| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M I Yousef, S Roychoudhury, K S Jafaar, P Slama, K K Kesari, M Abd El-Nabi Kame. Aluminum oxide and zinc oxide induced nanotoxicity in rat brain, heart, and lung. Physiological research. 2022-09-19. PMID:36121020. |
on the other hand, a significant decrease in the levels of antioxidant enzymes, total antioxidant capacity (tac), reduced glutathione (gsh), paraoxonase 1 (pon1), neurotransmitters (dopamine - da, and serotonin - ser), and the activity of acetylcholine esterase (ache) in the brain, heart, and lung were found. |
2022-09-19 |
2023-08-14 |
rat |
| Ombretta Paladino, Arianna Moranda, Carla Falug. Spatiotemporal role of muscarinic signaling in early chick development: exposure to cholinomimetic agents by a mathematical model. Cell biology and toxicology. 2022-09-13. PMID:36098822. |
cholinomimetic substances exert their toxic activity on organisms as they inhibit the functionality of the cholinergic system by completely or partially replacing the ach molecule both at the level of the ache active site and at the level of acetylcholine receptors. |
2022-09-13 |
2023-08-14 |
chicken |
| Katelyn N Sette, Navatha Alugabelly, Lauren B Glenn, Shirley X Guo-Ross, M Katherine Parkes, Juliet R Wilson, Caitlin N Seay, Russell L Car. The Mechanistic Basis for the Toxicity Difference Between Juvenile Rats and Mice following Exposure to the Agricultural Insecticide Chlorpyrifos. Toxicology. 2022-09-12. PMID:36096317. |
at high exposure levels, organophosphorus insecticides (ops) exert their toxicity in mammals through the inhibition of brain acetylcholinesterase (ache) leading to the accumulation of acetylcholine in cholinergic synapses and hyperactivity of the nervous system. |
2022-09-12 |
2023-08-14 |
mouse |
| Farida Begum, Najeeb Ur Rehman, Ajmal Khan, Sajid Iqbal, Rehan Zafar Paracha, Jalal Uddin, Ahmed Al-Harrasi, Muhammad Arif Lodh. 2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer's therapy: Frontiers in pharmacology. vol 13. 2022-09-05. PMID:36059999. |
it is a multifactorial disease, developed by the breakdown of the neurotransmitter acetylcholine via acetylcholinesterase (ache). |
2022-09-05 |
2023-08-14 |
Not clear |
| H F Seabra, A C Campello, E F G Chagas, L P A Martins, R B Suzuki, M O Ruiz, E A Donadi, W Baleot. The role of cholinesterases in chagas disease. Parasitology international. 2022-08-27. PMID:36029960. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze acetylcholine (ach) in neural synaptic clefts and are primarily found in erythrocytes and blood plasma, respectively. |
2022-08-27 |
2023-08-14 |
Not clear |
| Dávid Somogyvári, Anna Farkas, Mária Mörtl, János Győr. Behavioral and biochemical alterations induced by acute clothianidin and imidacloprid exposure in the killer shrimp, Dikerogammarus villosus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022-07-31. PMID:35908639. |
the acute effects were investigated at the behavioral (immobility time and swimming activity) and biochemical (glutathione s-transferase [gst] and acetylcholine esterase [ache] activity) levels. |
2022-07-31 |
2023-08-14 |
Not clear |
| Huilin Yu, Junhui Zhang, Yinghong Chen, Juan Chen, Yang Qiu, Yan Zhao, Honghao Li, Shengyao Xia, Shiguo Chen, Jiajin Zh. The adverse effects of fluxapyroxad on the neurodevelopment of zebrafish embryos. Chemosphere. 2022-07-21. PMID:35863420. |
flu at a concentration of 1 mg/l significantly decreased dopamine level and notably altered acetylcholinesterase (ache) activity and acetylcholine (ach) content. |
2022-07-21 |
2023-08-14 |
zebrafish |
| Martha Velueta-Viveros, Macarena Martínez-Bailén, Adrián Puerta, Laura L Romero-Hernández, Vladimír Křen, Penélope Merino-Montiel, Sara Montiel-Smith, Miguel X Fernandes, Antonio J Moreno-Vargas, José M Padrón, Óscar López, José G Fernández-Bolaño. Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease. Bioorganic chemistry. vol 127. 2022-07-02. PMID:35779403. |
in particular, we have focused our attention on modulating the activity of cholinesterases (ache, buche) in order to restore the levels of the neurotransmitter acetylcholine, and of o-glcnacase (oga), which is associated with hyperphosphorylation of tau protein, in turn related to the formation of neurofibrillary tangles in the brain. |
2022-07-02 |
2023-08-14 |
Not clear |
| Nancy D Asen, Rotimi E Aluk. Acetylcholinesterase and butyrylcholinesterase inhibitory activities of antioxidant peptides obtained from enzymatic pea protein hydrolysates and their ultrafiltration peptide fractions. Journal of food biochemistry. 2022-06-27. PMID:35758753. |
practical applications: alzheimer's disease (ad) has multiple pathological pathways in addition to the loss of acetylcholine (ach) catalyzed by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2022-06-27 |
2023-08-14 |
Not clear |
