| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qipeng Shi, Huaran Yang, Yangli Chen, Na Zheng, Xiaoyu Li, Xianfeng Wang, Weikai Ding, Bangjun Zhan. Developmental Neurotoxicity of Trichlorfon in Zebrafish Larvae. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446277. |
furthermore, trichlorfon significantly inhibited ache activity, accompanied by decreased acetylcholine, dopamine and serotonin content in larvae. |
2023-07-14 |
2023-08-14 |
zebrafish |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
| Anushree Chandrashekhar Gade, Manikanta Murahari, Parasuraman Pavadai, Maushmi Shailesh Kuma. Virtual Screening of a Marine Natural Product Database for In Silico Identification of a Potential Acetylcholinesterase Inhibitor. Life (Basel, Switzerland). vol 13. issue 6. 2023-06-28. PMID:37374081. |
acetylcholinesterase (ache) hydrolyses acetylcholine and induces amyloid-beta aggregation. |
2023-06-28 |
2023-08-14 |
Not clear |
| Shubhangi Setia, Anjalee Chiwhan. Intermediate Syndrome Due to Organophosphate Poisoning: A Case Report. Cureus. vol 15. issue 5. 2023-06-27. PMID:37362485. |
ache is responsible for breaking down acetylcholine (ach) at the neuromuscular junction into acetic acid and choline. |
2023-06-27 |
2023-08-14 |
Not clear |
| Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. |
for the two major cholinesterases, butyrylcholinesterase (bche) and acetylcholinesterase (ache), increased bche activity observed in individuals with ad has been suggested to deplete acetylcholine levels. |
2023-06-26 |
2023-08-14 |
Not clear |
| Abhinav Anand, Navneet Khurana, Satinder Kaur, Nemat Ali, Abdullah F AlAsmari, Mohammad Waseem, Muzaffar Iqbal, Faris M Alzahrani, Neha Sharm. The multifactorial role of vanillin in amelioration of aluminium chloride and D-galactose induced Alzheimer's disease in mice. European journal of pharmacology. 2023-06-17. PMID:37329974. |
these include oxidative stress, overexpression of acetylcholinesterase (ache), depletion of acetylcholine levels, increased beta-secretase mediated conversion of amyloid precursor protein (app) to amyloid beta (abeta), accumulation of abeta oligomers, decrease in brain derived neurotrophic factor (bdnf) and accelerated neuronal apoptosis due to elevated levels of caspase-3. |
2023-06-17 |
2023-08-14 |
mouse |
| Arunachalam Muthuraman, Muthusamy Ramesh, Fazlina Mustaffa, Ahmed Nadeem, Shamama Nishat, Nallupillai Paramakrishnan, Khian Giap Li. In Silico and In Vitro Methods in the Characterization of Beta-Carotene as Pharmaceutical Material via Acetylcholine Esterase Inhibitory Actions. Molecules (Basel, Switzerland). vol 28. issue 11. 2023-06-11. PMID:37298835. |
the binding properties of beta-carotene (bc) to acetylcholine esterase (ache) proteins were characterized using the molecular docking method. |
2023-06-11 |
2023-08-14 |
zebrafish |
| Lenka Pulkrabkova, Lubica Muckova, Martina Hrabinova, Ales Sorf, Tereza Kobrlova, Petr Jost, Dagmar Bezdekova, Jan Korabecny, Daniel Jun, Ondrej Souku. Differentiated SH-SY5Y neuroblastoma cells as a model for evaluation of nerve agent-associated neurotoxicity. Archives of toxicology. 2023-05-23. PMID:37221426. |
despite a clear mechanism of their lethality caused by the irreversible inhibition of acetylcholinesterase (ache) and manifested via overstimulation of peripheral nicotinic and muscarinic acetylcholine (ach) receptors, the mechanism for central neurotoxicity responsible for acute or delayed symptoms of the poisoning has not been thoroughly uncovered. |
2023-05-23 |
2023-08-14 |
Not clear |
| Hongyan Pei, Lei He, Meiling Shi, Xiangjuan Guo, Weijia Chen, Jianming Li, Zhongmei He, Rui D. PI3K-Akt signaling pathway based on network pharmacology for the anti-Alzheimer's disease effect of licorice stem flavonoids. Aging. vol 15. 2023-05-11. PMID:37166431. |
results: of brain homogenate supernatant assay demonstrated that glycyrrhiza glabra stem and leaf flavonoids had a significant effect on the levels of oxidative indicators superoxide dismutase (sod), catalase (cat), malonaldehyde (mda), acetylcholine (ach), acetylcholinesterase (ache), caspase-3, caspase-9 and serum inflammatory factors tnf-α, il-6 and il-1β. |
2023-05-11 |
2023-08-14 |
mouse |
| Anushree Pant, M Vasundhar. Endophytic fungi: a potential source for drugs against central nervous system disorders. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. 2023-05-10. PMID:37165297. |
acetylcholine esterase (ache) inhibition is frequently used to assess in vitro neuroprotective activity along with cytotoxicity-induced neuronal cell lines. |
2023-05-10 |
2023-08-14 |
Not clear |
| Muslum Gok, Cigdem Cicek, Ebru Bodu. Butyrylcholinesterase in lipid metabolism: A new outlook. Journal of neurochemistry. 2023-05-02. PMID:37129444. |
