| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abdussamat Güze. Relationship Between Phenolic Content Determined by LC-MS/MS and Antioxidant Capacity and Enzyme Inhibition of Cyclotrichium Niveum L. Chemistry & biodiversity. 2023-03-09. PMID:36891984. |
the phytochemical composition of the plant, inhibition of acetylcholinesterase (ache) (which hydrolyzes the neurotransmitter acetylcholine), inhibition of paraoxonase for antiatherosclerotic activity (hpon 1) (which detoxifies organophosphates), and antioxidant capacity of this plant. |
2023-03-09 |
2023-08-14 |
Not clear |
| Sanjay Yadav, Punita Aggarwal, Faiz Khan, Gopal Khodve, Dibyasundar Padhy, Poonam Yadav, Sugato Banerje. β-sitosterol protects against Aluminium chloride-mediated neurotoxicity. Current Alzheimer research. 2023-03-09. PMID:36892031. |
the corticohippocampal region of the brain was isolated for acetylcholinesterase (ache), acetylcholine (ach), and gsh estimation. |
2023-03-09 |
2023-08-14 |
mouse |
| Atallah F Ahmed, Zhi-Hong Wen, Ahmed H Bakheit, Omer A Basudan, Hazem A Ghabbour, Abdullah Al-Ahmari, Chien-Wei Fen. A Major Plants (Basel, Switzerland). vol 11. issue 5. 2023-03-08. PMID:35270118. |
a study of molecular docking and molecular dynamic (md) simulation of ir3g and its aglycone isorhamnetin (ir) against human acetylcholine esterase (ache), monoamine oxidase b (mao-b), and polo-like kinase-2 (plk2) was performed and further outlined a putative mechanism in modulating neurodegenerative diseases such as pd. |
2023-03-08 |
2023-08-16 |
human |
| Long Sun, Xian Li, Chenjing Ma, Zhao He, Xin Zhang, Chengye Wang, Min Zhao, Jin Gan, Ying Fen. Improving Effect of the Policosanol from Foods (Basel, Switzerland). vol 11. issue 14. 2023-03-08. PMID:35885338. |
after mwm testing, the levels of acetylcholine (ach), acetylcholinesterase (ache), superoxide dismutase (sod), malondialdehyde (mda), and glutathione (gsh) that were present in brain tissue were determined using assay kits. |
2023-03-08 |
2023-08-16 |
mouse |
| Marlene Valentino, Anna Imbriano, Angelo Tricase, Flavio Della Pelle, Dario Compagnone, Eleonora Macchia, Luisa Torsi, Paolo Bollella, Nicoletta Ditarant. Electropolymerized molecularly imprinted polypyrrole film for dimethoate sensing: investigation on template removal after the imprinting process. Analytical methods : advancing methods and applications. 2023-03-02. PMID:36861684. |
dmt is an inhibitor of acetylcholinesterase (ache), which can lead to the accumulation of acetylcholine and result in symptoms related to the autonomous and central nervous systems. |
2023-03-02 |
2023-08-14 |
Not clear |
| Aleksandar R Zivkovic, Georgina M Paul, Stefan Hofer, Karsten Schmidt, Thorsten Brenner, Markus A Weigand, Sebastian O Decke. Increased Enzymatic Activity of Acetylcholinesterase Indicates the Severity of the Sterile Inflammation and Predicts Patient Outcome following Traumatic Injury. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830636. |
acetylcholinesterase (ache), an enzyme responsible for the hydrolysis of acetylcholine, plays an essential role in controlling cholinergic activity. |
2023-02-25 |
2023-08-14 |
Not clear |
| Preeti Bhatt, Manju Solra, Smarak Islam Chaudhury, Subinoy Ran. Metal Coordination-Driven Supramolecular Nanozyme as an Effective Colorimetric Biosensor for Neurotransmitters and Organophosphorus Pesticides. Biosensors. vol 13. issue 2. 2023-02-25. PMID:36832043. |
the detection strategy for op chemicals was based on the inhibition of acetylcholine esterase (ache) activity: a key enzyme that is responsible for the hydrolysis of acetylthiocholine (atch). |
2023-02-25 |
2023-08-14 |
Not clear |
| Aravinda Babu, Mathew John, M J Liji, E Maria, S J Bhaskar, B K Binukmar, Ayyiliath M Sajith, Eeda Koti Reddy, K V Dileep, K Suni. Sub-pocket-focused designing of tacrine derivatives as potential acetylcholinesterase inhibitors. Computers in biology and medicine. vol 155. 2023-02-25. PMID:36841058. |
human acetylcholinesterase (hache) has a potential role in the management of acetylcholine, one of the neurotransmitters that modulate the overall activity of cholinergic system, ache inhibitors have a greater impact in the therapeutics. |
2023-02-25 |
2023-08-14 |
human |
| Christina Rabeler, TaiXi Gong, Danielle Ireland, Olivier Cochet-Escartin, Eva-Maria S Collin. Acetylcholinesterase Activity Staining in Freshwater Planarians. Current protocols. vol 3. issue 2. 2023-02-17. PMID:36799654. |
the serine hydrolase acetylcholinesterase (ache) is an important neuronal enzyme which catalyzes the hydrolysis of the neurotransmitter acetylcholine and other choline esters. |
2023-02-17 |
2023-08-14 |
Not clear |
| Christina Rabeler, TaiXi Gong, Danielle Ireland, Olivier Cochet-Escartin, Eva-Maria S Collin. Acetylcholinesterase Activity Staining in Freshwater Planarians. Current protocols. vol 3. issue 2. 2023-02-17. PMID:36799654. |
the breakdown of acetylcholine by ache terminates synaptic transmission and regulates neuromuscular communication. |
