| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Surbhi Jaiswal, Brijeshwar Singh, Isha Dhingra, Abhijeet Joshi, Prashant Kodgir. Bioremediation and Bioscavenging for elimination of Organophosphorus threats: An approach using enzymatic advancements. Environmental research. 2024-04-10. PMID:38599448. |
these compounds inhibit the action of the acetylcholinesterase enzyme (ache) by phosphorylation, which prevents the breakdown of acetylcholine (ach) neurotransmitters into choline and acetate. |
2024-04-10 |
2024-04-13 |
human |
| Jae Yeon Park, Seong Doo Kang, Yun Gon Son, Ju Yeon Kim, Gihwan Lee, Kwang Dong Kim, Sang Won Lee, Jeong Yoon Ki. Eucalyptus globulus leaf-isolated isorhapontin serves as a natural insecticide via acetylcholinesterase inhibition. Pesticide biochemistry and physiology. vol 200. 2024-04-08. PMID:38582576. |
acetylcholinesterase (ache) inhibitors cause insect death by preventing the hydrolysis of the neurotransmitter acetylcholine, which overstimulates the nervous system. |
2024-04-08 |
2024-04-10 |
Not clear |
| Zahra Nekoukar, Homa Talabaki, Zakaria Zakariaei, Mahdi Mesri, Hossein Azade. Management of organophosphorus poisoning and the role of magnesium sulfate: A scoping review of literature. Clinical and experimental emergency medicine. 2024-04-07. PMID:38583865. |
organophosphorus agents are easily absorbed via respiratory, gastrointestinal, and dermal routes, and inhibit the acetylcholine transferase enzyme (ache), which is responsible for the majority of toxicity caused by organophosphates in the body. |
2024-04-07 |
2024-04-10 |
Not clear |
| Zahra Nekoukar, Homa Talabaki, Zakaria Zakariaei, Mahdi Mesri, Hossein Azade. Management of organophosphorus poisoning and the role of magnesium sulfate: A scoping review of literature. Clinical and experimental emergency medicine. 2024-04-07. PMID:38583865. |
inhibition of ache results in the accumulation of acetylcholine (ach) in synapses and stimulation of cholinergic receptors. |
2024-04-07 |
2024-04-10 |
Not clear |
| Asmaa R Hashim, Dina W Bashir, Eman Rashad, Mona K Galal, Maha M Rashad, Heba M A Khalil, Nasrallah M Deraz, El-Gharbawy S . Neuroprotective Assessment of Betaine against Copper Oxide Nanoparticle-Induced Neurotoxicity in the Brains of Albino Rats: A Histopathological, Neurochemical, and Molecular Investigation. ACS chemical neuroscience. 2024-04-02. PMID:38564598. |
significant decrease in glutathione (gsh), and downregulation of acetylcholine esterase (ache), nuclear factor erythroid 2-like protein 2 (nrf-2), and superoxide dismutase (sod). |
2024-04-02 |
2024-04-05 |
rat |
| Xiujuan Huang, Yuanyuan Cheng, Qi Zhou, Yifeng Tu, Jilin Ya. A simple fluorescence detection of acetylcholinesterase with peroxidase-like catalysis from iodide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 313. 2024-03-15. PMID:38490124. |
acetylcholinesterase (ache) is an important enzyme in the central and peripheral nervous system that regulates the balance of the neurotransmitter acetylcholine. |
2024-03-15 |
2024-03-18 |
Not clear |
| Anantha Krishnan Dhanabalan, Praveen Kumar, Saranya Vasudevan, Arkadiusz Chworos, Devadasan Velmuruga. Identification of a novel drug molecule for neurodegenerative disease from marine algae through Journal of biomolecular structure & dynamics. 2024-03-08. PMID:38456260. |
identification of a novel drug molecule for neurodegenerative disease from marine algae through cognitive functions are lost due to the rapid hydrolysis of acetylcholine including acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2024-03-08 |
2024-03-10 |
Not clear |
| Bichu Cheng, Qi Wang, Yi An, Fener Che. Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease. Natural product reports. 2024-03-07. PMID:38450550. |
covering: 2006 to 2023(-)-galantamine is a natural product with distinctive structural features and potent inhibitory activity against acetylcholine esterase (ache). |
2024-03-07 |
2024-03-09 |
Not clear |
| Mennat-Allah M Hassan, Sara A Wahdan, Reem N El-Naga, Tamer M Abdelghany, Ebtehal El-Demerdas. Ondansetron attenuates cisplatin-induced behavioral and cognitive impairment through downregulation of NOD-like receptor inflammasome pathway. Toxicology and applied pharmacology. 2024-03-04. PMID:38437957. |
it increased the acetylcholine (ach) level and decreased the level of the acetylcholine esterase enzyme (ache). |
2024-03-04 |
2024-03-07 |
rat |
