| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hisashi Inoue, Teruyuki Tachibana, Tomohiro Bito, Jiro Arim. Acetylation of amines and alcohols catalyzed by acetylcholinesterase from Pseudomonas aeruginosa PAO1. Enzyme and microbial technology. vol 165. 2023-02-08. PMID:36753877. |
therefore, we evaluated acetylation of the amine and hydroxyl group by ache, using acetylcholine and ethyl acetate as the acetyl donor. |
2023-02-08 |
2023-08-14 |
Not clear |
| Melvin Selim Atay, Suat Sari, Ebru Bodu. Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase. The protein journal. 2023-01-17. PMID:36648628. |
cholinesterase enzyme family consists of acetylcholinesterase (ache, 3.1.1.7), the major enzyme responsible for hydrolysis of acetylcholine at cholinergic synapses, and butyrylcholinesterase (bche, 3.1.1.8) a detoxification enzyme of plasma. |
2023-01-17 |
2023-08-14 |
human |
| Asma Gholami, Dariush Minai-Tehrani, Leif A Eriksso. In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor. Scientific reports. vol 13. issue 1. 2023-01-12. PMID:36635365. |
studies show that a lack of acetylcholine and butyrylcholine due to the overexpression of enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) may lead to reduced communication between neuron cells. |
2023-01-12 |
2023-08-14 |
Not clear |
| Atilla Topcu, Sinan Saral, Aykut Ozturk, Ozlem Saral, Ali Koray Kay. The effect of the calcium channel blocker nimodipine on hippocampal BDNF/Ach levels in rats with experimental cognitive impairment. Neurological research. 2023-01-04. PMID:36598971. |
nimodipine appears to possess the potential to reverse cognitive impairment-induced dysfunction in learning and memory through its regulatory effect on the brain-derived neurotrophic factor (bdnf), acetylcholine (ach), and acetylcholinesterase (ache) pathway in the hippocampus and prefrontal cortex. |
2023-01-04 |
2023-08-14 |
rat |
| Aso Hameed Hasan, Sonam Shakya, Faiq H S Hussain, Sankaranarayanan Murugesan, Subhash Chander, Mohammad Rizki Fadhil Pratama, Shajarahtunnur Jamil, Basundhara Das, Subhrajit Biswas, Joazaizulfazli Jamali. Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids. Journal of biomolecular structure & dynamics. 2023-01-02. PMID:36591704. |
the major enzyme responsible for the hydrolytic breakdown of the neurotransmitter acetylcholine (ach) is acetylcholinesterase (ache). |
2023-01-02 |
2023-08-14 |
Not clear |
| Duraisamy Kempuraj, Eric Zhang, Suneel Gupta, Ramesh C Gupta, Nishant R Sinha, Rajiv R Moha. Carbofuran pesticide toxicity to the eye. Experimental eye research. 2022-12-26. PMID:36572166. |
carbofuran and its two major metabolites (3-hydroxycarbofuran and 3-ketocarbofuran) are reversible inhibitors of acetylcholinesterase (ache) which regulates acetylcholine (ach), a neurohumoral chemical that plays an important role in corneal wound healing. |
2022-12-26 |
2023-08-14 |
human |
| Ashish Patel, Drashti Shah, Yug Patel, Stuti Patel, Meshwa Mehta, Tushar Bambharoliy. A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Current drug targets. 2022-12-14. PMID:36515018. |
acetylcholinesterase (ache) has obtained a renewed interest as a therapeutic target in alzheimer's disease (ad) due to increased neural cells' function by increasing the concentration of acetylcholine. |
2022-12-14 |
2023-08-14 |
Not clear |
| Jesko Kaiser, Christoph G W Gertzen, Tamara Bernauer, Georg Höfner, Karin V Niessen, Thomas Seeger, Franz F Paintner, Klaus T Wanner, Franz Worek, Horst Thiermann, Holger Gohlk. A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment. Toxicology letters. vol 373. 2022-12-12. PMID:36503818. |
organophosphorus compounds (opcs) are highly toxic compounds that can block acetylcholine esterase (ache) and thereby indirectly lead to an overstimulation of muscarinic and nicotinic acetylcholine receptors (nachrs). |
2022-12-12 |
2023-08-14 |
Not clear |
| Modeline Jean-Pierre, Lindsay T Michalovicz, Kimberly A Kelly, James P O'Callaghan, Lubov Nathanson, Nancy Klimas, Travis J A Craddoc. A pilot reverse virtual screening study suggests toxic exposures caused long-term epigenetic changes in Gulf War Illness. Computational and structural biotechnology journal. vol 20. 2022-11-24. PMID:36420170. |
ache inhibition induces an acetylcholine build-up, disrupting signals between nerves and muscles, which in high doses leads to asphyxiation. |
2022-11-24 |
2023-08-14 |
human |
| Fatima Javed Mirza, Saadia Zahid, Sanila Amber, Sumera, Hira Jabeen, Noreen Asim, Syed Adnan Ali Sha. Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364071. |
multitargeted molecular docking and dynamic simulation studies of bioactive compounds from alzheimer's disease (ad) has been associated with the hallmark features of cholinergic dysfunction, amyloid beta (aβ) aggregation and impaired synaptic transmission, which makes the associated proteins, such as β-site amyloid precursor protein cleaving enzyme 1 (bace i), acetylcholine esterase (ache) and synapsin i, ii and iii, major targets for therapeutic intervention. |
2022-11-11 |
2023-08-14 |
Not clear |
