| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiyun Wu, Yiteng Xia, Kun Dai, Panzhu Bai, Kenneth K L Kwan, Maggie S S Guo, Tina T X Dong, Karl W K Tsi. Solar light induces the release of acetylcholine from skin keratinocytes affecting melanogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 7. 2021-03-01. PMID:32519787. |
the expression levels of choline acetyltransferase (chat), acetylcholinesterase (ache), vesicular acetylcholine transporter (vacht), and synaptophysin, were upregulated during differentiation of keratinocytes. |
2021-03-01 |
2023-08-13 |
human |
| Agnieszka Zagórska, Anna Jaromi. Perspectives for New and More Efficient Multifunctional Ligands for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland). vol 25. issue 15. 2021-03-01. PMID:32717806. |
herein, we highlight major targets associated with ad, ranging from acetylcholine esterase (ache), beta-site amyloid precursor protein cleaving enzyme 1 (bace-1), glycogen synthase kinase 3 beta (gsk-3β), |
2021-03-01 |
2023-08-13 |
Not clear |
| Xiaohe Luo, Marianne Lauwers, Paul G Layer, Chunyi We. Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration. Frontiers in cell and developmental biology. vol 8. 2021-02-16. PMID:33585459. |
acetylcholinesterase (ache), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. |
2021-02-16 |
2023-08-13 |
Not clear |
| Omowumi T Kayode, Damilare E Rotimi, Tomilola D Olaolu, Oluyomi Stephen Adeyem. Ketogenic diet improves and restores redox status and biochemical indices in monosodium glutamate-induced rat testicular toxicity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-02-11. PMID:32434144. |
in the pre-treatment, the administration of msg resulted in a significant (p < 0.05) decrease in the testis-body weight ratio, alkaline phosphatase (alp), acetylcholine esterase (ache), cholesterol, triglycerides (tg), nitric oxide (no), glycogen, protein and antioxidant enzymes in the testis. |
2021-02-11 |
2023-08-13 |
rat |
| Sukesh Narayan Sinha, Kumpati Rajesh Kumar, Ramakrishna Ungarala, Dileshwar Kumar, Abhijeet Deshpande, K Vasudev, Naveen Kumar Boiroju, Amrisha Singh, R Pandu Naik, Sunil Pokharaka. Toxicokinetic analysis of commonly used pesticides using data on acute poisoning cases from Hyderabad, South India. Chemosphere. vol 268. 2021-02-10. PMID:33485672. |
organophosphorus pesticides (ops) interfere with the activity of acetylcholinesterase (ache), a vital enzyme that regulates the functioning of the nervous system, resulting in acetylcholine (ach) accumulation at the synapses and myoneural junctions. |
2021-02-10 |
2023-08-13 |
human |
| İrem Bozbey, Zeynep Özdemir, Harun Uslu, Azime Berna Özçelik, Fatma Sezer Şenol, İlkay Erdoğan Orhan, Mehtap Uysa. A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies. Mini reviews in medicinal chemistry. vol 20. issue 11. 2021-02-02. PMID:31660824. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach), which is a significant neurotransmitter for regulation of cognition in animals. |
2021-02-02 |
2023-08-13 |
Not clear |
| Tomoyo Horio, Aisa Ozawa, Junichi Kamiie, Motoharu Sakau. Immunohistochemical analysis for acetylcholinesterase and choline acetyltransferase in mouse cerebral cortex after traumatic brain injury. The Journal of veterinary medical science. vol 82. issue 6. 2021-02-02. PMID:32321871. |
acetylcholine (ach), a neurotransmitter synthesized and hydrolyzed by choline acetyltransferase (chat) and acetylcholinesterase (ache), respectively, in the central nervous system, has the potential to regulate glial cells' states, i.e., non-reactive and reactive states. |
