| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laksmi Anusha Vinjavarapu, Srikanth Yadava, Harikrishna Reddy Dontiboina, Guntupalli Chakravarthi, Ramakrishna Kakarl. Neuroprotective effects of Indole 3-carbinol against Scopolamine-Induced cognitive and memory impairment in rats: modulation of oxidative stress, inflammatory and cholinergic pathways. Metabolic brain disease. vol 40. issue 4. 2025-03-18. PMID:40100291. |
the findings revealed that i3c administration markedly enhanced cognitive performance in the y-maze and nor tests, which were attributed to decreased ache activity and increased acetylcholine (ach) levels. |
2025-03-18 |
2025-03-21 |
rat |
| Jiangong Jiang, Shuxin Zhao, Xinjie Guo, Wenzhen Liu, Huixue Duan, Xinyuan Zhou, Rongyu Li, Yanhong Chang, Haiyang Yu, Xinxin Du, Xing H. Toxic effects of combined exposure to carbamazepine and triclosan on adult zebrafish (Danio rerio): Insights into acute mortality, neurotransmitters, biochemical response, and histopathology. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2025-03-14. PMID:40086681. |
compared with exposure to either cbz or tcs alone, co-exposure to cbz and tcs at equivalent toxic concentrations can lead to a profound increase in gamma-aminobutyric acid (gaba) and a reduction in acetylcholine (ach) and acetylcholinesterase (ache) levels. |
2025-03-14 |
2025-03-17 |
zebrafish |
| Ahmed A Al-Karmalawy, Ahmed F Mohamed, Heba Nasr Shalaby, Ayman Abo Elmaaty, Riham A El-Shiekh, Mohamed A Zeidan, Radwan Alnajjar, Abdullah Yahya Abdullah Alzahrani, Mohammed H Al Mughram, Moataz A Shaldam, Haytham O Tawfi. Donepezil-based rational design of RSC medicinal chemistry. 2025-03-04. PMID:40027342. |
obviously, acetylcholine esterase (ache) is the primary enzyme responsible for breaking down acetylcholine (ach) with a much more prominent effect than butyrylcholine esterase (buche). |
2025-03-04 |
2025-03-06 |
Not clear |
| Tamilarasi Sambu Periyasamy, Ajay Kasivishwanathan, Gilbert Roy, Nishu Sekar, Hariprasath Lakshmana. Phytocompounds of Senecio candicans as potential acetylcholinesterase inhibitors targeting Alzheimer's disease: A structure-based virtual screening and molecular dynamics simulation study. Computational biology and chemistry. vol 117. 2025-03-02. PMID:40024051. |
alzheimer's disease (ad) is a chronic neurodegenerative disorder characterized by cognitive decline due to the accumulation of amyloid-beta plaques, neurofibrillary tangles, and decreased acetylcholine levels caused by acetylcholinesterase (ache) activity. |
2025-03-02 |
2025-03-05 |
Not clear |
| Zhangchi Xiao, Yong Li, Yulun Nie, Liqiang Lu, Chao Yan. A Cu Analytica chimica acta. vol 1346. 2025-02-28. PMID:40021329. |
this compound irreversibly inhibits acetylcholinesterase (ache) in the human nervous system, resulting in the accumulation of acetylcholine (ach), which is detrimental. |
2025-02-28 |
2025-03-04 |
human |
| Shaimaa A A Ahmed, Ali Adel Ali Ahmed, Gehad E Elshopakey, Elsayed M Younis, Abdelwahab A Abdelwarith, Mai Farag Saad, Simon J Davies, Rowida E Ibrahim, Asmaa Edree. Alleviative potential of dietary essential oils against nickel toxicity triggers neurobehavioral abnormalities, biochemical dysfunction, and histopathological alterations in Nile tilapia. Veterinary research communications. vol 49. issue 2. 2025-02-18. PMID:39964622. |
the ni exposure also depressed brain acetylcholine esterase (ache) (cv = 0.54-1.10), blood total protein (cv = 3.23-21.87%), albumin (cv = 1.62-13.47%), and globulin (cv = 1.91-24.72%). |
