| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatima Javed Mirza, Saadia Zahid, Sanila Amber, Sumera, Hira Jabeen, Noreen Asim, Syed Adnan Ali Sha. Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364071. |
multitargeted molecular docking and dynamic simulation studies of bioactive compounds from alzheimer's disease (ad) has been associated with the hallmark features of cholinergic dysfunction, amyloid beta (aβ) aggregation and impaired synaptic transmission, which makes the associated proteins, such as β-site amyloid precursor protein cleaving enzyme 1 (bace i), acetylcholine esterase (ache) and synapsin i, ii and iii, major targets for therapeutic intervention. |
2022-11-11 |
2023-08-14 |
Not clear |
| Lennart V J van Melis, Harm J Heusinkveld, Celine Langendoen, Anouk Peters, Remco H S Westerin. Organophosphate insecticides disturb neuronal network development and function via non-AChE mediated mechanisms. Neurotoxicology. 2022-11-08. PMID:36347328. |
the primary insecticidal mode of action of op insecticides relies on (irreversible) binding to acetylcholine esterase (ache), with -oxon metabolites having a much higher potency for ache inhibition than the parent compounds. |
2022-11-08 |
2023-08-14 |
Not clear |
| Nancy D Asen, Ogadimma D Okagu, Chibuike C Udenigwe, Rotimi E Aluk. Frontiers in nutrition. vol 9. 2022-11-07. PMID:36337665. |
compounds with structural similarities to the neurotransmitter (acetylcholine) are mostly used to inhibit the activity of acetylcholinesterase (ache) in alzheimer's disease (ad) therapy. |
2022-11-07 |
2023-08-14 |
Not clear |
| Mohamed Jawed Ahsan, Amena Ali, Abuzer Ali, Arunkumar Thiriveedhi, Mohammed A Bakht, Mohammad Yusuf, Salahuddin, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamim. Pyrazoline Containing Compounds as Therapeutic Targets for Neurodegenerative Disorders. ACS omega. vol 7. issue 43. 2022-11-07. PMID:36340076. |
pyrazolines were discovered to have beneficial effects in the management of ad and were revealed to be inhibitors of acetylcholine esterase (ache) and beta-amyloid (a |
2022-11-07 |
2023-08-14 |
Not clear |
| Shuling Xu, Min Li, Xia Li, Yanhui Jiang, Linlin Yu, Yue Zhao, Liyuan Wen, Qingwang Xu. Engineering an Ag/Au bimetallic nanoparticle-based acetylcholinesterase SERS biosensor for in situ sensitive detection of organophosphorus pesticide residues in food. Analytical and bioanalytical chemistry. 2022-11-05. PMID:36333614. |
the combination of ache and choline oxidase (cho) can hydrolyze acetylcholine (atch) to generate h |
2022-11-05 |
2023-08-14 |
Not clear |
| Zhikun Zhang, Liu Zhang, Ping Han, Qingju Li. A luminescent probe based on terbium-based metal-organic frameworks for organophosphorus pesticides detection. Mikrochimica acta. vol 189. issue 11. 2022-11-02. PMID:36319758. |
terbium-based metal-organic frameworks (tb-mof) prepared under mild conditions was utilized to construct a fluorescence probe for determination of organophosphorus pesticides (ops) coupled with acetylcholinesterase (ache), acetylcholine chloride (ach), and choline oxidase (cho). |
2022-11-02 |
2023-08-14 |
Not clear |
| Teodorico C Ramalho, Alexandre A de Castro, Daniel H S Leal, Jessika P Teixeira, Elaine Fontes Ferreira de Cunha, Kamil Kuc. Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro data. Current medicinal chemistry. 2022-10-14. PMID:36239718. |
these toxic substances act through the inhibition of the acetylcholinesterase (ache) enzyme, which results in elevated synaptic acetylcholine (ach) levels, leading to serious adverse effects under the cholinergic syndrome. |
