| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Zhang, Yu Wang, Donghui Wu, Qilin Zhao, Yaoyao Chen, Yushu Li, Jian Sun, Xiurong Yan. Fluorescent assay for acetylcholinesterase activity and inhibitor screening based on lanthanide organic/inorganic hybrid materials. Analytical methods : advancing methods and applications. 2023-12-20. PMID:38116865. |
it is of great significance for the clinical diagnosis of alzheimer's disease (ad) to achieve the on-site activity evaluation of acetylcholinesterase (ache), the hydrolase of acetylcholine (ach). |
2023-12-20 |
2023-12-23 |
Not clear |
| João P C Veras, Victor L B França, Hernandes F Carvalho, Valder N Freir. Noncovalent binding of carbofuran to acetylcholinesterase from Homo sapiens, Danio rerio, Apis mellifera and Caenorhabditis elegans: Homology modelling, molecular docking and dynamics, and quantum biochemistry description. Chemico-biological interactions. 2023-12-15. PMID:38101596. |
this pesticide is a potent inhibitor of acetylcholinesterase (ache), which acts by preventing the hydrolysis of acetylcholine (ach). |
2023-12-15 |
2023-12-18 |
human |
| Narayanarao Alla, Sujatha Palatheeya, Siva Reddy Challa, Ramakrishna Kakarl. Tangeretin confers neuroprotection, cognitive and memory enhancement in global cerebral ischemia in rats. 3 Biotech. vol 14. issue 1. 2023-12-11. PMID:38074289. |
further, acetylcholine esterase (ache) enzyme activity, acetylcholine (ach), oxidative stress markers (ros, sod, mda, and cat), inflammation (il-6 and tnf-α), and apoptotic markers (cytochrome c, caspase 9, and caspase 3) in bccao rats were measured following tangeretin (5,10, and 20 mg/kg, oral) treatment. |
2023-12-11 |
2023-12-17 |
rat |
| Sneha Hariharan, Smarika Chauhan, Eswar Marcharla, Carlton Ranjith Wilson Alphonse, Rajesh Kannan Rajaretinam, Swamynathan Ganesa. Developmental toxicity and neurobehavioral effects of sodium selenite and selenium nanoparticles on zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). vol 266. 2023-12-09. PMID:38070396. |
the nerve conductions and stimuli responses evaluated through acetylcholine esterase (ache) and cortisol assays, revealed a decrease in the activity in a dose-dependent manner of sodse and sens. |
2023-12-09 |
2023-12-17 |
zebrafish |
| Xiao Shi, Peng Liu, Yanyan Ma, Mingyuan Li, Zhenyu Zhang, Xinyue Zhang, Dahua Shi, Xinxin S. Identification of a 2-phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells. Chemical biology & drug design. 2023-11-27. PMID:38009562. |
acetylcholinesterase (ache) is a serine hydrolase with classical function to degrade acetylcholine and terminate neurotransmission. |
2023-11-27 |
2023-11-29 |
Not clear |
| Pavani K, D S N B K Prasanth, Murthy K R Shadakshara, Sheikh F Ahmad, Ramanjaneyulu Seemaladinne, Mithun Rudrapal, Praveen Kumar Pasal. Citronellal as a Promising Candidate for Alzheimer's Disease Treatment: A Comprehensive Study on In Silico and In Vivo Anti-Acetylcholine Esterase Activity. Metabolites. vol 13. issue 11. 2023-11-25. PMID:37999229. |
one of the primary therapeutic approaches for managing alzheimer's disease (ad) involves the modulation of acetylcholine esterase (ache) activity to elevate acetylcholine (ach) levels inside the brain. |
2023-11-25 |
2023-11-28 |
mouse |
| Showkat Ahmad Mir, Jamoliddin Razzokov, Vishwajeet Mukherjee, Iswar Baitharu, Binata Naya. An exploration of the binding prediction of anatoxin-a and atropine to acetylcholinesterase enzyme using multi-level computer simulations. Physical biology. 2023-11-14. PMID:37963412. |
acetylcholinesterase (ache) is crucial for the breakdown of acetylcholine to acetate and choline, while the inhibition of ache by anatoxin-a (atx-a) results in severe health complications. |
2023-11-14 |
2023-11-20 |
Not clear |
| Leila Vahdatiraad, Behrooz Heidari, Sevda Zarei, Tooraj Sohrabi, Hossein Ghafour. Protective effects of HSP Inducer on diazinon-exposed stellate sturgeon (Acipenser stellatus) fry: Insights on HSP70 gene expression, immune response, and enzyme indices. PloS one. vol 18. issue 11. 2023-11-13. PMID:37956191. |
to achieve this, several factors were analyzed, including the hsp70 gene expression, levels of immunity markers (lysozyme, igm, and c3), antioxidant status, and the activity of acetylcholine esterase (ache). |
2023-11-13 |
2023-11-20 |
cat |
| Ritu, Prakash Chandra, Asmita Da. "Cholinergic side Effect-Free anticancer drugs: paving the way for safer and more effective cancer treatment". Journal of biomolecular structure & dynamics. 2023-10-27. PMID:37885319. |
it appears that irinotecan or its metabolites directly interact with ache and inhibit its role of converting acetylcholine to choline, leading to an accumulation of acetylcholine and subsequent symptoms of the cholinergic syndrome. |
2023-10-27 |
2023-11-08 |
human |
| Sushil K Jain, Jeffrey Justin Margret, Marissa Lall. Positive association of acetylcholine esterase (AChE) with the neutrophil-to-lymphocyte ratio and HbA1c, and a negative association with hydrogen sulfide (H Free radical biology & medicine. 2023-10-22. PMID:37866755. |
