| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K V Dileep, Kentaro Ihara, Chiemi Mishima-Tsumagari, Mutsuko Kukimoto-Niino, Mayumi Yonemochi, Kazuharu Hanada, Mikako Shirouzu, Kam Y J Zhan. Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery. International journal of biological macromolecules. 2022-05-08. PMID:35526766. |
being the first marketed drug for ad, tacrine reversibly inhibits ache and thereby slows the breakdown of the chemical messenger acetylcholine (ach) in the brain. |
2022-05-08 |
2023-08-13 |
human |
| Faheem Hyder Pottoo, Abdallah Mohammad Ibrahim, Ali Alammar, Rida Alsinan, Mahdi Aleid, Ali Alshehhi, Muruj Alshehri, Supriya Mishra, Noora Alhajr. Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases. Pharmaceuticals (Basel, Switzerland). vol 15. issue 4. 2022-04-23. PMID:35455405. |
tq has been shown in clinical studies to block acetylcholinesterase (ache) activity, which increases acetylcholine (ach). |
2022-04-23 |
2023-08-13 |
Not clear |
| Mukesh K Dhillon, Jagdish Jaba, Pallavi Mishra, Mir Asif Iquebal, Sarika Jaiswal, Aditya K Tanwar, Nareshkumar Bharat, Naveen Arora, Suraj Prasad Mishra, Shyam Prasad Gogineni, Fazil Hasan, Anil Rai, Dinesh Kumar, Hari C Sharm. Whole genome sequencing of spotted stem borer, Chilo partellus, reveals multiple genes encoding enzymes for detoxification of insecticides. Functional & integrative genomics. 2022-04-15. PMID:35426546. |
also, target receptors related to insecticide action, 4 acetylcholinesterase (ache), 14 γ-aminobutyric acid (gaba), and 15 nicotinic acetylcholine (nachr) receptors were detected. |
2022-04-15 |
2023-08-13 |
Not clear |
| Tesfaye Hailemariam Barkae, Abdallah M Zeid, Guobao X. Highly Sensitive Detection of the Insecticide Azamethiphos by Tris(2,2'-bipyridine)ruthenium(II) Electrogenerated Chemiluminescence. Sensors (Basel, Switzerland). vol 22. issue 7. 2022-04-12. PMID:35408132. |
ache is a vital enzyme for neurotransmission because it metabolizes acetylcholine neurotransmitter at the synaptic cleft and terminates synaptic transmission. |
2022-04-12 |
2023-08-13 |
Not clear |
| Congying Chen, Lingling Bu, Huan Liu, Yifeng Rang, Huiying Huang, Xueman Xiao, Genghua Ou, Chunhong Li. Learning and memory impairment induced by 1,4-butanediol is regulated by ERK1/2-CREB-BDNF signaling pathways in PC12 cells. Metabolic brain disease. 2022-03-29. PMID:35348994. |
assay kits results showed that 1,4-bd decreased the levels of glutathione (gsh), glutathione peroxidase (gsh-px), superoxide dismutase (sod), acetylcholine (ach) and increased the levels of malondialdehyde (mda), nitric oxide (no) and acetylcholinesterase (ache). |
2022-03-29 |
2023-08-13 |
Not clear |
| Dara Dastan, Reza Zhiyani, Kiana Fasihi, Ahmad Ebad. An arginine-rich peptide inhibits AChE: template-based design, molecular modeling, synthesis, and biological evaluation. Journal of molecular modeling. vol 28. issue 4. 2022-03-08. PMID:35258696. |
ache, as a well-known target in ad, decreases the acetylcholine (ach) in cholinergic synapse and, besides, increases the rate of amyloid-beta (aβ) aggregation. |
2022-03-08 |
2023-08-13 |
Not clear |
| Lukas G Schnitzler, Kathrin Baumgartner, Anna Kolb, Benedikt Braun, Christoph Westerhause. Acetylcholinesterase Activity Influenced by Lipid Membrane Area and Surface Acoustic Waves. Micromachines. vol 13. issue 2. 2022-02-25. PMID:35208411. |
according to the current model of nerve propagation, the function of acetylcholinesterase (ache) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ach) in the synaptic cleft to acetic acid (acetate) and choline. |
2022-02-25 |
2023-08-13 |
Not clear |
