| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos Roca, Carlos Requena, Víctor Sebastián-Pérez, Sony Malhotra, Chris Radoux, Concepción Pérez, Ana Martinez, Juan Antonio Páez, Tom L Blundell, Nuria E Campill. Identification of new allosteric sites and modulators of AChE through computational and experimental tools. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-07-05. PMID:29873262. |
acetylcholinesterase (ache), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for amyloidosis in alzheimer's disease through interaction with amyloid β-peptide. |
2018-07-05 |
2023-08-13 |
Not clear |
| Volker Strauss, Maria Cecilia Rey Moreno, Jeanette Vogt, Martina Dammann, Steffen Schneider, Sibylle Gröters, Bennard van Ravenzwaa. Acetylcholinesterase measurement in various brain regions and muscles of juvenile, adolescent, and adult rats. Toxicology mechanisms and methods. vol 27. issue 9. 2018-05-23. PMID:28671028. |
several insecticides, chemicals, and drugs are known to inhibit acetylcholinesterase (ache) activity, responsible for the cleavage of the neurotransmitter acetylcholine. |
2018-05-23 |
2023-08-13 |
rat |
| Anders Allgardsson, C David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekströ. An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-08. PMID:28867801. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. |
2018-05-08 |
2023-08-13 |
Not clear |
| Paula Rayane de Souza, Kelma Sirleide de Souza, Caio Rodrigo Dias de Assis, Marlyete Chagas de Araújo, Kaline Catiely Campos Silva, Juliett de Fátima Xavier da Silva, Andreia Cybelle Marques Ferreira, Valdir Luna da Silva, Mônica Lúcia Adam, Luiz Bezerra de Carvalho, Ranilson de Souza Bezerr. Acetylcholinesterase of mangrove oyster Crassostrea rhizophorae: A highly thermostable enzyme with promising features for estuarine biomonitoring. Aquatic toxicology (Amsterdam, Netherlands). vol 197. 2018-05-07. PMID:29462762. |
acetylcholinesterase (ache; ec 3.1.1.7) is an enzyme of the group of serine esterases that acts on the hydrolysis of the neurotransmitter acetylcholine allowing the intermittence of the nerve impulses responsible for the neuronal communication. |
2018-05-07 |
2023-08-13 |
Not clear |
| Irini Doytchinova, Mariyana Atanasova, Iva Valkova, Georgi Stavrakov, Irena Philipova, Zvetanka Zhivkova, Dimitrina Zheleva-Dimitrova, Spiro Konstantinov, Ivan Dimitro. Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-05-01. PMID:29651876. |
the inhibition of the enzyme acetylcholinesterase (ache) increases the levels of the neurotransmitter acetylcholine and symptomatically improves the affected cognitive function. |
2018-05-01 |
2023-08-13 |
Not clear |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
acetylcholinesterase (ache) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2017-11-29 |
2023-08-13 |
Not clear |
| Neeraj Kumar, Kishore Kumar Krishnani, Narendra Pratap Sing. Oxidative and cellular stress as bioindicators for metal contamination in freshwater mollusk Lamellidens marginalis. Environmental science and pollution research international. vol 24. issue 19. 2017-11-20. PMID:28537033. |
aspartate amino transferase (ast), alanine amino transferase (alt), and lipid peroxidation (lpo) were significantly (p < 0.01) higher, while neurotransmitter enzymes such as acetylcholine esterase (ache) were significantly inhibited in muscle of l. marginalis (p < 0.01) collected from different sampling sites. |
2017-11-20 |
2023-08-13 |
cat |
| Mohammad Nazim, Akio Masuda, Mohammad Alinoor Rahman, Farhana Nasrin, Jun-Ichi Takeda, Kenji Ohe, Bisei Ohkawara, Mikako Ito, Kinji Ohn. Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms. Nucleic acids research. vol 45. issue 3. 2017-10-30. PMID:28180311. |
acetylcholinesterase (ache), encoded by the ache gene, hydrolyzes the neurotransmitter acetylcholine to terminate synaptic transmission. |
2017-10-30 |
2023-08-13 |
human |
| Shuaizhang Li, Ruili Huang, Samuel Solomon, Yitong Liu, Bin Zhao, Michael F Santillo, Menghang Xi. Identification of acetylcholinesterase inhibitors using homogenous cell-based assays in quantitative high-throughput screening platforms. Biotechnology journal. vol 12. issue 5. 2017-10-25. PMID:28294544. |
acetylcholinesterase (ache) is an enzyme responsible for metabolism of acetylcholine, a neurotransmitter associated with muscle movement, cognition, and other neurobiological processes. |
2017-10-25 |
2023-08-13 |
human |
| Sultan Darves. Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27040140. |
the serine hydrolase butyrylcholinesterase (bche), like the related enzyme acetylcholinesterase (ache), co-regulates metabolism of the neurotransmitter acetylcholine. |
2017-10-02 |
2023-08-13 |
mouse |
