| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Parker L Andersen, Patrick Vermette, Abdelouahed Khalil, Jacek M Witkowski, Tamas Fülö. Characterization of three-dimensional rat central nervous system culture maturation, with applications to monitor cholinergic integrity. Biotechnology progress. vol 36. issue 4. 2021-08-04. PMID:32012477. |
results support that embryo-derived rat central nervous system (cns) reaggregate cultures develop into mature-like tissues, comparable to in vivo maturation, including the following characteristics: (a) progressive reduction in cell proliferation (reduced anti-ki-67 immunoreactivity), (b) progressive restriction of long neurite growth potential (as explant cultures), and (c) increased and sustained synaptic enzyme (acetylcholine esterase, ache) activity. |
2021-08-04 |
2023-08-13 |
rat |
| Ümit M Koçyiğit, Hayreddin Gezegen, Parham Taslim. Synthesis, characterization, and biological studies of chalcone derivatives containing Schiff bases: Synthetic derivatives for the treatment of epilepsy and Alzheimer's disease. Archiv der Pharmazie. vol 353. issue 12. 2021-08-03. PMID:32815568. |
in addition, the inhibitory effects of the newly synthesized compounds on the activities of hca and acetylcholinesterase (ache) were investigated in vitro, using the esterase and acetylcholine iodide method. |
2021-08-03 |
2023-08-13 |
human |
| Irina Zueva, Oksana Lenina, Ramilya Kayumova, Konstantin Petrov, Patrick Masso. Protective effects of m-(tert-butyl) trifluoroacetophenone, a transition state analogue of acetylcholine, against paraoxon toxicity and memory impairments. Chemico-biological interactions. vol 345. 2021-08-02. PMID:34147486. |
m-(tert-butyl) trifluoroacetophenone (tfk), a slow-binding inhibitor of acetylcholinesterase (ache), a transition state analog of acetylcholine, was investigated as a potential neuroprotectant of central and peripheral ache against organophosphate paraoxon (pox) toxicity. |
2021-08-02 |
2023-08-13 |
mouse |
| Immacolata Vecchio, Luca Sorrentino, Annamaria Paoletti, Rosario Marra, Mariamena Arbitri. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. Journal of central nervous system disease. vol 13. 2021-07-22. PMID:34285627. |
one of the causes leading to ad is the decrease of neurotransmitter acetylcholine (ach) levels in the brain, in part due to a higher activity of acetylcholinesterase (ache), the enzyme responsible for its degradation. |
2021-07-22 |
2023-08-13 |
Not clear |
| Asieh Karimani, Nasrin Ramezani, Amir Afkhami Goli, Mohammad Hossein Nazem Shirazi, Hosein Nourani, Amir Moghaddam Jafar. Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function. Toxicology reports. vol 8. 2021-07-20. PMID:34277358. |
this investigation intends to explore mood, spatial learning, and memory dysfunction, acetylcholine esterase (ache) activity, and neurodegeneration-related gene expression in the cortex and hippocampus regions of mice exposed to dzn for 63 consecutive days (subchronic exposure). |
2021-07-20 |
2023-08-13 |
mouse |
| Wansiri Innok, Asadhawut Hiranrat, Netnapa Chana, Thanyada Rungrotmongkol, Panita Kongsun. In silico and in vitro anti-AChE activity investigations of constituents from Mytragyna speciosa for Alzheimer's disease treatment. Journal of computer-aided molecular design. vol 35. issue 3. 2021-07-13. PMID:33439402. |
acetylcholinesterase (ache), one of the major therapeutic strategies for the treatment of alzheimer's disease (ad) is to increase the acetylcholine (ach) level in the brain by inhibiting the biological activity of ache. |
2021-07-13 |
2023-08-13 |
Not clear |
| Simon Miguel M Lopez, Jeremey S Aguilar, Jerene Bashia B Fernandez, Angelic Gayle J Lao, Mitzi Rain R Estrella, Mark Kevin P Devanadera, Cydee Marie V Ramones, Aaron Joseph L Villaraza, Leonardo A Guevarra, Myla R Santiago-Bautista, Librado A Santiag. Neuroactive venom compounds obtained from The journal of venomous animals and toxins including tropical diseases. vol 27. 2021-07-13. PMID:34249120. |
