| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ben Haddad, Jeneen Khalil, Hind Al Khashali, Ravel Ray, Stuti Goel, Ban Darweesh, Kai-Ling Coleman, Caroline Wozniak, Robert Ranzenberger, Brooke Lopo, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. The role of leptin in regulation of the soluble amyloid precursor protein α (sAPPα) levels in lung cancer cell media. Scientific reports. vol 14. issue 1. 2024-02-28. PMID:38418632. |
a549 cell treatment with leptin increased acetylcholine levels and blocked the activities of ache and p53. |
2024-02-28 |
2024-03-02 |
human |
| Xin Zhang, Xin Tong, Xuexi Tang, Yixin Yang, Luyuchen Zhang, Xiaotong Zhan, Xinxin Zhan. Behavioral toxicity of TDCPP in marine zooplankton: Evidence from feeding and swimming responses, molecular dynamics and metabolomics of rotifers. The Science of the total environment. 2024-02-24. PMID:38401740. |
all tdcpp test concentrations suppressed ache activity, causing excessive accumulation of acetylcholine within rotifers, thereby disturbing the neural innervation of corona cilia. |
2024-02-24 |
2024-02-27 |
Not clear |
| Alexey Ivanov, Rezeda Shamagsumova, Marina Larina, Gennady Evtugy. Electrochemical Acetylcholinesterase Sensors for Anti-Alzheimer's Disease Drug Determination. Biosensors. vol 14. issue 2. 2024-02-23. PMID:38392012. |
these consequences can be compensated by the inhibition of acetylcholinesterase (ache) followed by a decrease in the rate of acetylcholine hydrolysis. |
2024-02-23 |
2024-02-25 |
Not clear |
| Joana Ribeiro, Henrique Araújo-Silva, Mário Fernandes, Joilna Alves da Silva, Francisco das Chagas L Pinto, Otília Deusdenia L Pessoa, Hélcio Silva Santos, Jane Eire Silva Alencar de Menezes, Andreia C Gome. Petrosamine isolated from marine sponge Petrosia sp. demonstrates protection against neurotoxicity in vitro and in vivo. Natural products and bioprospecting. vol 14. issue 1. 2024-02-22. PMID:38383833. |
a crucial hallmark associated with this disease is associated with the deficiency of the brain neurotransmitter acetylcholine, due to an affected acetylcholinesterase (ache) activity. |
2024-02-22 |
2024-02-24 |
zebrafish |
| Burcu Yeliz Kollayan, Derya Cansiz, Merih Beler, Ismail Unal, Ebru Emekli-Alturfan, Sebnem Ercalik Yalcinkay. Effects of low-dose ionizing radiation on the molecular pathways linking neurogenesis and autism spectrum disorders in zebrafish embryos. Drug and chemical toxicology. 2024-02-22. PMID:38384198. |
at the end of 72 hours post-fertilization, locomotor activity, oxidant-antioxidant status, and acetylcholine esterase (ache) activity were analyzed. |
2024-02-22 |
2024-02-24 |
zebrafish |
| Hitesh Kumar, Ashok Kumar Datusalia, Gopal L Khati. Virtual screening of acetylcholinesterase inhibitors through pharmacophore-based 3D-QSAR modeling, ADMET, molecular docking, and MD simulation studies. In silico pharmacology. vol 12. issue 1. 2024-02-19. PMID:38370859. |
many studies showed that targeting acetylcholinesterase enzyme (ache) to improve acetylcholine can be an effective option to treat ad. |
2024-02-19 |
2024-02-21 |
Not clear |
| Varish Ahmad, Ibrahim Alotibi, Anwar A Alghamdi, Aftab Ahmad, Qazi Mohammad Sajid Jamal, Supriya Srivastav. Computational Approaches to Evaluate the Acetylcholinesterase Binding Interaction with Taxifolin for the Management of Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338420. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that break down and reduce the level of the neurotransmitter acetylcholine (ach). |
