| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Camila Fabiani, Brunella Biscussi, Juan Pablo Munafo, Ana Paula Murray, Jeremias Corradi, Silvia Susana Antollin. Molecular pharmacology. 2021-12-31. PMID:34969831. |
since cholinergic deficit is a major factor in this disease, two molecular targets for its treatment are the acetylcholinesterase (ache) and the nicotinic acetylcholine receptors (nachrs). |
2021-12-31 |
2023-08-13 |
Not clear |
| Sultan Alshehri, Syed Sarim Ima. Rosinidin Attenuates Lipopolysaccharide-Induced Memory Impairment in Rats: Possible Mechanisms of Action Include Antioxidant and Anti-Inflammatory Effects. Biomolecules. vol 11. issue 12. 2021-12-24. PMID:34944391. |
the biochemical assessment was carried out of acetylcholine esterase (ache), endogenous antioxidants (gsh, sod, gpx, and catalase), oxidative stress marker mda, neuroinflammatory markers (il-6, il-1β, tnf-α, and nf-κb), and bdnf. |
2021-12-24 |
2023-08-13 |
rat |
| Venkatesh Gunasekaran, Jinu Avarachan, Anitta Augustine, Abdul Khayum, Arivukkarasu . 3-O-Acetyl-11-keto-β-boswellic acid ameliorates acquired, consolidated and recognitive memory deficits through the regulation of hippocampal PPAR γ, MMP9 and MMP2 genes in dementia model. Heliyon. vol 7. issue 12. 2021-12-20. PMID:34926858. |
akba administration diminished the acetylcholine esterase (ache) activity and preserved brain gaba and glutamate mediated neuronal excitability. |
2021-12-20 |
2023-08-13 |
rat |
| Muhammad Musaddiq Shah, Wen Ren, Joseph Irudayaraj, Abdulrahim A Sajini, Muhammad Ishtiaq Ali, Bashir Ahma. Colorimetric Detection of Organophosphate Pesticides Based on Acetylcholinesterase and Cysteamine Capped Gold Nanoparticles as Nanozyme. Sensors (Basel, Switzerland). vol 21. issue 23. 2021-12-10. PMID:34884060. |
the detection assay was performed by stepwise addition of ache, parathion ethyl (pe)-a candidate op, acetylcholine chloride (ach), c-aunps, and 3, 3', 5, 5'-tetramethylbenzidine (tmb) in the buffer solution. |
2021-12-10 |
2023-08-13 |
Not clear |
| Sumei Wang, Qian Zhao, Gaochun Li, Mengwei Wang, Hongliang Liu, Xingchen Yu, Jingwen Chen, Pei Li, Lixin Dong, Guoyu Zhou, Yushan Cui, Mengru Wang, Li Liu, Aiguo Wan. The cholinergic system, intelligence, and dental fluorosis in school-aged children with low-to-moderate fluoride exposure. Ecotoxicology and environmental safety. vol 228. 2021-12-07. PMID:34808511. |
cholinergic system was assessed by the detection of choline acetyltransferase (chat), acetylcholinesterase (ache) and acetylcholine (ach) levels in serum. |
2021-12-07 |
2023-08-13 |
Not clear |
| Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. |
bche plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (ache) through hydrolyzing acetylcholine (ach). |
2021-12-04 |
2023-08-13 |
Not clear |
| Ryohei Tanaka-Kanegae, Koichiro Hamad. A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents. PloS one. vol 16. issue 10. 2021-11-30. PMID:34637466. |
cholinergic neurons utilize choline (ch) to synthetize acetylcholine (ach) and contain a high-affinity ch transporter, ch acetyltransferase (chat), ach receptors, and acetylcholinesterase (ache). |
2021-11-30 |
2023-08-13 |
Not clear |
| Bala Murali Krishna Vasamsetti, Kyongmi Chon, Juyeong Kim, Jin-A Oh, Chang-Young Yoon, Hong-Hyun Par. Transcriptome-Based Identification of Genes Responding to the Organophosphate Pesticide Phosmet in Genes. vol 12. issue 11. 2021-11-30. PMID:34828343. |
opps exert their neurotoxic effects by inhibiting acetylcholine esterase (ache). |
2021-11-30 |
2023-08-13 |
zebrafish |
| Sílvia Chaves, Katalin Várnagy, M Amélia Santo. Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity. Current medicinal chemistry. vol 28. issue 35. 2021-11-25. PMID:33602068. |
currently available drugs are used, mainly to compensate the decline of the neurotransmitter acetylcholine by acetylcholinesterase (ache) inhibition, though they only provide temporary symptomatic benefits and cannot stop ad progression. |
2021-11-25 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
acetylcholinesterase (ache), hydrolase enzyme, regulates the hydrolysis of acetylcholine neurotransmitter in the neurons. |
2021-11-23 |
2023-08-13 |
Not clear |
| Tri Yuliani, Sebastian Lobentanzer, Jochen Klei. Central cholinergic function and metabolic changes in streptozotocin-induced rat brain injury. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33448390. |
high-affinity choline uptake, choline acetyltransferase, and acetylcholine esterase (ache) activities in the hippocampus were reduced by 16%, 28%, and 30%, respectively. |
2021-11-17 |
2023-08-13 |
rat |
| Xiangguang Chen, Junyue Zheng, Miaomiao Teng, Jie Zhang, Le Qian, Manman Duan, Yi Cheng, Wentian Zhao, Zhao Wang, Chengju Wan. Tralopyril affects locomotor activity of zebrafish (Danio rerio) by impairing tail muscle tissue, the nervous system, and energy metabolism. Chemosphere. vol 286. issue Pt 3. 2021-11-17. PMID:34391112. |