2021-02-02 |
2023-08-13 |
mouse |
| Engy Medhat, Laila Rashed, Marwa Abdelgwad, Basma Emad Aboulhoda, Mohamed Mansour Khalifa, Shimaa Saad El-Di. Exercise enhances the effectiveness of vitamin D therapy in rats with Alzheimer's disease: emphasis on oxidative stress and inflammation. Metabolic brain disease. vol 35. issue 1. 2021-01-29. PMID:31691146. |
the following parameters were assessed in rat brain tissues: acetylcholine esterase (ache) activity, levels of amyloid β 42 and tau proteins, dopamine brain neurotransmitter, bdnf and ngf by elisa. |
2021-01-29 |
2023-08-13 |
rat |
| Ghadha Ibrahim Foua. Combination of Omega 3 and Coenzyme Q10 Exerts Neuroprotective Potential Against Hypercholesterolemia-Induced Alzheimer's-Like Disease in Rats. Neurochemical research. vol 45. issue 5. 2021-01-29. PMID:32124160. |
moreover, hypercholesterolemia resulted in decreased acetylcholine (ach) levels and increased acetylcholine-esterase (ache) activity, along with an increment of tumor necrosis factor and amyloid-β 42. |
2021-01-29 |
2023-08-13 |
rat |
| Walaa M S Ahmed, Naglaa M Abdel-Azeem, Marwa A Ibrahim, Nermeen A Helmy, Abeer M Rad. Neuromodulatory effect of cinnamon oil on behavioural disturbance, CYP1A1, iNOStranscripts and neurochemical alterations induced by deltamethrin in rat brain. Ecotoxicology and environmental safety. vol 209. 2021-01-29. PMID:33385678. |
rat behaviour, brain acetylcholine esterase (ache), serotonin, oxidative stress profile were assessed. |
2021-01-29 |
2023-08-13 |
rat |
| Edward J Okello, Joshua Mathe. Comparative Kinetics of Acetyl- and Butyryl-Cholinesterase Inhibition by Green Tea Catechins|Relevance to the Symptomatic Treatment of Alzheimer's Disease. Nutrients. vol 12. issue 4. 2021-01-27. PMID:32326457. |
acetyl-cholinesterase (ache) and butyryl-cholinesterase (buche) are attractive therapeutic targets in the treatment of ad since inhibition of these enzymes can be used to restore synaptic concentrations of acetylcholine. |
2021-01-27 |
2023-08-13 |
Not clear |
| Kevin B Temeyer, Kristie G Schlechte, Pia U Olafson, Barbara S Drolet, Jason P Tidwell, Weste L A Osbrink, Allan T Showler, Aaron D Gross, Adalberto A Pérez de Leó. Association of Salivary Cholinesterase With Arthropod Vectors of Disease. Journal of medical entomology. vol 57. issue 6. 2021-01-27. PMID:32459332. |
acetylcholinesterase (ache) was previously reported to be present in saliva of the southern cattle tick, rhipicephalus (boophilus) microplus (canestrini), with proposed potential functions to 1) reduce acetylcholine toxicity during rapid engorgement, 2) modulate host immune responses, and 3) to influence pathogen transmission and establishment in the host. |
2021-01-27 |
2023-08-13 |
cattle |
| Samar S Elblehi, Omnia I El Euony, Yasser S El-Saye. Apoptosis and astrogliosis perturbations and expression of regulatory inflammatory factors and neurotransmitters in acrylamide-induced neurotoxicity under ω3 fatty acids protection in rats. Neurotoxicology. vol 76. 2021-01-20. PMID:31647937. |
moreover, it reduced neurotransmitters (acetylcholine, gaba, serotonin and noradrenaline levels) and increased ache activity in brain tissues. |
2021-01-20 |
2023-08-13 |
rat |
| Jayeong Hwang, Kumju Youn, Yeongseon Ji, Seonah Lee, Gyutae Lim, Jinhyuk Lee, Chi-Tang Ho, Sun-Hee Leem, Mira Ju. Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone. Nutrients. vol 12. issue 5. 2021-01-20. PMID:32344943. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) mediate the degradation of acetylcholine (ach), a primary neurotransmitter in the brain. |