2025-02-18 |
2025-02-23 |
Not clear |
| Anupama Shinde, Rajesh Sharma, Prem Kumar, Tarkeshwar Kumar, Kotha Sammi Reddy, Neeraj Kuma. Combined effect of mercury and ammonia toxicity and its mitigation through selenium nanoparticles in fish. Aquatic toxicology (Amsterdam, Netherlands). vol 280. 2025-02-15. PMID:39954588. |
the activity of acetylcholine esterase (ache), was significantly inhibited by hg + nh₃ toxicity. |
2025-02-15 |
2025-02-18 |
cat |
| Dina H Dawood, Manal M Anwa. Recent advances in the therapeutic insights of thiazole scaffolds as acetylcholinesterase inhibitors. European journal of medicinal chemistry. vol 287. 2025-02-12. PMID:39938408. |
acetylcholinesterase inhibitors promote cholinergic transmission via blocking ache, which is implicated in the degradation and deficiency of acetylcholine. |
2025-02-12 |
2025-02-15 |
Not clear |
| Zhi-Hua Zhou, Hai-Yan Xing, Yan Liang, Jie Gao, Yang Liu, Ting Zhang, Li Zhu, Jia-Long Qian, Chuan Zhou, Gang L. [Molecular mechanism of verbascoside in promoting acetylcholine release of neurotransmitter]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 2. 2025-02-10. PMID:39929615. |
the effects of oc1 on acetylcholine esterase(ache) activity in ad models were detected. |
2025-02-10 |
2025-02-13 |
rat |
| D J Obiol, A Vietri, J P Munafó, M D Costabel, S S Antollin. In silico exploration of cholinergic activity and neuroprotection of novel caffeine analogues. Biochemical and biophysical research communications. vol 750. 2025-01-30. PMID:39884004. |
two main strategies involve the inhibition of acetylcholinesterase (ache) and/or the stimulation of acetylcholine receptors (achr). |
2025-01-30 |
2025-02-02 |
human |
| K Al-Taee, L Al-Helal. HYDROGEN SULFIDE AND CYSTATHIONINE γ-LYASE LEVELS FOR PATIENTS WITH PARKINSON'S DISEASE. Georgian medical news. issue 356. 2025-01-24. PMID:39855178. |
the research includes studying the levels of hydrogen sulphide (h2s) and cystathionine γ-lyase (cse) with some biochemical parameters in the serum of patients with pd in mosul city (iraq), which include serotonin (sert), dopamine (da), sphingomyelin (sm), vitamin b12, acetylcholine esterase (ache), monoamine oxidase (mao), creatine kinase (ck), aspartate aminotransferase (ast), alanine aminotransferase (alt). |
2025-01-24 |
2025-01-28 |
Not clear |
| Poorna Shri, K P Singh, Varsha Rani, D P Nagar, J Acharya, A S B Bhaska. N-acetylcysteine prevents cholinergic and non-cholinergic toxic effects induced by nerve agent poisoning in rats. Toxicology research. vol 14. issue 1. 2025-01-20. PMID:39830891. |
organophosphorus nerve agent, vx [(o-ethyl s-diisopropylaminomethyl) methylphosphonothioate] compound interferes with acetylcholine signaling by targeting the ache enzyme. |
2025-01-20 |
2025-01-23 |
rat |
| Suparna Ghosh, Bhaskar Das, Sandipan Jana, Keithellakpam Ojit Singh, Nanaocha Sharma, Pulok K Mukherjee, Pallab Kanti Halda. Mechanistic insight into neuroprotective effect of standardized ginger chemo varieties from Manipur, India in scopolamine induced learning and memory impaired mice. Metabolic brain disease. vol 40. issue 1. 2025-01-15. PMID:39812875. |
gv6 significantly improved brain ache and bche activity, acetylcholine (ach) level, markedly alleviated the antioxidant parameters, and reversed the neuroinflammation. |
2025-01-15 |
2025-01-17 |
mouse |
| Sinan Saral, Tolga Mercantepe, Atilla Topçu, Ali Koray Kaya, Aykut Öztür. Dexmedetomidine Improves Learning Functions in Male Rats Modeling Cognitive Impairment by Modulating the BDNF/TrkB/CREB Signaling Pathway. Life (Basel, Switzerland). vol 14. issue 12. 2025-01-14. PMID:39768379. |
