| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wanjun Zhang, Ruiqi Fan, Sunlin Luo, Ying Liu, Yongpeng Jin, Yongchen Li, Mengqin Xiong, Yiqiang Chen, Li Jia, Xiaoyan Yua. Combined effects of chlorpyrifos and cyfluthrin on neurobehavior and neurotransmitter levels in larval zebrafish. Journal of applied toxicology : JAT. 2022-04-26. PMID:35470462. |
combined exposure to chlorpyrifos and cyfluthrin exhibited distinct joint action modes in terms of neurobehavior, ache activity, and neurotransmitter levels, thereby providing an experimental basis for assessing the combined exposure to chlorpyrifos and cyfluthrin's environmental risk. |
2022-04-26 |
2023-08-13 |
zebrafish |
| Tesfaye Hailemariam Barkae, Abdallah M Zeid, Guobao X. Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2'-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence. Sensors (Basel, Switzerland). vol 22. issue 7. 2022-04-12. PMID:35408132. |
ache is a vital enzyme for neurotransmission because it metabolizes acetylcholine neurotransmitter at the synaptic cleft and terminates synaptic transmission. |
2022-04-12 |
2023-08-13 |
Not clear |
| Shuaizhang Li, Andrew J Li, Jinghua Zhao, Michael F Santillo, Menghang Xi. Acetylcholinesterase Inhibition Assays for High-Throughput Screening. Methods in molecular biology (Clifton, N.J.). vol 2474. 2022-03-16. PMID:35294755. |
acetylcholinesterase (ache) hydrolyzes acetylcholine (ach), a vital neurotransmitter that regulates muscle movement and brain function, including memory, attention, and learning. |
2022-03-16 |
2023-08-13 |
human |
| Lukas G Schnitzler, Kathrin Baumgartner, Anna Kolb, Benedikt Braun, Christoph Westerhause. Acetylcholinesterase Activity Influenced by Lipid Membrane Area and Surface Acoustic Waves. Micromachines. vol 13. issue 2. 2022-02-25. PMID:35208411. |
according to the current model of nerve propagation, the function of acetylcholinesterase (ache) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ach) in the synaptic cleft to acetic acid (acetate) and choline. |
2022-02-25 |
2023-08-13 |
Not clear |
| Juan Bellas, Diego Rial, Juliana Valdés, Leticia Vidal-Liñán, Juan I Bertucci, Soledad Muniategui, Víctor M León, Juan A Campill. Linking biochemical and individual-level effects of chlorpyrifos, triphenyl phosphate, and bisphenol A on sea urchin (Paracentrotus lividus) larvae. Environmental science and pollution research international. 2022-02-15. PMID:35165844. |
the antioxidant enzymes glutathione reductase (gr) and catalase (cat), the phase ii detoxification enzyme glutathione s-transferase (gst), and the neurotransmitter catabolism enzyme acetylcholinesterase (ache) were assessed in combination with responses at the individual level (larval growth). |
2022-02-15 |
2023-08-13 |
cat |
| Yu Wang, Dongxu Wang, Kai Yin, Yachen Liu, Hongmin Lu, Hongjing Zhao, Mingwei Xin. Lycopene attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/NF-κB balance in sulfamethoxazole-induced neurotoxicity in grass carp (Ctenopharyngodon Idella). Fish & shellfish immunology. 2022-01-15. PMID:35032680. |
firstly, brain injury induced by smz exposure was suggested by the damage of bbb (decreases of claudins, occludin and zonula occludens), and the decrease of neurotransmitter activity (ache). |
2022-01-15 |
2023-08-13 |
Not clear |
| Thais Agues-Barbosa, Francisco Carlos da Silva Junior, Jackson Nazareno Gomes de Lima, Silvia Regina Batistuzzo de Medeiros, Ana Carolina Luchiar. Behavioral genetics of alcohol's effects in three zebrafish (Danio rerio) populations. Progress in neuro-psychopharmacology & biological psychiatry. 2021-12-16. PMID:34915060. |
we analyzed the behavioral responses and mrna expression involved in neurotransmitter metabolism - th1, tph1, ache, ada1, gaba1, gad1b, and bdnf. |
2021-12-16 |
2023-08-13 |
zebrafish |
| Sílvia Chaves, Katalin Várnagy, M Amélia Santo. Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity. Current medicinal chemistry. vol 28. issue 35. 2021-11-25. PMID:33602068. |
currently available drugs are used, mainly to compensate the decline of the neurotransmitter acetylcholine by acetylcholinesterase (ache) inhibition, though they only provide temporary symptomatic benefits and cannot stop ad progression. |
2021-11-25 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
acetylcholinesterase (ache), hydrolase enzyme, regulates the hydrolysis of acetylcholine neurotransmitter in the neurons. |
2021-11-23 |
2023-08-13 |
Not clear |
| Jiyeon Han, Zhi Du, Mi Hee Li. Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer's Disease. Accounts of chemical research. vol 54. issue 20. 2021-11-10. PMID:34606227. |
finally, the loss of cholinergic transmission mediated by the neurotransmitter acetylcholine (ach) contributes to cognitive deficits observed in ad.in this account, we illustrate the design principles for small-molecule-based chemical tools with reactivities against metal-free aβ, metal-bound aβ, ros, and ache. |
