| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weronika Bagrowska, Angelika Karasewicz, Artur Gór. Comprehensive analysis of acetylcholinesterase inhibitor and reactivator complexes: implications for drug design and antidote development. Drug discovery today. 2024-10-30. PMID:39476946. |
the main function of acetylcholinesterase (ache) is to regulate the levels of one of the most important neurotransmitters: acetylcholine. |
2024-10-30 |
2024-11-02 |
Not clear |
| Hsiao-Yun Huang, Hung-Yi Hsu, Cheng-Yu Kuo, Mao-Lun Wu, Chien-Chen Lai, Gary Ro-Lin Chang, Yu-Ju Li. Heterologous expressing melittin in a probiotic yeast to evaluate its function for promoting NSC-34 regeneration. Applied microbiology and biotechnology. vol 108. issue 1. 2024-10-28. PMID:39466458. |
growth-related gene expressions were evaluated, including microtubule-associated protein 2 (map2), microtubule-associated protein tau (mapt), growth-associated protein 43 (gap-43), choline acetyltransferase (chat), vesicular acetylcholine transporter (vacht), and acetylcholine esterase (ache). |
2024-10-28 |
2024-10-31 |
bee |
| Qingyu Zhang, Siyuan Zheng, Xiaoqing Pei, Yuxin Zhang, Gang Wang, Hongfeng Zha. The effects of microplastics exposure on quail's hypothalamus: Neurotransmission disturbance, cytokine imbalance and ROS/TGF-β/Akt/FoxO3a signaling disruption. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-10-23. PMID:39442781. |
moreover, the decrease of acetylcholinesterase (ache) activity and increasing acetylcholine (ach) indicated that ps-mps exposure caused hypothalamic neurotransmission disturbance. |
2024-10-23 |
2024-10-26 |
Not clear |
| H H Awad, I Abulyazid, E M S El-Kholy, H S Mohammed, H K Abdelhakim, A M Fad. Neurotoxicity, Cytotoxicity, and Genotoxicity of Phyto-radio Synthesized Selenium Nanoparticles in Culex pipiens Complex. Biological trace element research. 2024-10-23. PMID:39443338. |
the current study was conducted to evaluate the impact of senps on the detoxification enzymes, acetylcholine esterase (ache), glutathione s-transferase (gst), and α-carboxyl esterase (α-care), in larval instars of culex pipiens complex at the lc |
2024-10-23 |
2024-10-26 |
Not clear |
| Krishna Jee, Rishabh Gaur, Jai Prakash Kadian, Meenu, Muhammad Murtaza, Sanjay Kumar Verma, Bharati Malik, Shilp. A Review on Phytochemical Constituents Used as Current Treatment Strategies for Neurodegenerative Disease. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2024-10-17. PMID:39415572. |
berberin (bbr), which is an isoquinoline class of alkaloid and isolated from the plant hydrastis condenses and berberis aaristata, has both acetylcholine esterase (ache) inhibiting properties as well as monoamine oxidase (mao) inhibiting properties involved in the betterment of ad by decreasing the production of reactive oxygen species (ros). |
2024-10-17 |
2024-10-19 |
Not clear |
| Farshad Mirzavi, Arezoo Rajabian, Hossein Hosseini, Azar Hossein. Herniarin ameliorates acrylamide-induced neurotoxicity in rat: involvement of neuro-inflammation and acetylcholinesterase. Natural product research. 2024-10-17. PMID:39415605. |
after treatment, the animals were sacrificed and biochemical markers including superoxide dismutase (sod), catalase activity, malondialdehyde (mda), nitric oxide (no), thiols and acetylcholine esterase (ache) level were evaluated. |
2024-10-17 |
2024-10-19 |
rat |