2022-10-14 |
2023-08-14 |
Not clear |
| Qiaoya Ma, Chen Li, Ya He, Pan Liu, Fuhua Gong, Wanggang Zhan. Isorhapontigenin prevents β‑amyloid‑associated cognitive impairments through activation of the PI3K/AKT/GSK‑3β pathway. Acta neurobiologiae experimentalis. vol 82. issue 3. 2022-10-10. PMID:36214721. |
aβ1‑42 is significantly associated with memory deficits and it can increase the level of acetylcholine, promote the activity of acetylcholinesterase (ache), and cause cognitive dysfunction. |
2022-10-10 |
2023-08-14 |
rat |
| Mohammad Golam Sabbir, Robert C Speth, Benedict C Albens. Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) Protein in the Hippocampus and Temporal Cortex of a Subset of Individuals with Alzheimer's Disease, Parkinson's Disease, or Frontotemporal Dementia: Implications for Patient Survival. Journal of Alzheimer's disease : JAD. 2022-09-26. PMID:36155524. |
dysfunction of cholinergic neurotransmission is a hallmark of alzheimer's disease (ad); forming the basis for using acetylcholine (ach) esterase (ache) inhibitors to mitigate symptoms of ach deficiency in ad. |
2022-09-26 |
2023-08-14 |
Not clear |
| Fang Wang, Teng Jia, Yu Wang, Haiyuan Hu, Yuying Wang, Li Chang, Xiaojun Shen, Gaisheng Li. Polycyclic aromatic hydrocarbons exposure was associated with microRNA differential expression and neurotransmitter changes: a cross-sectional study in coal miners. Environmental science and pollution research international. 2022-09-26. PMID:36161575. |
compared to the low pah exposure group, the high-exposure group had higher levels of 5-hydroxytryptamine (5-ht), epinephrine (e), and acetylcholine (ach), and lower levels of acetylcholinesterase (ache). |
2022-09-26 |
2023-08-14 |
human |
| Hafiz Muhammad Abdullah Asif, Shagufta Kamal, Aziz-Ur Rehman, Shahid Rasool, Muhammad Sajid Hamid Akas. Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues. ACS omega. vol 7. issue 36. 2022-09-19. PMID:36119993. |
considering the importance of acetylcholine esterase (ache, bche) and α-glucosidase in the treatment of alzheimer's disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (ache), α-glucosidase, urease, lipoxygenase (lox), and butyrylcholinesterase (bche) inhibitors is described. |
2022-09-19 |
2023-08-14 |
Not clear |
| M I Yousef, S Roychoudhury, K S Jafaar, P Slama, K K Kesari, M Abd El-Nabi Kame. Aluminum oxide and zinc oxide induced nanotoxicity in rat brain, heart, and lung. Physiological research. 2022-09-19. PMID:36121020. |
on the other hand, a significant decrease in the levels of antioxidant enzymes, total antioxidant capacity (tac), reduced glutathione (gsh), paraoxonase 1 (pon1), neurotransmitters (dopamine - da, and serotonin - ser), and the activity of acetylcholine esterase (ache) in the brain, heart, and lung were found. |
2022-09-19 |
2023-08-14 |
rat |
| Ombretta Paladino, Arianna Moranda, Carla Falug. Spatiotemporal role of muscarinic signaling in early chick development: exposure to cholinomimetic agents by a mathematical model. Cell biology and toxicology. 2022-09-13. PMID:36098822. |
cholinomimetic substances exert their toxic activity on organisms as they inhibit the functionality of the cholinergic system by completely or partially replacing the ach molecule both at the level of the ache active site and at the level of acetylcholine receptors. |
2022-09-13 |
2023-08-14 |
chicken |
