| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunting Wang, Xueling Wu, Wujiang Ren, Yanxia Liu, Xueling Dai, Shuo Wang, Qing Huo, Yaxuan Su. Protective effects of fisetin in an Aβ1-42-induced rat model of Alzheimer's disease. Folia neuropathologica. vol 61. issue 2. 2023-08-17. PMID:37587894. |
meanwhile, fisetin also significantly attenuated ab1-42-induced cholinergic dysfunction such as elevated the activity of choline acetyltransferase (chat) and reduced the activity of acetylcholine esterase (ache). |
2023-08-17 |
2023-09-07 |
rat |
| - Liu Xianchu, - Peng Huan, - Liu Min. Asiatic acid ameliorates life and health span in fruit fly. Pakistan journal of pharmaceutical sciences. vol 36. issue 3. 2023-08-15. PMID:37580921. |
moreover, asiatic acid inhibited acetylcholine (ache) activity to alter cholinergic system in aging process. |
2023-08-15 |
2023-09-07 |
cat |
| Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. |
2023-08-14 |
2023-09-07 |
Not clear |
| Feifei Xu, Xinyang Li, Chen Chen, Zhigang Liang, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu, Yao Ce. A dual-emission ratiometric fluorescence strategy with enzyme-based inhibition for organophosphorus pesticides determination. Mikrochimica acta. vol 190. issue 8. 2023-07-29. PMID:37516685. |
the substrate acetylcholine was catalyzed by acetylcholinesterase (ache) to produce thiocholine (tch). |
2023-07-29 |
2023-08-14 |
Not clear |
| Selen Ayaz, Sude Uluçay, Ayşem Üzer, Yusuf Dilgin, Reşat Apa. A novel acetylcholinesterase inhibition based colorimetric biosensor for the detection of paraoxon ethyl using CUPRAC reagent as chromogenic oxidant. Talanta. vol 266. issue Pt 1. 2023-07-27. PMID:37499364. |
a novel colorimetric biosensor for the sensitive and selective detection of an organophosphate pesticide, paraoxon ethyl (poe), was developed based on its inhibitory effect on the acetylcholine esterase (ache) enzyme. |
2023-07-27 |
2023-08-14 |
Not clear |
| Linlin Song, Qian Zhang, Lei Min, Xinyu Guo, Wenqiang Gao, Lin Cui, Chun-Yang Zhan. Electrochemiluminescence enhanced by isolating ACQphores in imine-linked covalent organic framework for organophosphorus pesticide assay. Talanta. vol 266. issue Pt 1. 2023-07-23. PMID:37481885. |
acetylcholinesterase (ache) can enzymatically hydrolyze acetylcholine (ach) to generate acetic acid. |
2023-07-23 |
2023-08-14 |
Not clear |
| Alexandru Graur, Patricia Sinclair, Amanda K Schneeweis, Daniel T Pak, Nadine Kabban. The human acetylcholinesterase C-terminal T30 peptide activates neuronal growth through alpha 7 nicotinic acetylcholine receptors and the mTOR pathway. Scientific reports. vol 13. issue 1. 2023-07-15. PMID:37454238. |
acetylcholinesterase (ache) is a highly conserved enzyme responsible for the regulation of acetylcholine signaling within the brain and periphery. |
2023-07-15 |
2023-08-14 |
human |
| Qipeng Shi, Huaran Yang, Yangli Chen, Na Zheng, Xiaoyu Li, Xianfeng Wang, Weikai Ding, Bangjun Zhan. Developmental Neurotoxicity of Trichlorfon in Zebrafish Larvae. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446277. |
furthermore, trichlorfon significantly inhibited ache activity, accompanied by decreased acetylcholine, dopamine and serotonin content in larvae. |
2023-07-14 |
2023-08-14 |
zebrafish |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
| Anushree Chandrashekhar Gade, Manikanta Murahari, Parasuraman Pavadai, Maushmi Shailesh Kuma. Virtual Screening of a Marine Natural Product Database for In Silico Identification of a Potential Acetylcholinesterase Inhibitor. Life (Basel, Switzerland). vol 13. issue 6. 2023-06-28. PMID:37374081. |
acetylcholinesterase (ache) hydrolyses acetylcholine and induces amyloid-beta aggregation. |
2023-06-28 |
2023-08-14 |
Not clear |
| Shubhangi Setia, Anjalee Chiwhan. Intermediate Syndrome Due to Organophosphate Poisoning: A Case Report. Cureus. vol 15. issue 5. 2023-06-27. PMID:37362485. |
ache is responsible for breaking down acetylcholine (ach) at the neuromuscular junction into acetic acid and choline. |
2023-06-27 |
2023-08-14 |
Not clear |
| Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. |
for the two major cholinesterases, butyrylcholinesterase (bche) and acetylcholinesterase (ache), increased bche activity observed in individuals with ad has been suggested to deplete acetylcholine levels. |
2023-06-26 |
2023-08-14 |
Not clear |