2021-01-20 |
2023-08-13 |
Not clear |
| Mohamad Rima, Yara Lattouf, Maroun Abi Younes, Erika Bullier, Pascal Legendre, Jean-Marie Mangin, Elim Hon. Dynamic regulation of the cholinergic system in the spinal central nervous system. Scientific reports. vol 10. issue 1. 2021-01-19. PMID:32948826. |
in 1-day-old embryos, we show that spinal motoneurons express presynaptic cholinergic genes including choline acetyltransferase (chata), vesicular acetylcholine transporters (vachta, vachtb), high-affinity choline transporter (hacta) and acetylcholinesterase (ache), while nicotinic acetylcholine receptor (nachr) subunits are mainly expressed in interneurons. |
2021-01-19 |
2023-08-13 |
zebrafish |
| Dan Wu, Shuyu Zhang, Na Sun, Beiwei Zhu, Songyi Li. Neuroprotective Function of a Novel Hexapeptide QMDDQ from Shrimp via Activation of the PKA/CREB/BNDF Signaling Pathway and Its Structure-Activity Relationship. Journal of agricultural and food chemistry. vol 68. issue 24. 2021-01-13. PMID:32452680. |
biochemical results revealed that both peptides exhibited neuroprotective effects by increasing acetylcholine (ach) content and inhibiting acetylcholinesterase (ache) activity in pc12 cells; qmddq was more active than kmddq. |
2021-01-13 |
2023-08-13 |
mouse |
| Tao Li, Jason Berberich, Endalkachew Sahle-Demessie, Eunice Varughes. A disposable acetylcholine esterase sensor for As(III) determination in groundwater matrix based on 4-acetoxyphenol hydrolysis. Analytical methods : advancing methods and applications. vol 11. issue 40. 2021-01-10. PMID:32021658. |
to address this issue, an inhibition-based acetylcholine esterase (ache) sensor was developed to determine as(iii) in groundwater. |
2021-01-10 |
2023-08-13 |
Not clear |
| Ehsan H Abu Zeid, Bouthaina A Khalifa, Enas N Said, Ahmed H Arisha, Rasha M Red. Neurobehavioral and immune-toxic impairments induced by organic methyl mercury dietary exposure in Nile tilapia Oreochromis niloticus. Aquatic toxicology (Amsterdam, Netherlands). vol 230. 2021-01-04. PMID:33264694. |
mehg significantly decreased brain acetylcholine esterase (ache) and serum immunoglobulin m (igm) levels in all the exposed groups. |
2021-01-04 |
2023-08-13 |
Not clear |
| Piyoosh Sharma, Manish Kumar Tripathi, Sushant Kumar Shrivastav. Cholinesterase as a Target for Drug Development in Alzheimer's Disease. Methods in molecular biology (Clifton, N.J.). vol 2089. 2020-12-29. PMID:31773661. |
herein, we describe the role of acetylcholine sterase (ache) and related hypothesis in ad along with the pharmacological and chemical aspects of the available cholinesterase inhibitors. |
2020-12-29 |
2023-08-13 |
Not clear |
| Alaa Alachkar, Sheikh Azimullah, Mohamed Lotfy, Ernest Adeghate, Shreesh K Ojha, Rami Beiram, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sade. Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats. Molecules (Basel, Switzerland). vol 25. issue 7. 2020-12-28. PMID:32235506. |
were evaluated on the course of kindling development, kindling-induced memory deficit, oxidative stress levels (glutathione (gsh), malondialdehyde (mda), catalase (cat), and superoxide dismutase (sod)), various brain neurotransmitters (histamine (ha), acetylcholine (ach), γ-aminobutyric acid (gaba)), and glutamate (glu), acetylcholine esterase (ache) activity, and c-fos protein expression in pentylenetetrazole (ptz, 40 mg/kg) kindled rats. |
2020-12-28 |
2023-08-13 |
rat |