| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryan J Yoder, Qinggeng Zhuang, Jeremy M Beck, Andrew Franjesevic, Travis G Blanton, Sydney Sillart, Tyler Secor, Leah Guerra, Jason D Brown, Carolyn Reid, Craig A McElroy, Özlem Doğan Ekici, Christopher S Callam, Christopher M Hada. Study of ACS medicinal chemistry letters. vol 8. issue 6. 2020-10-01. PMID:28626522. |
the aged ache is unable to hydrolyze acetylcholine, resulting in accumulation of the neurotransmitter in the central nervous system (cns) and elsewhere. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wenwen Lian, Hao Jia, Lvjie Xu, Wei Zhou, De Kang, Ailin Liu, Guanhua D. Multi-Protection of DL0410 in Ameliorating Cognitive Defects in D-Galactose Induced Aging Mice. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29276489. |
the acetylcholine level and ache activity were not altered by d-galactose but were slightly affected by dl0410 in the brain. |
2020-10-01 |
2023-08-13 |
mouse |
| Etta Y L Liu, Miranda L Xu, Yan Jin, Qiyun Wu, Tina T X Dong, Karl W K Tsi. Genistein, a Phytoestrogen in Soybean, Induces the Expression of Acetylcholinesterase via G Protein-Coupled Receptor 30 in PC12 Cells. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29535608. |
in parallel, the expression of tetrameric form of proline-rich membrane anchor (prima)-linked acetyl-cholinesterase (g4 ache), a key enzyme to hydrolyze acetylcholine in cholinergic synapses, was induced in a dose-dependent manner: this induction included the associated protein prima. |
2020-10-01 |
2023-08-13 |
Not clear |
| Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P Che. Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535625. |
butyrylcholinesterase (bche), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (ache) but with the capability to degrade a broad range of bioactive esters. |
2020-10-01 |
2023-08-13 |
mouse |
| Mohd Babu Khan, Bhagath Kumar Palaka, Tuleshwori Devi Sapam, Naidu Subbarao, Dinakara Rao Ampasal. Screening and analysis of acetyl-cholinesterase (AChE) inhibitors in the context of Alzheimer's disease. Bioinformation. vol 14. issue 8. 2020-10-01. PMID:30310249. |
an ache enzyme is a member of hydrolase family is activated by acetylcholine (ach), so, targeting the ache enzyme with the potential inhibitor may block the binding of the ach. |
2020-10-01 |
2023-08-13 |
Not clear |
| Azadeh Karami, Maria Eriksdotter, Ahmadul Kadir, Ove Almkvist, Agneta Nordberg, Taher Darreh-Shor. CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer's Disease. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31680850. |
currently, three of four ad drugs act by inhibiting the acetylcholine (ach) degrading enzyme, acetylcholinesterase (ache). |
2020-10-01 |
2023-08-13 |
Not clear |
| Zahiruddin Othman, Rahimah Zakaria, Nik Hazlina Nik Hussain, Asma' Hassan, Nazlahshaniza Shafin, Badriya Al-Rahbi, Asma Hayati Ahma. Potential Role of Honey in Learning and Memory. Medical sciences (Basel, Switzerland). vol 3. issue 2. 2020-09-30. PMID:29083387. |
these studies show that tualang honey improves morphology of memory-related brain areas, reduces brain oxidative stress, increases brain-derived neurotrophic factor (bdnf) and acetylcholine (ach) concentrations, and reduces acetylcholinesterase (ache) in the brain homogenates. |
2020-09-30 |
2023-08-13 |
human |
| Edna Blotnick-Rubin, Lili Angliste. Fine Localization of Acetylcholinesterase in the Synaptic Cleft of the Vertebrate Neuromuscular Junction. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29725289. |
this localization pattern of ache is suggested to ensure full hydrolysis of acetylcholine (ach) bouncing off receptors, thus eliminating its unnecessary detrimental reattachment. |
2020-09-30 |
2023-08-13 |
mouse |
| Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul-Ain, Tassadaq H Jafar, Rabia Rasool, Aasia Kalsoom, Muhammad A Ghafoor, Sheikh A Sehgal, Kalamegam Gauthaman, Muhammad I Naseer, Mohammed H Al-Qahtani, Peter N Pushpara. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30123124. |
the serum samples were further analyzed for biomarkers such as 8-hydroxydeoxyguanosine (8-ohdg), 4-hydroxynonenal (4-hne), tumor necrosis factor-alpha (tnf-α), cyclooxygenase-2 (cox-2), matrix metalloproteinase-8 (mmp-8), isoprostanes-2 alpha (isop-2α), and acetylcholine esterase (ache) using conventional enzyme linked immunosorbent assay (elisa) method. |
2020-09-30 |
2023-08-13 |
rat |
| Huixin Chen, Xiang Wu, Xinmei Gu, Yiying Zhou, Luying Ye, Ke Zhang, Hanbo Pan, Jialing Wang, Hua Wei, Binbin Zhu, C Benjamin Naman, Shinghung Mak, Paul R Carlier, Wei Cui, Yifan Ha. Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30483056. |
furthermore, a10e substantially enhanced choline acetyltransferase (chat)-positive area and decreased ache activity, in the hippocampus regions of surgery-treated mice, indicating that a10e could prevent surgery-induced dysfunction of cholinergic system, possibly via increasing the synthesis of acetylcholine and the inhibition of ache. |
2020-09-30 |
