| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bonan Liu, Jiayuan Kou, Fuyan Li, Da Huo, Jiaran Xu, Xiaoxi Zhou, Dehao Meng, Murtaza Ghulam, Bobkov Artyom, Xu Gao, Ning Ma, Dong Ha. Lemon essential oil ameliorates age-associated cognitive dysfunction via modulating hippocampal synaptic density and inhibiting acetylcholinesterase. Aging. vol 12. issue 9. 2021-02-26. PMID:32392535. |
the effects of leo on learning and memory were examined using the morris water maze (mwm) test, novel object recognition test, and correlative indicators, including a neurotransmitter (acetylcholinesterase, ache), a nerve growth factor (brain-derived neurotrophic factor, bdnf), a postsynaptic marker (psd95), and presynaptic markers (synapsin-1, and synaptophysin), in app/ps1 mice. |
2021-02-26 |
2023-08-13 |
mouse |
| Prayasee Baruah, Abhinandan Das, Debojit Paul, Suman Chakrabarty, Kripamoy Aguan, Sivaprasad Mitr. Sulfonylurea Class of Antidiabetic Drugs Inhibit Acetylcholinesterase Activity: Unexplored Auxiliary Pharmacological Benefit toward Alzheimer's Disease. ACS pharmacology & translational science. vol 4. issue 1. 2021-02-23. PMID:33615172. |
all these drugs were found to exhibit moderate to strong inhibitory efficiency on the neurotransmitter degrading enzyme acetylcholinesterase (ache) with gly (ic |
2021-02-23 |
2023-08-13 |
Not clear |
| İrem Bozbey, Zeynep Özdemir, Harun Uslu, Azime Berna Özçelik, Fatma Sezer Şenol, İlkay Erdoğan Orhan, Mehtap Uysa. A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies. Mini reviews in medicinal chemistry. vol 20. issue 11. 2021-02-02. PMID:31660824. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach), which is a significant neurotransmitter for regulation of cognition in animals. |
2021-02-02 |
2023-08-13 |
Not clear |
| Tomoyo Horio, Aisa Ozawa, Junichi Kamiie, Motoharu Sakau. Immunohistochemical analysis for acetylcholinesterase and choline acetyltransferase in mouse cerebral cortex after traumatic brain injury. The Journal of veterinary medical science. vol 82. issue 6. 2021-02-02. PMID:32321871. |
acetylcholine (ach), a neurotransmitter synthesized and hydrolyzed by choline acetyltransferase (chat) and acetylcholinesterase (ache), respectively, in the central nervous system, has the potential to regulate glial cells' states, i.e., non-reactive and reactive states. |
2021-02-02 |
2023-08-13 |
mouse |
| Engy Medhat, Laila Rashed, Marwa Abdelgwad, Basma Emad Aboulhoda, Mohamed Mansour Khalifa, Shimaa Saad El-Di. Exercise enhances the effectiveness of vitamin D therapy in rats with Alzheimer's disease: emphasis on oxidative stress and inflammation. Metabolic brain disease. vol 35. issue 1. 2021-01-29. PMID:31691146. |
the following parameters were assessed in rat brain tissues: acetylcholine esterase (ache) activity, levels of amyloid β 42 and tau proteins, dopamine brain neurotransmitter, bdnf and ngf by elisa. |
2021-01-29 |
2023-08-13 |
rat |
| Jayeong Hwang, Kumju Youn, Yeongseon Ji, Seonah Lee, Gyutae Lim, Jinhyuk Lee, Chi-Tang Ho, Sun-Hee Leem, Mira Ju. Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone. Nutrients. vol 12. issue 5. 2021-01-20. PMID:32344943. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) mediate the degradation of acetylcholine (ach), a primary neurotransmitter in the brain. |
2021-01-20 |
2023-08-13 |
Not clear |
| Cassandra Schmitt, Eric Peterson, Audrey Willis, Naveen Kumar, Michelle McManus, Seenivasan Subbiah, Jordan Crag. Transgenerational effects of developmental exposure to chlorpyrifos-oxon in zebrafish (DANIO RERIO). Toxicology and applied pharmacology. vol 408. 2021-01-11. PMID:33049267. |
abstract summary: this study identified a correlation between cpo exposure during f0 development and significant differences in f2 behavioral, ache activity and neurotransmitter concentration. |
2021-01-11 |
2023-08-13 |
zebrafish |
| Ewa Baranowska-Wójcik, Dominik Szwajgier, Anna Winiarska-Miecza. Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors. Nutrients. vol 12. issue 3. 2020-12-21. PMID:32155927. |
acetylcholinesterase (ache) plays a significant role in the process through hydrolysis of the acetylcholine neurotransmitter. |
2020-12-21 |
2023-08-13 |
Not clear |
| Hulya Akıncıoğlu, İlhami Gülçi. Potent Acetylcholinesterase Inhibitors: Potential Drugs for Alzheimer's Disease. Mini reviews in medicinal chemistry. vol 20. issue 8. 2020-11-09. PMID:31902355. |
ache hydrolyzes ach to acetate and choline, as an important neurotransmitter substance. |
2020-11-09 |
2023-08-13 |
Not clear |
| Ryan J Yoder, Qinggeng Zhuang, Jeremy M Beck, Andrew Franjesevic, Travis G Blanton, Sydney Sillart, Tyler Secor, Leah Guerra, Jason D Brown, Carolyn Reid, Craig A McElroy, Özlem Doğan Ekici, Christopher S Callam, Christopher M Hada. Study of ACS medicinal chemistry letters. vol 8. issue 6. 2020-10-01. PMID:28626522. |
the aged ache is unable to hydrolyze acetylcholine, resulting in accumulation of the neurotransmitter in the central nervous system (cns) and elsewhere. |
2020-10-01 |
2023-08-13 |
Not clear |
| Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P Che. Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535625. |