| Kalyani Bindu Karunakaran, Anand Thiyagaraj, Kirankumar Santhakuma. Novel insights on acetylcholinesterase inhibition by Convolvulus pluricaulis, scopolamine and their combination in zebrafish. Natural products and bioprospecting. vol 12. issue 1. 2022-02-25. PMID:35212831. |
acetylcholinesterase (ache) inhibitors increase the retention of acetylcholine (ach) in synapses. |
2022-02-25 |
2023-08-13 |
human |
| Akshi Deshwal, Arshdeep Kaur Gill, Surajmal Nain, Debabrata Patra, Subhabrata Mait. Inhibitory effect of nucleotides on acetylcholine esterase activity and its microflow-based actuation in blood plasma. Chemical communications (Cambridge, England). 2022-02-23. PMID:35194626. |
the inhibitory effect of nucleotides on the catalytic activity of acetylcholine esterase (ache) was rationalized and a similar inhibition trend was observed when analyzing the macroscopic fluid flow generated by surface immobilized ache. |
2022-02-23 |
2023-08-13 |
Not clear |
| Amina E Essawy, Soad Ahmed El-Sayed, Ehab Tousson, Horeya S Abd El-Gawad, Reem Hasaballah Alhasani, Heba-Tallah Abd Elrahim Abd Elkade. Anti-kindling effect of Ginkgo biloba leaf extract and L-carnitine in the pentylenetetrazol model of epilepsy. Environmental science and pollution research international. 2022-02-23. PMID:35194715. |
the oxidative stress, antioxidant, and neurochemical parameters, viz., malondialdehyde (mda), nitric oxide (no), reduced glutathione (gsh), superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), acetylcholine esterase (ache), dopamine (da), norepinephrine (ne), and serotonin (5-ht), in the hippocampal and hypothalamic regions have been evaluated. |
2022-02-23 |
2023-08-13 |
rat |
| Jian Zhang, Jing Cao, Ailian Geng, Haihong Wang, Qin Chu, Zhixun Yan, Xiaoyue Zhang, Yao Zhang, Huagui Li. UHPLC-QTOF/MS-based comparative metabolomics in pectoralis major of fast- and slow-growing chickens at market ages. Food science & nutrition. vol 10. issue 2. 2022-02-14. PMID:35154685. |
in addition, the glycerophospholipid metabolism pathway was found to be associated with chicken meat flavor and the accumulation of sn-glycerol 3-phosphate and acetylcholine was more predominant in byc than that in cobb500, which were catalyzed by glycerophosphocholine phosphodiesterase (gpcpd1, ec:3.1.4.2), choline o-acetyltransferase (chat, ec:2.3.1.6), and acetylcholinesterase (ache, ec:3.1.1.7). |
2022-02-14 |
2023-08-13 |
chicken |
| Ann-Cathrin Haigis, Richard Ottermanns, Andreas Schiwy, Henner Hollert, Jessica Legrad. Getting more out of the zebrafish light dark transition test. Chemosphere. 2022-02-06. PMID:35124091. |
as a proof of principle 5-day old zebrafish (danio rerio) eleutheroembryos exposed to either endocrine disruptors (ed's) or acetylcholine esterase (ache) inhibitors were investigated. |
2022-02-06 |
2023-08-13 |
zebrafish |
| Xian-Tao L. Alzheimer's disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels. Metabolic brain disease. 2022-01-31. PMID:35098414. |
to enhance the declined level of acetylcholine (ach) resulting from loss of cholinergic neurons, acetylcholinesterase (ache) inhibitors are developed and successfully approved for ad treatment in the clinic, with a limited therapeutic effectiveness. |
2022-01-31 |
2023-08-13 |
Not clear |
| Ankit Ganeshpurkar, Ravi Singh, Devendra Kumar, Pravin Gore, Shalini Shivhare, Divya Sardana, Swetha Rayala, Ashok Kumar, Sushil Kumar Sing. Identification of sulfonamide based butyrylcholinesterase inhibitors through scaffold hopping approach. International journal of biological macromolecules. 2022-01-29. PMID:35090939. |
