| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Liu, Wei Ha, Eshbakova Komila Alibekovna, Rui Ma, Yan-Ping Sh. Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO Nanoscale. 2023-10-20. PMID:37860933. |
inhibiting ache is a common strategy for reducing the degradation of neurotransmitter acetylcholine, in order to treat early-stage ad. |
2023-10-20 |
2023-11-08 |
Not clear |
| Yasser I Hamza, Ahmed S Bream, Mohammed A Mahmoud, Mohamed A M El-Tabak. Environmental impacts of industrial activities on floral coverage with special emphasis on detoxification enzyme activities in Cataglyphis savignyi as pollution biomarker. Environmental science and pollution research international. 2023-10-18. PMID:37851257. |
in contrast, ache increases, which might be due to heavy metals enhancing acetylcholine activity at synapses. |
2023-10-18 |
2023-11-08 |
Not clear |
| Omyma Rabie, Heba A S El-Nashar, Mina Y George, Taghreed A Majrashi, Tarfah Al-Warhi, Fatma E Hassan, Wagdy M Eldehna, Nada M Mostaf. Phytochemical profiling and neuroprotective activity of Callistemon subulatus leaves against cyclophosphamide-induced chemobrain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-10-05. PMID:37797461. |
in addition, cse counteracted the effect of cpa on hippocampal acetylcholinesterase (ache) activity enhancing the level of acetylcholine. |
2023-10-05 |
2023-10-07 |
rat |
| Zefei Li, Heyuan Sh. Study on the active ingredients of Shenghui decoction inhibiting acetylcholinesterase based on molecular docking and molecular dynamics simulation. Medicine. vol 102. issue 38. 2023-09-25. PMID:37746985. |
two simulation models (model i and ii) containing ache and acetylcholine (ach) were constructed, in which model ii contained the best-docked ligand. |
2023-09-25 |
2023-10-07 |
Not clear |
| Acharya Balkrishna, Kunal Bhattacharya, Sunil Shukla, Anurag Varshne. Neuroprotection by Polyherbal Medicine Divya-Medha-Vati Against Scopolamine-Induced Cognitive Impairment Through Modulation of Oxidative Stress, Acetylcholine Activity, and Cell Signaling. Molecular neurobiology. 2023-09-14. PMID:37707741. |
it also elevated acetylcholine esterase (ache) activity, and reduced antioxidant (superoxide dismutase and catalase) activity in cortex tissue. |
2023-09-14 |
2023-10-07 |
mouse |
| Xin Wang, Shengyuan Shao, Tianyu Zhang, Qianqian Zhang, Dinglong Yang, Jianmin Zha. Effects of exposure to nanoplastics on the gill of mussels Mytilus galloprovincialis: An integrated perspective from multiple biomarkers. Marine environmental research. vol 191. 2023-09-14. PMID:37708618. |
significant inductions of total antioxidant capacity (t-aoc) and inhibition of acetylcholine (ache) activity were detected after 7 days of ps-nps exposure. |
2023-09-14 |
2023-10-07 |
Not clear |
| Zainabu Majid, Qi Zhang, Zhansen Yang, Huilian Che, Nan Chen. A Multi-Enzyme Cascade Response for the Colorimetric Recognition of Organophosphorus Pesticides Utilizing Core-Shell Pd@Pt Nanoparticles with High Peroxidase-like Activity. Foods (Basel, Switzerland). vol 12. issue 17. 2023-09-09. PMID:37685251. |
their limits are closely monitored since their residual hinders the capability of acetylcholinesterase (ache) and brings out a threatening accumulation of the neurotransmitter acetylcholine (ach), which affects human well-being. |
2023-09-09 |
2023-10-07 |
human |
| Izaz Monir Kamal, Anamika Das, Sanjukta Datta, Kaninika Paul, Sasanka Chakrabarti, Saikat Chakrabarti, Paramita Bhattacharje. A Novel spice-antioxidant-based nano-vehicle as a putative green alternative of synthetic AChE inhibitor drugs. Journal of biomolecular structure & dynamics. 2023-08-28. PMID:37639732. |
the present treatment for alzheimer's disease (ad) involves well known synthetic acetylcholine esterase (ache) inhibitor drugs which besides having short duration of action also have deleterious impact on human health. |
2023-08-28 |
2023-09-07 |
human |
| Aleksandar R Zivkovic, Karsten Schmidt, Stefan Hofer, Thorsten Brenner, Markus A Weigand, Sebastian O Decke. Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis. Biomedicines. vol 11. issue 8. 2023-08-26. PMID:37626609. |
