| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Ding, Chongdan Xiang, Xintong Li, Haibo Chen, Xiaoxia Shi, Xin Li, Chushan Huang, Yunjiang Yu, Jianying Qi, Adela Jing Li, Lijuan Zhang, Guocheng H. Photoaged microplastics induce neurotoxicity via oxidative stress and abnormal neurotransmission in zebrafish larvae (Danio rerio). The Science of the total environment. 2023-04-17. PMID:37068667. |
similarly, exposure to p-ps significantly increased neurotransmitter (5-ht, gaba, da, and ach) levels and activity of ache, chat, and che. |
2023-04-17 |
2023-08-14 |
cat |
| Wenchao Wang, Huijuan Zhang, Luting Wei, Yi Ma, Huiling Jiang, Calista N T Yuen, Jihui Zhang, Hailong Wu, Yilin Sh. Microcystin-leucine arginine causes brain injury and functional disorder in Lithobates catesbeianus tadpoles by oxidative stress and inflammation. Aquatic toxicology (Amsterdam, Netherlands). vol 258. 2023-03-29. PMID:36989925. |
in the hippocampal and hypothalamic regions, the number of vacuolated neuropils increased with increasing mc-lr exposure concentration, while the expression of genes associated with neuronal development (lgals1, cacna2d2, and nlgn4x) and neurotransmitter transmission (slc6a13 and ache) was significantly down-regulated. |
2023-03-29 |
2023-08-14 |
Not clear |
| Abdussamat Güze. Relationship Between Phenolic Content Determined by LC-MS/MS and Antioxidant Capacity and Enzyme Inhibition of Cyclotrichium Niveum L. Chemistry & biodiversity. 2023-03-09. PMID:36891984. |
the phytochemical composition of the plant, inhibition of acetylcholinesterase (ache) (which hydrolyzes the neurotransmitter acetylcholine), inhibition of paraoxonase for antiatherosclerotic activity (hpon 1) (which detoxifies organophosphates), and antioxidant capacity of this plant. |
2023-03-09 |
2023-08-14 |
Not clear |
| Christina Rabeler, TaiXi Gong, Danielle Ireland, Olivier Cochet-Escartin, Eva-Maria S Collin. Acetylcholinesterase Activity Staining in Freshwater Planarians. Current protocols. vol 3. issue 2. 2023-02-17. PMID:36799654. |
the serine hydrolase acetylcholinesterase (ache) is an important neuronal enzyme which catalyzes the hydrolysis of the neurotransmitter acetylcholine and other choline esters. |
2023-02-17 |
2023-08-14 |
Not clear |
| Aso Hameed Hasan, Sonam Shakya, Faiq H S Hussain, Sankaranarayanan Murugesan, Subhash Chander, Mohammad Rizki Fadhil Pratama, Shajarahtunnur Jamil, Basundhara Das, Subhrajit Biswas, Joazaizulfazli Jamali. Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids. Journal of biomolecular structure & dynamics. 2023-01-02. PMID:36591704. |
the major enzyme responsible for the hydrolytic breakdown of the neurotransmitter acetylcholine (ach) is acetylcholinesterase (ache). |
2023-01-02 |
2023-08-14 |
Not clear |
| Jeremy Neylon, Jarrad N Fuller, Chris van der Poel, Jarrod E Church, Sebastian Dworki. Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish. Journal of developmental biology. vol 10. issue 4. 2022-11-22. PMID:36412643. |
organophosphate (op) insecticides are used to eliminate agricultural threats posed by insects, through inhibition of the neurotransmitter acetylcholinesterase (ache). |
2022-11-22 |
2023-08-14 |
zebrafish |
| Xumin Lin, Yixi Zhang, Baojun Yang, Lingchun Zhang, Yunru Chen, Zewen Li. Multiple acetylcholinesterases in Pardosa pseudoannulata brain worked collaboratively to provide protection from organophosphorus insecticides. Ecotoxicology and environmental safety. vol 248. 2022-11-21. PMID:36410143. |