butyrylcholinesterase (bche), a hydrolytic enzyme, is responsible for the termination of the action of acetylcholine besides acetylcholinesterase (ache) in the synaptic cleft of the brain. |
2022-01-29 |
2023-08-13 |
Not clear |
| Mayada R Farag, Mahmoud Alagawany, Attia A A Moselhy, Enas N Said, Tamer A Ismail, Alessandro Di Cerbo, Nicola Pugliese, Mona M Ahme. The Neonicotinoid Thiacloprid Interferes with the Development, Brain Antioxidants, and Neurochemistry of Chicken Embryos and Alters the Hatchling Behavior: Modulatory Potential of Phytochemicals. Biology. vol 11. issue 1. 2022-01-21. PMID:35053072. |
th also decreased the brain level of monoamines and amino acid neurotransmitters and decreased the activities of acetylcholine esterase (ache) and na |
2022-01-21 |
2023-08-13 |
chicken |
| Y Cañizares-Carmenate, N-H Nam, R Díaz-Amador, N T Thuan, P T P Dung, F Torrens, H Pham-The, F Perez-Gimenez, J A Castillo-Gari. Ligand-based discovery of new potential acetylcholinesterase inhibitors for Alzheimer's disease treatment. SAR and QSAR in environmental research. 2022-01-20. PMID:35048766. |
finally, the model was used to predict ache inhibition by a group of quinazolinones and benzothiadiazine 1,1-dioxides obtained by chemical synthesis, resulting in 14 drug candidates with in silico activity comparable to acetylcholine. |
2022-01-20 |
2023-08-13 |
Not clear |
| Asmaa Magdy Zaazaa, Bosy Azmy Abd El-Motelp, Naglaa A Ali, Ahmed M Youssef, Mohamed Aly Sayed, Safaa H Mohame. Stem cell-derived exosomes and copper sulfide nanoparticles attenuate the progression of neurodegenerative disorders induced by cadmium in rats. Heliyon. vol 8. issue 1. 2022-01-14. PMID:35028441. |
however, the activities of each acetylcholine (ach), acetylcholinesterase (ache), total antioxidant status (tac) were measured. |
2022-01-14 |
2023-08-13 |
rat |
| Wei Li, Yikun Qi, Chuan Gao, Yucan Liu, Jinming Dua. A sensitive approach for screening acetylcholinesterase inhibition of water samples using ultra-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1190. 2022-01-14. PMID:35030473. |
a sensitive assay was developed to evaluate inhibitory effects of aqueous solution on acetylcholinesterase (ache) activity via measuring hydrolysis rates of acetylcholine (ach) based on ultra-performance liquid chromatography-tandem mass spectrometry (uplc-ms/ms). |
2022-01-14 |
2023-08-13 |
Not clear |
| Mingxian Lan, Xi Gao, Xiuan Duan, Hongmei Li, Hang Yu, Jinliang Li, Yueqin Zhao, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Guoxing W. Nematicidal activity of tirotundin and parthenolide isolated from Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2022-01-05. PMID:34983315. |
nematicidal activity of tirotundin and parthenolide isolated from acetylcholinesterase (ache) is an enzyme that catalyzes acetylcholine into choline and acetic acid. |
2022-01-05 |
2023-08-13 |
Not clear |
| Mohammad Reza Safdari, Farzaneh Shakeri, Ameneh Mohammadi, Bahram Bibak, Peiman Alesheikh, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebka. Role of Herbal Medicines in the Management of Brain Injury. Advances in experimental medicine and biology. vol 1328. 2022-01-04. PMID:34981485. |
the different mechanisms for improvement in brain injury by these medicinal plants include hif-1 (hypoxia-inducible factor 1) signaling, free-radical scavenging, reduction of nitric oxide (no) toxicity and acetylcholine esterase (ache) activity, decrease of pakt and its downstream targets, downregulation of the aquaporin-4 (aqp-4) and tlr4/nf-ĸb/tnf-α signal, reduction in malondialdehyde and no levels, increasing neuronal density in the hippocampus, and inhibition of oxidative stress. |
2022-01-04 |
2023-08-13 |
Not clear |