2021-11-10 |
2023-08-13 |
Not clear |
| Heather B Patisaul, Mamta Behl, Linda S Birnbaum, Arlene Blum, Miriam L Diamond, Seth Rojello Fernández, Helena T Hogberg, Carol F Kwiatkowski, Jamie D Page, Anna Soehl, Heather M Stapleto. Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers. Environmental health perspectives. vol 129. issue 10. 2021-10-09. PMID:34612677. |
to date, the toxicity of organophosphate esters has primarily been studied regarding their use as pesticides and their effects on the neurotransmitter acetylcholinesterase (ache). |
2021-10-09 |
2023-08-13 |
human |
| Paulomi Dey, Bishnupada Roy, Rahul Mohant. A kaempferol derivative isolated from Lysimachia ramosa (Wall ex. Duby) induced alteration of acetyl cholinesterase and nitric oxide synthase in Raillietina echinobothrida. Veterinary parasitology. vol 296. 2021-09-28. PMID:34214945. |
the isolated active compound was characterized to be a kaempferol derivative which showed potent anthelmintic activity against r. echinobothrida by changing surface ultrastructure and also inhibiting the activity of two neurotransmitter enzymes: acetyl cholinesterase (ache) and nitric oxide synthase (nos), both of which are known to perform dynamic roles in the intracellular communication mediated through neuromuscular system. |
2021-09-28 |
2023-08-13 |
Not clear |
| Oksana Gerlits, Matthew P Blakeley, David A Keen, Zoran Radić, Andrey Kovalevsk. Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure. Current research in structural biology. vol 3. 2021-09-21. PMID:34541552. |
the active center geometry of ache, already highly evolved for the efficient catalysis, was thus indicative of only minor conformational adjustments to accommodate the tetrahedral intermediate in the hydrolysis of the neurotransmitter acetylcholine (ach). |
2021-09-21 |
2023-08-13 |
human |
| Xu Zhao, Ling Zhang, Xu Yan, Li Zhang, Yang Lu, Jialin Pan, Meiling Zhang, Chenguang Wang, Hui Suo, Xiaoteng Jia, Xiaomin Liu, Geyu L. A near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on NaErF Talanta. vol 235. 2021-09-15. PMID:34517642. |
a near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on naerf acetylcholinesterase (ache), as an important neurotransmitter, is widely present in the peripheral and central nervous systems. |
2021-09-15 |
2023-08-13 |
Not clear |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |
| Immacolata Vecchio, Luca Sorrentino, Annamaria Paoletti, Rosario Marra, Mariamena Arbitri. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. Journal of central nervous system disease. vol 13. 2021-07-22. PMID:34285627. |
one of the causes leading to ad is the decrease of neurotransmitter acetylcholine (ach) levels in the brain, in part due to a higher activity of acetylcholinesterase (ache), the enzyme responsible for its degradation. |
2021-07-22 |
2023-08-13 |
Not clear |
| Andrea Castaneda, Ricardo Ferraz, Mónica Vieira, Isabel Cardoso, Vitor Vasconcelos, Rosário Martin. Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer's Disease. Marine drugs. vol 19. issue 6. 2021-07-05. PMID:34208482. |
in this review, we aimed to compile the research works focused in the anti-ad potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (bace1) as a fundamental enzyme in the generation of β-amyloid (aβ), the inhibition of the enzyme acetylcholinesterase (ache) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms. |
2021-07-05 |
2023-08-13 |
Not clear |
| M V K Reddy, K Y Rao, G Anusha, G M Kumar, A G Damu, Kakarla Raghava Reddy, Nagaraj P Shetti, Tejraj M Aminabhavi, Peddiahgari Vasu Govardhana Redd. In-vitro evaluation of antioxidant and anticholinesterase activities of novel pyridine, quinoxaline and s-triazine derivatives. Environmental research. vol 199. 2021-07-01. PMID:33991570. |
cholinesterase enzymes such as acetylcholinesterase (ache) and butyrylcholinesterase (buche) cause hydrolysis of acetylcholine (ach), a neurotransmitter responsible for the cognitive functions of the brain such as acquiring knowledge and comprehension. |
2021-07-01 |
2023-08-13 |
Not clear |
| Kevin G McGarry, Kevin E Schill, Tyson P Winters, Erin E Lemmon, Carol L Sabourin, Jill A Harvilchuck, Robert A Moye. Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31879781. |
disruption of cholinergic function through the inhibition of acetylcholinesterase (ache) leads to the accumulation of the neurotransmitter acetylcholine. |
2021-06-09 |
2023-08-13 |
Not clear |
| Leila Sadeghi, Reza Yekta, Gholamreza Dehgha. The inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602852. |
acetylcholine is a fast-acting neurotransmitter in synapses and neuromuscular junctions that is decreased in alzheimer's disease (ad) by hyper‑activation of acetylcholinesterase (ache), which leads to progressive loss of memory and neurobehavioral abnormalities. |
2021-06-07 |
2023-08-13 |
rat |