| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen D Richbart, Justin C Merritt, Nicholas A Nolan, Piyali Dasgupt. Acetylcholinesterase and human cancers. Advances in cancer research. vol 152. 2021-09-13. PMID:34353435. |
the enzyme acetylcholinesterase (ache) is a serine hydrolase whose primary function is to degrade acetylcholine (ach) and terminate neurotransmission. |
2021-09-13 |
2023-08-13 |
human |
| Paula Moyano, José Manuel García, Jimena García, Adela Pelayo, Pilar Muñoz-Calero, María Teresa Frejo, Maria Jose Anadon, Maria Victoria Naval, Andrea Flores, Vega Alejandra Mirat, Javier Del Pin. Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt/β-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 152. 2021-09-06. PMID:33930485. |
our results show that cpf (0.01-100 μm), following one-day and fourteen-days treatment, respectively, induced ros generation and lipid peroxidation, and acetylcholine accumulation due to ache inhibition, wnt/β-catenin up- or downregulation depending on the cpf treatment concentration, and ache-r and ache-s overexpression, with the latter being mediated through gsk-3β activity alteration. |
2021-09-06 |
2023-08-13 |
human |
| Alaa Alachkar, Mohamed Lotfy, Ernest Adeghate, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sade. Ameliorating effects of histamine H3 receptor antagonist E177 on acute pentylenetetrazole-induced memory impairments in rats. Behavioural brain research. vol 405. 2021-09-02. PMID:33626390. |
were evaluated on acute pentylenetetrazole (ptz)-induced memory impairments, oxidative stress levels (glutathione (gsh), malondialdehyde (mda), catalase (cat), and superoxide dismutase (sod)), various brain neurotransmitters (histamine (ha), acetylcholine (ach), γ-aminobutyric acid (gaba)), and glutamate (glu), acetylcholine esterase (ache) activity, and c-fos protein expression in rats. |
2021-09-02 |
2023-08-13 |
rat |
| Yue Zhao, Yifei Dong, Qi Ge, Pengbo Cui, Na Sun, Songyi Li. Neuroprotective effects of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cell damage through enhancing energy metabolism and upregulation of the PKA/BDNF/NGF signaling pathway. Food & function. vol 12. issue 17. 2021-09-02. PMID:34259275. |
ndeelnk exerted the neuroprotective effect by improving the acetylcholine (ach) level and reducing the acetylcholinesterase (ache) activity in pc12 cells. |
2021-09-02 |
2023-08-13 |
Not clear |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |
| Spencer W Todd, Eric W Lumsden, Yasco Aracava, Jacek Mamczarz, Edson X Albuquerque, Edna F R Pereir. Gestational exposures to organophosphorus insecticides: From acute poisoning to developmental neurotoxicity. Neuropharmacology. vol 180. 2021-08-27. PMID:32814088. |
their broad-spectrum insecticidal effectiveness is accounted for by the irreversible inhibition of acetylcholinesterase (ache), the enzyme that catalyzes acetylcholine (ach) hydrolysis, in the nervous system of insects. |
2021-08-27 |
2023-08-13 |
Not clear |
| Xiao Chen, Min Zhang, Mukhtar Ahmed, Krishna Mohan Surapaneni, Vishnu Priya Veeraraghavan, Palanisamy Arulselva. Neuroprotective effects of ononin against the aluminium chloride-induced Alzheimer's disease in rats. Saudi journal of biological sciences. vol 28. issue 8. 2021-08-07. PMID:34354404. |
the acetylcholine esterase (ache) activity was studied by standard method. |
2021-08-07 |
2023-08-13 |
rat |
| Chonny Herrera-Acevedo, Camilo Perdomo-Madrigal, Kenyi Herrera-Acevedo, Ericsson Coy-Barrera, Luciana Scotti, Marcus Tullius Scott. Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database. Molecular diversity. vol 25. issue 3. 2021-08-06. PMID:34132933. |