2024-02-10 |
2024-02-12 |
Not clear |
| F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. |
conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. |
2024-02-09 |
2024-02-11 |
human |
| Marwa E A El-Shamarka, Wael Mahmoud Aboulthana, Nagwa Ibrahim Omar, Marwa M Mahfou. Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study. Inflammopharmacology. 2024-02-08. PMID:38329710. |
moreover, t. chebula extract improved the brain integrity by lowering levels of interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), β-amyloid (aβ) content, monocyte chemoattractant protein-1 (mcp-1) and acetylcholine esterase (ache) significantly (p ≤ 0.05) in a dose dependent manner compared to brain of diabetic rats. |
2024-02-08 |
2024-02-10 |
rat |
| Yi-Long Lu, Jing Su, Jian-Wei Li, Wen-Rong X. A molecular container providing supramolecular protection against acetylcholine hydrolysis. Organic & biomolecular chemistry. 2024-02-07. PMID:38323382. |
alzheimer's disease (ad) is characterized by cognitive decline, often attributed to the deficiency of acetylcholine, which can undergo hydrolysis by acetylcholinesterase (ache) within the biological milieu. |
2024-02-07 |
2024-02-09 |
Not clear |
| Yi-Long Lu, Jing Su, Jian-Wei Li, Wen-Rong X. A molecular container providing supramolecular protection against acetylcholine hydrolysis. Organic & biomolecular chemistry. 2024-02-07. PMID:38323382. |
our study revealed highly efficient host-guest interactions with a binding ratio of 1 : 3, resulting in a significant reduction in acetylcholine hydrolysis from 91.1% to 7.4% in the presence of ache under otherwise identical conditions. |
2024-02-07 |
2024-02-09 |
Not clear |
| Keisuke Obara, Haruka Mori, Suzune Ihara, Kento Yoshioka, Yoshio Tanak. Inhibitory Actions of Antidepressants, Hypnotics, and Anxiolytics on Recombinant Human Acetylcholinesterase Activity. Biological & pharmaceutical bulletin. vol 47. issue 1. 2024-02-06. PMID:38296462. |
if these drugs also inhibit acetylcholinesterase (ache) activity, they may contribute to the suppression of ad progression by increasing brain acetylcholine concentrations. |
2024-02-06 |
2024-02-09 |
human |
| Rafal Madaj, Bartłomiej Gostyński, Arkadiusz Chworos, Marek Cypry. Novichok Nerve Agents as Inhibitors of Acetylcholinesterase-In Silico Study of Their Non-Covalent Binding Affinity. Molecules (Basel, Switzerland). vol 29. issue 2. 2024-01-23. PMID:38257251. |
quantum mechanical calculations, molecular docking, and molecular dynamics (md) with molecular mechanics generalized-born surface area (mm/gbsa) were applied to assess quantitatively differences between the binding energies of acetylcholine (ach; the natural agonist of ache) and neurotoxic, synthetic correlatives (so-called "novichoks", and selected compounds from the g- and v-series). |
2024-01-23 |
2024-01-25 |
Not clear |
| Abraham Asuk. Neuroprotective Effects of Virgin Coconut Oil Supplemented Diet against Sodium Benzoate-induced Acetylcholinesterase Dysfunction and Cognitive Impairment: Role of Nrf2/NfKb Signaling Pathway. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 37. issue 2. 2024-01-20. PMID:38243570. |
the brain was processed for nrf-2, nf-kb, and acetylcholine esterase (ache) gene expression levels. |
2024-01-20 |
2024-01-22 |
rat |
| Ahlam H Mahmoud, Doaa M Elhefnawei, Mohamed A El-Desouky, Mai O Kadr. Reciprocal crosslink among MeCP2/BDNF /CREB signaling pinpointed in autism spectrum disorder. Toxicology reports. vol 12. 2024-01-17. PMID:38229920. |
