| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gonzalo E Fenoy, Waldemar A Marmisollé, Omar Azzaroni, Wolfgang Knol. Acetylcholine biosensor based on the electrochemical functionalization of graphene field-effect transistors. Biosensors & bioelectronics. vol 148. 2020-06-18. PMID:31665672. |
we present a new strategy of acetylcholinesterease (ache) immobilization on graphene field-effect transistors (gfets) for building up acetylcholine sensors. |
2020-06-18 |
2023-08-13 |
Not clear |
| Cuneyt Caglayan, Yeliz Demir, Sefa Kucukler, Parham Taslimi, Fatih Mehmet Kandemir, İlhami Gulçi. The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach. Journal of food biochemistry. vol 43. issue 2. 2020-06-12. PMID:31353640. |
in our work, it was purposed to investigate the effects of sodium arsenite (sa) and hesperidin (hsp) administered to rats on some metabolic enzymes including carbonic anhydrase (ca), aldose reductase (ar), paraoxonase-1 (pon1), α-glycosidase (α-gly), butyrylcholine esterase (bche), acetylcholine esterase (ache) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. |
2020-06-12 |
2023-08-13 |
human |
| Cristina Romero Rocamora, Kalavathy Ramasamy, Siong Meng Lim, Abu Bakar Abdul Majeed, Snezana Agatonovic-Kustri. HPTLC based approach for bioassay-guided evaluation of antidiabetic and neuroprotective effects of eight essential oils of the Lamiaceae family plants. Journal of pharmaceutical and biomedical analysis. vol 178. 2020-06-04. PMID:31618702. |
hptlc hyphenated with microchemical (dpph•, p-anisaldehyde, and ferric chloride) derivatizations, was used to evaluate antioxidant activity, presence of phytosterols and terpenoids, and polyphenolic content, while the combination with biochemical (α-amylase and acetylcholine esterase (ache) enzymatic) derivatizations was used to asses α-amylase and ache inhibitory activities. |
2020-06-04 |
2023-08-13 |
Not clear |
| Peng Zhang, Caixia Fu, Yuzhe Xiao, Qian Zhang, Caifeng Din. Copper(II) complex as a turn on fluorescent sensing platform for acetylcholinesterase activity with high sensitivity. Talanta. vol 208. 2020-06-04. PMID:31816742. |
a "turn on" fluorometric assay is described herein for ache activity detection, according to the specific enzyme catalyzed reaction of acetylcholine (atch) by ache, which generates thiocholine (tch) as the product. |
2020-06-04 |
2023-08-13 |
Not clear |
| Hua Fang, Hua-Feng Li, Miao Yang, Ren Liao, Ru-Rong Wang, Quan-Yun Wang, Peng-Cheng Zheng, Fang-Xiang Zhang, Jian-Ping Zhan. NF-κB signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via RCAN1 in neonatal rats with hypoxic-ischemic brain damage. Cell cycle (Georgetown, Tex.). vol 18. issue 9. 2020-05-27. PMID:30990350. |
expression of rcan1, nf-κb signaling pathway-related genes and glial fibrillary acidic protein (gfap), s-100β and acetylcholine (ach) level, and acetylcholinesterase (ache) activity were determined with neuron apoptosis detected to further explore the function of nf-κb signaling pathway. |
2020-05-27 |
2023-08-13 |
rat |
| Sahar Fanoudi, Mohaddeseh S Alavi, Mahmoud Hosseini, Hamid R Sadeghni. Nigella sativa and thymoquinone attenuate oxidative stress and cognitive impairment following cerebral hypoperfusion in rats. Metabolic brain disease. vol 34. issue 4. 2020-04-30. PMID:31016464. |