| Noshaba Afshin, Nadia Mushtaq, Mushtaq Ahmed, Naila Sher, Sadeq K Alhag, Fatma Mohamed Ameen Khalil, Laila A Al-Shuraym, Hajra Hameed, Farhad Badshah, Riaz Hussai. Biogenic synthesis of AgNPs via polyherbal formulation: Mechanistic neutralization and toxicological impact on acetylcholinesterase from Bungarus sindanus venom. Microscopy research and technique. 2024-10-05. PMID:39367638. |
inhibiting ache leads to acetylcholine buildup, affecting neurotransmission. |
2024-10-05 |
2024-10-07 |
Not clear |
| José Luis Gómez-Olivares, Rosa María López-Durán, Sergio Enríquez-Flores, Gabriel López-Velázquez, Ignacio De La Mora-De La Mora, Itzhel García-Torres, Rubí Viedma-Rodríguez, Rafael Valencia-Quintana, Mirta Milić, Luis Antonio Flores-Lópe. Preliminary exploration of the expression of acetylcholinesterase in normal human T lymphocytes and leukemic Jurkat T cells. Biomedical reports. vol 21. issue 5. 2024-09-14. PMID:39268406. |
the classic enzymatic function of acetylcholinesterase (ache) is the hydrolysis of acetylcholine (ach) in the neuronal synapse. |
2024-09-14 |
2024-09-16 |
human |
| Xueying Xu, Ximeng Ma, Jun Dou, Wenkai Chen, Jiying Chen, Mingsen Zhou, Anfu Shen, Xiangjiang Li. β-ionone inhibits the grazing of Daphnia sinensis by reducing the activity of acetylcholinesterase. Journal of hazardous materials. vol 479. 2024-09-10. PMID:39255669. |
transcriptomic analysis showed that β-ionone could significantly inhibit the expression of acetylcholinesterase (ache) mrna, while metabolomics further revealed that β-ionone could significantly increase the level of acetylcholine (ach) in d. sinensis. |
2024-09-10 |
2024-09-13 |
Not clear |
| Aditya Ganeshpurkar, Ankit Ganeshpurkar, Pushpendra Kumar Khangar, Likhit Akotkar, Swati Jain, Harshal Prajapati, Nazneen Dube. In Silico Investigation of Suillin Derived from Suillus luteus Mushroom (Agaricomycetes) Targeting Acetylcholinesterase: Docking and Virtual Screening Study. International journal of medicinal mushrooms. vol 26. issue 11. 2024-09-06. PMID:39241165. |
suillin, derived from suillus luteus mushrooms, shows promise as a mixed-type ache inhibitor, crucial for maintaining acetylcholine levels in neurodegenerative disorders like alzheimer's disease. |
2024-09-06 |
2024-09-09 |
Not clear |
| Narayanarao Alla, Sujatha Palatheeya, Siva Reddy Challa, Ramakrishna Kakarl. Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats. Metabolic brain disease. 2024-08-13. PMID:39136806. |
hyperactivation of acetylcholine esterase (ache), oxidative stress, and inflammation are reported to cause memory and cognitive impairment in global cerebral ischemia. |
2024-08-13 |
2024-08-16 |
rat |
| Narayanarao Alla, Sujatha Palatheeya, Siva Reddy Challa, Ramakrishna Kakarl. Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats. Metabolic brain disease. 2024-08-13. PMID:39136806. |
further, morin improved memory and cognition in bccao rats by decreasing the ache enzyme activity and enhancing the acetylcholine (ach) levels. |
2024-08-13 |
2024-08-16 |
rat |
| Leonardo V F Ferreira, Taináh M R Santos, Camila A Tavares, Hassan Rasouli, Teodorico C Ramalh. Atomistic Origins of Resurrection of Aged Acetylcholinesterase by Quinone Methide Precursors. Molecules (Basel, Switzerland). vol 29. issue 15. 2024-08-10. PMID:39125089. |
nerve agents are organophosphates (ops) that act as potent inhibitors of acetylcholinesterase (ache), the enzyme responsible for the hydrolysis of acetylcholine. |
2024-08-10 |
2024-08-13 |
Not clear |
| Mahmoud K F El-Sayed, Manal M Elshahawi, Fatma S M Abu El-Azm, Eslam M Hosni, Mahmoud Kamal, Yasmeen M Al. Synthesis, molecular modelling and evaluation of larvicidal efficacy of annulated Benzo[h]chromenes against Culex pipiens L. Larvae. Scientific reports. vol 14. issue 1. 2024-08-08. PMID:39117743. |