2023-02-17 |
2023-08-14 |
Not clear |
| Stergiani-Chrysovalanti Peitzika, Eleni Pontik. A Review on Recent Approaches on Molecular Docking Studies of Novel Compounds Targeting Acetylcholinesterase in Alzheimer Disease. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36770750. |
low levels of acetylcholine and abnormal levels of beta-amyloid, t protein aggregation, inflammation, and oxidative stress, have been associated with ad, and therefore, research has been oriented towards the cholinergic system and primarily on acetylcholinesterase (ache) inhibitors. |
2023-02-11 |
2023-08-14 |
Not clear |
| Hisashi Inoue, Teruyuki Tachibana, Tomohiro Bito, Jiro Arim. Acetylation of amines and alcohols catalyzed by acetylcholinesterase from Pseudomonas aeruginosa PAO1. Enzyme and microbial technology. vol 165. 2023-02-08. PMID:36753877. |
therefore, we evaluated acetylation of the amine and hydroxyl group by ache, using acetylcholine and ethyl acetate as the acetyl donor. |
2023-02-08 |
2023-08-14 |
Not clear |
| Melvin Selim Atay, Suat Sari, Ebru Bodu. Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase. The protein journal. 2023-01-17. PMID:36648628. |
cholinesterase enzyme family consists of acetylcholinesterase (ache, 3.1.1.7), the major enzyme responsible for hydrolysis of acetylcholine at cholinergic synapses, and butyrylcholinesterase (bche, 3.1.1.8) a detoxification enzyme of plasma. |
2023-01-17 |
2023-08-14 |
human |
| Asma Gholami, Dariush Minai-Tehrani, Leif A Eriksso. In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor. Scientific reports. vol 13. issue 1. 2023-01-12. PMID:36635365. |
studies show that a lack of acetylcholine and butyrylcholine due to the overexpression of enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) may lead to reduced communication between neuron cells. |
2023-01-12 |
2023-08-14 |
Not clear |
| Atilla Topcu, Sinan Saral, Aykut Ozturk, Ozlem Saral, Ali Koray Kay. The effect of the calcium channel blocker nimodipine on hippocampal BDNF/Ach levels in rats with experimental cognitive impairment. Neurological research. 2023-01-04. PMID:36598971. |
nimodipine appears to possess the potential to reverse cognitive impairment-induced dysfunction in learning and memory through its regulatory effect on the brain-derived neurotrophic factor (bdnf), acetylcholine (ach), and acetylcholinesterase (ache) pathway in the hippocampus and prefrontal cortex. |
2023-01-04 |
2023-08-14 |
rat |
| Aso Hameed Hasan, Sonam Shakya, Faiq H S Hussain, Sankaranarayanan Murugesan, Subhash Chander, Mohammad Rizki Fadhil Pratama, Shajarahtunnur Jamil, Basundhara Das, Subhrajit Biswas, Joazaizulfazli Jamali. Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids. Journal of biomolecular structure & dynamics. 2023-01-02. PMID:36591704. |
the major enzyme responsible for the hydrolytic breakdown of the neurotransmitter acetylcholine (ach) is acetylcholinesterase (ache). |
2023-01-02 |
2023-08-14 |
Not clear |
| Duraisamy Kempuraj, Eric Zhang, Suneel Gupta, Ramesh C Gupta, Nishant R Sinha, Rajiv R Moha. Carbofuran pesticide toxicity to the eye. Experimental eye research. 2022-12-26. PMID:36572166. |
carbofuran and its two major metabolites (3-hydroxycarbofuran and 3-ketocarbofuran) are reversible inhibitors of acetylcholinesterase (ache) which regulates acetylcholine (ach), a neurohumoral chemical that plays an important role in corneal wound healing. |
2022-12-26 |
2023-08-14 |
human |
| Ashish Patel, Drashti Shah, Yug Patel, Stuti Patel, Meshwa Mehta, Tushar Bambharoliy. A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Current drug targets. 2022-12-14. PMID:36515018. |
acetylcholinesterase (ache) has obtained a renewed interest as a therapeutic target in alzheimer's disease (ad) due to increased neural cells' function by increasing the concentration of acetylcholine. |
2022-12-14 |
2023-08-14 |
Not clear |
| Jesko Kaiser, Christoph G W Gertzen, Tamara Bernauer, Georg Höfner, Karin V Niessen, Thomas Seeger, Franz F Paintner, Klaus T Wanner, Franz Worek, Horst Thiermann, Holger Gohlk. A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment. Toxicology letters. vol 373. 2022-12-12. PMID:36503818. |
organophosphorus compounds (opcs) are highly toxic compounds that can block acetylcholine esterase (ache) and thereby indirectly lead to an overstimulation of muscarinic and nicotinic acetylcholine receptors (nachrs). |
2022-12-12 |
2023-08-14 |
Not clear |
| Modeline Jean-Pierre, Lindsay T Michalovicz, Kimberly A Kelly, James P O'Callaghan, Lubov Nathanson, Nancy Klimas, Travis J A Craddoc. A pilot reverse virtual screening study suggests toxic exposures caused long-term epigenetic changes in Gulf War Illness. Computational and structural biotechnology journal. vol 20. 2022-11-24. PMID:36420170. |
ache inhibition induces an acetylcholine build-up, disrupting signals between nerves and muscles, which in high doses leads to asphyxiation. |
2022-11-24 |
2023-08-14 |
human |