| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia Cichon, Weronika Grabowska, Leslaw Gorniak, Maksymilian Stela, Piotr Harmata, Michal Ceremuga, Michal Bija. Mechanistic and Therapeutic Insights into Flavonoid-Based Inhibition of Acetylcholinesterase: Implications for Neurodegenerative Diseases. Nutrients. vol 17. issue 1. 2025-01-11. PMID:39796512. |
ache, a serine hydrolase that plays a crucial role in cholinergic neurotransmission, is a key target in the treatment of cognitive impairments due to its function in acetylcholine hydrolysis. |
2025-01-11 |
2025-01-14 |
Not clear |
| Natalia Cichon, Weronika Grabowska, Leslaw Gorniak, Maksymilian Stela, Piotr Harmata, Michal Ceremuga, Michal Bija. Mechanistic and Therapeutic Insights into Flavonoid-Based Inhibition of Acetylcholinesterase: Implications for Neurodegenerative Diseases. Nutrients. vol 17. issue 1. 2025-01-11. PMID:39796512. |
in vitro, in vivo, and in silico analyses reveal that these flavonoids effectively interact with both the active and peripheral anionic sites of ache, resulting in increased acetylcholine levels and the stabilization of cholinergic signaling. |
2025-01-11 |
2025-01-14 |
Not clear |
| Hanane Naeimi, Maryam Taheri, Hossein Ghafouri, Asadollah Mohammad. Investigation of Thiazolidine-2,4-Dione Derivatives as Acetylcholinesterase Inhibitors: Synthesis, In Vitro Biological Activities and In Silico Studies. ChemistryOpen. 2025-01-11. PMID:39797425. |
the inhibition of acetylcholinesterase (ache), an enzyme responsible for the inactivation and decrease in acetylcholine in the cholinergic pathway, has been considered an attractive target for small-molecule drug discovery in alzheimer's disease (ad) therapy. |
2025-01-11 |
2025-01-14 |
Not clear |
| Ysaías J Alvarado, Lenin González-Paz, José L Paz, Marcos A Loroño-González, Julio Santiago Contreras, Carla Lossada, Alejandro Vivas, Yovani Marrero-Ponce, Felix Martinez-Rios, Patricia Rodriguez-Lugo, Yanpiero Balladores, Joan Vera-Villalobo. Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study. Biology. vol 13. issue 12. 2025-01-08. PMID:39765732. |
the enzyme acetylcholinesterase (ache) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ach). |
2025-01-08 |
2025-01-13 |
human |
| David Griffiths, Jami Hanif, Jacob McCammon, Luke McMaster, Cameron Gemmel. Accidental Organophosphate Poisoning in a Patient Due to a Bed Bug Pesticide in the United Kingdom: A Case Report. Cureus. vol 16. issue 12. 2025-01-06. PMID:39759751. |
as irreversible inhibitors of the enzyme acetylcholinesterase (ache), they reduce anti-cholinesterase activity and therefore increase acetylcholine (ach) levels at the neuromuscular junction (nmj). |
2025-01-06 |
2025-01-08 |
Not clear |
| Ting Zeng, Chengwei Zhang, Lili Sun, Haiyan X. Water-Soluble Ginseng Oligosaccharides Prevent Scopolamine-Induced Cholinergic Dysfunction and Inflammatory Cytokine Overexpression. Cell biochemistry and biophysics. 2025-01-03. PMID:39751741. |
the effect of wgos on the cholinergic system was evaluated by measuring acetylcholine (ach) neurotransmitter concentration and acetylcholinesterase (ache) activity in the hippocampus. |
2025-01-03 |
2025-01-05 |
mouse |
| Brenda Rufino da Silva, Joyce Maria Ferreira Alexandre Lima, Marcela Bermudez Echeverry, Carlos Alberto-Silv. Haloperidol-Induced Catalepsy and Its Correlations with Acetylcholinesterase Activity in Different Brain Structures of Mice. Neurology international. vol 16. issue 6. 2024-12-27. PMID:39728751. |
hal blocks the function of presynaptic d2 receptors on cholinergic interneurons, leading to the release of acetylcholine (ach), which is hydrolyzed by the enzyme acetylcholinesterase (ache). |