the enzyme acetylcholinesterase (ache) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. |
2021-08-06 |
2023-08-13 |
Not clear |
| Jiska Kentrop, Vladimir Savransky, Steven D Klaassen, Tomas van Groningen, Sara Bohnert, Alex S Cornelissen, Laura Cochrane, John Barry, Marloes J A Joose. Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model. Regulatory toxicology and pharmacology : RTP. vol 119. 2021-08-05. PMID:33212192. |
organophosphates (ops) irreversibly inhibit ache, the enzyme responsible for termination of acetylcholine signal transduction. |
2021-08-05 |
2023-08-13 |
Not clear |
| Parker L Andersen, Patrick Vermette, Abdelouahed Khalil, Jacek M Witkowski, Tamas Fülö. Characterization of three-dimensional rat central nervous system culture maturation, with applications to monitor cholinergic integrity. Biotechnology progress. vol 36. issue 4. 2021-08-04. PMID:32012477. |
results support that embryo-derived rat central nervous system (cns) reaggregate cultures develop into mature-like tissues, comparable to in vivo maturation, including the following characteristics: (a) progressive reduction in cell proliferation (reduced anti-ki-67 immunoreactivity), (b) progressive restriction of long neurite growth potential (as explant cultures), and (c) increased and sustained synaptic enzyme (acetylcholine esterase, ache) activity. |
2021-08-04 |
2023-08-13 |
rat |
| Ümit M Koçyiğit, Hayreddin Gezegen, Parham Taslim. Synthesis, characterization, and biological studies of chalcone derivatives containing Schiff bases: Synthetic derivatives for the treatment of epilepsy and Alzheimer's disease. Archiv der Pharmazie. vol 353. issue 12. 2021-08-03. PMID:32815568. |
in addition, the inhibitory effects of the newly synthesized compounds on the activities of hca and acetylcholinesterase (ache) were investigated in vitro, using the esterase and acetylcholine iodide method. |
2021-08-03 |
2023-08-13 |
human |
| Irina Zueva, Oksana Lenina, Ramilya Kayumova, Konstantin Petrov, Patrick Masso. Protective effects of m-(tert-butyl) trifluoroacetophenone, a transition state analogue of acetylcholine, against paraoxon toxicity and memory impairments. Chemico-biological interactions. vol 345. 2021-08-02. PMID:34147486. |
m-(tert-butyl) trifluoroacetophenone (tfk), a slow-binding inhibitor of acetylcholinesterase (ache), a transition state analog of acetylcholine, was investigated as a potential neuroprotectant of central and peripheral ache against organophosphate paraoxon (pox) toxicity. |
2021-08-02 |
2023-08-13 |
mouse |
| Immacolata Vecchio, Luca Sorrentino, Annamaria Paoletti, Rosario Marra, Mariamena Arbitri. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. Journal of central nervous system disease. vol 13. 2021-07-22. PMID:34285627. |
one of the causes leading to ad is the decrease of neurotransmitter acetylcholine (ach) levels in the brain, in part due to a higher activity of acetylcholinesterase (ache), the enzyme responsible for its degradation. |
2021-07-22 |
2023-08-13 |
Not clear |
| Asieh Karimani, Nasrin Ramezani, Amir Afkhami Goli, Mohammad Hossein Nazem Shirazi, Hosein Nourani, Amir Moghaddam Jafar. Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function. Toxicology reports. vol 8. 2021-07-20. PMID:34277358. |
this investigation intends to explore mood, spatial learning, and memory dysfunction, acetylcholine esterase (ache) activity, and neurodegeneration-related gene expression in the cortex and hippocampus regions of mice exposed to dzn for 63 consecutive days (subchronic exposure). |
2021-07-20 |
2023-08-13 |
mouse |
