| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao Hu, Cerasela Zoica Din. Nanoporous gold electrode for ultrasensitive detection of neurotoxin fasciculin. Analytica chimica acta. vol 1085. 2020-03-16. PMID:31522735. |
acetylcholinesterase (ache), an efficient biocatalyst known to hydrolyze the neurotransmitter acetylcholine, could be inactivated in the presence of insecticides, nerve agents or other drug inhibitors to thus result in disrupted neurotransmission. |
2020-03-16 |
2023-08-13 |
Not clear |
| Lilai Yuan, Le Qian, Yu Qian, Jia Liu, Ke Yang, Ying Huang, Chengju Wang, Yingren Li, Xiyan M. Bisphenol F-Induced Neurotoxicity toward Zebrafish Embryos. Environmental science & technology. vol 53. issue 24. 2020-03-16. PMID:31702913. |
additionally, no significant change was found in neurotransmitter levels (5-hydroxytryptamine, dopamine, and acetylcholine) or acetylcholinesterase (ache) enzyme activity after bpf exposure, indicating that bpf may not affect neurotransmission. |
2020-03-16 |
2023-08-13 |
zebrafish |
| Oksana Gerlits, Xiaotian Kong, Xiaolin Cheng, Troy Wymore, Donald K Blumenthal, Palmer Taylor, Zoran Radić, Andrey Kovalevsk. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. The Journal of biological chemistry. vol 294. issue 27. 2020-03-10. PMID:31138650. |
inhibited ache cannot hydrolyze the neurotransmitter acetylcholine leading to its build-up at the cholinergic synapses and creating an acute cholinergic crisis. |
2020-03-10 |
2023-08-13 |
human |
| Yasmina M Abd-Elhakim, Nabela I El-Sharkawy, Hesham H Mohammed, Lamiaa L M Ebraheim, Mostafa A Shalab. Camel milk rescues neurotoxic impairments induced by fenpropathrin via regulating oxidative stress, apoptotic, and inflammatory events in the brain of rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 135. 2020-02-17. PMID:31838190. |
the levels of dopamine (dopa) neurotransmitter, acetylcholinesterase (ache) enzyme, oxidative stress, and inflammatory markers were determined. |
2020-02-17 |
2023-08-13 |
rat |
| Pablo Zambrano, Mario Suwalsky, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka, Benjamin Sepúlveda, María J Gallardo, Luis F Aguila. The acetylcholinesterase (AChE) inhibitor and anti-Alzheimer drug donepezil interacts with human erythrocytes. Biochimica et biophysica acta. Biomembranes. vol 1861. issue 6. 2020-02-14. PMID:30904408. |
this drug is a specific inhibitor of the enzyme acetylcholinesterase (ache), whose main physiological function is to hydrolyze the neurotransmitter acetylcholine. |
2020-02-14 |
2023-08-13 |
human |
| Sina Parvaz, Reza Taheri-Ledari, Mir Saeed Esmaeili, Mahboubeh Rabbani, Ali Malek. A brief survey on the advanced brain drug administration by nanoscale carriers: With a particular focus on AChE reactivators. Life sciences. vol 240. 2020-01-13. PMID:31760098. |
one of the most important categories of these hydrophilic medications, are reactivators for acetyl cholinesterase (ache) enzyme that facilitates the breakdown of acetylcholine (as a neurotransmitter). |
2020-01-13 |
2023-08-13 |
Not clear |
| Honglei Wang, Liqun Zhou, Zhen Meng, Meile Su, Shouhua Zhang, Pinzhen Huang, Fen Jiang, Xinjun Liao, Zigang Cao, Huiqiang L. Clethodim exposure induced development toxicity and behaviour alteration in early stages of zebrafish life. Environmental pollution (Barking, Essex : 1987). vol 255. issue Pt 1. 2020-01-07. PMID:31541821. |
these could be due to reduced ache activity and disturbed gene expression of gaba, dopamine and glutamatergic neurotransmitter systems, which thus altered the locomotor behaviour. |
2020-01-07 |
2023-08-13 |
zebrafish |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |
| Zrinka Kovarik, Jarosław Kalisiak, Nikolina Maček Hrvat, Maja Katalinić, Tamara Zorbaz, Suzana Žunec, Carol Green, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. Chemistry (Weinheim an der Bergstrasse, Germany). vol 25. issue 16. 2019-11-26. PMID:30458057. |
acetylcholinesterase (ache), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (ops), such as nerve agents and pesticides, can be reactivated by oximes. |
2019-11-26 |
2023-08-13 |
mouse |
| Muhammed Khairujjaman Mazumder, Shuvasish Choudhur. Tea polyphenols as multi-target therapeutics for Alzheimer's disease: An in silico study. Medical hypotheses. vol 125. 2019-08-27. PMID:30902161. |
with neurodegeneration, the level of the neurotransmitter acetylcholine (ach), as well as acetylcholinesterase (ache), decreases in the synaptic cleft, called cholinergic deficiency. |
2019-08-27 |
2023-08-13 |
Not clear |
| Tahira Javed, Rabia Habib, Sania Ghafoor, Baseerat Rumman, Sliha Awan, Leonel J M Ntepe, Sajida Batool, Syed M Nurulai. Association of status of acetylcholinesterase and ACHE gene 3' UTR variants (rs17228602, rs17228616) with drug addiction vulnerability in pakistani population. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31129131. |
acetylecholine (ach), a cholinergic neurotransmitter hydrolyzed by acetylcholinesterase (ache), is an essential neurotransmitter and neuromodulator in central and peripheral nervous system and has regulatory influence on numerous neuronal functions including addiction. |