| Katelyn N Sette, Navatha Alugabelly, Lauren B Glenn, Shirley X Guo-Ross, M Katherine Parkes, Juliet R Wilson, Caitlin N Seay, Russell L Car. The Mechanistic Basis for the Toxicity Difference Between Juvenile Rats and Mice following Exposure to the Agricultural Insecticide Chlorpyrifos. Toxicology. 2022-09-12. PMID:36096317. |
at high exposure levels, organophosphorus insecticides (ops) exert their toxicity in mammals through the inhibition of brain acetylcholinesterase (ache) leading to the accumulation of acetylcholine in cholinergic synapses and hyperactivity of the nervous system. |
2022-09-12 |
2023-08-14 |
mouse |
| Farida Begum, Najeeb Ur Rehman, Ajmal Khan, Sajid Iqbal, Rehan Zafar Paracha, Jalal Uddin, Ahmed Al-Harrasi, Muhammad Arif Lodh. 2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer's therapy: Frontiers in pharmacology. vol 13. 2022-09-05. PMID:36059999. |
it is a multifactorial disease, developed by the breakdown of the neurotransmitter acetylcholine via acetylcholinesterase (ache). |
2022-09-05 |
2023-08-14 |
Not clear |
| H F Seabra, A C Campello, E F G Chagas, L P A Martins, R B Suzuki, M O Ruiz, E A Donadi, W Baleot. The role of cholinesterases in chagas disease. Parasitology international. 2022-08-27. PMID:36029960. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze acetylcholine (ach) in neural synaptic clefts and are primarily found in erythrocytes and blood plasma, respectively. |
2022-08-27 |
2023-08-14 |
Not clear |
| Dávid Somogyvári, Anna Farkas, Mária Mörtl, János Győr. Behavioral and biochemical alterations induced by acute clothianidin and imidacloprid exposure in the killer shrimp, Dikerogammarus villosus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022-07-31. PMID:35908639. |
the acute effects were investigated at the behavioral (immobility time and swimming activity) and biochemical (glutathione s-transferase [gst] and acetylcholine esterase [ache] activity) levels. |
2022-07-31 |
2023-08-14 |
Not clear |
| Huilin Yu, Junhui Zhang, Yinghong Chen, Juan Chen, Yang Qiu, Yan Zhao, Honghao Li, Shengyao Xia, Shiguo Chen, Jiajin Zh. The adverse effects of fluxapyroxad on the neurodevelopment of zebrafish embryos. Chemosphere. 2022-07-21. PMID:35863420. |
flu at a concentration of 1 mg/l significantly decreased dopamine level and notably altered acetylcholinesterase (ache) activity and acetylcholine (ach) content. |
2022-07-21 |
2023-08-14 |
zebrafish |
| Martha Velueta-Viveros, Macarena Martínez-Bailén, Adrián Puerta, Laura L Romero-Hernández, Vladimír Křen, Penélope Merino-Montiel, Sara Montiel-Smith, Miguel X Fernandes, Antonio J Moreno-Vargas, José M Padrón, Óscar López, José G Fernández-Bolaño. Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease. Bioorganic chemistry. vol 127. 2022-07-02. PMID:35779403. |
in particular, we have focused our attention on modulating the activity of cholinesterases (ache, buche) in order to restore the levels of the neurotransmitter acetylcholine, and of o-glcnacase (oga), which is associated with hyperphosphorylation of tau protein, in turn related to the formation of neurofibrillary tangles in the brain. |
2022-07-02 |
2023-08-14 |
Not clear |
| Nancy D Asen, Rotimi E Aluk. Acetylcholinesterase and butyrylcholinesterase inhibitory activities of antioxidant peptides obtained from enzymatic pea protein hydrolysates and their ultrafiltration peptide fractions. Journal of food biochemistry. 2022-06-27. PMID:35758753. |
practical applications: alzheimer's disease (ad) has multiple pathological pathways in addition to the loss of acetylcholine (ach) catalyzed by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2022-06-27 |
2023-08-14 |
Not clear |