| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isaac Omwenga, Shensheng Zhao, Laetitia Kanja, Hans Mol, Ivonne M C M Rietjens, Jochem Louiss. Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry. Archives of toxicology. vol 95. issue 4. 2021-11-03. PMID:33651127. |
organophosphate pesticides (ops) are known to inhibit acetylcholine esterase (ache), a critical effect used to establish health-based guidance values. |
2021-11-03 |
2023-08-13 |
human |
| Edward C Meek, Russell L Carr, Janice E Chamber. In vitro age-related differences in rats to organophosphates. Toxicology in vitro : an international journal published in association with BIBRA. vol 72. 2021-10-22. PMID:33497710. |
the mechanism of toxic action for organophosphates (ops) is the persistent inhibition of acetylcholinesterase (ache) resulting in accumulation of acetylcholine and subsequent hyperstimulation of the nervous system. |
2021-10-22 |
2023-08-13 |
rat |
| Qiyun Wu, Panzhu Bai, Yingjie Xia, Queenie W S Lai, Maggie S S Guo, Kun Dai, Zhongyu Zheng, Christine S J Ling, Tina T X Dong, Rongbiao Pi, Karl W K Tsi. Solar light induces expression of acetylcholinesterase in skin keratinocytes: Signalling mediated by activator protein 1 transcription factor. Neurochemistry international. vol 141. 2021-10-18. PMID:33038610. |
acetylcholinesterase (ache) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. |
2021-10-18 |
2023-08-13 |
Not clear |
| Namrita Halder, Girdhari La. Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity. Frontiers in immunology. vol 12. 2021-10-14. PMID:33936095. |
the cholinergic system includes the neurotransmitter\ molecule, acetylcholine (ach), cholinergic receptors (achrs), choline acetyltransferase (chat) enzyme, and acetylcholinesterase (ache) enzyme. |
2021-10-14 |
2023-08-13 |
Not clear |
| Eng Leng Saw, James T Pearson, Daryl O Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J A Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katar. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular diabetology. vol 20. issue 1. 2021-10-05. PMID:33618724. |
recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (nncs) that comprises of choline acetyltransferase (chat), choline transporter 1 (cht1), vesicular acetylcholine transporter (vacht), acetylcholinesterase (ache) and type-2 muscarinic ach receptors (m |
2021-10-05 |
2023-08-13 |
Not clear |
| Ahsaan Ahmed, Shamim Akhtar, Nousheen Mushtaq, Shazia Haider, Rabya Munawar, Hassaan Ahmed Siddique, Arifa Akram, Zafar Saeed Saify, Muhammad Ari. 1,3-di-4-piperidylpropane derivatives as potential acetyl cholinesterase antagonists: Molecular docking, synthesis, and biological evaluation. Pakistan journal of pharmaceutical sciences. vol 34. issue 3. 2021-10-04. PMID:34602406. |
acetylcholine esterase (ache) is a key biological target responsible for the management of cholinergic transmission, and its inhibitors are used for the therapy of alzheimer's disease. |
2021-10-04 |
2023-08-13 |
Not clear |
| Thomson Patrick Joseph, Fang Zhou, Liu Yang Sai, Hanyu Chen, Stanley Li Lin, Melitta Schachne. Duloxetine ameliorates valproic acid-induced hyperactivity, anxiety-like behavior, and social interaction deficits in zebrafish. Autism research : official journal of the International Society for Autism Research. 2021-10-04. PMID:34605202. |
asd-like elevated acetylcholine esterase (ache) activity and reduced akt-mtor signaling was observed in zebrafish whole brain. |
2021-10-04 |
2023-08-13 |
zebrafish |
| Donald A Godfrey, Lissette Carlson, Jami L Park, C David Ros. Enzymes of acetylcholine metabolism in the rat inferior colliculus. Brain research. vol 1766. 2021-09-21. PMID:33991492. |
we have used microdissection of freeze-dried sections combined with radiometric assays to map the distributions in the rat inferior colliculus of the activities of choline acetyltransferase (chat), which catalyzes synthesis of acetylcholine, and acetylcholinesterase (ache), which catalyzes its breakdown by hydrolysis. |
2021-09-21 |
2023-08-13 |
rat |
| Oksana Gerlits, Matthew P Blakeley, David A Keen, Zoran Radić, Andrey Kovalevsk. Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure. Current research in structural biology. vol 3. 2021-09-21. PMID:34541552. |
acetylcholinesterase (ache) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. |
2021-09-21 |
2023-08-13 |
human |
| Oksana Gerlits, Matthew P Blakeley, David A Keen, Zoran Radić, Andrey Kovalevsk. Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure. Current research in structural biology. vol 3. 2021-09-21. PMID:34541552. |
the active center geometry of ache, already highly evolved for the efficient catalysis, was thus indicative of only minor conformational adjustments to accommodate the tetrahedral intermediate in the hydrolysis of the neurotransmitter acetylcholine (ach). |