2019-07-22 |
2023-08-13 |
human |
| Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Le. Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease. International journal of molecular sciences. vol 20. issue 4. 2019-07-17. PMID:30823604. |
acetylcholinesterase (ache) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. |
2019-07-17 |
2023-08-13 |
human |
| Agung Nugroho, Jong-Hyuk Park, Jae Sue Choi, Kyoung-Sik Park, Joon-Pyo Hong, Hee-Juhn Par. Structure determination and quantification of a new flavone glycoside with anti-acetylcholinesterase activity from the herbs of Elsholtzia ciliata. Natural product research. vol 33. issue 6. 2019-06-20. PMID:29224362. |
acetylcholinesterase (ache) inhibition activity was assayed to find anti-alzheimer's activity, since this enzyme increases the concentration of acetylcholine (ach), a neurotransmitter, responsible for brain's memory. |
2019-06-20 |
2023-08-13 |
Not clear |
| Rimpi Arora, Rahul Deshmuk. Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats. Molecular neurobiology. vol 54. issue 9. 2019-05-23. PMID:27744573. |
stz-infused rats showed significant learning and memory deficit which was associated with an increase in oxidative stress (lipid peroxidation and nitrite), compromised antioxidant defense (reduced glutathione), neurotransmitter alterations (ache, dopamine, noradrenaline, 5-hydroxytryptamine, gama amino butyric acid, and glutamate), and elevation in neuroinflammatory cytokine (il-1 β, il-6, and tnf-α) levels. |
2019-05-23 |
2023-08-13 |
rat |
| Neeraj Kumar, K K Krishnani, Narendra Pratap Sing. Oxidative and Cellular Metabolic Stress of Fish: An Appealing Tool for Biomonitoring of Metal Contamination in the Kolkata Wetland, a Ramsar Site. Archives of environmental contamination and toxicology. vol 76. issue 3. 2019-05-02. PMID:30607445. |
the biochemical marker as antioxidative status, i.e., catalase, superoxide dismutase (sod), and glutathione-s-transferase (gst) in liver and gill, were remarkably higher (p < 0.01) at some of the sampling sites, but catalase in brain, sod in kidney, gst in brain and kidney, and neurotransmitter as acetylcholine esterase (ache) in brain were not significant (p > 0.05) among the sampling sites. |
2019-05-02 |
2023-08-13 |
Not clear |
| Mridula Saxena, Ragini Dube. Target Enzyme in Alzheimer's Disease: Acetylcholinesterase Inhibitors. Current topics in medicinal chemistry. vol 19. issue 4. 2019-04-24. PMID:30706815. |
the enzyme acetylcholinesterase enzyme (ache) is the key enzyme in the hydrolysis of the neurotransmitter acetylcholine and is also the target of most of the clinically used drugs for the treatment of ad but these drugs provide only symptomatic treatment and have the limitation of loss of therapeutic efficacy with time. |
2019-04-24 |
2023-08-13 |
Not clear |
| Qiyun Wu, Aster H Y Fung, Miranda L Xu, Kaman Poon, Etta Y L Liu, Xiang P Kong, Ping Yao, Qing P Xiong, Tina T X Dong, Karl W K Tsi. Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells. The Journal of biological chemistry. vol 293. issue 37. 2019-04-09. PMID:30076217. |
acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine in neurons. |
2019-04-09 |
2023-08-13 |
Not clear |
| Neeraj Kumar, Kishore Kumar Krishnani, Narendra Pratap Sing. Comparative study of selenium and selenium nanoparticles with reference to acute toxicity, biochemical attributes, and histopathological response in fish. Environmental science and pollution research international. vol 25. issue 9. 2019-01-23. PMID:29332272. |
cat, sod, and gst were significantly elevated (p < 0.01) when exposed to se and se-nps, and similarly, a neurotransmitter enzyme (acetylcholine esterase (ache)) was significantly inhibited in a time- and dose-dependent manner. |
2019-01-23 |
2023-08-13 |
cat |
| Caio R D Assis, Amanda G Linhares, Mariana P Cabrera, Vagne M Oliveira, Kaline C C Silva, Marina Marcuschi, Elba V M Maciel Carvalho, Ranilson S Bezerra, Luiz B Carvalh. Erythrocyte acetylcholinesterase as biomarker of pesticide exposure: new and forgotten insights. Environmental science and pollution research international. vol 25. issue 19. 2018-12-20. PMID:29797194. |
acetylcholinesterase (ache) acts on the hydrolysis of acetylcholine, rapidly removing this neurotransmitter at cholinergic synapses and neuromuscular junctions as well as in neuronal growth and differentiation, modulation of cell adhesion ("electrotactins") and aryl-acylamidase activity (aaa). |
2018-12-20 |
2023-08-13 |
Not clear |
| Nazish U Tanoli, Sheraz A K Tanoli, Antonio G Ferreira, Mazhar Mehmood, Sana Gul, Julia L Monteiro, Lucas C C Vieira, Tiago Venâncio, Arlene G Correa, Zaheer Ul-Ha. Characterization of the interactions between coumarin-derivatives and acetylcholinesterase: Examination by NMR and docking simulations. Journal of molecular modeling. vol 24. issue 8. 2018-11-02. PMID:30008113. |
the rapid hydrolysis of the principal neurotransmitter into choline and acetate by acetylcholinesterase (ache) at synapses causes the loss of cognitive response that becomes the real cause of ad. |
2018-11-02 |
2023-08-13 |
Not clear |