| Abhinav Anand, Navneet Khurana, Satinder Kaur, Nemat Ali, Abdullah F AlAsmari, Mohammad Waseem, Muzaffar Iqbal, Faris M Alzahrani, Neha Sharm. The multifactorial role of vanillin in amelioration of aluminium chloride and D-galactose induced Alzheimer's disease in mice. European journal of pharmacology. 2023-06-17. PMID:37329974. |
these include oxidative stress, overexpression of acetylcholinesterase (ache), depletion of acetylcholine levels, increased beta-secretase mediated conversion of amyloid precursor protein (app) to amyloid beta (abeta), accumulation of abeta oligomers, decrease in brain derived neurotrophic factor (bdnf) and accelerated neuronal apoptosis due to elevated levels of caspase-3. |
2023-06-17 |
2023-08-14 |
mouse |
| Arunachalam Muthuraman, Muthusamy Ramesh, Fazlina Mustaffa, Ahmed Nadeem, Shamama Nishat, Nallupillai Paramakrishnan, Khian Giap Li. In Silico and In Vitro Methods in the Characterization of Beta-Carotene as Pharmaceutical Material via Acetylcholine Esterase Inhibitory Actions. Molecules (Basel, Switzerland). vol 28. issue 11. 2023-06-11. PMID:37298835. |
the binding properties of beta-carotene (bc) to acetylcholine esterase (ache) proteins were characterized using the molecular docking method. |
2023-06-11 |
2023-08-14 |
zebrafish |
| Lenka Pulkrabkova, Lubica Muckova, Martina Hrabinova, Ales Sorf, Tereza Kobrlova, Petr Jost, Dagmar Bezdekova, Jan Korabecny, Daniel Jun, Ondrej Souku. Differentiated SH-SY5Y neuroblastoma cells as a model for evaluation of nerve agent-associated neurotoxicity. Archives of toxicology. 2023-05-23. PMID:37221426. |
despite a clear mechanism of their lethality caused by the irreversible inhibition of acetylcholinesterase (ache) and manifested via overstimulation of peripheral nicotinic and muscarinic acetylcholine (ach) receptors, the mechanism for central neurotoxicity responsible for acute or delayed symptoms of the poisoning has not been thoroughly uncovered. |
2023-05-23 |
2023-08-14 |
Not clear |
| Hongyan Pei, Lei He, Meiling Shi, Xiangjuan Guo, Weijia Chen, Jianming Li, Zhongmei He, Rui D. PI3K-Akt signaling pathway based on network pharmacology for the anti-Alzheimer's disease effect of licorice stem flavonoids. Aging. vol 15. 2023-05-11. PMID:37166431. |
results: of brain homogenate supernatant assay demonstrated that glycyrrhiza glabra stem and leaf flavonoids had a significant effect on the levels of oxidative indicators superoxide dismutase (sod), catalase (cat), malonaldehyde (mda), acetylcholine (ach), acetylcholinesterase (ache), caspase-3, caspase-9 and serum inflammatory factors tnf-α, il-6 and il-1β. |
2023-05-11 |
2023-08-14 |
mouse |
| Anushree Pant, M Vasundhar. Endophytic fungi: a potential source for drugs against central nervous system disorders. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. 2023-05-10. PMID:37165297. |
acetylcholine esterase (ache) inhibition is frequently used to assess in vitro neuroprotective activity along with cytotoxicity-induced neuronal cell lines. |
2023-05-10 |
2023-08-14 |
Not clear |
| Muslum Gok, Cigdem Cicek, Ebru Bodu. Butyrylcholinesterase in lipid metabolism: A new outlook. Journal of neurochemistry. 2023-05-02. PMID:37129444. |
cholinesterase enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) are traditionally associated with the termination of acetylcholine mediated neural signaling. |
2023-05-02 |
2023-08-14 |
Not clear |
| Yuting Xue, Haotian Zhong, Bin Liu, Shuo Qin, Zhengbo Chen, Kai Li, Lirong Zheng, Xia Zu. Colorimetric identification of multiple terpenoids based on bimetallic FeCu/NPCs nanozymes. Analytical biochemistry. 2023-04-27. PMID:37105389. |
terpenoids act as inhibitors of acetylcholinesterase (ache) and reduce the hydrolysis of acetylcholine (atch), providing insight into establishing a simple and distinct assay for terpenoids. |
2023-04-27 |
2023-08-14 |
Not clear |
| Baihan Zeng, Luming Qi, Sha Wu, Nannan Liu, Jie Wang, Kaidi Nie, Lina Xia, Shuguang Y. Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia. Journal of visualized experiments : JoVE. issue 194. 2023-04-24. PMID:37092814. |
further, integration analysis indicated that the intervention effects were associated with cyp1a1, ache, and mgam, as well as the adjustment of l-kynurenine, corticosterone, acetylcholine, and raffinose, mainly involving tryptophan metabolism pathway. |
2023-04-24 |
2023-08-14 |
mouse |