in the present study, we investigated the effect of hydroalcoholic extract of n. sativa seeds (nse) and its active constituent, thymoquinone (tq), on learning and memory deficits, hippocampal acetylcholine esterase (ache) activity, and markers of redox status, mainly lipid peroxidation and superoxide dismutase (sod) activity following cerebral hypoperfusion in rats. |
2020-04-30 |
2023-08-13 |
rat |
| Azime Berna Özçelik, Zeynep Özdemir, Suat Sari, Semra Utku, Mehtap Uysa. A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies. Pharmacological reports : PR. vol 71. issue 6. 2020-04-27. PMID:31675671. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach). |
2020-04-27 |
2023-08-13 |
Not clear |
| Christoph Fenzl, Christa Genslein, Alexander Zöpfl, Antje J Baeumner, Thomas Hirsc. A photonic crystal based sensing scheme for acetylcholine and acetylcholinesterase inhibitors. Journal of materials chemistry. B. vol 3. issue 10. 2020-04-08. PMID:32262377. |
we demonstrate this unique combination by successfully detecting acetylcholine (ach) and acetylcholinesterase (ache) inhibitors. |
2020-04-08 |
2023-08-13 |
human |
| Li Su, Xinai Yu, Wenjie Qin, Wenpei Dong, Chengke Wu, Yan Zhang, Guojiang Mao, Suling Fen. One-step analysis of glucose and acetylcholine in water based on the intrinsic peroxidase-like activity of Ni/Co LDHs microspheres. Journal of materials chemistry. B. vol 5. issue 1. 2020-04-08. PMID:32263440. |
we also extended the one-step method to detect acetylcholine (ach) by taking advantage of the specific catalytic reaction of acetylcholinesterase (ache) and choline oxidase (chox). |
2020-04-08 |
2023-08-13 |
Not clear |
| Fernanda D'Avila da Silva, Pablo Andrei Nogara, Estael Ochoa-Rodríguez, Yanier Nuñez-Figueredo, Maylin Wong-Guerra, Denis Broock Rosemberg, João Batista Teixeira da Roch. Molecular docking and in vitro evaluation of a new hybrid molecule (JM-20) on cholinesterase activity from different sources. Biochimie. vol 168. 2020-04-06. PMID:31770565. |
the main function of ache is the hydrolysis of the neurotransmitter acetylcholine (ach) at the neuromuscular and in cholinergic brain synapses. |
2020-04-06 |
2023-08-13 |
human |
| Yi Cao, Laia Herrero-Nogareda, Nina Cedergree. A comparative study of acetylcholinesterase and general-esterase activity assays using different substrates, in vitro and in vivo exposures and model organisms. Ecotoxicology and environmental safety. vol 189. 2020-03-25. PMID:31759743. |
we showed that ache activity could be measured with the substrate acetylthiocholine iodide (achi) but not with acetylcholine bromide (achb) and only in in vitro assays. |
2020-03-25 |
2023-08-13 |
Not clear |
| Xiao Hu, Cerasela Zoica Din. Nanoporous gold electrode for ultrasensitive detection of neurotoxin fasciculin. Analytica chimica acta. vol 1085. 2020-03-16. PMID:31522735. |
acetylcholinesterase (ache), an efficient biocatalyst known to hydrolyze the neurotransmitter acetylcholine, could be inactivated in the presence of insecticides, nerve agents or other drug inhibitors to thus result in disrupted neurotransmission. |
2020-03-16 |
2023-08-13 |
Not clear |
| Lilai Yuan, Le Qian, Yu Qian, Jia Liu, Ke Yang, Ying Huang, Chengju Wang, Yingren Li, Xiyan M. Bisphenol F-Induced Neurotoxicity toward Zebrafish Embryos. Environmental science & technology. vol 53. issue 24. 2020-03-16. PMID:31702913. |
additionally, no significant change was found in neurotransmitter levels (5-hydroxytryptamine, dopamine, and acetylcholine) or acetylcholinesterase (ache) enzyme activity after bpf exposure, indicating that bpf may not affect neurotransmission. |
