| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fernanda D'Avila da Silva, Pablo Andrei Nogara, Estael Ochoa-Rodríguez, Yanier Nuñez-Figueredo, Maylin Wong-Guerra, Denis Broock Rosemberg, João Batista Teixeira da Roch. Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources. Biochimie. vol 168. 2020-04-06. PMID:31770565. |
the main function of ache is the hydrolysis of the neurotransmitter acetylcholine (ach) at the neuromuscular and in cholinergic brain synapses. |
2020-04-06 |
2023-08-13 |
human |
| Yi Cao, Laia Herrero-Nogareda, Nina Cedergree. A comparative study of acetylcholinesterase and general-esterase activity assays using different substrates, in vitro and in vivo exposures and model organisms. Ecotoxicology and environmental safety. vol 189. 2020-03-25. PMID:31759743. |
we showed that ache activity could be measured with the substrate acetylthiocholine iodide (achi) but not with acetylcholine bromide (achb) and only in in vitro assays. |
2020-03-25 |
2023-08-13 |
Not clear |
| Xiao Hu, Cerasela Zoica Din. Nanoporous gold electrode for ultrasensitive detection of neurotoxin fasciculin. Analytica chimica acta. vol 1085. 2020-03-16. PMID:31522735. |
acetylcholinesterase (ache), an efficient biocatalyst known to hydrolyze the neurotransmitter acetylcholine, could be inactivated in the presence of insecticides, nerve agents or other drug inhibitors to thus result in disrupted neurotransmission. |
2020-03-16 |
2023-08-13 |
Not clear |
| Lilai Yuan, Le Qian, Yu Qian, Jia Liu, Ke Yang, Ying Huang, Chengju Wang, Yingren Li, Xiyan M. Bisphenol F-Induced Neurotoxicity toward Zebrafish Embryos. Environmental science & technology. vol 53. issue 24. 2020-03-16. PMID:31702913. |
additionally, no significant change was found in neurotransmitter levels (5-hydroxytryptamine, dopamine, and acetylcholine) or acetylcholinesterase (ache) enzyme activity after bpf exposure, indicating that bpf may not affect neurotransmission. |
2020-03-16 |
2023-08-13 |
zebrafish |
| Lilly Toker, Israel Silman, Tzviya Zeev-Ben-Mordehai, Joel L Sussman, Lawrence M Schopfer, Oksana Lockridg. Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers. Chemico-biological interactions. vol 319. 2020-03-16. PMID:32087110. |
acetylcholinesterase (ache) terminates cholinergic neurotransmission by hydrolyzing acetylcholine. |
2020-03-16 |
2023-08-13 |
Not clear |
| Oksana Gerlits, Xiaotian Kong, Xiaolin Cheng, Troy Wymore, Donald K Blumenthal, Palmer Taylor, Zoran Radić, Andrey Kovalevsk. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. The Journal of biological chemistry. vol 294. issue 27. 2020-03-10. PMID:31138650. |
inhibited ache cannot hydrolyze the neurotransmitter acetylcholine leading to its build-up at the cholinergic synapses and creating an acute cholinergic crisis. |
2020-03-10 |
2023-08-13 |
human |
| Messele Fentabil, Mulu Gebremedhin, John Barry, John Mikler, Laura Cochran. In vivo efficacy of the Reactive Skin Decontamination Lotion (RSDL®) kit against organophosphate and carbamate pesticides. Chemico-biological interactions. vol 318. 2020-03-10. PMID:32044340. |
the pesticides inhibit acetylcholinesterase (ache) leading to signs and symptoms of hyperactivity of organs due to accumulation of acetylcholine. |
2020-03-10 |
2023-08-13 |
Not clear |
| Ye Yuan, Minjie Zhao, Ludivine Riffault-Valois, Saïd Ennahar, Martine Bergaentzlé, Eric Marchion. Online acetylcholinesterase inhibition evaluation by high-performance liquid chromatography-mass spectrometry hyphenated with an immobilized enzyme reactor. Journal of chromatography. A. vol 1609. 2020-02-27. PMID:31526637. |
the ache inhibitory strengths were evaluated and compared by the corresponding acetylcholine peak areas (mass signal) obtained after a chromatographic separation and the elution through the imer. |
2020-02-27 |
2023-08-13 |
Not clear |
| Pablo Zambrano, Mario Suwalsky, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka, Benjamin Sepúlveda, María J Gallardo, Luis F Aguila. The acetylcholinesterase (AChE) inhibitor and anti-Alzheimer drug donepezil interacts with human erythrocytes. Biochimica et biophysica acta. Biomembranes. vol 1861. issue 6. 2020-02-14. PMID:30904408. |
this drug is a specific inhibitor of the enzyme acetylcholinesterase (ache), whose main physiological function is to hydrolyze the neurotransmitter acetylcholine. |
2020-02-14 |
2023-08-13 |
human |
| Charlotte Whitmore, Christopher D Lindsay, Mike Bird, Samuel J Gore, Helen Rice, Rebecca L Williams, Christopher M Timperley, A Christopher Gree. Assessment of false transmitters as treatments for nerve agent poisoning. Toxicology letters. vol 321. 2020-01-27. PMID:31830555. |