2023-08-13 |
mouse |
| Adriana M Dos Santos, Ariele C Moreira, Bianca Rebelo Lopes, Mariana F Fracola, Fernando G de Almeida, Odair C Bueno, Quezia B Cass, Dulce Helena F Souz. Acetylcholinesterases from Leaf-Cutting ant Enzyme research. vol 2019. 2020-09-30. PMID:31354985. |
acetylcholinesterases from leaf-cutting ant acetylcholinesterase (ache) is responsible for catalyzing the hydrolysis of the neurotransmitter acetylcholine (ach) leading to acetate and choline (ch) release. |
2020-09-30 |
2023-08-13 |
Not clear |
| Adam Kostelnik, Alexander Cegan, Miroslav Pohank. Acetylcholinesterase Inhibitors Assay Using Colorimetric pH Sensitive Strips and Image Analysis by a Smartphone. International journal of analytical chemistry. vol 2017. 2020-09-29. PMID:28286520. |
ache degrades acetylcholine into choline and acetic acid which causes color change of acid-base indicator. |
2020-09-29 |
2023-08-13 |
Not clear |
| Qing-Guang Liu, Lin Liu, Qiang-Min Huang, Thi-Tham Nguyen, Yan-Tao Ma, Jia-Min Zha. Decreased Spontaneous Electrical Activity and Acetylcholine at Myofascial Trigger Spots after Dry Needling Treatment: A Pilot Study. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-29. PMID:28592980. |
the aims of this study are to investigate the changes in spontaneous electrical activities (seas) and in acetylcholine (ach), acetylcholine receptor (achr), and acetylcholine esterase (ache) levels after dry needling at myofascial trigger spots in model rats. |
2020-09-29 |
2023-08-13 |
rat |
| Rohit Pardeshi, Nityanand Bolshette, Kundlik Gadhave, Mohammad Arfeen, Sahabuddin Ahmed, Rohitash Jamwal, Bruce D Hammock, Mangala Lahkar, Sumanta Kumar Goswam. Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer's Disease-Like Complications of Diabetes. Frontiers in pharmacology. vol 10. 2020-09-28. PMID:31068802. |
the activity of acetylcholinesterase (ache) which metabolizes acetylcholine was increased in the brain of diabetic rats. |
2020-09-28 |
2023-08-13 |
rat |
| Qing-Guang Liu, Qiang-Min Huang, Lin Liu, Thi-Tham Nguye. Structural and functional abnormalities of motor endplates in rat skeletal model of myofascial trigger spots. Neuroscience letters. vol 711. 2020-09-28. PMID:31398457. |
c1 and m1 were used for acetylcholine (ach) content measurement, while c2 and m2 were utilized for acetylcholinesterase (ache) staining. |
2020-09-28 |
2023-08-13 |
human |
| Ming-Yang Liu, Fan Zeng, Yue Shen, Yu-Ying Wang, Ning Zhang, Fang Gen. Bioguided Isolation and Structure Identification of Acetylcholinesterase Enzyme Inhibitors from Drynariae Rhizome. Journal of analytical methods in chemistry. vol 2020. 2020-09-28. PMID:32185082. |
here, a high-throughput assay monitoring the transformation of iodized choline from iodized acetylcholine catalyzed by ache was established based on uplc-ms/ms. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yameng Han, Zhongju Ye, Fuyan Wang, Tianyu Chen, Lin Wei, Langxing Chen, Lehui Xia. Single-particle enumeration-based ultrasensitive enzyme activity quantification with fluorescent polymer nanoparticles. Nanoscale. vol 11. issue 31. 2020-09-11. PMID:31353389. |
acetylcholinesterase (ache) plays a vital role in nerve conduction through rapidly hydrolyzing the neurotransmitter acetylcholine (ach) and is correlated with alzheimer's disease. |
2020-09-11 |
2023-08-13 |
human |
| Rui Jin, Zihao Xing, Deshuai Kong, Xu Yan, Fangmeng Liu, Yuan Gao, Peng Sun, Xishuang Liang, Geyu L. Sensitive colorimetric sensor for point-of-care detection of acetylcholinesterase using cobalt oxyhydroxide nanoflakes. Journal of materials chemistry. B. vol 7. issue 8. 2020-07-23. PMID:32255162. |
in this sensor, ache catalytically hydrolyzed acetylcholine (ach) to produce choline, which was further efficiently oxidized by cho to yield h |
2020-07-23 |
2023-08-13 |
Not clear |
| Xuzhi Li, Meie Wang, Rong Jiang, Liping Zheng, Weiping Che. Evaluation of joint toxicity of heavy metals and herbicide mixtures in soils to earthworms (Eisenia fetida). Journal of environmental sciences (China). vol 94. 2020-07-10. PMID:32563477. |
the responses of multiple biomarkers, including the activities of catalase (cat), superoxide dismutase (sod), glutathione reductase (gr) and acetylcholine esterase (ache), the concentrations of glycogen, soluble protein (sp), malonaldehyde (mda), and metallothionein (mt), and the neutral red uptake test (nru), were investigated. |
2020-07-10 |
2023-08-13 |
cat |
| Huan Xu, Lingke Chen, Xiao Zhang, Xuliang Jiang, Weitian Tian, Weifeng Yu, Xiangrui Wang, Jie Tian, Diansan S. Central cholinergic neuronal degeneration promotes the development of postoperative cognitive dysfunction. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 7. 2020-06-25. PMID:30626892. |
the impact of anesthesia/surgery (appendectomy) on learning and memory and the levels of choline acetyltransferase (chat), acetylcholinesterase (ache), vesicular acetylcholine transporter (vacht), and choline transporter (cht) in adult and aged mice were measured. |
2020-06-25 |
2023-08-13 |
mouse |