| Yun Ju Choi, Hee Jin Song, Ji Eun Kim, Su Jin Lee, You Jeong Jin, Yu Jeong Roh, Ayun Seol, Hye Sung Kim, Dae Youn Hwan. Dysregulation of the Enteric Nervous System in the Mid Colon of Complement Component 3 Knockout Mice with Constipation Phenotypes. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743302. |
excitatory transmission analysis revealed similar suppression of the 5-hydroxytryptamine (5-ht) concentration, expression of 5-ht receptors, acetylcholine (ach) concentration, ach esterase (ache) activity, and expression of muscarinic ach receptors (machrs), despite the machrs downstream signaling pathway being activated in the mid colon of c3 ko mice. |
2022-06-24 |
2023-08-14 |
mouse |
| Grażyna Budryn, Iwona Majak, Joanna Grzelczyk, Dominik Szwajgier, Alejandro Rodríguez-Martínez, Horacio Pérez-Sánche. Hydroxybenzoic Acids as Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745206. |
one of the symptoms of alzheimer's disease (ad) is low acetylcholine level due to high acetylcholinesterase (ache) activity. |
2022-06-24 |
2023-08-14 |
Not clear |
| Martina Bortolami, Fabiana Pandolfi, Valeria Tudino, Antonella Messore, Valentina Noemi Madia, Daniela De Vita, Roberto Di Santo, Roberta Costi, Isabella Romeo, Stefano Alcaro, Marisa Colone, Annarita Stringaro, Alba Espargaró, Raimon Sabatè, Luigi Scipion. Design, Synthesis, and In Vitro, In Silico and In Cellulo Evaluation of New Pyrimidine and Pyridine Amide and Carbamate Derivatives as Multi-Functional Cholinesterase Inhibitors. Pharmaceuticals (Basel, Switzerland). vol 15. issue 6. 2022-06-24. PMID:35745594. |
the standard approach is represented by the cholinesterase inhibitors (cheis) that restore the levels of acetylcholine (ach) by inhibiting the acetylcholinesterase (ache). |
2022-06-24 |
2023-08-14 |
Not clear |
| Ahlam G Khalifa, Walaa A Moselhy, Hanaa M Mohammed, Fatma Khalil, Mohamed Shaban, El-Shaymaa El-Nahass, Hessah Mohammed Al-Muzafar, Kamal Adel Amin, Khaled A Abdo. Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway. Toxics. vol 10. issue 6. 2022-06-23. PMID:35736911. |
in addition, brain antioxidant/oxidant, serum neurotransmitters such as acetylcholine esterase (ache) and monoamine oxidase (mao), jak2 and stat3 gene and proteins expression were measured. |
2022-06-23 |
2023-08-14 |
rat |
| Deniz Kantar, Alev Duygu Acun, Betül Danışma. Effects of thymoquinone on scopolamine-induced spatial and echoic memory changes through regulation of lipid peroxidation and cholinergic impairment. Behavioural brain research. 2022-06-19. PMID:35718231. |
then, the brain homogenates content of thiobarbituric-acid-reactive-substances (tbars), 4-hydroxy-2-nonenal (4-hne) and acetylcholine (ach)/acetylcholine (ache) activity were biochemically determined. |
2022-06-19 |
2023-08-14 |
rat |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. |
2022-06-15 |
2023-08-14 |
Not clear |
| Xiao-Ping Zhang Wang Xu Yang Shu, Jian-Hua Wan. CoOOH nanosheets ensure ratiometric fluorescence assay of acetylcholinesterase. Talanta. vol 249. 2022-06-14. PMID:35700646. |
the acetylcholine (atch) was catalytically hydrolyzed by ache to enzymatic thiocholine (tch), which decomposed coooh to co |
2022-06-14 |
2023-08-14 |
Not clear |
| Asaad Khalid, Mohnad Abdalla, Maria Saeed, Muhammad Nabeel Ghayur, Surya Kant Kalauni, Mohammed Albratty, Hassan A Alhazmi, Mohammed Ahmed Mesaik, Anwarul Hassan Gilani, Zaheer Ul-Ha. Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations. Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684298. |
ache plays an essential role in the nervous system by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2022-06-10 |
2023-08-14 |
Not clear |
| Nupur Vasdev, Mayank Handa, Prashant Kesharwani, Rahul Shukl. Rosemary oil low energy nanoemulsion: Optimization, µrheology, Journal of biomaterials science. Polymer edition. 2022-06-10. PMID:35686513. |
acetylcholinesterase (ache) inhibitors prevent the lysis of acetylcholine in the brain and prevent dementia. |
2022-06-10 |
2023-08-14 |
human |
| Yan-Ling Su, Dong Liu, Yao-Jie Liu, Yang-Lin Ji, Gui-Shan Liu, Ji-Li-Te Wang, Biao Wang, Hao Wan. Phlorizin alleviates cholinergic memory impairment and regulates gut microbiota in d-galactose induced mice. Experimental gerontology. 2022-06-06. PMID:35660419. |
furthermore, a neurotransmitter of acetylcholine (ach) was enhanced, while acetylcholinesterase (ache) activity was inhibited by phlorizin administration. |
2022-06-06 |
2023-08-14 |
mouse |
| Jatinder Dhaliwal, Navneet Dhaliwal, Ansab Akhtar, Anurag Kuhad, Kanwaljit Chopr. Tetramethylpyrazine Attenuates Cognitive Impairment Via Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis in Type 2 Diabetic Rats. Neurochemical research. 2022-06-06. PMID:35665448. |
acetylcholinesterase (ache) and choline acetytransferase (chat) activity, acetylcholine (ach) levels, oxidative stress, apoptotic (bcl-2, bax, caspase-3), and inflammatory markers (tnf-α, il-1β, and nf-kβ) were assessed. |
2022-06-06 |
2023-08-14 |
rat |