the neurotransmitters gamma amino-butyric acid (gaba), acetylcholine (ach), and acetylcholinesterase (ache) in addition to, the gene expressions of brain-derived neurotrophic factor (bdnf), camp response element-binding protein (creb), and methyl-cpg-binding protein 2 (mecp2) and the dna damage comet analysis at different time intervals of the study, were assessed. |
2024-01-17 |
2024-01-19 |
rat |
| Ashwaq H Bataw. The International journal of neuroscience. vol 134. issue 1. 2024-01-16. PMID:35634646. |
alzheimer's disease (ad) appears as a result of an increase in the accumulation of amyloid beta peptide (aβ) and a decrease in neurotransmitters (acetylcholine) within the brain cells which may be due to increase in acetylcholinesterase (ache) activity and change in expression of apolipoprotein e4 (apoe4) and clusterin (clu) genes. |
2024-01-16 |
2024-01-19 |
Not clear |
| Wenkai Chen, Jun Dou, Xueying Xu, Ximeng Ma, Jiying Chen, Xiangjiang Li. β-cyclocitral, a novel AChE inhibitor, contributes to the defense of Microcystis aeruginosa against Daphnia grazing. Journal of hazardous materials. vol 465. 2023-12-26. PMID:38147752. |
it could induce the accumulation of acetylcholine (ach) by inhibiting ache activity in d. sinensis. |
2023-12-26 |
2023-12-29 |
Not clear |
| Géssica Oliveira Mendes, Moysés Fagundes de Araújo Neto, Deyse Brito Barbosa, Mayra Ramos do Bomfim, Lorena Silva Matos Andrade, Paulo Batista de Carvalho, Tiago Alves de Oliveira, Daniel Luciano Falkoski, Eduardo Habib Bechelane Maia, Marcelo Siqueira Valle, Laila Cristina Moreira Damázio, Alisson Marques da Silva, Alex Gutterres Taranto, Franco Henrique Andrade Leit. Identification of Potential Multitarget Compounds against Alzheimer's Disease through Pharmacophore-Based Virtual Screening. Pharmaceuticals (Basel, Switzerland). vol 16. issue 12. 2023-12-23. PMID:38139772. |
this study aims to present new multipurpose compounds capable of simultaneously inhibiting acetylcholinesterase (ache), butyrylcholinesterase (bche)-responsible for recycling acetylcholine in the synaptic cleft-and beta-secretase 1 (bace-1)-responsible for the generation of amyloid-β plaques. |
2023-12-23 |
2023-12-25 |
Not clear |
| Sandeep Kour, Nancy Sharma, Randeep Singh, Sumit G Gandhi, Puja Ohr. Metarhabditis amsactae: A Potential Biopesticide Isolated from Punjab (India) with Potent Insecticidal Activity and Immunomodulatory Effects against Galleria mellonella (Lepidoptera: Pyralidae). Journal of invertebrate pathology. 2023-12-22. PMID:38135246. |
to evaluate the immunomodulatory effects of m. amsactae, g. mellonella larvae were infected with 100 ijs/l and activities of antioxidant and detoxifying enzymes viz., superoxide dismutase (sod), catalase (cat), ascorbate peroxidase (apox), phenol oxidase (po), glutathione-s-transferase (gst) and acetylcholine esterase (ache) were appraised after 12, 24, 36 and 48h of nematode exposure. |
2023-12-22 |
2023-12-25 |
cat |
| Hussian Maanaki, Terry Xu, Guibing Chen, Xiuxia Du, Jun Wan. Development of integrated smartphone/resistive biosensor for on-site rapid environmental monitoring of organophosphate pesticides in food and water. Biosensors & bioelectronics: X. vol 15. 2023-12-21. PMID:38124900. |
the biosensor leverages the hydrolytic activity of acetylcholinesterase (ache) to its substrate, acetylcholine (ach), and unique transport properties of polyaniline nanofibers (pannfs) of chitosan/ache/pannf/carbon nanotube (cnt) nanocomposite film on a gold interdigitated electrode. |
2023-12-21 |
2023-12-23 |
Not clear |