neuroactive venom compounds obtained from spider venom is a rich cocktail of neuroactive compounds designed to prey capture and defense against predators that act on neuronal membrane proteins, in particular, acetylcholinesterases (ache) that regulate synaptic transmission through acetylcholine (ach) hydrolysis - an excitatory neurotransmitter - and beta-secretases (bace) that primarily cleave amyloid precursor proteins (app), which are, in turn, relevant in the structural integrity of neurons. |
2021-07-13 |
2023-08-13 |
spider |
| Miroslav Pohank. Pharmacological Influencing of The Cholinergic Anti-inflammatory Pathway in Infectious Diseases and Inflammatory Pathologies. Mini reviews in medicinal chemistry. vol 21. issue 6. 2021-07-12. PMID:33208075. |
it consists of terminations of the vagal nerve into blood, acetylcholine released from the terminations, macrophages and other cells having α7 nicotinic acetylcholine receptor (α7 nachr), calcium ions crossing through the receptor and interacting with nuclear factors, and erythrocytes with acetylcholinesterase (ache) terminating the neurotransmission. |
2021-07-12 |
2023-08-13 |
Not clear |
| Prabhat Upadhyay, Rashmi Shukla, Kavindra Nath Tiwari, G P Dubey, Sunil Kumar Mishr. Neuroprotective effect of Reinwardtia indica against scopolamine induced memory-impairment in rat by attenuating oxidative stress. Metabolic brain disease. vol 35. issue 5. 2021-07-09. PMID:32026225. |
acetylcholine levels, acetylcholinesterase (ache), antioxidant enzymes (sod, cat & gsh), histopathology of the brain and biochemical test were also performed at the end of the treatment period. |
2021-07-09 |
2023-08-13 |
rat |
| Prabhat Upadhyay, Rashmi Shukla, Kavindra Nath Tiwari, G P Dubey, Sunil Kumar Mishr. Neuroprotective effect of Reinwardtia indica against scopolamine induced memory-impairment in rat by attenuating oxidative stress. Metabolic brain disease. vol 35. issue 5. 2021-07-09. PMID:32026225. |
the aeri at higher dose also counteracted the scopolamine-induced decrease in acetylcholine levels, increase in ache activity, and decrease in antioxidant enzymes activities. |
2021-07-09 |
2023-08-13 |
rat |
| Cong Lu, Rongjing Gao, Jingwei Lv, Ying Chen, Shuying Li, Lijing Zhang, Nana Zhang, Yongquan Wang, Bei Fan, Xinmin Liu, Fengzhong Wan. Neuroprotective effects of soy isoflavones on chronic ethanol-induced dementia in male ICR mice. Food & function. vol 11. issue 11. 2021-07-07. PMID:33124635. |
si administration significantly improved the cognitive performance in the mwm and pa tests, regulated the acetylcholinesterase (ache) activity and acetylcholine (ach) level, elevated the synaptic plasticity-related protein expressions and inhibited neuron apoptosis-related protein expressions in the cortex and hippocampus of mice. |
2021-07-07 |
2023-08-13 |
mouse |
| Koichiro Yoshimaru, Yusuke Yanagi, Satoshi Obata, Yoshiaki Takahashi, Keiko Irie, Atsuko Omori, Toshiharu Matsuura, Tomoaki Taguch. Acetylcholinesterase staining for the pathological diagnosis of Hirschsprung's disease. Surgery today. vol 51. issue 2. 2021-07-05. PMID:32577882. |
since then, the combination of rectal mucosal biopsy and rubeanic acid-amplificated ache staining has been brought about by the following milestones: the discovery that the submucosal plexus and the intermuscular plexus had the same level of nerve migration; the findings of research on acetylcholine (ach) and acetylcholinesterase (ache) in the intestinal tract; and the establishment of a rubeanic acid amplification method. |
2021-07-05 |
2023-08-13 |
Not clear |
| Andrea Castaneda, Ricardo Ferraz, Mónica Vieira, Isabel Cardoso, Vitor Vasconcelos, Rosário Martin. Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer's Disease. Marine drugs. vol 19. issue 6. 2021-07-05. PMID:34208482. |
in this review, we aimed to compile the research works focused in the anti-ad potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (bace1) as a fundamental enzyme in the generation of β-amyloid (aβ), the inhibition of the enzyme acetylcholinesterase (ache) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms. |