the mode of action of these compounds was explored through molecular docking studies, indicating their potential as acetylcholine esterase (ache) inhibitors and nicotinic acetylcholine receptors (nachr) blockers. |
2024-08-08 |
2024-08-12 |
Not clear |
| Fatima Ezzahra Laghchioua, Carlos F M da Silva, Diana C G A Pinto, José A S Cavaleiro, Ricardo F Mendes, Filipe A Almeida Paz, Maria A F Faustino, El Mostapha Rakib, M Graça P M S Neves, Florbela Pereira, Nuno M M Mour. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS chemical neuroscience. 2024-07-22. PMID:39037949. |
since acetylcholinesterase (ache) is a critical enzyme in the nervous system, responsible for breaking down the neurotransmitter acetylcholine, its inhibition holds a significant interest in the treatment of various neurological disorders. |
2024-07-22 |
2024-07-25 |
Not clear |
| Fatima Ezzahra Laghchioua, Carlos F M da Silva, Diana C G A Pinto, José A S Cavaleiro, Ricardo F Mendes, Filipe A Almeida Paz, Maria A F Faustino, El Mostapha Rakib, M Graça P M S Neves, Florbela Pereira, Nuno M M Mour. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS chemical neuroscience. 2024-07-22. PMID:39037949. |
therefore, it is crucial to develop efficient ache inhibitors capable of increasing acetylcholine levels, ultimately leading to improved cholinergic neurotransmission. |
2024-07-22 |
2024-07-25 |
Not clear |
| Göksun Demirel, Sonia Sanajou, Anıl Yirün, Deniz Arca Çakır, Aylin Balcı Özyurt, Aysel Berkkan, Terken Baydar, Pınar Erkekoğl. Walnut oil: a promising nutraceutical in reducing oxidative stress and improving cholinergic activity in an Toxicology research. vol 13. issue 4. 2024-07-03. PMID:38957781. |
additionally, wo showed a significant reduction in tau protein levels (2-fold), increased acetylcholine (ach) levels (12%), and decreased acetylcholine esterase (ache) activity (~50%). |
2024-07-03 |
2024-07-06 |
human |
| Giovana R Oliveira, Matheus Gallas-Lopes, Rafael Chitolina, Leonardo M Bastos, Stefani M Portela, Thailana Stahlhofer-Buss, Darlan Gusso, Rosane Gomez, Angela T S Wyse, Ana P Herrmann, Angelo Piat. Evaluation of behavioral and neurochemical changes induced by carbofuran in zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-06-26. PMID:38925284. |
research has revealed that this pesticide acts as an inhibitor of acetylcholinesterase (ache), inducing an accumulation of acetylcholine in the brain. |
2024-06-26 |
2024-06-29 |
zebrafish |
| Behjat Pouramiri, Maryam Abbasi, Elahe Hadadianpou. Design, Green Synthesis and in silico Studies of New Substituted Naphtho[1,2-e][1,3]Oxazines as Potential Acetylcholinesterase Inhibitors. Chemistry & biodiversity. 2024-06-26. PMID:38923807. |
acetylcholinesterase (ache) inhibitors as the primary pharmacotherapy for numerous neurodegenerative conditions, leveraging their capacity to modulate acetylcholine levels crucial for cognitive function. |
2024-06-26 |
2024-06-29 |
Not clear |
| Sundaram Mohanthi, Jesudass Sutha, Murugesh Gayathri, Mathan Rames. Evaluation of the citalopram toxicity on early development of zebrafish: Morphological, physiological and biochemical responses. Environmental pollution (Barking, Essex : 1987). 2024-06-21. PMID:38906410. |
a significant decrease in acetylcholine esterase (ache) activity was also observed in citalopram exposed groups. |
2024-06-21 |
2024-06-24 |
cat |