the brain-derived neurotrophic factor (bdnf), acetylcholine (ach) and acetylcholinesterase (ache) levels were determined by elisa. |
2025-01-14 |
2025-01-16 |
rat |
| Fabian Springer, Marian Freisleben, Sebastian Muschik, Franz Worek, Thomas Seeger, Lorenz Meinel, Karin Veronika Niesse. Characterization of cell membrane fragments containing muscle type nAChR from Tetronarce californica after preparation using high pressure homogenization. Toxicology letters. 2025-01-13. PMID:39805477. |
organophosphorus compounds inhibit ache, leading to accumulation of acetylcholine in the synaptic cleft and subsequently to a cholinergic crisis, in part through desensitization of nachr. |
2025-01-13 |
2025-01-16 |
Not clear |
| Natalia Cichon, Weronika Grabowska, Leslaw Gorniak, Maksymilian Stela, Piotr Harmata, Michal Ceremuga, Michal Bija. Mechanistic and Therapeutic Insights into Flavonoid-Based Inhibition of Acetylcholinesterase: Implications for Neurodegenerative Diseases. Nutrients. vol 17. issue 1. 2025-01-11. PMID:39796512. |
ache, a serine hydrolase that plays a crucial role in cholinergic neurotransmission, is a key target in the treatment of cognitive impairments due to its function in acetylcholine hydrolysis. |
2025-01-11 |
2025-01-14 |
Not clear |
| Natalia Cichon, Weronika Grabowska, Leslaw Gorniak, Maksymilian Stela, Piotr Harmata, Michal Ceremuga, Michal Bija. Mechanistic and Therapeutic Insights into Flavonoid-Based Inhibition of Acetylcholinesterase: Implications for Neurodegenerative Diseases. Nutrients. vol 17. issue 1. 2025-01-11. PMID:39796512. |
in vitro, in vivo, and in silico analyses reveal that these flavonoids effectively interact with both the active and peripheral anionic sites of ache, resulting in increased acetylcholine levels and the stabilization of cholinergic signaling. |
2025-01-11 |
2025-01-14 |
Not clear |
| Hanane Naeimi, Maryam Taheri, Hossein Ghafouri, Asadollah Mohammad. Investigation of Thiazolidine-2,4-Dione Derivatives as Acetylcholinesterase Inhibitors: Synthesis, In Vitro Biological Activities and In Silico Studies. ChemistryOpen. 2025-01-11. PMID:39797425. |
the inhibition of acetylcholinesterase (ache), an enzyme responsible for the inactivation and decrease in acetylcholine in the cholinergic pathway, has been considered an attractive target for small-molecule drug discovery in alzheimer's disease (ad) therapy. |
2025-01-11 |
2025-01-14 |
Not clear |
| Ysaías J Alvarado, Lenin González-Paz, José L Paz, Marcos A Loroño-González, Julio Santiago Contreras, Carla Lossada, Alejandro Vivas, Yovani Marrero-Ponce, Felix Martinez-Rios, Patricia Rodriguez-Lugo, Yanpiero Balladores, Joan Vera-Villalobo. Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study. Biology. vol 13. issue 12. 2025-01-08. PMID:39765732. |
the enzyme acetylcholinesterase (ache) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ach). |
2025-01-08 |
2025-01-13 |
human |
| David Griffiths, Jami Hanif, Jacob McCammon, Luke McMaster, Cameron Gemmel. Accidental Organophosphate Poisoning in a Patient Due to a Bed Bug Pesticide in the United Kingdom: A Case Report. Cureus. vol 16. issue 12. 2025-01-06. PMID:39759751. |
as irreversible inhibitors of the enzyme acetylcholinesterase (ache), they reduce anti-cholinesterase activity and therefore increase acetylcholine (ach) levels at the neuromuscular junction (nmj). |
2025-01-06 |
2025-01-08 |
Not clear |