cholinesterase enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) are traditionally associated with the termination of acetylcholine mediated neural signaling. |
2023-05-02 |
2023-08-14 |
Not clear |
| Yuting Xue, Haotian Zhong, Bin Liu, Shuo Qin, Zhengbo Chen, Kai Li, Lirong Zheng, Xia Zu. Colorimetric identification of multiple terpenoids based on bimetallic FeCu/NPCs nanozymes. Analytical biochemistry. 2023-04-27. PMID:37105389. |
terpenoids act as inhibitors of acetylcholinesterase (ache) and reduce the hydrolysis of acetylcholine (atch), providing insight into establishing a simple and distinct assay for terpenoids. |
2023-04-27 |
2023-08-14 |
Not clear |
| Baihan Zeng, Luming Qi, Sha Wu, Nannan Liu, Jie Wang, Kaidi Nie, Lina Xia, Shuguang Y. Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia. Journal of visualized experiments : JoVE. issue 194. 2023-04-24. PMID:37092814. |
further, integration analysis indicated that the intervention effects were associated with cyp1a1, ache, and mgam, as well as the adjustment of l-kynurenine, corticosterone, acetylcholine, and raffinose, mainly involving tryptophan metabolism pathway. |
2023-04-24 |
2023-08-14 |
mouse |
| Hongxin Zhang, Xuegang Li, Xue Zhou, Pengqi Gong, Yong Zha. U-fiber-based biosensor for temperature-compensated acetylcholine-specific measurement. Optics letters. vol 48. issue 8. 2023-04-14. PMID:37058661. |
label-free detection of acetylcholine (ach) was achieved by immobilizing acetylcholinesterase (ache) on optical fibers. |
2023-04-14 |
2023-08-14 |
Not clear |
| Mohammad Ashafaq, Sohail Hussain, Saeed Alshahrani, Rahimullah Siddiqui, Mohammad Intakhab Alam, Manal Mohamed Elhassan Taha, Yosif Almoshari, Saad S Alqahtani, Abdulmajeed M Jali, Hashim M Aljohan. Neuroprotective Effects of Nano-Curcumin against Cypermethrin Associated Oxidative Stress and Up-Regulation of Apoptotic and Inflammatory Gene Expression in Rat Brains. Antioxidants (Basel, Switzerland). vol 12. issue 3. 2023-03-29. PMID:36978892. |
the toxic effects are supposed to be mediated by modifying the sodium channels, reducing na-k atpase, acetylcholine esterase (ache), and monoamine oxidase (mao). |
2023-03-29 |
2023-08-14 |
rat |
| Wonn Shweyi Thet Tun, Apichart Saenchoopa, Sakda Daduang, Jureerat Daduang, Sirinan Kulchat, Rina Patramano. Electrochemical biosensor based on cellulose nanofibers/graphene oxide and acetylcholinesterase for the detection of chlorpyrifos pesticide in water and fruit juice. RSC advances. vol 13. issue 14. 2023-03-27. PMID:36968027. |
ache is an enzyme that is essential for neurotransmission and catalyzes the conversion of acetylcholine (atch) into thiocholine and acetic acid. |
2023-03-27 |
2023-08-14 |
Not clear |
| Vahulabaranan Rajagopalan, Swethaa Venkataraman, Devi Sri Rajendran, Vaidyanathan Vinoth Kumar, Vaithyanathan Vasanth Kumar, Gayathri Rangasam. Acetylcholinesterase biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine neurotransmitter: A literature review. Environmental research. 2023-03-22. PMID:36948285. |
over the past few decades, acetylcholinesterase (ache) biosensors have emerged as a sensitive and reliable tool for the electrochemical detection of neurotoxic pesticides and acetylcholine. |
2023-03-22 |
2023-08-14 |
human |
| Vahulabaranan Rajagopalan, Swethaa Venkataraman, Devi Sri Rajendran, Vaidyanathan Vinoth Kumar, Vaithyanathan Vasanth Kumar, Gayathri Rangasam. Acetylcholinesterase biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine neurotransmitter: A literature review. Environmental research. 2023-03-22. PMID:36948285. |
this review summarizes the advancements in ache biosensors for electrochemical detection of neurotoxic pesticides and acetylcholine over the past two decades. |
2023-03-22 |
2023-08-14 |
human |
| Jeyaraj Jeyavani, Baskaralingam Vaseehara. Combined toxic effects of environmental predominant microplastics and ZnO nanoparticles in freshwater snail Pomaceae paludosa. Environmental pollution (Barking, Essex : 1987). 2023-03-12. PMID:36907240. |
where alteration in acetylcholine esterase (ache) activity and decreased digestive enzymes (esterase and alkaline phosphatase) activities were observed in both individual and combined exposed groups. |
2023-03-12 |
2023-08-14 |
cat |
| b' Rudolf Vrabec, Gerald Blunden, Lucie Cahl\\xc3\\xadkov\\xc3\\xa. Natural Alkaloids as Multi-Target Compounds towards Factors Implicated in Alzheimer\'s Disease. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901826.' |
the current treatment, based on the cholinergic hypothesis, is only symptomatic and mainly involves the restoration of acetylcholine (ach) levels through the inhibition of acetylcholinesterase (ache). |
2023-03-11 |
2023-08-14 |
Not clear |