| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| De Lu Zhang, Jing Zhang, Chun Xiang Hu, Gao Hong Wang, Dun Hai Li, Yong Ding Li. Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins. Aquatic toxicology (Amsterdam, Netherlands). vol 157. 2015-03-02. PMID:25456236. |
ache and mao activities were significantly inhibited, suggesting neurotransmitter inactivation/conduction function abnormalities in zebrafish liver. |
2015-03-02 |
2023-08-13 |
human |
| Sibhghatulla Shaikh, Anupriya Verma, Saimeen Siddiqui, Syed S Ahmad, Syed M D Rizvi, Shazi Shakil, Deboshree Biswas, Divya Singh, Mohmmad H Siddiqui, Shahnawaz Shakil, Shams Tabrez, Mohammad A Kama. Current acetylcholinesterase-inhibitors: a neuroinformatics perspective. CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059296. |
ache is a serine protease, which hydrolyses the neurotransmitter, acetylcholine into acetate and choline thereby terminating neurotransmission. |
2015-01-07 |
2023-08-12 |
Not clear |
| Shin-Ichi Yokota, Kaai Nakamura, Midori Ando, Hiroyasu Kamei, Fumihiko Hakuno, Shin-Ichiro Takahashi, Shigenobu Shibat. Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver. FEBS open bio. vol 4. 2014-11-10. PMID:25383314. |
because parasympathetic nervous system activity tends to attenuate the secretion of very-low-density-lipoprotein-triglyceride (vldl-tg) and increase tg stores in the liver, and serum cholinesterase activity is elevated in fatty liver disease, the inhibition of the parasympathetic neurotransmitter acetylcholinesterase (ache) may have some influence on hepatic lipid metabolism. |
2014-11-10 |
2023-08-13 |
mouse |
| Sony Pandey, Ayinampudi Sree, Dipti Priya Sethi, Chityal Ganesh Kumar, Sudha Kakollu, Lipsa Chowdhury, Soumya Suchismita Das. A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds. Microbial cell factories. vol 13. issue 1. 2014-10-28. PMID:24528673. |
acetylcholinesterase (ache) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. |
2014-10-28 |
2023-08-12 |
Not clear |
| Faiyaz Ahmed, Raza Murad Ghalib, P Sasikala, K K Mueen Ahme. Cholinesterase inhibitors from botanicals. Pharmacognosy reviews. vol 7. issue 14. 2014-06-24. PMID:24347920. |
decreased concentration of the neurotransmitter, acetylcholine (ach), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat ad and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2014-06-24 |
2023-08-12 |
Not clear |
| Sengottayan Senthil-Natha. Physiological and biochemical effect of neem and other Meliaceae plants secondary metabolites against Lepidopteran insects. Frontiers in physiology. vol 4. 2014-06-24. PMID:24391591. |
acethylcholine esterase (ache) is a key enzyme that terminates nerve impulses by catalyzing the hydrolysis of neurotransmitter, acetylcholine, in the nervous system of various organisms. |
2014-06-24 |
2023-08-12 |
Not clear |
| Sibelle Feitosa da Cunha Xavier Soares, Andréia Aguiar Vieira, Reinaldo Teixeira Delfino, José Daniel Figueroa-Villa. NMR determination of Electrophorus electricus acetylcholinesterase inhibition and reactivation by neutral oximes. Bioorganic & medicinal chemistry. vol 21. issue 18. 2014-03-26. PMID:23916150. |
the main target of ops is the inhibition of acetylcholinesterase (ache), an enzyme necessary for the control of the neurotransmitter acetylcholine (ach). |
2014-03-26 |
2023-08-12 |
Not clear |
| Leticia Vidal-Liñán, Juan Bella. Practical procedures for selected biomarkers in mussels, Mytilus galloprovincialis--implications for marine pollution monitoring. The Science of the total environment. vol 461-462. 2014-03-05. PMID:23712116. |
antioxidant enzymes (catalase [cat] and glutathione peroxidase [gpx]), a phase ii detoxification enzyme (glutathione s-transferase [gst]) and a neurotransmitter catabolism enzyme (acetylcholinesterase [ache]), were considered. |
2014-03-05 |
2023-08-12 |
cat |
| Miroslav Pohanka, Vojtech Adam, Rene Kize. An acetylcholinesterase-based chronoamperometric biosensor for fast and reliable assay of nerve agents. Sensors (Basel, Switzerland). vol 13. issue 9. 2014-02-27. PMID:23999806. |
the enzyme acetylcholinesterase (ache) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. |
2014-02-27 |
2023-08-12 |
Not clear |
| Ana Paula Murray, María Belén Faraoni, María Julia Castro, Natalia Paola Alza, Valeria Cavallar. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381530. |
the fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme ache, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with alzheimer's disease and alleviating the symptoms of this neurological disorder. |
2014-01-01 |
2023-08-12 |
Not clear |
| G A Reid, N Chilukuri, S Darves. Butyrylcholinesterase and the cholinergic system. Neuroscience. vol 234. 2013-10-25. PMID:23305761. |
the cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (chat) and its action terminated by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2013-10-25 |
2023-08-12 |
mouse |
| Márcio M Costa, Aleksandro S da Silva, Francine C Paim, Raqueli França, Guilherme L Dornelles, Gustavo R Thomé, Jonas D S Serres, Roberta Schmatz, Rosélia M Spanevello, Jamile F Gonçalves, Maria Rosa C Schetinger, Cinthia M A Mazzanti, Sonia T A Lopes, Silvia G Monteir. Cholinesterase as inflammatory markers in a experimental infection by Trypanosoma evansi in rabbits. Anais da Academia Brasileira de Ciencias. vol 84. issue 4. 2013-07-11. PMID:23011112. |
the increased activities of ache and bche probably have a pro-inflammatory purpose, attempting to reduce the concentration of acetylcholine, a neurotransmitter which has an anti-inflammatory property. |
2013-07-11 |
2023-08-12 |
rat |
| Konstantin A Petrov, Artem I Malomouzh, Irina V Kovyazina, Eric Krejci, Alexandra D Nikitashina, Svetlana E Proskurina, Vladimir V Zobov, Evgeny E Nikolsk. Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation. The European journal of neuroscience. vol 37. issue 2. 2013-06-27. PMID:23121214. |
acetylcholinesterase (ache) is an enzyme that hydrolyses the neurotransmitter acetylcholine, thereby limiting spillover and duration of action. |
2013-06-27 |
2023-08-12 |
rat |
| Konstantin A Petrov, Artem I Malomouzh, Irina V Kovyazina, Eric Krejci, Alexandra D Nikitashina, Svetlana E Proskurina, Vladimir V Zobov, Evgeny E Nikolsk. Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation. The European journal of neuroscience. vol 37. issue 2. 2013-06-27. PMID:23121214. |
changes in the effectiveness of neurotransmitter release and/or the sensitivity of the postsynaptic membrane), another mechanism exists based on the prompt regulation of ache activity. |
2013-06-27 |
2023-08-12 |
rat |
| Zrinka Kovarik, Nikolina Maček, Rakesh K Sit, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22960624. |
organophosphates (op) inhibit acetylcholinesterase (ache, ec 3.1.1.7), both in peripheral tissues and central nervous system (cns), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ach). |
2013-05-28 |
2023-08-12 |
Not clear |
| Kevin B Temeyer, Alexander P Tuckow, Danett K Brake, Andrew Y Li, Adalberto A Pérez de Leó. Acetylcholinesterases of blood-feeding flies and ticks. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23036311. |
ache hydrolyzes the neurotransmitter, acetylcholine, but may have additional roles in physiology and development. |
2013-05-28 |
2023-08-12 |
human |
| David A Hicks, Natalia Z Makova, Natalia N Nalivaeva, Anthony J Turne. Characterisation of acetylcholinesterase release from neuronal cells. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047022. |
although acetylcholinesterase (ache) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised. |
2013-05-28 |
2023-08-12 |
mouse |
| Gulseher Sarah Sirin, Yanzi Zhou, Lee Lior-Hoffmann, Shenglong Wang, Yingkai Zhan. Aging mechanism of soman inhibited acetylcholinesterase. The journal of physical chemistry. B. vol 116. issue 40. 2013-02-25. PMID:22984913. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ach) and terminates synaptic signals. |
2013-02-25 |
2023-08-12 |
Not clear |
| Laura E Sperling, Janine Klaczinski, Corina Schütz, Lydia Rudolph, Paul G Laye. Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1. PloS one. vol 7. issue 5. 2013-01-24. PMID:22570738. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine, but can also exert 'non-classical', morpho-regulatory effects on developing neurons such as stimulation of neurite outgrowth. |
2013-01-24 |
2023-08-12 |
mouse |
| Mathilde M Triquigneaux, Marilyn Ehrenshaft, Esther Roth, Israel Silman, Yakov Ashani, Ronald P Mason, Lev Weiner, Leesa J Deterdin. Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. The Biochemical journal. vol 448. issue 1. 2013-01-14. PMID:22888904. |
the principal role of ache (acetylcholinesterase) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. |
2013-01-14 |
2023-08-12 |
Not clear |