nerve agents inhibit acetylcholinesterase (ache), leading to a build-up of acetylcholine (ach) and overstimulation at cholinergic synapses. |
2020-01-27 |
2023-08-13 |
human |
| Mohammad Samare, Ali N Samareh, Soolmaz Safari, Reza Zaree, Delaram Moghadam, Abooalfazl Azhdarpoor, Ahmad Badeenezhad, Saeid Rostam. A survey of the secondary exposure to organophosphate and organochlorine pesticides and the impact of preventive factors in female villagers. Chemosphere. vol 240. 2020-01-23. PMID:31563724. |
in addition, the activity of acetylcholine esterase (ache), total antioxidant capacity (tac), and serum levels of malondialdehyde (mda) were evaluated in all participants. |
2020-01-23 |
2023-08-13 |
human |
| Fatima Zahra Ouardi, Hammou Anarghou, Hafsa Malqui, Nabila Ouasmi, Mohammed Chigr, Mohamed Najimi, Fatiha Chig. Gestational and Lactational Exposure to Malathion Affects Antioxidant Status and Neurobehavior in Mice Pups and Offspring. Journal of molecular neuroscience : MN. vol 69. issue 1. 2020-01-21. PMID:30637616. |
in the present work, we investigated the effect of an organophosphate pesticide, i.e., malathion, administrated peri- and postnatally on the antioxidant system as well as on acetylcholine esterase (ache) activity in the brains of mice pups during the three postnatal weeks. |
2020-01-21 |
2023-08-13 |
mouse |
| Jinal B Thakkar, Shweta Gupta, C Ratna Prabh. Acetylcholine esterase enzyme doped multiwalled carbon nanotubes for the detection of organophosphorus pesticide using cyclic voltammetry. International journal of biological macromolecules. vol 137. 2020-01-15. PMID:31247229. |
use of immobilized acetylcholine esterase (ache) for detecting organophosphorus pesticides in water sources and body fluids can bring down the detection costs dramatically. |
2020-01-15 |
2023-08-13 |
Not clear |
| Fikret Türkan, Parham Taslimi, Fatma Zerrin Salta. Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease. Journal of biochemical and molecular toxicology. vol 33. issue 8. 2020-01-13. PMID:30974029. |
in this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (ache), α-glycosidase, α-amylase, and butyrylcholinesterase (bche). |
2020-01-13 |
2023-08-13 |
Not clear |
| Sina Parvaz, Reza Taheri-Ledari, Mir Saeed Esmaeili, Mahboubeh Rabbani, Ali Malek. A brief survey on the advanced brain drug administration by nanoscale carriers: With a particular focus on AChE reactivators. Life sciences. vol 240. 2020-01-13. PMID:31760098. |
one of the most important categories of these hydrophilic medications, are reactivators for acetyl cholinesterase (ache) enzyme that facilitates the breakdown of acetylcholine (as a neurotransmitter). |
2020-01-13 |
2023-08-13 |
Not clear |
| Eunjin Sohn, Hye-Sun Lim, Yu Jin Kim, Bu-Yeo Kim, Joo-Hwan Kim, Soo-Jin Jeon. Nutrients. vol 11. issue 6. 2019-12-30. PMID:31141948. |
acetylcholine (ach) levels and acetylcholinesterase (ache) activity were measured via an enzyme-linked immunosorbent assay (elisa). |
2019-12-30 |
2023-08-13 |
mouse |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |
| Pamela T Wong, Somnath Bhattacharjee, Jayme Cannon, Shengzhuang Tang, Kelly Yang, Sierra Bowden, Victoria Varnau, Jessica J O'Konek, Seok Ki Cho. Reactivity and mechanism of α-nucleophile scaffolds as catalytic organophosphate scavengers. Organic & biomolecular chemistry. vol 17. issue 16. 2019-12-02. PMID:30942252. |
in addition to op reactivity, several compounds in the pam class displayed a dual mode of activity, as they retained the ability to reactivate pox-inhibited acetylcholine esterase (ache). |
2019-12-02 |
2023-08-13 |
Not clear |
| Yifan Chen, Gang Cheng, Rongfeng Hu, Shengqi Chen, Wenjie Lu, Song Gao, Hongmei Xia, Bin Wang, Chaojie Sun, Xiangjiang Nie, Qiang Shen, Wenyou Fan. A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study. AAPS PharmSciTech. vol 20. issue 7. 2019-12-02. PMID:31485857. |
huperzine a (hup a), extracted from the chinese medicinal plant huperzia serrata, is a reversible and highly selective second-generation acetylcholine esterase (ache) inhibitor for treating alzheimer's disease (ad), but it suffers from low bioavailability in the brain. |
2019-12-02 |
2023-08-13 |
Not clear |
| Zrinka Kovarik, Jarosław Kalisiak, Nikolina Maček Hrvat, Maja Katalinić, Tamara Zorbaz, Suzana Žunec, Carol Green, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. Chemistry (Weinheim an der Bergstrasse, Germany). vol 25. issue 16. 2019-11-26. PMID:30458057. |
acetylcholinesterase (ache), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (ops), such as nerve agents and pesticides, can be reactivated by oximes. |
2019-11-26 |
2023-08-13 |
mouse |