acetylcholinesterase (ache) is an essential neurotransmitter hydrolase in nervous systems of animals and its number varies among species. |
2022-11-21 |
2023-08-14 |
spider |
| Nancy D Asen, Ogadimma D Okagu, Chibuike C Udenigwe, Rotimi E Aluk. Frontiers in nutrition. vol 9. 2022-11-07. PMID:36337665. |
compounds with structural similarities to the neurotransmitter (acetylcholine) are mostly used to inhibit the activity of acetylcholinesterase (ache) in alzheimer's disease (ad) therapy. |
2022-11-07 |
2023-08-14 |
Not clear |
| Xue Li, Xinjun Liao, Chao Chen, Li Zhang, Sujie Sun, Mengqi Wan, Jieping Liu, Ling Huang, Dou Yang, Hongmei Hu, Xiaoyin Ma, Zilin Zhong, Fasheng Liu, Guanghua Xiong, Huiqiang Lu, Jianjun Chen, Zigang Ca. Propranolol hydrochloride induces neurodevelopmental toxicity and locomotor disorders in zebrafish larvae. Neurotoxicology. vol 93. 2022-11-07. PMID:36341947. |
additionally, exposure to propranolol hydrochloride could induce oxidative stress, alter the activities of ache and atpase, and disrupt the expression of genes involved in neurodevelopment and neurotransmitter pathways. |
2022-11-07 |
2023-08-14 |
zebrafish |
| Jeyaraj Jeyavani, Ashokkumar Sibiya, Narayanan Gopi, Shahid Mahboob, Khalid A Al-Ghanim, Fahad Al-Misned, Zubair Ahmed, Mian Nadeem Riaz, Balasubramanian Palaniappan, Marimuthu Govindarajan, Baskaralingam Vaseehara. Ingestion and impacts of water-borne polypropylene microplastics on Daphnia similis. Environmental science and pollution research international. 2022-09-22. PMID:36136182. |
additionally, the amount of the neurotransmitter enzyme acetylcholinesterase (ache) activity was decreased. |
2022-09-22 |
2023-08-14 |
cat |
| Farida Begum, Najeeb Ur Rehman, Ajmal Khan, Sajid Iqbal, Rehan Zafar Paracha, Jalal Uddin, Ahmed Al-Harrasi, Muhammad Arif Lodh. 2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer's therapy: Frontiers in pharmacology. vol 13. 2022-09-05. PMID:36059999. |
it is a multifactorial disease, developed by the breakdown of the neurotransmitter acetylcholine via acetylcholinesterase (ache). |
2022-09-05 |
2023-08-14 |
Not clear |
| Dou Yang, Fasheng Liu, Mengqi Wan, Jieping Liu, Ling Huang, Chao Chen, Xue Li, Li Zhang, Xiaobing Ding, Xinjun Liao, Guanghua Xiong, Huiqiang Lu, Juhua Xiao, Zigang Ca. Pamiparib Induces Neurodevelopmental Defects and Cerebral Haemorrhage in Zebrafish Embryos via Inhibiting Notch Signalling. Molecular neurobiology. 2022-08-18. PMID:35982279. |
in addition, pamiparib exposure leads to downregulation of acetylcholinesterase (ache) and adenosine triphosphate (atpase) activities, and upregulation of oxidative stress which then leads to apoptosis and disrupts the gene expression involved in the neurodevelopment, neurotransmitter pathways and parkinson's disease (pd) like symptoms. |
2022-08-18 |
2023-08-14 |
zebrafish |
| Martha Velueta-Viveros, Macarena Martínez-Bailén, Adrián Puerta, Laura L Romero-Hernández, Vladimír Křen, Penélope Merino-Montiel, Sara Montiel-Smith, Miguel X Fernandes, Antonio J Moreno-Vargas, José M Padrón, Óscar López, José G Fernández-Bolaño. Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease. Bioorganic chemistry. vol 127. 2022-07-02. PMID:35779403. |
in particular, we have focused our attention on modulating the activity of cholinesterases (ache, buche) in order to restore the levels of the neurotransmitter acetylcholine, and of o-glcnacase (oga), which is associated with hyperphosphorylation of tau protein, in turn related to the formation of neurofibrillary tangles in the brain. |
2022-07-02 |
2023-08-14 |
Not clear |
| Karina Pereira Luduvico, Luiza Spohr, Mayara Sandrielly Soares de Aguiar, Fernanda Cardoso Teixeira, Natália Pontes Bona, Julia Eisenhardt de Mello, Roselia Maria Spanevello, Francieli Moro Stefanell. LPS-induced impairment of Na Metabolic brain disease. 2022-06-27. PMID:35759073. |
this neurotransmitter is hydrolyzed by acetylcholinesterase (ache), which plays other cellular roles in processes such as inflammation and oxidative stress. |
2022-06-27 |
2023-08-14 |
Not clear |
| Asaad Khalid, Mohnad Abdalla, Maria Saeed, Muhammad Nabeel Ghayur, Surya Kant Kalauni, Mohammed Albratty, Hassan A Alhazmi, Mohammed Ahmed Mesaik, Anwarul Hassan Gilani, Zaheer Ul-Ha. Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations. Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684298. |
ache plays an essential role in the nervous system by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yan-Ling Su, Dong Liu, Yao-Jie Liu, Yang-Lin Ji, Gui-Shan Liu, Ji-Li-Te Wang, Biao Wang, Hao Wan. Phlorizin alleviates cholinergic memory impairment and regulates gut microbiota in d-galactose induced mice. Experimental gerontology. 2022-06-06. PMID:35660419. |
furthermore, a neurotransmitter of acetylcholine (ach) was enhanced, while acetylcholinesterase (ache) activity was inhibited by phlorizin administration. |
2022-06-06 |
2023-08-14 |
mouse |
| Kritika Kumari, Laishram R Sing. Trimethylamine N-oxide might impair cholinergic system by affecting the structural integrity of Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555536. |
acetylcholinesterase (ache) is an important enzyme responsible for the breakdown of neurotransmitter, acetylcholine and therefore plays a crucial role in neuronal plasticity. |
2022-05-13 |
2023-08-13 |
human |
| Wanjun Zhang, Ruiqi Fan, Sunlin Luo, Ying Liu, Yongpeng Jin, Yongchen Li, Mengqin Xiong, Yiqiang Chen, Li Jia, Xiaoyan Yua. Combined effects of chlorpyrifos and cyfluthrin on neurobehavior and neurotransmitter levels in larval zebrafish. Journal of applied toxicology : JAT. 2022-04-26. PMID:35470462. |
to evaluate the risk of combined exposure, we examined the effects of both compounds, separately and together, on motor activity, acetylcholinesterase (ache) activity, and neurotransmitter levels in larval zebrafish. |
2022-04-26 |
2023-08-13 |
zebrafish |
| Wanjun Zhang, Ruiqi Fan, Sunlin Luo, Ying Liu, Yongpeng Jin, Yongchen Li, Mengqin Xiong, Yiqiang Chen, Li Jia, Xiaoyan Yua. Combined effects of chlorpyrifos and cyfluthrin on neurobehavior and neurotransmitter levels in larval zebrafish. Journal of applied toxicology : JAT. 2022-04-26. PMID:35470462. |
combined exposure to chlorpyrifos and cyfluthrin exhibited distinct joint action modes in terms of neurobehavior, ache activity, and neurotransmitter levels, thereby providing an experimental basis for assessing the combined exposure to chlorpyrifos and cyfluthrin's environmental risk. |
2022-04-26 |
2023-08-13 |
zebrafish |
| Tesfaye Hailemariam Barkae, Abdallah M Zeid, Guobao X. Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2'-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence. Sensors (Basel, Switzerland). vol 22. issue 7. 2022-04-12. PMID:35408132. |
ache is a vital enzyme for neurotransmission because it metabolizes acetylcholine neurotransmitter at the synaptic cleft and terminates synaptic transmission. |
2022-04-12 |
2023-08-13 |
Not clear |