| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| De Lu Zhang, Si Yi Liu, Jing Zhang, Jian Kun Zhang, Chun Xiang Hu, Yong Ding Li. Respiratory toxicity of cyanobacterial aphantoxins from Aphanizomenon flos-aquae DC-1 in the zebrafish gill. Aquatic toxicology (Amsterdam, Netherlands). vol 176. 2017-01-20. PMID:27130970. |
gill acetylcholinesterase (ache) and monoamine oxidase (mao) activities were inhibited significantly, suggesting an alteration of neurotransmitter inactivation in zebrafish gills. |
2017-01-20 |
2023-08-13 |
human |
| Michael F Santillo, Yitong Li. A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y). Journal of pharmacological and toxicological methods. vol 76. 2016-09-12. PMID:26165232. |
acetylcholinesterase (ache) is an enzyme responsible for metabolism of the neurotransmitter acetylcholine, and inhibition of ache can have therapeutic applications (e.g., drugs for alzheimer's disease) or neurotoxic consequences (e.g., pesticides). |
2016-09-12 |
2023-08-13 |
human |
| Saw Simeon, Nuttapat Anuwongcharoen, Watshara Shoombuatong, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E S Wikberg, Chanin Nantasenama. Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking. PeerJ. vol 4. 2016-09-07. PMID:27602288. |
acetylcholinesterase (ache) is an enzyme that catalyzes the breakdown of the neurotransmitter acetylcholine that is essential for cognition and memory. |
2016-09-07 |
2023-08-13 |
human |
| Sehan Lee, Mace G Barro. Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches. Toxicological sciences : an official journal of the Society of Toxicology. vol 148. issue 1. 2016-08-16. PMID:26202430. |
acetylcholinesterase (ache), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. |
2016-08-16 |
2023-08-13 |
Not clear |
| Mansour A Al-Hazmi, Sayed M Rawi, Nadia Ms Arafa, Abeer Wagas, Ayat Os Montasse. The potent effects of ginseng root extract and memantine on cognitive dysfunction in male albino rats. Toxicology and industrial health. vol 31. issue 6. 2016-02-18. PMID:23406953. |
ginseng extract in a dose-dependent manner appears effective as memantine and can improve memory impairment through the retrieved homeostasis via neurotransmitter levels and ache activities in rat brain areas with partial effect on the histological feature of the brain tissue. |
2016-02-18 |
2023-08-12 |
rat |
| Maleeha Waqar, Sidra Batoo. In silico analysis of binding of neurotoxic venom ligands with acetylcholinesterase for therapeutic use in treatment of Alzheimer's disease. Journal of theoretical biology. vol 372. 2015-12-31. PMID:25747777. |
acetylcholinesterases (ache) are enzymes that function in hydrolyzing the neurotransmitter acetylcholine. |
2015-12-31 |
2023-08-13 |
Not clear |
| Zongming Ren, Xu Zhang, Xiaoguang Wang, Pingping Qi, Biao Zhang, Yang Zeng, Rongshu Fu, Mingsheng Mia. AChE inhibition: one dominant factor for swimming behavior changes of Daphnia magna under DDVP exposure. Chemosphere. vol 120. 2015-12-18. PMID:25112705. |
as a key enzyme that hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses of both vertebrates and invertebrates, acetylcholinesterase (ache) is strongly inhibited by organophosphates. |
2015-12-18 |
2023-08-13 |
Not clear |
| Kosuke Yamamoto, Satoshi Shida, Yoshihiro Honda, Mariko Shono, Hiroshi Miyake, Suguru Oguri, Hikaru Sakamoto, Yoshie S Momonok. Overexpression of acetylcholinesterase gene in rice results in enhancement of shoot gravitropism. Biochemical and biophysical research communications. vol 465. issue 3. 2015-11-27. PMID:26277389. |
acetylcholine (ach), a known neurotransmitter in animals and acetylcholinesterase (ache) exists widely in plants, although its role in plant signal transduction is unclear. |
2015-11-27 |
2023-08-13 |
Not clear |
| Da Xiao, Yan-Hui Lu, Qing-Li Shang, Dun-Lun Song, Xi-Wu Ga. Gene silencing of two acetylcholinesterases reveals their cholinergic and non-cholinergic functions in Rhopalosiphum padi and Sitobion avenae. Pest management science. vol 71. issue 4. 2015-11-16. PMID:24729410. |
the function of acetylcholinesterase (ache) is to terminate synaptic transmission by hydrolysing the neurotransmitter acetylcholine (ach) in the synaptic cleft, and thus it is an effective target for organophosphate (op) and carbamate (cb) insecticides. |
2015-11-16 |
2023-08-13 |
Not clear |
| Ying Li, Shan Hai, Yan Zhou, Bi Rong Don. Cholinesterase inhibitors for rarer dementias associated with neurological conditions. The Cochrane database of systematic reviews. issue 3. 2015-10-02. PMID:25734590. |
