, Jingjing Yao, Xitian Peng, Lijun Peng, Jiao Liu, Wenting Zheng, Wei Yan, Ning Lua. Neurotoxicity of Combined Exposure to the Heavy Metals (Pb and As) in Zebrafish ( Toxics. vol 12. issue 4. 2024-04-26. PMID:38668505. |
to elucidate the underlying mechanisms, we examined changes in acetylcholinesterase (ache) activity, neurotransmitter (dopamine, 5-hydroxytryptamine) levels, hpi axis-related hormone (cortisol and epinephrine) contents and neurodevelopment-related gene expression in zebrafish brain. |
2024-04-26 |
2024-04-28 |
zebrafish |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Jae Yeon Park, Seong Doo Kang, Yun Gon Son, Ju Yeon Kim, Gihwan Lee, Kwang Dong Kim, Sang Won Lee, Jeong Yoon Ki. Eucalyptus globulus leaf-isolated isorhapontin serves as a natural insecticide via acetylcholinesterase inhibition. Pesticide biochemistry and physiology. vol 200. 2024-04-08. PMID:38582576. |
acetylcholinesterase (ache) inhibitors cause insect death by preventing the hydrolysis of the neurotransmitter acetylcholine, which overstimulates the nervous system. |
2024-04-08 |
2024-04-10 |
Not clear |
| Xiujuan Huang, Yuanyuan Cheng, Qi Zhou, Yifeng Tu, Jilin Ya. A simple fluorescence detection of acetylcholinesterase with peroxidase-like catalysis from iodide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 313. 2024-03-15. PMID:38490124. |
acetylcholinesterase (ache) is an important enzyme in the central and peripheral nervous system that regulates the balance of the neurotransmitter acetylcholine. |
2024-03-15 |
2024-03-18 |
Not clear |
| Xintong Li, Tong Zheng, Jiayi Zhang, Haibo Chen, Chongdan Xiang, Yanan Sun, Yao Dang, Ping Ding, Guocheng Hu, Yunjiang Y. Photoaged polystyrene microplastics result in neurotoxicity associated with neurotransmission and neurodevelopment in zebrafish larvae (Danio rerio). Environmental research. 2024-02-24. PMID:38401682. |
motor neuron development was disrupted by transgenic (hb9-gfp) zebrafish larvae exposed to a-ps, with significant alterations in neurotransmitter levels (ach, da, 5-ht, and gaba) and enzyme activity (ache, chat, and che). |
2024-02-24 |
2024-02-27 |
zebrafish |
| Joana Ribeiro, Henrique Araújo-Silva, Mário Fernandes, Joilna Alves da Silva, Francisco das Chagas L Pinto, Otília Deusdenia L Pessoa, Hélcio Silva Santos, Jane Eire Silva Alencar de Menezes, Andreia C Gome. Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo. Natural products and bioprospecting. vol 14. issue 1. 2024-02-22. PMID:38383833. |
a crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (ache) activity. |
2024-02-22 |
2024-02-24 |
zebrafish |
| Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). |
2024-02-10 |
2024-02-12 |
Not clear |
| F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. |
conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. |
2024-02-09 |
2024-02-11 |
human |
| Jia Liu, Wei Ha, Eshbakova Komila Alibekovna, Rui Ma, Yan-Ping Sh. Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO Nanoscale. 2023-10-20. PMID:37860933. |
inhibiting ache is a common strategy for reducing the degradation of neurotransmitter acetylcholine, in order to treat early-stage ad. |
2023-10-20 |
2023-11-08 |
Not clear |
| Zainabu Majid, Qi Zhang, Zhansen Yang, Huilian Che, Nan Chen. A Multi-Enzyme Cascade Response for the Colorimetric Recognition of Organophosphorus Pesticides Utilizing Core-Shell Pd@Pt Nanoparticles with High Peroxidase-like Activity. Foods (Basel, Switzerland). vol 12. issue 17. 2023-09-09. PMID:37685251. |
their limits are closely monitored since their residual hinders the capability of acetylcholinesterase (ache) and brings out a threatening accumulation of the neurotransmitter acetylcholine (ach), which affects human well-being. |
2023-09-09 |
2023-10-07 |
human |
| Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. |
2023-08-14 |
2023-09-07 |
Not clear |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |