| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miroslav Pohank. Pharmacological Influencing of The Cholinergic Anti-inflammatory Pathway in Infectious Diseases and Inflammatory Pathologies. Mini reviews in medicinal chemistry. vol 21. issue 6. 2021-07-12. PMID:33208075. |
it consists of terminations of the vagal nerve into blood, acetylcholine released from the terminations, macrophages and other cells having α7 nicotinic acetylcholine receptor (α7 nachr), calcium ions crossing through the receptor and interacting with nuclear factors, and erythrocytes with acetylcholinesterase (ache) terminating the neurotransmission. |
2021-07-12 |
2023-08-13 |
Not clear |
| Prabhat Upadhyay, Rashmi Shukla, Kavindra Nath Tiwari, G P Dubey, Sunil Kumar Mishr. Neuroprotective effect of Reinwardtia indica against scopolamine induced memory-impairment in rat by attenuating oxidative stress. Metabolic brain disease. vol 35. issue 5. 2021-07-09. PMID:32026225. |
acetylcholine levels, acetylcholinesterase (ache), antioxidant enzymes (sod, cat & gsh), histopathology of the brain and biochemical test were also performed at the end of the treatment period. |
2021-07-09 |
2023-08-13 |
rat |
| Prabhat Upadhyay, Rashmi Shukla, Kavindra Nath Tiwari, G P Dubey, Sunil Kumar Mishr. Neuroprotective effect of Reinwardtia indica against scopolamine induced memory-impairment in rat by attenuating oxidative stress. Metabolic brain disease. vol 35. issue 5. 2021-07-09. PMID:32026225. |
the aeri at higher dose also counteracted the scopolamine-induced decrease in acetylcholine levels, increase in ache activity, and decrease in antioxidant enzymes activities. |
2021-07-09 |
2023-08-13 |
rat |
| Cong Lu, Rongjing Gao, Jingwei Lv, Ying Chen, Shuying Li, Lijing Zhang, Nana Zhang, Yongquan Wang, Bei Fan, Xinmin Liu, Fengzhong Wan. Neuroprotective effects of soy isoflavones on chronic ethanol-induced dementia in male ICR mice. Food & function. vol 11. issue 11. 2021-07-07. PMID:33124635. |
si administration significantly improved the cognitive performance in the mwm and pa tests, regulated the acetylcholinesterase (ache) activity and acetylcholine (ach) level, elevated the synaptic plasticity-related protein expressions and inhibited neuron apoptosis-related protein expressions in the cortex and hippocampus of mice. |
2021-07-07 |
2023-08-13 |
mouse |
| Koichiro Yoshimaru, Yusuke Yanagi, Satoshi Obata, Yoshiaki Takahashi, Keiko Irie, Atsuko Omori, Toshiharu Matsuura, Tomoaki Taguch. Acetylcholinesterase staining for the pathological diagnosis of Hirschsprung's disease. Surgery today. vol 51. issue 2. 2021-07-05. PMID:32577882. |
since then, the combination of rectal mucosal biopsy and rubeanic acid-amplificated ache staining has been brought about by the following milestones: the discovery that the submucosal plexus and the intermuscular plexus had the same level of nerve migration; the findings of research on acetylcholine (ach) and acetylcholinesterase (ache) in the intestinal tract; and the establishment of a rubeanic acid amplification method. |
2021-07-05 |
2023-08-13 |
Not clear |
| Andrea Castaneda, Ricardo Ferraz, Mónica Vieira, Isabel Cardoso, Vitor Vasconcelos, Rosário Martin. Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer's Disease. Marine drugs. vol 19. issue 6. 2021-07-05. PMID:34208482. |
in this review, we aimed to compile the research works focused in the anti-ad potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (bace1) as a fundamental enzyme in the generation of β-amyloid (aβ), the inhibition of the enzyme acetylcholinesterase (ache) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms. |
2021-07-05 |
2023-08-13 |
Not clear |
| M V K Reddy, K Y Rao, G Anusha, G M Kumar, A G Damu, Kakarla Raghava Reddy, Nagaraj P Shetti, Tejraj M Aminabhavi, Peddiahgari Vasu Govardhana Redd. In-vitro evaluation of antioxidant and anticholinesterase activities of novel pyridine, quinoxaline and s-triazine derivatives. Environmental research. vol 199. 2021-07-01. PMID:33991570. |
cholinesterase enzymes such as acetylcholinesterase (ache) and butyrylcholinesterase (buche) cause hydrolysis of acetylcholine (ach), a neurotransmitter responsible for the cognitive functions of the brain such as acquiring knowledge and comprehension. |
2021-07-01 |
2023-08-13 |
Not clear |
| Junyi Chen, Yadan Zhang, Yao Chai, Zhao Meng, Yahan Zhang, Longming Chen, Dongqin Quan, Yongan Wang, Qingbin Meng, Chunju L. Synergistic enhancement of the emergency treatment effect of organophosphate poisoning by a supramolecular strategy. Chemical science. vol 12. issue 14. 2021-06-25. PMID:34163757. |
these compounds irreversibly inhibit acetylcholinesterase (ache), resulting in the accumulation of acetylcholine (ach) and overstimulation of ach receptors. |
2021-06-25 |
2023-08-13 |
Not clear |
| Yaojie Liu, Ying Liu, Yatu Guo, Lin Xu, Hao Wan. Phlorizin exerts potent effects against aging induced by D-galactose in mice and PC12 cells. Food & function. vol 12. issue 5. 2021-06-22. PMID:33565551. |
on the other hand, phlorizin increased the levels of interleukin-2 (il-2) and acetylcholine (ach), reduced the release of interleukin-6 (il-6), aspartate aminotransferase (ast) and alanine aminotransferase (alt), and decreased the activity of acetylcholinesterase (ache) in the brain, improved the expression of antioxidant genes related to the nuclear factor e2-related factor 2 (nrf2) pathway, and reduced the occurrence of morphological lesions in the hippocampus and liver. |
2021-06-22 |
2023-08-13 |
mouse |
| Alice Courties, Jeremy Boussier, Jérôme Hadjadj, Nader Yatim, Laura Barnabei, Hélène Péré, David Veyer, Solen Kernéis, Nicolas Carlier, Frédéric Pène, Frédéric Rieux-Laucat, Bruno Charbit, Vincent Bondet, Darragh Duffy, Francis Berenbaum, Benjamin Terrier, Jérémie Sella. Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients. Scientific reports. vol 11. issue 1. 2021-06-18. PMID:34088975. |
additionally, whole-blood expression of native alpha-7 nicotinic subunit and its negative dominant duplicate (chrfam7a), choline acetyltransferase and acetylcholine esterase (ache) were determined. |
2021-06-18 |
2023-08-13 |
Not clear |
| Monica A Silva, Alessandra S Kiametis, Werner Trepto. Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature. Journal of chemical information and modeling. vol 60. issue 7. 2021-06-17. PMID:32096991. |
ache is important for neurotransmission at neuromuscular junctions and cholinergic brain synapses by hydrolyzing acetylcholine into acetate and choline. |
2021-06-17 |
2023-08-13 |
Not clear |
| Chen Wang, Amit Fischer, Avner Ehrlich, Yaakov Nahmias, Itamar Willne. Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin. Chemical science. vol 11. issue 17. 2021-06-15. PMID:34122910. |
the enzymes glucose oxidase (gox), acetylcholine esterase (ache) and urease that drive biocatalytic transformations to alter ph, are integrated into ph-responsive dna-based hydrogels. |
2021-06-15 |
2023-08-13 |
Not clear |
| Asmaa F Khafaga, Sara E El-Kazaz, Ahmed E Noreldi. Boswellia serrata suppress fipronil-induced neuronal necrosis and neurobehavioral alterations via promoted inhibition of oxidative/inflammatory/apoptotic pathways. The Science of the total environment. vol 785. 2021-06-10. PMID:33933775. |
conversely, significant (p > 0.05) up regulation of catalase (cat), glutathione peroxidase (gsh-px), gamma-aminobutyric acid (gaba), and acetylcholine esterase (ache) has reported in bse-co-treated groups. |
2021-06-10 |
2023-08-13 |
rat |
| Kevin G McGarry, Kevin E Schill, Tyson P Winters, Erin E Lemmon, Carol L Sabourin, Jill A Harvilchuck, Robert A Moye. Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31879781. |
disruption of cholinergic function through the inhibition of acetylcholinesterase (ache) leads to the accumulation of the neurotransmitter acetylcholine. |
2021-06-09 |
2023-08-13 |
Not clear |
| Leila Sadeghi, Reza Yekta, Gholamreza Dehgha. The inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602852. |
acetylcholine is a fast-acting neurotransmitter in synapses and neuromuscular junctions that is decreased in alzheimer's disease (ad) by hyper‑activation of acetylcholinesterase (ache), which leads to progressive loss of memory and neurobehavioral abnormalities. |
2021-06-07 |
2023-08-13 |
rat |
| Dan Wu, Xiaomeng Xu, Na Sun, Dongmei Li, Beiwei Zhu, Songyi Li. AGLPM and QMDDQ peptides exert a synergistic action on memory improvement against scopolamine-induced amnesiac mice. Food & function. vol 11. issue 12. 2021-06-07. PMID:33242042. |
furthermore, combination treatment with qmddq and aglpm could significantly reduce the acetylcholinesterase (ache) level and increase the acetylcholine (ach) level in the hippocampus, and noticeably improve the pathological morphology of the neuron cells in hippocampal regions ca1 and ca2 and dentate gyrus (dg). |
2021-06-07 |
2023-08-13 |
mouse |
| Shani Vaknine, Hermona Sore. Central and peripheral anti-inflammatory effects of acetylcholinesterase inhibitors. Neuropharmacology. vol 168. 2021-05-27. PMID:32143069. |
acetylcholinesterase (ache) inhibitors modulate acetylcholine hydrolysis and hence play a key role in determining the cholinergic tone and in implementing its impact on the cholinergic blockade of inflammatory processes. |
2021-05-27 |
2023-08-13 |
mouse |
| G A Toledo-Ibarra, M I Girón-Pérez, C E Covantes-Rosales, G H Ventura-Ramón, G Pérez-Sánchez, A López-Torres, K J G Diaz-Resendiz, E Becerril-Villanueva, L Pavó. Alterations in the non-neuronal cholinergic system induced by in-vitro exposure to diazoxon in spleen mononuclear cells of Nile tilapia (O. niloticus). Fish & shellfish immunology. vol 108. 2021-05-17. PMID:33285167. |
therefore, the aim of this work was to evaluate the activity of ache, acetylcholine (ach) concentration, and the expression of nicotinic ach receptors (nachr) and muscarinic ach receptors (machr) in spleen mononuclear cells (smnc) of nile tilapia (o. niloticus) exposed in vitro to diazoxon, a diazinon metabolite. |
2021-05-17 |
2023-08-13 |
Not clear |
| Unnati N Ahir, Trupti K Vyas, Kelvin D Gandhi, Priti R Faldu, Kamlesh G Pate. In Vitro Efficacy for Chlorpyrifos Degradation by Novel Isolate Tistrella sp. AUC10 Isolated from Chlorpyrifos Contaminated Field. Current microbiology. vol 77. issue 9. 2021-05-14. PMID:32361846. |
organophosphate pesticides have acute neurotoxicity because they suppress acetylcholine esterase (ache) which regulates the enzyme of neurotransmitters by reducing acetylcholine concentration at synaptic junctions. |
2021-05-14 |
2023-08-13 |
Not clear |
| Unnati N Ahir, Trupti K Vyas, Kelvin D Gandhi, Priti R Faldu, Kamlesh G Pate. In Vitro Efficacy for Chlorpyrifos Degradation by Novel Isolate Tistrella sp. AUC10 Isolated from Chlorpyrifos Contaminated Field. Current microbiology. vol 77. issue 9. 2021-05-14. PMID:32361846. |
on exposure to op, ache is inactivated and leads to accumulation of acetylcholine in the junction. |
2021-05-14 |
2023-08-13 |
Not clear |