cholinesterase inhibitors are hypothesised to work by inhibiting the enzyme acetylcholinesterase (ache) which breaks down the neurotransmitter acetylcholine. |
2015-10-02 |
2023-08-13 |
Not clear |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
acetylcholinesterase (ache) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. |
2015-07-20 |
2023-08-13 |
Not clear |
| Izabela G Arruda, Francisco E G Guimarães, Romildo J Ramos, Nirton C S Vieir. Self-assembly of SiO2 nanoparticles for the potentiometric detection of neurotransmitter acetylcholine and its inhibitor. Journal of nanoscience and nanotechnology. vol 14. issue 9. 2015-07-16. PMID:25924313. |
the biological regulator of this neurotransmitter is acetylcholinesterase (ache), an enzyme that catalyzes the hydrolysis of ach to choline and acetic acid. |
2015-07-16 |
2023-08-13 |
human |
| Shani Shenhar-Tsarfaty, Shlomo Berliner, Natan M Bornstein, Hermona Sore. Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24254221. |
acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (ache and bche, respectively), which are also expressed in the serum. |
2015-04-06 |
2023-08-12 |
Not clear |
| Jonah Cheung, Veena Beri, Kazuro Shiomi, Terrone L Rosenberr. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24573600. |
acetylcholinesterase (ache) is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. |
2015-04-06 |
2023-08-12 |
human |
| Shuang Yu, Ling Chen, Xing-hui Cai, Xiao-ge Song, Yue Zhang, Yang Zhang, Rui Song, Yi-fang L. [Effect of manual acupuncture stimulation of "Baihui" (GV 20) and "Dazhui" (GV 14) on contents of 5-HT, dopamine and ACh and expression of 5-HT mRNA, DA mRNA and AChE mRNA in the hippocampus in methamphetamine addiction rats]. Zhen ci yan jiu = Acupuncture research. vol 39. issue 5. 2015-03-12. PMID:25518108. |
to observe the effect of manual acupuncture stimulation on changes of hippocampal monoamine neurotransmitter levels and expression of 5-hydorxytryptamine (5-ht) mrna, dopamine (da) mrna and acetylcholine esterase (ache) mrna in methamphetamine addiction rats, so as to explore its mechanism underlying improvement of drug addiction. |
2015-03-12 |
2023-08-13 |
rat |
| De Lu Zhang, Jing Zhang, Chun Xiang Hu, Gao Hong Wang, Dun Hai Li, Yong Ding Li. Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins. Aquatic toxicology (Amsterdam, Netherlands). vol 157. 2015-03-02. PMID:25456236. |
morphological alterations and changes in neurotransmitter conduction functions of acetylcholinesterase (ache) and monoamine oxidase (mao) in zebrafish liver were detected at different time points 1-24h post-exposure. |
2015-03-02 |
2023-08-13 |
human |
| De Lu Zhang, Jing Zhang, Chun Xiang Hu, Gao Hong Wang, Dun Hai Li, Yong Ding Li. Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins. Aquatic toxicology (Amsterdam, Netherlands). vol 157. 2015-03-02. PMID:25456236. |
ache and mao activities were significantly inhibited, suggesting neurotransmitter inactivation/conduction function abnormalities in zebrafish liver. |
2015-03-02 |
2023-08-13 |
human |
| Sibhghatulla Shaikh, Anupriya Verma, Saimeen Siddiqui, Syed S Ahmad, Syed M D Rizvi, Shazi Shakil, Deboshree Biswas, Divya Singh, Mohmmad H Siddiqui, Shahnawaz Shakil, Shams Tabrez, Mohammad A Kama. Current acetylcholinesterase-inhibitors: a neuroinformatics perspective. CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059296. |
ache is a serine protease, which hydrolyses the neurotransmitter, acetylcholine into acetate and choline thereby terminating neurotransmission. |
2015-01-07 |
2023-08-12 |
Not clear |
| Shin-Ichi Yokota, Kaai Nakamura, Midori Ando, Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi, Shigenobu Shibat. Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver. FEBS open bio. vol 4. 2014-11-10. PMID:25383314. |
because parasympathetic nervous system activity tends to attenuate the secretion of very-low-density-lipoprotein-triglyceride (vldl-tg) and increase tg stores in the liver, and serum cholinesterase activity is elevated in fatty liver disease, the inhibition of the parasympathetic neurotransmitter acetylcholinesterase (ache) may have some influence on hepatic lipid metabolism. |
2014-11-10 |
2023-08-13 |
mouse |
| Sony Pandey, Ayinampudi Sree, Dipti Priya Sethi, Chityal Ganesh Kumar, Sudha Kakollu, Lipsa Chowdhury, Soumya Suchismita Das. A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds. Microbial cell factories. vol 13. issue 1. 2014-10-28. PMID:24528673. |
acetylcholinesterase (ache) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. |
2014-10-28 |
2023-08-12 |
Not clear |