| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Ju Choi, Hee Jin Song, Ji Eun Kim, Su Jin Lee, You Jeong Jin, Yu Jeong Roh, Ayun Seol, Hye Sung Kim, Dae Youn Hwan. Dysregulation of the Enteric Nervous System in the Mid Colon of Complement Component 3 Knockout Mice with Constipation Phenotypes. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743302. |
excitatory transmission analysis revealed similar suppression of the 5-hydroxytryptamine (5-ht) concentration, expression of 5-ht receptors, acetylcholine (ach) concentration, ach esterase (ache) activity, and expression of muscarinic ach receptors (machrs), despite the machrs downstream signaling pathway being activated in the mid colon of c3 ko mice. |
2022-06-24 |
2023-08-14 |
mouse |
| Grażyna Budryn, Iwona Majak, Joanna Grzelczyk, Dominik Szwajgier, Alejandro Rodríguez-Martínez, Horacio Pérez-Sánche. Hydroxybenzoic Acids as Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745206. |
one of the symptoms of alzheimer's disease (ad) is low acetylcholine level due to high acetylcholinesterase (ache) activity. |
2022-06-24 |
2023-08-14 |
Not clear |
| Martina Bortolami, Fabiana Pandolfi, Valeria Tudino, Antonella Messore, Valentina Noemi Madia, Daniela De Vita, Roberto Di Santo, Roberta Costi, Isabella Romeo, Stefano Alcaro, Marisa Colone, Annarita Stringaro, Alba Espargaró, Raimon Sabatè, Luigi Scipion. Design, Synthesis, and In Vitro, In Silico and In Cellulo Evaluation of New Pyrimidine and Pyridine Amide and Carbamate Derivatives as Multi-Functional Cholinesterase Inhibitors. Pharmaceuticals (Basel, Switzerland). vol 15. issue 6. 2022-06-24. PMID:35745594. |
the standard approach is represented by the cholinesterase inhibitors (cheis) that restore the levels of acetylcholine (ach) by inhibiting the acetylcholinesterase (ache). |
2022-06-24 |
2023-08-14 |
Not clear |
| Ahlam G Khalifa, Walaa A Moselhy, Hanaa M Mohammed, Fatma Khalil, Mohamed Shaban, El-Shaymaa El-Nahass, Hessah Mohammed Al-Muzafar, Kamal Adel Amin, Khaled A Abdo. Deltamethrin and Its Nanoformulations Induce Behavioral Alteration and Toxicity in Rat Brain through Oxidative Stress and JAK2/STAT3 Signaling Pathway. Toxics. vol 10. issue 6. 2022-06-23. PMID:35736911. |
in addition, brain antioxidant/oxidant, serum neurotransmitters such as acetylcholine esterase (ache) and monoamine oxidase (mao), jak2 and stat3 gene and proteins expression were measured. |
2022-06-23 |
2023-08-14 |
rat |
| Deniz Kantar, Alev Duygu Acun, Betül Danışma. Effects of thymoquinone on scopolamine-induced spatial and echoic memory changes through regulation of lipid peroxidation and cholinergic impairment. Behavioural brain research. 2022-06-19. PMID:35718231. |
then, the brain homogenates content of thiobarbituric-acid-reactive-substances (tbars), 4-hydroxy-2-nonenal (4-hne) and acetylcholine (ach)/acetylcholine (ache) activity were biochemically determined. |
2022-06-19 |
2023-08-14 |
rat |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. |
2022-06-15 |
2023-08-14 |
Not clear |
| Xiao-Ping Zhang Wang Xu Yang Shu, Jian-Hua Wan. CoOOH nanosheets ensure ratiometric fluorescence assay of acetylcholinesterase. Talanta. vol 249. 2022-06-14. PMID:35700646. |
the acetylcholine (atch) was catalytically hydrolyzed by ache to enzymatic thiocholine (tch), which decomposed coooh to co |
2022-06-14 |
2023-08-14 |
Not clear |
| Asaad Khalid, Mohnad Abdalla, Maria Saeed, Muhammad Nabeel Ghayur, Surya Kant Kalauni, Mohammed Albratty, Hassan A Alhazmi, Mohammed Ahmed Mesaik, Anwarul Hassan Gilani, Zaheer Ul-Ha. Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations. Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684298. |
ache plays an essential role in the nervous system by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2022-06-10 |
2023-08-14 |
Not clear |
| Nupur Vasdev, Mayank Handa, Prashant Kesharwani, Rahul Shukl. Rosemary oil low energy nanoemulsion: Optimization, µrheology, Journal of biomaterials science. Polymer edition. 2022-06-10. PMID:35686513. |
acetylcholinesterase (ache) inhibitors prevent the lysis of acetylcholine in the brain and prevent dementia. |
2022-06-10 |
2023-08-14 |
human |
| Yan-Ling Su, Dong Liu, Yao-Jie Liu, Yang-Lin Ji, Gui-Shan Liu, Ji-Li-Te Wang, Biao Wang, Hao Wan. Phlorizin alleviates cholinergic memory impairment and regulates gut microbiota in d-galactose induced mice. Experimental gerontology. 2022-06-06. PMID:35660419. |
furthermore, a neurotransmitter of acetylcholine (ach) was enhanced, while acetylcholinesterase (ache) activity was inhibited by phlorizin administration. |
2022-06-06 |
2023-08-14 |
mouse |
| Jatinder Dhaliwal, Navneet Dhaliwal, Ansab Akhtar, Anurag Kuhad, Kanwaljit Chopr. Tetramethylpyrazine Attenuates Cognitive Impairment Via Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis in Type 2 Diabetic Rats. Neurochemical research. 2022-06-06. PMID:35665448. |
acetylcholinesterase (ache) and choline acetytransferase (chat) activity, acetylcholine (ach) levels, oxidative stress, apoptotic (bcl-2, bax, caspase-3), and inflammatory markers (tnf-α, il-1β, and nf-kβ) were assessed. |