2020-03-16 |
2023-08-13 |
zebrafish |
| Lilly Toker, Israel Silman, Tzviya Zeev-Ben-Mordehai, Joel L Sussman, Lawrence M Schopfer, Oksana Lockridg. Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers. Chemico-biological interactions. vol 319. 2020-03-16. PMID:32087110. |
acetylcholinesterase (ache) terminates cholinergic neurotransmission by hydrolyzing acetylcholine. |
2020-03-16 |
2023-08-13 |
Not clear |
| Oksana Gerlits, Xiaotian Kong, Xiaolin Cheng, Troy Wymore, Donald K Blumenthal, Palmer Taylor, Zoran Radić, Andrey Kovalevsk. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. The Journal of biological chemistry. vol 294. issue 27. 2020-03-10. PMID:31138650. |
inhibited ache cannot hydrolyze the neurotransmitter acetylcholine leading to its build-up at the cholinergic synapses and creating an acute cholinergic crisis. |
2020-03-10 |
2023-08-13 |
human |
| Messele Fentabil, Mulu Gebremedhin, John Barry, John Mikler, Laura Cochran. In vivo efficacy of the Reactive Skin Decontamination Lotion (RSDL®) kit against organophosphate and carbamate pesticides. Chemico-biological interactions. vol 318. 2020-03-10. PMID:32044340. |
the pesticides inhibit acetylcholinesterase (ache) leading to signs and symptoms of hyperactivity of organs due to accumulation of acetylcholine. |
2020-03-10 |
2023-08-13 |
Not clear |
| Ye Yuan, Minjie Zhao, Ludivine Riffault-Valois, Saïd Ennahar, Martine Bergaentzlé, Eric Marchion. Online acetylcholinesterase inhibition evaluation by high-performance liquid chromatography-mass spectrometry hyphenated with an immobilized enzyme reactor. Journal of chromatography. A. vol 1609. 2020-02-27. PMID:31526637. |
the ache inhibitory strengths were evaluated and compared by the corresponding acetylcholine peak areas (mass signal) obtained after a chromatographic separation and the elution through the imer. |
2020-02-27 |
2023-08-13 |
Not clear |
| Pablo Zambrano, Mario Suwalsky, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka, Benjamin Sepúlveda, María J Gallardo, Luis F Aguila. The acetylcholinesterase (AChE) inhibitor and anti-Alzheimer drug donepezil interacts with human erythrocytes. Biochimica et biophysica acta. Biomembranes. vol 1861. issue 6. 2020-02-14. PMID:30904408. |
this drug is a specific inhibitor of the enzyme acetylcholinesterase (ache), whose main physiological function is to hydrolyze the neurotransmitter acetylcholine. |
2020-02-14 |
2023-08-13 |
human |
| Charlotte Whitmore, Christopher D Lindsay, Mike Bird, Samuel J Gore, Helen Rice, Rebecca L Williams, Christopher M Timperley, A Christopher Gree. Assessment of false transmitters as treatments for nerve agent poisoning. Toxicology letters. vol 321. 2020-01-27. PMID:31830555. |
nerve agents inhibit acetylcholinesterase (ache), leading to a build-up of acetylcholine (ach) and overstimulation at cholinergic synapses. |
2020-01-27 |
2023-08-13 |
human |
| Mohammad Samare, Ali N Samareh, Soolmaz Safari, Reza Zaree, Delaram Moghadam, Abooalfazl Azhdarpoor, Ahmad Badeenezhad, Saeid Rostam. A survey of the secondary exposure to organophosphate and organochlorine pesticides and the impact of preventive factors in female villagers. Chemosphere. vol 240. 2020-01-23. PMID:31563724. |
in addition, the activity of acetylcholine esterase (ache), total antioxidant capacity (tac), and serum levels of malondialdehyde (mda) were evaluated in all participants. |
2020-01-23 |
2023-08-13 |
human |