butyrylcholinesterase (bche), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (ache) but with the capability to degrade a broad range of bioactive esters. |
2020-10-01 |
2023-08-13 |
mouse |
| Adriana M Dos Santos, Ariele C Moreira, Bianca Rebelo Lopes, Mariana F Fracola, Fernando G de Almeida, Odair C Bueno, Quezia B Cass, Dulce Helena F Souz. Acetylcholinesterases from Leaf-Cutting ant Enzyme research. vol 2019. 2020-09-30. PMID:31354985. |
acetylcholinesterases from leaf-cutting ant acetylcholinesterase (ache) is responsible for catalyzing the hydrolysis of the neurotransmitter acetylcholine (ach) leading to acetate and choline (ch) release. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yameng Han, Zhongju Ye, Fuyan Wang, Tianyu Chen, Lin Wei, Langxing Chen, Lehui Xia. Single-particle enumeration-based ultrasensitive enzyme activity quantification with fluorescent polymer nanoparticles. Nanoscale. vol 11. issue 31. 2020-09-11. PMID:31353389. |
acetylcholinesterase (ache) plays a vital role in nerve conduction through rapidly hydrolyzing the neurotransmitter acetylcholine (ach) and is correlated with alzheimer's disease. |
2020-09-11 |
2023-08-13 |
human |
| Bo Cheng, Fen Jiang, Meile Su, Liqun Zhou, Hua Zhang, Zigang Cao, Xinjun Liao, Guanghua Xiong, Juhua Xiao, Fasheng Liu, Huiqiang L. Effects of lincomycin hydrochloride on the neurotoxicity of zebrafish. Ecotoxicology and environmental safety. vol 201. 2020-09-08. PMID:32474209. |
in addition, the swimming behavior of zebrafish larvae decreased with the increase of lincomycin hydrochloride concentration, but the angular velocity and meandering degree increased, which might be due to the decreased activity of ache and atpase, as well as the decreased expression of genes related to neurodevelopment and neurotransmitter system, leading to the change of their motor behaviors. |
2020-09-08 |
2023-08-13 |
zebrafish |
| Axel Eduardo Rico-Sánchez, Alexis Joseph Rodríguez-Romero, Jacinto Elías Sedeño-Díaz, Eugenia López-Lópe. Assessment of seasonal and spatial variations of biochemical markers in Corydalus sp. (Megaloptera: Corydalidae), a non-conventional biomonitor, in a mountain cloud forest in Mexico. Environmental science and pollution research international. vol 27. issue 24. 2020-07-28. PMID:32474780. |
we assessed the health condition of this river system using a non-conventional biomonitor, corydalus sp., with a set of early-warning biomarkers including lipid peroxidation levels (lpo) and antioxidant activity, superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), and the neurotransmitter acetylcholinesterase (ache) considering their spatial and temporal variations. |
2020-07-28 |
2023-08-13 |
human |
| Fernanda D'Avila da Silva, Pablo Andrei Nogara, Estael Ochoa-Rodríguez, Yanier Nuñez-Figueredo, Maylin Wong-Guerra, Denis Broock Rosemberg, João Batista Teixeira da Roch. Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources. Biochimie. vol 168. 2020-04-06. PMID:31770565. |
the main function of ache is the hydrolysis of the neurotransmitter acetylcholine (ach) at the neuromuscular and in cholinergic brain synapses. |
2020-04-06 |
2023-08-13 |
human |
| Xiao Hu, Cerasela Zoica Din. Nanoporous gold electrode for ultrasensitive detection of neurotoxin fasciculin. Analytica chimica acta. vol 1085. 2020-03-16. PMID:31522735. |
acetylcholinesterase (ache), an efficient biocatalyst known to hydrolyze the neurotransmitter acetylcholine, could be inactivated in the presence of insecticides, nerve agents or other drug inhibitors to thus result in disrupted neurotransmission. |
2020-03-16 |
2023-08-13 |
Not clear |
| Lilai Yuan, Le Qian, Yu Qian, Jia Liu, Ke Yang, Ying Huang, Chengju Wang, Yingren Li, Xiyan M. Bisphenol F-Induced Neurotoxicity toward Zebrafish Embryos. Environmental science & technology. vol 53. issue 24. 2020-03-16. PMID:31702913. |
additionally, no significant change was found in neurotransmitter levels (5-hydroxytryptamine, dopamine, and acetylcholine) or acetylcholinesterase (ache) enzyme activity after bpf exposure, indicating that bpf may not affect neurotransmission. |
2020-03-16 |
2023-08-13 |
zebrafish |
| Oksana Gerlits, Xiaotian Kong, Xiaolin Cheng, Troy Wymore, Donald K Blumenthal, Palmer Taylor, Zoran Radić, Andrey Kovalevsk. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. The Journal of biological chemistry. vol 294. issue 27. 2020-03-10. PMID:31138650. |
inhibited ache cannot hydrolyze the neurotransmitter acetylcholine leading to its build-up at the cholinergic synapses and creating an acute cholinergic crisis. |
2020-03-10 |
2023-08-13 |
human |
| Yasmina M Abd-Elhakim, Nabela I El-Sharkawy, Hesham H Mohammed, Lamiaa L M Ebraheim, Mostafa A Shalab. Camel milk rescues neurotoxic impairments induced by fenpropathrin via regulating oxidative stress, apoptotic, and inflammatory events in the brain of rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 135. 2020-02-17. PMID:31838190. |
the levels of dopamine (dopa) neurotransmitter, acetylcholinesterase (ache) enzyme, oxidative stress, and inflammatory markers were determined. |
2020-02-17 |
2023-08-13 |
rat |