| Wansiri Innok, Asadhawut Hiranrat, Netnapa Chana, Thanyada Rungrotmongkol, Panita Kongsun. In silico and in vitro anti-AChE activity investigations of constituents from Mytragyna speciosa for Alzheimer's disease treatment. Journal of computer-aided molecular design. vol 35. issue 3. 2021-07-13. PMID:33439402. |
acetylcholinesterase (ache), one of the major therapeutic strategies for the treatment of alzheimer's disease (ad) is to increase the acetylcholine (ach) level in the brain by inhibiting the biological activity of ache. |
2021-07-13 |
2023-08-13 |
Not clear |
| Simon Miguel M Lopez, Jeremey S Aguilar, Jerene Bashia B Fernandez, Angelic Gayle J Lao, Mitzi Rain R Estrella, Mark Kevin P Devanadera, Cydee Marie V Ramones, Aaron Joseph L Villaraza, Leonardo A Guevarra, Myla R Santiago-Bautista, Librado A Santiag. Neuroactive venom compounds obtained from The journal of venomous animals and toxins including tropical diseases. vol 27. 2021-07-13. PMID:34249120. |
neuroactive venom compounds obtained from spider venom is a rich cocktail of neuroactive compounds designed to prey capture and defense against predators that act on neuronal membrane proteins, in particular, acetylcholinesterases (ache) that regulate synaptic transmission through acetylcholine (ach) hydrolysis - an excitatory neurotransmitter - and beta-secretases (bace) that primarily cleave amyloid precursor proteins (app), which are, in turn, relevant in the structural integrity of neurons. |
2021-07-13 |
2023-08-13 |
spider |
| Miroslav Pohank. Pharmacological Influencing of The Cholinergic Anti-inflammatory Pathway in Infectious Diseases and Inflammatory Pathologies. Mini reviews in medicinal chemistry. vol 21. issue 6. 2021-07-12. PMID:33208075. |
it consists of terminations of the vagal nerve into blood, acetylcholine released from the terminations, macrophages and other cells having α7 nicotinic acetylcholine receptor (α7 nachr), calcium ions crossing through the receptor and interacting with nuclear factors, and erythrocytes with acetylcholinesterase (ache) terminating the neurotransmission. |
2021-07-12 |
2023-08-13 |
Not clear |
| Prabhat Upadhyay, Rashmi Shukla, Kavindra Nath Tiwari, G P Dubey, Sunil Kumar Mishr. Neuroprotective effect of Reinwardtia indica against scopolamine induced memory-impairment in rat by attenuating oxidative stress. Metabolic brain disease. vol 35. issue 5. 2021-07-09. PMID:32026225. |
acetylcholine levels, acetylcholinesterase (ache), antioxidant enzymes (sod, cat & gsh), histopathology of the brain and biochemical test were also performed at the end of the treatment period. |
2021-07-09 |
2023-08-13 |
rat |
| Prabhat Upadhyay, Rashmi Shukla, Kavindra Nath Tiwari, G P Dubey, Sunil Kumar Mishr. Neuroprotective effect of Reinwardtia indica against scopolamine induced memory-impairment in rat by attenuating oxidative stress. Metabolic brain disease. vol 35. issue 5. 2021-07-09. PMID:32026225. |
the aeri at higher dose also counteracted the scopolamine-induced decrease in acetylcholine levels, increase in ache activity, and decrease in antioxidant enzymes activities. |
2021-07-09 |
2023-08-13 |
rat |
| Cong Lu, Rongjing Gao, Jingwei Lv, Ying Chen, Shuying Li, Lijing Zhang, Nana Zhang, Yongquan Wang, Bei Fan, Xinmin Liu, Fengzhong Wan. Neuroprotective effects of soy isoflavones on chronic ethanol-induced dementia in male ICR mice. Food & function. vol 11. issue 11. 2021-07-07. PMID:33124635. |
si administration significantly improved the cognitive performance in the mwm and pa tests, regulated the acetylcholinesterase (ache) activity and acetylcholine (ach) level, elevated the synaptic plasticity-related protein expressions and inhibited neuron apoptosis-related protein expressions in the cortex and hippocampus of mice. |
2021-07-07 |
2023-08-13 |
mouse |