2024-12-27 |
2024-12-29 |
mouse |
| Mohammed Sakib Musa, Md Tahsinul Islam, Wasif Billah, Md Siam Hossain, Md Shirajuce Shalakin Rahat, Imren Bayil, Yeasmin Akter Munni, Sumon Gangul. Structure-based virtual screening of Trachyspermum ammi metabolites targeting acetylcholinesterase for Alzheimer's disease treatment. PloS one. vol 19. issue 12. 2024-12-17. PMID:39689077. |
the cholinergic hypothesis posits that the degradation of acetylcholine by acetylcholinesterase (ache) contributes to ad development. |
2024-12-17 |
2024-12-21 |
human |
| Stavroula Kostoudi, Nikolaos Iatridis, Dimitra Hadjipavlou-Litina, Eleni Pontiki, Georgios Pampalaki. Chemical, In Cellulo, and In Silico Characterization of the Aminocholine Analogs of VG. International journal of molecular sciences. vol 25. issue 23. 2024-12-17. PMID:39684368. |
v-type nerve agents are exceedingly toxic chemical warfare agents that irreversibly inhibit acetylcholinesterase (ache), leading to acetylcholine accumulation in synapses and the disruption of neurotransmission. |
2024-12-17 |
2024-12-21 |
Not clear |
| Xumin Lin, Baojun Yang, Xiaowei Yuan, Zewen Li. Overexpression of ace2 compensating for the acetylcholinesterase activity loss from ace1 mutations accelerated the development of eggs and early nymphs in Nilaparvata lugens. International journal of biological macromolecules. 2024-12-08. PMID:39647749. |
acetylcholinesterase (ache) guarantees the acetylcholine signal in insect central nervous system, and is the target of organophosphorus and carbamate insecticides, towards which resistance was often reported due to ache mutations. |
2024-12-08 |
2024-12-11 |
Not clear |
| Xumin Lin, Baojun Yang, Xiaowei Yuan, Zewen Li. Overexpression of ace2 compensating for the acetylcholinesterase activity loss from ace1 mutations accelerated the development of eggs and early nymphs in Nilaparvata lugens. International journal of biological macromolecules. 2024-12-08. PMID:39647749. |
the double mutations in ache1 reduced total ache activity in metabolizing acetylcholine, such as low protein stability, substrate affinity and catalytic efficiency, which needed compensation in a special way. |
2024-12-08 |
2024-12-11 |
Not clear |
| Kalpana Rawat, Disha Tewari, Amisha Bisht, Subhash Chandra, Yewulsew Kebede Tiruneh, Hesham M Hassan, Ahmed Al-Emam, Emad Rashad Sindi, Al-Anood M Al-Die. Identification of AChE targeted therapeutic compounds for Alzheimer's disease: an in-silico study with DFT integration. Scientific reports. vol 14. issue 1. 2024-12-05. PMID:39638823. |
acetylcholinesterase (ache), which hydrolyzes acetylcholine, is a key drug target for treating ad. |
2024-12-05 |
2024-12-08 |
Not clear |
| Natalia Kurhaluk, Oleksandr Lukash, Piotr Kamiński, Halina Tkaczenk. L-Arginine and Intermittent Hypoxia Are Stress-Limiting Factors in Male Wistar Rat Models. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596428. |
in addition, our study investigated how the modulatory effect of the no synthase mechanism on the concentration of catecholamines (ca), such as adrenaline and noradrenaline, and their biosynthetic precursors (dopa, dopamine) varies depending on the cholinergic (acetylcholine, ach-acetylcholinesterase, ache) status in rats. |
2024-11-27 |
2024-11-29 |
rat |
| N Sabri, J Kamaldin, M Sivanathan, R Rasl. Study on the neurotoxicity of the temephos impregnated kenaf cellulose nanofiber (KCNF+T) aerosols against the female Aedes aegypti mosquitoes. Tropical biomedicine. vol 41. issue 3. 2024-11-16. PMID:39548782. |
