| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ann-Cathrin Haigis, Richard Ottermanns, Andreas Schiwy, Henner Hollert, Jessica Legrad. Getting more out of the zebrafish light dark transition test. Chemosphere. 2022-02-06. PMID:35124091. |
as a proof of principle 5-day old zebrafish (danio rerio) eleutheroembryos exposed to either endocrine disruptors (ed's) or acetylcholine esterase (ache) inhibitors were investigated. |
2022-02-06 |
2023-08-13 |
zebrafish |
| Xian-Tao L. Alzheimer's disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels. Metabolic brain disease. 2022-01-31. PMID:35098414. |
to enhance the declined level of acetylcholine (ach) resulting from loss of cholinergic neurons, acetylcholinesterase (ache) inhibitors are developed and successfully approved for ad treatment in the clinic, with a limited therapeutic effectiveness. |
2022-01-31 |
2023-08-13 |
Not clear |
| Ankit Ganeshpurkar, Ravi Singh, Devendra Kumar, Pravin Gore, Shalini Shivhare, Divya Sardana, Swetha Rayala, Ashok Kumar, Sushil Kumar Sing. Identification of sulfonamide based butyrylcholinesterase inhibitors through scaffold hopping approach. International journal of biological macromolecules. 2022-01-29. PMID:35090939. |
butyrylcholinesterase (bche), a hydrolytic enzyme, is responsible for the termination of the action of acetylcholine besides acetylcholinesterase (ache) in the synaptic cleft of the brain. |
2022-01-29 |
2023-08-13 |
Not clear |
| Mayada R Farag, Mahmoud Alagawany, Attia A A Moselhy, Enas N Said, Tamer A Ismail, Alessandro Di Cerbo, Nicola Pugliese, Mona M Ahme. The Neonicotinoid Thiacloprid Interferes with the Development, Brain Antioxidants, and Neurochemistry of Chicken Embryos and Alters the Hatchling Behavior: Modulatory Potential of Phytochemicals. Biology. vol 11. issue 1. 2022-01-21. PMID:35053072. |
th also decreased the brain level of monoamines and amino acid neurotransmitters and decreased the activities of acetylcholine esterase (ache) and na |
2022-01-21 |
2023-08-13 |
chicken |
| Y Cañizares-Carmenate, N-H Nam, R Díaz-Amador, N T Thuan, P T P Dung, F Torrens, H Pham-The, F Perez-Gimenez, J A Castillo-Gari. Ligand-based discovery of new potential acetylcholinesterase inhibitors for Alzheimer's disease treatment. SAR and QSAR in environmental research. 2022-01-20. PMID:35048766. |
finally, the model was used to predict ache inhibition by a group of quinazolinones and benzothiadiazine 1,1-dioxides obtained by chemical synthesis, resulting in 14 drug candidates with in silico activity comparable to acetylcholine. |
2022-01-20 |
2023-08-13 |
Not clear |
| Asmaa Magdy Zaazaa, Bosy Azmy Abd El-Motelp, Naglaa A Ali, Ahmed M Youssef, Mohamed Aly Sayed, Safaa H Mohame. Stem cell-derived exosomes and copper sulfide nanoparticles attenuate the progression of neurodegenerative disorders induced by cadmium in rats. Heliyon. vol 8. issue 1. 2022-01-14. PMID:35028441. |
however, the activities of each acetylcholine (ach), acetylcholinesterase (ache), total antioxidant status (tac) were measured. |
2022-01-14 |
2023-08-13 |
rat |
| Wei Li, Yikun Qi, Chuan Gao, Yucan Liu, Jinming Dua. A sensitive approach for screening acetylcholinesterase inhibition of water samples using ultra-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1190. 2022-01-14. PMID:35030473. |
a sensitive assay was developed to evaluate inhibitory effects of aqueous solution on acetylcholinesterase (ache) activity via measuring hydrolysis rates of acetylcholine (ach) based on ultra-performance liquid chromatography-tandem mass spectrometry (uplc-ms/ms). |
2022-01-14 |
2023-08-13 |
Not clear |
| Mingxian Lan, Xi Gao, Xiuan Duan, Hongmei Li, Hang Yu, Jinliang Li, Yueqin Zhao, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Guoxing W. Nematicidal activity of tirotundin and parthenolide isolated from Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2022-01-05. PMID:34983315. |
nematicidal activity of tirotundin and parthenolide isolated from acetylcholinesterase (ache) is an enzyme that catalyzes acetylcholine into choline and acetic acid. |
2022-01-05 |
2023-08-13 |
Not clear |
| Mohammad Reza Safdari, Farzaneh Shakeri, Ameneh Mohammadi, Bahram Bibak, Peiman Alesheikh, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebka. Role of Herbal Medicines in the Management of Brain Injury. Advances in experimental medicine and biology. vol 1328. 2022-01-04. PMID:34981485. |
the different mechanisms for improvement in brain injury by these medicinal plants include hif-1 (hypoxia-inducible factor 1) signaling, free-radical scavenging, reduction of nitric oxide (no) toxicity and acetylcholine esterase (ache) activity, decrease of pakt and its downstream targets, downregulation of the aquaporin-4 (aqp-4) and tlr4/nf-ĸb/tnf-α signal, reduction in malondialdehyde and no levels, increasing neuronal density in the hippocampus, and inhibition of oxidative stress. |