in conjunction with the metabolomics results, changes in dopamine (da) and acetylcholine (ach), acetylcholinesterase (ache) activity, and the expression of genes involved in neurodevelopment, indicate that tp may disrupt the nervous system in zebrafish larvae. |
2021-11-17 |
2023-08-13 |
zebrafish |
| Ghada Mahmoud Abdelwahab, Amira Mira, Yuan-Bin Cheng, Tarek A Abdelaziz, Mohamed Farid I Lahloub, Ashraf Taha Khali. Acetylcholine esterase inhibitory activity of green synthesized nanosilver by naphthopyrones isolated from marine-derived Aspergillus niger. PloS one. vol 16. issue 9. 2021-11-16. PMID:34506550. |
for the first time, some isolated naphtho-γ-pyrones from marine-derived aspergillus niger, flavasperone (1), rubrofusarin b (2), aurasperone a (3), fonsecinone a (4) in addition to one alkaloid aspernigrin a (7) were invistigated for their inhibitory activity of acetylcholine esterase ache, a hallmark of alzheimer's disease (ad). |
2021-11-16 |
2023-08-13 |
Not clear |
| b' Slavica Borkovi\\xc4\\x87-Miti\\xc4\\x87, Aleksandar Stojsavljevi\\xc4\\x87, Ljiljana Vujoti\\xc4\\x87, Sini\\xc5\\xa1a Mati\\xc4\\x87, Bojan Miti\\xc4\\x87, Dragan Manojlovi\\xc4\\x87, Sla\\xc4\\x91an Pavlovi\\xc4\\x8. Differences between antioxidant defense parameters and specific trace element concentrations in healthy, benign, and malignant brain tissues. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34285315.' |
the following antioxidant parameters were determined: activities of total, manganese-containing, and copper/zinc-containing superoxide dismutase (totsod, mnsod and cuznsod), activities of catalase, glutathione peroxidase, glutathione s-transferase, glutathione reductase and acetylcholine esterase (ache), the concentrations of glutathione and sulfhydryl groups and of manganese (mn), copper (cu), zinc (zn), and selenium (se). |
2021-11-15 |
2023-08-13 |
Not clear |
| Jacob Boos, Ahmed Shubbar, Werner J Geldenhuy. Dual monoamine oxidase B and acetylcholine esterase inhibitors for treating movement and cognition deficits in a Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. vol 30. issue 5. 2021-11-11. PMID:34744409. |
many patients with pd also exhibit memory loss in the later stages of disease progression, which is treated with acetylcholine esterase (ache) inhibitors. |
2021-11-11 |
2023-08-13 |
Not clear |
| Anu Joseph, S Parvathy, Koyikkal Karthikeya Varm. Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise. Journal of diabetes research. vol 2021. 2021-11-10. PMID:33708999. |
high carbohydrate and fat feeding led to hyperinsulinemic status with reduced acetylcholine esterase (ache) activity and impaired phosphorylation of irs1 along with increased lactate concentrations in the muscle. |
2021-11-10 |
2023-08-13 |
rat |
| Jiyeon Han, Zhi Du, Mi Hee Li. Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer's Disease. Accounts of chemical research. vol 54. issue 20. 2021-11-10. PMID:34606227. |
finally, the loss of cholinergic transmission mediated by the neurotransmitter acetylcholine (ach) contributes to cognitive deficits observed in ad.in this account, we illustrate the design principles for small-molecule-based chemical tools with reactivities against metal-free aβ, metal-bound aβ, ros, and ache. |
2021-11-10 |
2023-08-13 |
Not clear |
| Priyashi Rao, Dweipayan Goswami, Rakesh M Rawa. Revealing the molecular interplay of curcumin as Culex pipiens Acetylcholine esterase 1 (AChE1) inhibitor. Scientific reports. vol 11. issue 1. 2021-11-09. PMID:34471175. |
additionally, the inadequate use of organophosphates and carbamates which target acetylcholine esterase (ache), are known to develop resistance amongst vectors of transmission and are toxic to humans. |
2021-11-09 |
2023-08-13 |
Not clear |
| Doaa H Abdel-Naby, Noha M Deghiedy, Rasha R Rashed, Mona A El-Ghazal. Tailoring of chitosan/diacrylated pluronic system as a versatile nanoplatform for the amelioration of radiation-induced cognitive dysfunction. International journal of biological macromolecules. 2021-11-09. PMID:34740686. |
rats' cognitive and motor functions were assessed; 24 h later, rats were sacrificed, and the whole brain was separated for histopathological examination and biochemical estimation of brain content of acetylcholine esterase (ache), neurotransmitters, oxidative stress markers, and interleukin-1β. |
2021-11-09 |
2023-08-13 |
rat |
| Sean M Mooney-Leber, Dana Zeid, Prescilla Garcia-Trevizo, Laurel R Seemiller, Molly A Bogue, Stephen C Grubb, Gary Peltz, Thomas J Goul. Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains. Frontiers in psychiatry. vol 12. 2021-11-05. PMID:34733190. |
since cholinergic signaling is affected by genetic background, we examined the genetic relationship between activity levels of acetylcholinesterase (ache), the primary enzyme involved in the acetylcholine metabolism, and learning using a panel of 20 inbred mouse strains. |
2021-11-05 |
2023-08-13 |
mouse |