the study aimed to determine whether the kcnf+t aerosols are capable to elicit neurotoxicity in the adult mosquitoes via the respiratory exposure route by observing their behavioural response and measuring its body acetylcholine esterase (ache) activity. |
2024-11-16 |
2024-11-20 |
Not clear |
| Hani M Abdelsalam, Alaa Samy, Engy E A Mosaleem, Moustafa Salaheldin Abdelhami. The ameliorative potential of platelet-rich plasma and exosome on renal ischemia/reperfusion-induced uremic encephalopathy in rats. Scientific reports. vol 14. issue 1. 2024-11-07. PMID:39505968. |
serum kidney functions and acetylcholine esterase enzyme (ache) were evaluated. |
2024-11-07 |
2024-11-09 |
rat |
| Namrita Halder, Sourabh Yadav, Girdhari La. Neuroimmune communication of the cholinergic system in gut inflammation and autoimmunity. Autoimmunity reviews. 2024-11-05. PMID:39500481. |
it includes the neurotransmitter acetylcholine (ach), the enzyme required for the synthesis of ach (choline acetyltransferase, chat), the enzyme required for its degradation (acetylcholinesterase, ache), and cholinergic receptors (nicotinic acetylcholine receptors and muscarinic acetylcholine receptors). |
2024-11-05 |
2024-11-08 |
Not clear |
| Noreen Samad, Aqsa Hameed, Natasha Manzoor, Sadia Shoukat, Ali Irfan, Gamal A Shazly, Arslan Khalid, Umer Ejaz, Saima Khaliq, Emilio Mateev, Yousef A Bin Jarda. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Experimental gerontology. 2024-11-03. PMID:39490558. |
d-gal-induced decreased antioxidant enzymes, and acetylcholine levels, while increased oxidative stress markers, neuro-inflammatory cytokines, serotonin metabolism, and acetylcholinesterase (ache) activity were prevented by nn administration at both doses. |
2024-11-03 |
2024-11-06 |
rat |
| Bi Bi Fatemeh Mirjalili, Seyedeh Azita Fazeli Attar, Fereshteh Shir. Synthesis, biological evaluation and in silico study of 4-(benzo[d]thiazole-2-yl) phenols based on 4-hydroxy coumarin as acetylcholinesterase inhibitors. Scientific reports. vol 14. issue 1. 2024-11-03. PMID:39488512. |
alzheimer's disease, characterized by cognitive decline and memory loss, is associated with decreased acetylcholine levels due to acetylcholinesterase (ache) activity. |
2024-11-03 |
2024-11-05 |
Not clear |
| Md Tarikul Islam, Md Aktaruzzaman, Ahmed Saif, Al Riyad Hasan, Md Mehedi Hasan Sourov, Bratati Sikdar, Saira Rehman, Afrida Tabassum, Syed Abeed-Ul-Haque, Mehedi Hasan Sakib, Md Muntasir Alam Muhib, Md Ali Ahasan Setu, Faria Tasnim, Rifat Rayhan, Mohamed M Abdel-Daim, Md Obayed Raiha. Identification of acetylcholinesterase inhibitors from traditional medicinal plants for Alzheimer's disease using RSC advances. vol 14. issue 47. 2024-11-01. PMID:39483377. |
identification of acetylcholinesterase inhibitors from traditional medicinal plants for alzheimer's disease using acetylcholinesterase (ache) holds significance in alzheimer's disease (ad), where cognitive impairment correlates with insufficient acetylcholine levels. |
2024-11-01 |
2024-11-03 |
Not clear |
| Abdulelah Aljuaid, Osama Abdulaziz, Mamdouh Allahyani, Mazen Almehmadi, Abdullah Yahya Abdullah Alzahrani, Shivani Verma, Mohd Yusuf, Mohammad Asi. In Silico and ADMET Studies of Spiro-Quinazoline Compounds as Acetylcholine Esterase Inhibitors Against Alzheimer's Disease. CNS & neurological disorders drug targets. 2024-10-30. PMID:39473101. |
acetylcholinesterase (ache) inhibitors are used in primary pharmacotherapy for numerous neurodegenerative conditions, providing their capacity to modulate acetylcholine levels crucial for cognitive function. |
2024-10-30 |
2024-11-02 |
Not clear |