2021-09-21 |
2023-08-13 |
human |
| Motahareh Hassanzadeh, Farshid Hassanzadeh, Ghadam Ali Khodarahmi, Mahbobe Rostami, Fateme Azimi, Hamid Nadri, Farshad Homayouni Moghada. Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase. Research in pharmaceutical sciences. vol 16. issue 5. 2021-09-16. PMID:34522196. |
a significant decrease in acetylcholine level in the brain is common in most patients with alzheimer's disease, therefore acetylcholinesterase (ache) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. |
2021-09-16 |
2023-08-13 |
Not clear |
| Stephen D Richbart, Justin C Merritt, Nicholas A Nolan, Piyali Dasgupt. Acetylcholinesterase and human cancers. Advances in cancer research. vol 152. 2021-09-13. PMID:34353435. |
the enzyme acetylcholinesterase (ache) is a serine hydrolase whose primary function is to degrade acetylcholine (ach) and terminate neurotransmission. |
2021-09-13 |
2023-08-13 |
human |
| Paula Moyano, José Manuel García, Jimena García, Adela Pelayo, Pilar Muñoz-Calero, María Teresa Frejo, Maria Jose Anadon, Maria Victoria Naval, Andrea Flores, Vega Alejandra Mirat, Javier Del Pin. Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt/β-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 152. 2021-09-06. PMID:33930485. |
our results show that cpf (0.01-100 μm), following one-day and fourteen-days treatment, respectively, induced ros generation and lipid peroxidation, and acetylcholine accumulation due to ache inhibition, wnt/β-catenin up- or downregulation depending on the cpf treatment concentration, and ache-r and ache-s overexpression, with the latter being mediated through gsk-3β activity alteration. |
2021-09-06 |
2023-08-13 |
human |
| Alaa Alachkar, Mohamed Lotfy, Ernest Adeghate, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sade. Ameliorating effects of histamine H3 receptor antagonist E177 on acute pentylenetetrazole-induced memory impairments in rats. Behavioural brain research. vol 405. 2021-09-02. PMID:33626390. |
were evaluated on acute pentylenetetrazole (ptz)-induced memory impairments, oxidative stress levels (glutathione (gsh), malondialdehyde (mda), catalase (cat), and superoxide dismutase (sod)), various brain neurotransmitters (histamine (ha), acetylcholine (ach), γ-aminobutyric acid (gaba)), and glutamate (glu), acetylcholine esterase (ache) activity, and c-fos protein expression in rats. |
2021-09-02 |
2023-08-13 |
rat |
| Yue Zhao, Yifei Dong, Qi Ge, Pengbo Cui, Na Sun, Songyi Li. Neuroprotective effects of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cell damage through enhancing energy metabolism and upregulation of the PKA/BDNF/NGF signaling pathway. Food & function. vol 12. issue 17. 2021-09-02. PMID:34259275. |
ndeelnk exerted the neuroprotective effect by improving the acetylcholine (ach) level and reducing the acetylcholinesterase (ache) activity in pc12 cells. |
2021-09-02 |
2023-08-13 |
Not clear |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |
| Spencer W Todd, Eric W Lumsden, Yasco Aracava, Jacek Mamczarz, Edson X Albuquerque, Edna F R Pereir. Gestational exposures to organophosphorus insecticides: From acute poisoning to developmental neurotoxicity. Neuropharmacology. vol 180. 2021-08-27. PMID:32814088. |
their broad-spectrum insecticidal effectiveness is accounted for by the irreversible inhibition of acetylcholinesterase (ache), the enzyme that catalyzes acetylcholine (ach) hydrolysis, in the nervous system of insects. |
2021-08-27 |
2023-08-13 |
Not clear |
| Xiao Chen, Min Zhang, Mukhtar Ahmed, Krishna Mohan Surapaneni, Vishnu Priya Veeraraghavan, Palanisamy Arulselva. Neuroprotective effects of ononin against the aluminium chloride-induced Alzheimer's disease in rats. Saudi journal of biological sciences. vol 28. issue 8. 2021-08-07. PMID:34354404. |
the acetylcholine esterase (ache) activity was studied by standard method. |
2021-08-07 |
2023-08-13 |
rat |
| Chonny Herrera-Acevedo, Camilo Perdomo-Madrigal, Kenyi Herrera-Acevedo, Ericsson Coy-Barrera, Luciana Scotti, Marcus Tullius Scott. Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database. Molecular diversity. vol 25. issue 3. 2021-08-06. PMID:34132933. |
the enzyme acetylcholinesterase (ache) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. |
2021-08-06 |
2023-08-13 |
Not clear |
| Jiska Kentrop, Vladimir Savransky, Steven D Klaassen, Tomas van Groningen, Sara Bohnert, Alex S Cornelissen, Laura Cochrane, John Barry, Marloes J A Joose. Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model. Regulatory toxicology and pharmacology : RTP. vol 119. 2021-08-05. PMID:33212192. |
organophosphates (ops) irreversibly inhibit ache, the enzyme responsible for termination of acetylcholine signal transduction. |
2021-08-05 |
2023-08-13 |
Not clear |