2021-07-05 |
2023-08-13 |
Not clear |
| M V K Reddy, K Y Rao, G Anusha, G M Kumar, A G Damu, Kakarla Raghava Reddy, Nagaraj P Shetti, Tejraj M Aminabhavi, Peddiahgari Vasu Govardhana Redd. In-vitro evaluation of antioxidant and anticholinesterase activities of novel pyridine, quinoxaline and s-triazine derivatives. Environmental research. vol 199. 2021-07-01. PMID:33991570. |
cholinesterase enzymes such as acetylcholinesterase (ache) and butyrylcholinesterase (buche) cause hydrolysis of acetylcholine (ach), a neurotransmitter responsible for the cognitive functions of the brain such as acquiring knowledge and comprehension. |
2021-07-01 |
2023-08-13 |
Not clear |
| Junyi Chen, Yadan Zhang, Yao Chai, Zhao Meng, Yahan Zhang, Longming Chen, Dongqin Quan, Yongan Wang, Qingbin Meng, Chunju L. Synergistic enhancement of the emergency treatment effect of organophosphate poisoning by a supramolecular strategy. Chemical science. vol 12. issue 14. 2021-06-25. PMID:34163757. |
these compounds irreversibly inhibit acetylcholinesterase (ache), resulting in the accumulation of acetylcholine (ach) and overstimulation of ach receptors. |
2021-06-25 |
2023-08-13 |
Not clear |
| Yaojie Liu, Ying Liu, Yatu Guo, Lin Xu, Hao Wan. Phlorizin exerts potent effects against aging induced by D-galactose in mice and PC12 cells. Food & function. vol 12. issue 5. 2021-06-22. PMID:33565551. |
on the other hand, phlorizin increased the levels of interleukin-2 (il-2) and acetylcholine (ach), reduced the release of interleukin-6 (il-6), aspartate aminotransferase (ast) and alanine aminotransferase (alt), and decreased the activity of acetylcholinesterase (ache) in the brain, improved the expression of antioxidant genes related to the nuclear factor e2-related factor 2 (nrf2) pathway, and reduced the occurrence of morphological lesions in the hippocampus and liver. |
2021-06-22 |
2023-08-13 |
mouse |
| Alice Courties, Jeremy Boussier, Jérôme Hadjadj, Nader Yatim, Laura Barnabei, Hélène Péré, David Veyer, Solen Kernéis, Nicolas Carlier, Frédéric Pène, Frédéric Rieux-Laucat, Bruno Charbit, Vincent Bondet, Darragh Duffy, Francis Berenbaum, Benjamin Terrier, Jérémie Sella. Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients. Scientific reports. vol 11. issue 1. 2021-06-18. PMID:34088975. |
additionally, whole-blood expression of native alpha-7 nicotinic subunit and its negative dominant duplicate (chrfam7a), choline acetyltransferase and acetylcholine esterase (ache) were determined. |
2021-06-18 |
2023-08-13 |
Not clear |
| Monica A Silva, Alessandra S Kiametis, Werner Trepto. Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature. Journal of chemical information and modeling. vol 60. issue 7. 2021-06-17. PMID:32096991. |
ache is important for neurotransmission at neuromuscular junctions and cholinergic brain synapses by hydrolyzing acetylcholine into acetate and choline. |
2021-06-17 |
2023-08-13 |
Not clear |
| Chen Wang, Amit Fischer, Avner Ehrlich, Yaakov Nahmias, Itamar Willne. Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin. Chemical science. vol 11. issue 17. 2021-06-15. PMID:34122910. |
the enzymes glucose oxidase (gox), acetylcholine esterase (ache) and urease that drive biocatalytic transformations to alter ph, are integrated into ph-responsive dna-based hydrogels. |
2021-06-15 |
2023-08-13 |
Not clear |
| Asmaa F Khafaga, Sara E El-Kazaz, Ahmed E Noreldi. Boswellia serrata suppress fipronil-induced neuronal necrosis and neurobehavioral alterations via promoted inhibition of oxidative/inflammatory/apoptotic pathways. The Science of the total environment. vol 785. 2021-06-10. PMID:33933775. |
conversely, significant (p > 0.05) up regulation of catalase (cat), glutathione peroxidase (gsh-px), gamma-aminobutyric acid (gaba), and acetylcholine esterase (ache) has reported in bse-co-treated groups. |
2021-06-10 |
2023-08-13 |
rat |