| Gasmelseed Y Ahmed, Ahmed A Osman, Ahlam Mukhta. Acetylcholinesterase enzyme among cancer patients a potential diagnostic and prognostic indicator a multicenter case-control study. Scientific reports. vol 14. issue 1. 2024-03-01. PMID:38429330. |
acetylcholinesterase enzyme (ache) activity is impaired by a variety of inhibitors including organophosphorus pesticides, leading to the accumulation of acetylcholine. |
2024-03-01 |
2024-03-04 |
human |
| Ben Haddad, Jeneen Khalil, Hind Al Khashali, Ravel Ray, Stuti Goel, Ban Darweesh, Kai-Ling Coleman, Caroline Wozniak, Robert Ranzenberger, Brooke Lopo, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. The role of leptin in regulation of the soluble amyloid precursor protein α (sAPPα) levels in lung cancer cell media. Scientific reports. vol 14. issue 1. 2024-02-28. PMID:38418632. |
a549 cell treatment with leptin increased acetylcholine levels and blocked the activities of ache and p53. |
2024-02-28 |
2024-03-02 |
human |
| Xin Zhang, Xin Tong, Xuexi Tang, Yixin Yang, Luyuchen Zhang, Xiaotong Zhan, Xinxin Zhan. Behavioral toxicity of TDCPP in marine zooplankton: Evidence from feeding and swimming responses, molecular dynamics and metabolomics of rotifers. The Science of the total environment. 2024-02-24. PMID:38401740. |
all tdcpp test concentrations suppressed ache activity, causing excessive accumulation of acetylcholine within rotifers, thereby disturbing the neural innervation of corona cilia. |
2024-02-24 |
2024-02-27 |
Not clear |
| Alexey Ivanov, Rezeda Shamagsumova, Marina Larina, Gennady Evtugy. Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer's Disease Drug Determination. Biosensors. vol 14. issue 2. 2024-02-23. PMID:38392012. |
these consequences can be compensated by the inhibition of acetylcholinesterase (ache) followed by a decrease in the rate of acetylcholine hydrolysis. |
2024-02-23 |
2024-02-25 |
Not clear |
| Joana Ribeiro, Henrique Araújo-Silva, Mário Fernandes, Joilna Alves da Silva, Francisco das Chagas L Pinto, Otília Deusdenia L Pessoa, Hélcio Silva Santos, Jane Eire Silva Alencar de Menezes, Andreia C Gome. Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo. Natural products and bioprospecting. vol 14. issue 1. 2024-02-22. PMID:38383833. |
a crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (ache) activity. |
2024-02-22 |
2024-02-24 |
zebrafish |
| Burcu Yeliz Kollayan, Derya Cansiz, Merih Beler, Ismail Unal, Ebru Emekli-Alturfan, Sebnem Ercalik Yalcinkay. Effects of low-dose ionizing radiation on the molecular pathways linking neurogenesis and autism spectrum disorders in zebrafish embryos. Drug and chemical toxicology. 2024-02-22. PMID:38384198. |
at the end of 72 hours post-fertilization, locomotor activity, oxidant-antioxidant status, and acetylcholine esterase (ache) activity were analyzed. |
2024-02-22 |
2024-02-24 |
zebrafish |
| Hitesh Kumar, Ashok Kumar Datusalia, Gopal L Khati. Virtual screening of acetylcholinesterase inhibitors through pharmacophore-based 3D-QSAR modeling, ADMET, molecular docking, and MD simulation studies. In silico pharmacology. vol 12. issue 1. 2024-02-19. PMID:38370859. |
many studies showed that targeting acetylcholinesterase enzyme (ache) to improve acetylcholine can be an effective option to treat ad. |
2024-02-19 |
2024-02-21 |
Not clear |
| Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). |
2024-02-10 |
2024-02-12 |
Not clear |
| F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. |
conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. |
2024-02-09 |
2024-02-11 |
human |
| Marwa E A El-Shamarka, Wael Mahmoud Aboulthana, Nagwa Ibrahim Omar, Marwa M Mahfou. Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study. Inflammopharmacology. 2024-02-08. PMID:38329710. |
moreover, t. chebula extract improved the brain integrity by lowering levels of interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), β-amyloid (aβ) content, monocyte chemoattractant protein-1 (mcp-1) and acetylcholine esterase (ache) significantly (p ≤ 0.05) in a dose dependent manner compared to brain of diabetic rats. |
2024-02-08 |
2024-02-10 |
rat |
| Yi-Long Lu, Jing Su, Jian-Wei Li, Wen-Rong X. A molecular container providing supramolecular protection against acetylcholine hydrolysis. Organic & biomolecular chemistry. 2024-02-07. PMID:38323382. |
alzheimer's disease (ad) is characterized by cognitive decline, often attributed to the deficiency of acetylcholine, which can undergo hydrolysis by acetylcholinesterase (ache) within the biological milieu. |
2024-02-07 |
2024-02-09 |
Not clear |