2022-01-04 |
2023-08-13 |
Not clear |
| Camila Fabiani, Brunella Biscussi, Juan Pablo Munafo, Ana Paula Murray, Jeremias Corradi, Silvia Susana Antollin. Molecular pharmacology. 2021-12-31. PMID:34969831. |
since cholinergic deficit is a major factor in this disease, two molecular targets for its treatment are the acetylcholinesterase (ache) and the nicotinic acetylcholine receptors (nachrs). |
2021-12-31 |
2023-08-13 |
Not clear |
| Sultan Alshehri, Syed Sarim Ima. Rosinidin Attenuates Lipopolysaccharide-Induced Memory Impairment in Rats: Possible Mechanisms of Action Include Antioxidant and Anti-Inflammatory Effects. Biomolecules. vol 11. issue 12. 2021-12-24. PMID:34944391. |
the biochemical assessment was carried out of acetylcholine esterase (ache), endogenous antioxidants (gsh, sod, gpx, and catalase), oxidative stress marker mda, neuroinflammatory markers (il-6, il-1β, tnf-α, and nf-κb), and bdnf. |
2021-12-24 |
2023-08-13 |
rat |
| Venkatesh Gunasekaran, Jinu Avarachan, Anitta Augustine, Abdul Khayum, Arivukkarasu . 3-O-Acetyl-11-keto-β-boswellic acid ameliorates acquired, consolidated and recognitive memory deficits through the regulation of hippocampal PPAR γ, MMP9 and MMP2 genes in dementia model. Heliyon. vol 7. issue 12. 2021-12-20. PMID:34926858. |
akba administration diminished the acetylcholine esterase (ache) activity and preserved brain gaba and glutamate mediated neuronal excitability. |
2021-12-20 |
2023-08-13 |
rat |
| Muhammad Musaddiq Shah, Wen Ren, Joseph Irudayaraj, Abdulrahim A Sajini, Muhammad Ishtiaq Ali, Bashir Ahma. Colorimetric Detection of Organophosphate Pesticides Based on Acetylcholinesterase and Cysteamine Capped Gold Nanoparticles as Nanozyme. Sensors (Basel, Switzerland). vol 21. issue 23. 2021-12-10. PMID:34884060. |
the detection assay was performed by stepwise addition of ache, parathion ethyl (pe)-a candidate op, acetylcholine chloride (ach), c-aunps, and 3, 3', 5, 5'-tetramethylbenzidine (tmb) in the buffer solution. |
2021-12-10 |
2023-08-13 |
Not clear |
| Sumei Wang, Qian Zhao, Gaochun Li, Mengwei Wang, Hongliang Liu, Xingchen Yu, Jingwen Chen, Pei Li, Lixin Dong, Guoyu Zhou, Yushan Cui, Mengru Wang, Li Liu, Aiguo Wan. The cholinergic system, intelligence, and dental fluorosis in school-aged children with low-to-moderate fluoride exposure. Ecotoxicology and environmental safety. vol 228. 2021-12-07. PMID:34808511. |
cholinergic system was assessed by the detection of choline acetyltransferase (chat), acetylcholinesterase (ache) and acetylcholine (ach) levels in serum. |
2021-12-07 |
2023-08-13 |
Not clear |
| Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. |
bche plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (ache) through hydrolyzing acetylcholine (ach). |
2021-12-04 |
2023-08-13 |
Not clear |
| Ryohei Tanaka-Kanegae, Koichiro Hamad. A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents. PloS one. vol 16. issue 10. 2021-11-30. PMID:34637466. |
cholinergic neurons utilize choline (ch) to synthetize acetylcholine (ach) and contain a high-affinity ch transporter, ch acetyltransferase (chat), ach receptors, and acetylcholinesterase (ache). |
2021-11-30 |
2023-08-13 |
Not clear |
| Bala Murali Krishna Vasamsetti, Kyongmi Chon, Juyeong Kim, Jin-A Oh, Chang-Young Yoon, Hong-Hyun Par. Transcriptome-Based Identification of Genes Responding to the Organophosphate Pesticide Phosmet in Genes. vol 12. issue 11. 2021-11-30. PMID:34828343. |
opps exert their neurotoxic effects by inhibiting acetylcholine esterase (ache). |
2021-11-30 |
2023-08-13 |
zebrafish |
| Sílvia Chaves, Katalin Várnagy, M Amélia Santo. Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity. Current medicinal chemistry. vol 28. issue 35. 2021-11-25. PMID:33602068. |
currently available drugs are used, mainly to compensate the decline of the neurotransmitter acetylcholine by acetylcholinesterase (ache) inhibition, though they only provide temporary symptomatic benefits and cannot stop ad progression. |
2021-11-25 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
acetylcholinesterase (ache), hydrolase enzyme, regulates the hydrolysis of acetylcholine neurotransmitter in the neurons. |
2021-11-23 |
2023-08-13 |
Not clear |
| Tri Yuliani, Sebastian Lobentanzer, Jochen Klei. Central cholinergic function and metabolic changes in streptozotocin-induced rat brain injury. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33448390. |
high-affinity choline uptake, choline acetyltransferase, and acetylcholine esterase (ache) activities in the hippocampus were reduced by 16%, 28%, and 30%, respectively. |
2021-11-17 |
2023-08-13 |
rat |