| Lennart V J van Melis, Harm J Heusinkveld, Celine Langendoen, Anouk Peters, Remco H S Westerin. Organophosphate insecticides disturb neuronal network development and function via non-AChE mediated mechanisms. Neurotoxicology. 2022-11-08. PMID:36347328. |
the primary insecticidal mode of action of op insecticides relies on (irreversible) binding to acetylcholine esterase (ache), with -oxon metabolites having a much higher potency for ache inhibition than the parent compounds. |
2022-11-08 |
2023-08-14 |
Not clear |
| Nancy D Asen, Ogadimma D Okagu, Chibuike C Udenigwe, Rotimi E Aluk. Frontiers in nutrition. vol 9. 2022-11-07. PMID:36337665. |
compounds with structural similarities to the neurotransmitter (acetylcholine) are mostly used to inhibit the activity of acetylcholinesterase (ache) in alzheimer's disease (ad) therapy. |
2022-11-07 |
2023-08-14 |
Not clear |
| Mohamed Jawed Ahsan, Amena Ali, Abuzer Ali, Arunkumar Thiriveedhi, Mohammed A Bakht, Mohammad Yusuf, Salahuddin, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamim. Pyrazoline Containing Compounds as Therapeutic Targets for Neurodegenerative Disorders. ACS omega. vol 7. issue 43. 2022-11-07. PMID:36340076. |
pyrazolines were discovered to have beneficial effects in the management of ad and were revealed to be inhibitors of acetylcholine esterase (ache) and beta-amyloid (a |
2022-11-07 |
2023-08-14 |
Not clear |
| Shuling Xu, Min Li, Xia Li, Yanhui Jiang, Linlin Yu, Yue Zhao, Liyuan Wen, Qingwang Xu. Engineering an Ag/Au bimetallic nanoparticle-based acetylcholinesterase SERS biosensor for in situ sensitive detection of organophosphorus pesticide residues in food. Analytical and bioanalytical chemistry. 2022-11-05. PMID:36333614. |
the combination of ache and choline oxidase (cho) can hydrolyze acetylcholine (atch) to generate h |
2022-11-05 |
2023-08-14 |
Not clear |
| Zhikun Zhang, Liu Zhang, Ping Han, Qingju Li. A luminescent probe based on terbium-based metal-organic frameworks for organophosphorus pesticides detection. Mikrochimica acta. vol 189. issue 11. 2022-11-02. PMID:36319758. |
terbium-based metal-organic frameworks (tb-mof) prepared under mild conditions was utilized to construct a fluorescence probe for determination of organophosphorus pesticides (ops) coupled with acetylcholinesterase (ache), acetylcholine chloride (ach), and choline oxidase (cho). |
2022-11-02 |
2023-08-14 |
Not clear |
| Teodorico C Ramalho, Alexandre A de Castro, Daniel H S Leal, Jessika P Teixeira, Elaine Fontes Ferreira de Cunha, Kamil Kuc. Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro data. Current medicinal chemistry. 2022-10-14. PMID:36239718. |
these toxic substances act through the inhibition of the acetylcholinesterase (ache) enzyme, which results in elevated synaptic acetylcholine (ach) levels, leading to serious adverse effects under the cholinergic syndrome. |
2022-10-14 |
2023-08-14 |
Not clear |
| Qiaoya Ma, Chen Li, Ya He, Pan Liu, Fuhua Gong, Wanggang Zhan. Isorhapontigenin prevents β‑amyloid‑associated cognitive impairments through activation of the PI3K/AKT/GSK‑3β pathway. Acta neurobiologiae experimentalis. vol 82. issue 3. 2022-10-10. PMID:36214721. |
aβ1‑42 is significantly associated with memory deficits and it can increase the level of acetylcholine, promote the activity of acetylcholinesterase (ache), and cause cognitive dysfunction. |
2022-10-10 |
2023-08-14 |
rat |
| Mohammad Golam Sabbir, Robert C Speth, Benedict C Albens. Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) Protein in the Hippocampus and Temporal Cortex of a Subset of Individuals with Alzheimer's Disease, Parkinson's Disease, or Frontotemporal Dementia: Implications for Patient Survival. Journal of Alzheimer's disease : JAD. 2022-09-26. PMID:36155524. |
dysfunction of cholinergic neurotransmission is a hallmark of alzheimer's disease (ad); forming the basis for using acetylcholine (ach) esterase (ache) inhibitors to mitigate symptoms of ach deficiency in ad. |
2022-09-26 |
2023-08-14 |
Not clear |
| Fang Wang, Teng Jia, Yu Wang, Haiyuan Hu, Yuying Wang, Li Chang, Xiaojun Shen, Gaisheng Li. Polycyclic aromatic hydrocarbons exposure was associated with microRNA differential expression and neurotransmitter changes: a cross-sectional study in coal miners. Environmental science and pollution research international. 2022-09-26. PMID:36161575. |
compared to the low pah exposure group, the high-exposure group had higher levels of 5-hydroxytryptamine (5-ht), epinephrine (e), and acetylcholine (ach), and lower levels of acetylcholinesterase (ache). |
2022-09-26 |
2023-08-14 |
human |
| Hafiz Muhammad Abdullah Asif, Shagufta Kamal, Aziz-Ur Rehman, Shahid Rasool, Muhammad Sajid Hamid Akas. Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues. ACS omega. vol 7. issue 36. 2022-09-19. PMID:36119993. |
considering the importance of acetylcholine esterase (ache, bche) and α-glucosidase in the treatment of alzheimer's disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (ache), α-glucosidase, urease, lipoxygenase (lox), and butyrylcholinesterase (bche) inhibitors is described. |
2022-09-19 |
2023-08-14 |
Not clear |