acetylcholinesterase (ache), an enzyme primarily responsible for the hydrolysis of acetylcholine, has been proposed as a potential early indicator of sepsis onset. |
2023-08-26 |
2023-09-07 |
Not clear |
| Shohda A El-Maraghy, Aya Reda, Reham M Essam, Mona A Korta. The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism. Inflammopharmacology. 2023-08-19. PMID:37598127. |
moreover, nobiletin de-escalated hippocampal acetylcholinesterase (ache) activity and enhanced acetylcholine level while halting bace1 and amyloid-β levels. |
2023-08-19 |
2023-09-07 |
mouse |
| Yunting Wang, Xueling Wu, Wujiang Ren, Yanxia Liu, Xueling Dai, Shuo Wang, Qing Huo, Yaxuan Su. Protective effects of fisetin in an Aβ1-42-induced rat model of Alzheimer's disease. Folia neuropathologica. vol 61. issue 2. 2023-08-17. PMID:37587894. |
meanwhile, fisetin also significantly attenuated ab1-42-induced cholinergic dysfunction such as elevated the activity of choline acetyltransferase (chat) and reduced the activity of acetylcholine esterase (ache). |
2023-08-17 |
2023-09-07 |
rat |
| - Liu Xianchu, - Peng Huan, - Liu Min. Asiatic acid ameliorates life and health span in fruit fly. Pakistan journal of pharmaceutical sciences. vol 36. issue 3. 2023-08-15. PMID:37580921. |
moreover, asiatic acid inhibited acetylcholine (ache) activity to alter cholinergic system in aging process. |
2023-08-15 |
2023-09-07 |
cat |
| Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. |
2023-08-14 |
2023-09-07 |
Not clear |
| Feifei Xu, Xinyang Li, Chen Chen, Zhigang Liang, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu, Yao Ce. A dual-emission ratiometric fluorescence strategy with enzyme-based inhibition for organophosphorus pesticides determination. Mikrochimica acta. vol 190. issue 8. 2023-07-29. PMID:37516685. |
the substrate acetylcholine was catalyzed by acetylcholinesterase (ache) to produce thiocholine (tch). |
2023-07-29 |
2023-08-14 |
Not clear |
| Selen Ayaz, Sude Uluçay, Ayşem Üzer, Yusuf Dilgin, Reşat Apa. A novel acetylcholinesterase inhibition based colorimetric biosensor for the detection of paraoxon ethyl using CUPRAC reagent as chromogenic oxidant. Talanta. vol 266. issue Pt 1. 2023-07-27. PMID:37499364. |
a novel colorimetric biosensor for the sensitive and selective detection of an organophosphate pesticide, paraoxon ethyl (poe), was developed based on its inhibitory effect on the acetylcholine esterase (ache) enzyme. |
2023-07-27 |
2023-08-14 |
Not clear |
| Linlin Song, Qian Zhang, Lei Min, Xinyu Guo, Wenqiang Gao, Lin Cui, Chun-Yang Zhan. Electrochemiluminescence enhanced by isolating ACQphores in imine-linked covalent organic framework for organophosphorus pesticide assay. Talanta. vol 266. issue Pt 1. 2023-07-23. PMID:37481885. |
acetylcholinesterase (ache) can enzymatically hydrolyze acetylcholine (ach) to generate acetic acid. |
2023-07-23 |
2023-08-14 |
Not clear |
| Alexandru Graur, Patricia Sinclair, Amanda K Schneeweis, Daniel T Pak, Nadine Kabban. The human acetylcholinesterase C-terminal T30 peptide activates neuronal growth through alpha 7 nicotinic acetylcholine receptors and the mTOR pathway. Scientific reports. vol 13. issue 1. 2023-07-15. PMID:37454238. |
acetylcholinesterase (ache) is a highly conserved enzyme responsible for the regulation of acetylcholine signaling within the brain and periphery. |
2023-07-15 |
2023-08-14 |
human |
| Qipeng Shi, Huaran Yang, Yangli Chen, Na Zheng, Xiaoyu Li, Xianfeng Wang, Weikai Ding, Bangjun Zhan. Developmental Neurotoxicity of Trichlorfon in Zebrafish Larvae. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446277. |
furthermore, trichlorfon significantly inhibited ache activity, accompanied by decreased acetylcholine, dopamine and serotonin content in larvae. |
2023-07-14 |
2023-08-14 |
zebrafish |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
| Anushree Chandrashekhar Gade, Manikanta Murahari, Parasuraman Pavadai, Maushmi Shailesh Kuma. Virtual Screening of a Marine Natural Product Database for In Silico Identification of a Potential Acetylcholinesterase Inhibitor. Life (Basel, Switzerland). vol 13. issue 6. 2023-06-28. PMID:37374081. |
acetylcholinesterase (ache) hydrolyses acetylcholine and induces amyloid-beta aggregation. |
2023-06-28 |
2023-08-14 |
Not clear |