positive association of acetylcholine esterase (ache) with the neutrophil-to-lymphocyte ratio and hba1c, and a negative association with hydrogen sulfide (h the incidence of alzheimer's disease (ad) is higher in people over the age of 65 and in african americans (aa). |
2023-10-22 |
2023-11-08 |
Not clear |
| Jia Liu, Wei Ha, Eshbakova Komila Alibekovna, Rui Ma, Yan-Ping Sh. Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO Nanoscale. 2023-10-20. PMID:37860933. |
inhibiting ache is a common strategy for reducing the degradation of neurotransmitter acetylcholine, in order to treat early-stage ad. |
2023-10-20 |
2023-11-08 |
Not clear |
| Yasser I Hamza, Ahmed S Bream, Mohammed A Mahmoud, Mohamed A M El-Tabak. Environmental impacts of industrial activities on floral coverage with special emphasis on detoxification enzyme activities in Cataglyphis savignyi as pollution biomarker. Environmental science and pollution research international. 2023-10-18. PMID:37851257. |
in contrast, ache increases, which might be due to heavy metals enhancing acetylcholine activity at synapses. |
2023-10-18 |
2023-11-08 |
Not clear |
| Omyma Rabie, Heba A S El-Nashar, Mina Y George, Taghreed A Majrashi, Tarfah Al-Warhi, Fatma E Hassan, Wagdy M Eldehna, Nada M Mostaf. Phytochemical profiling and neuroprotective activity of Callistemon subulatus leaves against cyclophosphamide-induced chemobrain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-10-05. PMID:37797461. |
in addition, cse counteracted the effect of cpa on hippocampal acetylcholinesterase (ache) activity enhancing the level of acetylcholine. |
2023-10-05 |
2023-10-07 |
rat |
| Zefei Li, Heyuan Sh. Study on the active ingredients of Shenghui decoction inhibiting acetylcholinesterase based on molecular docking and molecular dynamics simulation. Medicine. vol 102. issue 38. 2023-09-25. PMID:37746985. |
two simulation models (model i and ii) containing ache and acetylcholine (ach) were constructed, in which model ii contained the best-docked ligand. |
2023-09-25 |
2023-10-07 |
Not clear |
| Acharya Balkrishna, Kunal Bhattacharya, Sunil Shukla, Anurag Varshne. Neuroprotection by Polyherbal Medicine Divya-Medha-Vati Against Scopolamine-Induced Cognitive Impairment Through Modulation of Oxidative Stress, Acetylcholine Activity, and Cell Signaling. Molecular neurobiology. 2023-09-14. PMID:37707741. |
it also elevated acetylcholine esterase (ache) activity, and reduced antioxidant (superoxide dismutase and catalase) activity in cortex tissue. |
2023-09-14 |
2023-10-07 |
mouse |
| Xin Wang, Shengyuan Shao, Tianyu Zhang, Qianqian Zhang, Dinglong Yang, Jianmin Zha. Effects of exposure to nanoplastics on the gill of mussels Mytilus galloprovincialis: An integrated perspective from multiple biomarkers. Marine environmental research. vol 191. 2023-09-14. PMID:37708618. |
significant inductions of total antioxidant capacity (t-aoc) and inhibition of acetylcholine (ache) activity were detected after 7 days of ps-nps exposure. |
2023-09-14 |
2023-10-07 |
Not clear |
| Zainabu Majid, Qi Zhang, Zhansen Yang, Huilian Che, Nan Chen. A Multi-Enzyme Cascade Response for the Colorimetric Recognition of Organophosphorus Pesticides Utilizing Core-Shell Pd@Pt Nanoparticles with High Peroxidase-like Activity. Foods (Basel, Switzerland). vol 12. issue 17. 2023-09-09. PMID:37685251. |
their limits are closely monitored since their residual hinders the capability of acetylcholinesterase (ache) and brings out a threatening accumulation of the neurotransmitter acetylcholine (ach), which affects human well-being. |
2023-09-09 |
2023-10-07 |
human |
| Izaz Monir Kamal, Anamika Das, Sanjukta Datta, Kaninika Paul, Sasanka Chakrabarti, Saikat Chakrabarti, Paramita Bhattacharje. A Novel spice-antioxidant-based nano-vehicle as a putative green alternative of synthetic AChE inhibitor drugs. Journal of biomolecular structure & dynamics. 2023-08-28. PMID:37639732. |
the present treatment for alzheimer's disease (ad) involves well known synthetic acetylcholine esterase (ache) inhibitor drugs which besides having short duration of action also have deleterious impact on human health. |
2023-08-28 |
2023-09-07 |
human |
| Aleksandar R Zivkovic, Karsten Schmidt, Stefan Hofer, Thorsten Brenner, Markus A Weigand, Sebastian O Decke. Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis. Biomedicines. vol 11. issue 8. 2023-08-26. PMID:37626609. |
acetylcholinesterase (ache), an enzyme primarily responsible for the hydrolysis of acetylcholine, has been proposed as a potential early indicator of sepsis onset. |
2023-08-26 |
2023-09-07 |
Not clear |
| Shohda A El-Maraghy, Aya Reda, Reham M Essam, Mona A Korta. The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism. Inflammopharmacology. 2023-08-19. PMID:37598127. |
moreover, nobiletin de-escalated hippocampal acetylcholinesterase (ache) activity and enhanced acetylcholine level while halting bace1 and amyloid-β levels. |
2023-08-19 |
2023-09-07 |
mouse |