2022-06-06 |
2023-08-14 |
rat |
| Masato Mashimo, Koichiro Kawashima, Takeshi Fuji. Non-neuronal Cholinergic Muscarinic Acetylcholine Receptors in the Regulation of Immune Function. Biological & pharmaceutical bulletin. vol 45. issue 6. 2022-06-01. PMID:35650095. |
immune cells such as t and b cells, monocytes and macrophages all express most of the cholinergic components of the nervous system, including acetylcholine (ach), choline acetyltransferase (chat), high affinity choline transporter, muscarinic and nicotinic ach receptors (machrs and nachrs, respectively), and acetylcholinesterase (ache). |
2022-06-01 |
2023-08-13 |
Not clear |
| Kritika Kumari, Laishram R Sing. Trimethylamine N-oxide might impair cholinergic system by affecting the structural integrity of Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555536. |
acetylcholinesterase (ache) is an important enzyme responsible for the breakdown of neurotransmitter, acetylcholine and therefore plays a crucial role in neuronal plasticity. |
2022-05-13 |
2023-08-13 |
human |
| Piyali Dasgupta, Stephen D Richbart, Austin T Akers, Jamie R Friedman, Sarah L Miles, Eric W Bow, John M Rimoldi, Yi Charlie Che. The choline acetyltransferase inhibitor BW813U inhibits angiogenesis and tumor growth in human lung adenocarcinoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555890. |
these include choline acetyl transferase enzyme (chat), vesicular acetylcholine transporter (vacht), acetylcholine esterase (ache) and choline transporter (cht). |
2022-05-13 |
2023-08-13 |
mouse |
| Khadija Boukholda, Brahim Gargouri, Bakhta Aouey, Abdelraheim Attaai, Mohamed Abd Elkodous, Mohamed Najimi, Bernd L Fiebich, Michèle Bouchard, Hamadi Fetou. Subacute silica nanoparticle exposure induced oxidative stress and inflammation in rat hippocampus combined with disruption of cholinergic system and behavioral functions. NanoImpact. vol 24. 2022-05-13. PMID:35559817. |
in addition, sinps significantly increased mrna expression level of genes related to inflammation (tnf-α, il-1β, il-6, and cox-2) and decreased mrna expression level of genes related to cholinergic system including choline acetyltransferase (chat), vesicular acetylcholine transporter (vacht), ache, muscarinic acetylcholine receptor m1 (m1achr) and nicotinic acetylcholine receptors (nachr). |
2022-05-13 |
2023-08-13 |
rat |
| Aishwarya Sriraman, Hannah Lee, C L Cadieu. Effects of Both Inherent Chemical Structure and Environment Conditions on the Enzyme-Small Molecule Relationship of a Non-Oxime Reactivator of Organophosphorus-Inhibited Human Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560488. |
organophosphorus (op) nerve agents and pesticides inhibit the enzyme acetylcholinesterase (ache) via a covalent interaction at the active site, resulting in a buildup of excess acetylcholine in the synaptic cleft. |
2022-05-13 |
2023-08-13 |
human |
| Tatsuro Saito, Yasutaka Nishida, Miyuki Tabata, Atsunobu Isobayashi, Hideyuki Tomizawa, Yuji Miyahara, Yoshiaki Sugizak. Molecular Interactions between an Enzyme and Its Inhibitor for Selective Detection of Limonene. Analytical chemistry. 2022-05-11. PMID:35543317. |
in these simulations, limonene was found to be captured at specific binding sites of ache by modifying the binding site of acetylcholine (ach), which induced inhibition of the catalytic activity of ache toward ach hydrolysis. |
2022-05-11 |
2023-08-13 |
Not clear |
| Mohadeseh Kalari, Zeinab Abbasi, Marzieh Dehghan Shasaltaneh, Ali Khaleghian, Zahra Moosavi-Neja. A Cobalt-Containing Compound as a Stronger Inhibitor than Galantamine to Inhibit Acetylcholinesterase Activity: A New Drug Candidate for Alzheimer's Disease Treatment. Journal of Alzheimer's disease : JAD. 2022-05-09. PMID:35527546. |
acetylcholinesterase (ache) regulates the transmission of neural messages by hydrolyzing acetylcholine in synaptic spaces. |
2022-05-09 |
2023-08-13 |
Not clear |
| Vasudevan Mani, Minhajul Arfeen, Sultan Sajid, Yasser Almogbe. Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain cholinergic transmission. Saudi journal of biological sciences. vol 29. issue 4. 2022-05-09. PMID:35531250. |
acetylcholine (ach) and acetylcholinesterase (ache) levels were estimated from brain homogenates to assess cholinergic transmission. |
2022-05-09 |
2023-08-13 |
rat |
| Bo-Yu Zhang, Xiao-Min Luo, Yi Ding, Bin Yang, Han-Yun Que, Rui Tan, Pu-Yang Gong, Jian G. [Mechanism of Tibetan medicine Ershiwuwei Shanhu Pills on scopolamine-induced learning and memory impairment in mice based on Keap1/Nrf2/HO-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 8. 2022-05-09. PMID:35531724. |
the expression of neuron specific nuclear protein(neun) in hippocampus and cortex of mice was determined by immunofluorescence assay, and the content of acetylcholine(ach) and the activity of acetylcholines-terase(ache) in hippocampus of mice by kits. |
2022-05-09 |
2023-08-13 |
mouse |