| Richard D Burke, Spencer W Todd, Eric Lumsden, Roger J Mullins, Jacek Mamczarz, William P Fawcett, Rao P Gullapalli, William R Randall, Edna F R Pereira, Edson X Albuquerqu. Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28791702. |
clinical manifestations of an acute exposure of humans to op insecticides include a well-defined cholinergic crisis that develops as a result of the irreversible inhibition of acetylcholinesterase (ache), the enzyme that hydrolyzes the neurotransmitter acetylcholine (ach). |
2017-09-07 |
2023-08-13 |
Not clear |
| Xiangkun Meng, Chunrui Li, Chunli Xiu, Jianhua Zhang, Jingjing Li, Lixin Huang, Yixi Zhang, Zewen Li. Identification and Biochemical Properties of Two New Acetylcholinesterases in the Pond Wolf Spider (Pardosa pseudoannulata). PloS one. vol 11. issue 6. 2017-07-24. PMID:27337188. |
acetylcholinesterase (ache), an important neurotransmitter hydrolase in both invertebrates and vertebrates, is targeted by organophosphorus and carbamate insecticides. |
2017-07-24 |
2023-08-13 |
spider |
| Kei M Lau, Amy G W Gong, Miranda L Xu, Candy T W Lam, Laura M L Zhang, Cathy W C Bi, D Cui, Anthony W M Cheng, Tina T X Dong, Karl W K Tsim, Huangquan Li. Transcriptional activity of acetylcholinesterase gene is regulated by DNA methylation during C2C12 myogenesis. Brain research. vol 1642. 2017-05-22. PMID:27021952. |
the expression of acetylcholinesterase (ache), an enzyme hydrolyzes neurotransmitter acetylcholine at vertebrate neuromuscular junction, is regulated during myogenesis, indicating the significance of muscle intrinsic factors in controlling the enzyme expression. |
2017-05-22 |
2023-08-13 |
mouse |
| Shelly Sharma, Partap Bir Singh, Pooja Chadha, Harvinder Singh Sain. Chlorpyrifos pollution: its effect on brain acetylcholinesterase activity in rat and treatment of polluted soil by indigenous Pseudomonas sp. Environmental science and pollution research international. vol 24. issue 1. 2017-03-24. PMID:27722883. |
this represents the antagonistic effect of cpf on ache which is a prime neurotransmitter present in all living beings including humans. |
2017-03-24 |
2023-08-13 |
rat |
| Stanton F McHardy, Hua-Yu Leo Wang, Shelby V McCowen, Matthew C Valde. Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015). Expert opinion on therapeutic patents. vol 27. issue 4. 2017-03-22. PMID:27967267. |
acetylcholinesterase (ache) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. |
2017-03-22 |
2023-08-13 |
Not clear |
| İlhami Gülçin, Andrea Scozzafava, Claudiu T Supuran, Hulya Akıncıoğlu, Zeynep Koksal, Fikret Turkan, Saleh Alwase. The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 6. 2017-02-21. PMID:26453427. |
acetylcholinesterase (ache) is responsible for acetyl choline (ach) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ach neurotransmitter at cholinergic synapses and neuromuscular junctions. |
2017-02-21 |
2023-08-13 |
human |
| Neeraj Kumar, K K Krishnani, S K Gupta, N P Sing. Cellular stress and histopathological tools used as biomarkers in Oreochromis mossambicus for assessing metal contamination. Environmental toxicology and pharmacology. vol 49. 2017-02-21. PMID:27992807. |
alt and ast, neurotransmitter enzymes in muscle ache, lipid peroxidation and histopathology in the liver and gill have been evaluated. |
2017-02-21 |
2023-08-13 |
Not clear |
| Y Chandrasekhar, E M Ramya, K Navya, G Phani Kumar, K R Anilakuma. Antidepressant like effects of hydrolysable tannins of Terminalia catappa leaf extract via modulation of hippocampal plasticity and regulation of monoamine neurotransmitters subjected to chronic mild stress (CMS). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 86. 2017-02-08. PMID:28012396. |
after behavioural tests, monoamine neurotransmitter, cortisol, ache, oxidative stress levels and mrna expression studies relevant to depression were assessed. |
2017-02-08 |
2023-08-13 |
mouse |
| Heidi Q Xie, Tuan Xu, Yangsheng Chen, Yunping Li, Yingjie Xia, Sherry L Xu, Lingyun Wang, Karl W K Tsim, Bin Zha. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27374124. |
acetylcholinesterase (ache; ec 3.1.1.7) is a vital functional enzyme in cholinergic neurotransmission which can rapidly hydrolyze neurotransmitter, acetylcholine, in the central and peripheral nervous systems. |
2017-01-30 |
2023-08-13 |
mouse |
| Cho Rong Kim, Soo Jung Choi, Yoon Kyung Kwon, Jae Kyeom Kim, Youn-Jung Kim, Gwi Gun Park, Dong-Hoon Shi. Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice. Biological & pharmaceutical bulletin. vol 39. issue 7. 2017-01-27. PMID:27374288. |
the pathogenesis of alzheimer's disease (ad) has been linked to the deficiency of neurotransmitter acetylcholine (ach) in the brain, and the main treatment strategy for improving ad symptoms is the inhibition of acetylcholinesterase (ache) activity. |
2017-01-27 |
2023-08-13 |
mouse |