| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nermin Eissa, Sheikh Azimullah, Petrilla Jayaprakash, Richard L Jayaraj, David Reiner, Shreesh K Ojha, Rami Beiram, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sade. The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammmation in sodium valproate induced autism in mice. Chemico-biological interactions. vol 312. 2019-10-07. PMID:31369746. |
histamine h3 receptor (h3r) and acetylcholine esterase (ache) are involved in several cognitive disorders such as alzheimer's disease, schizophrenia, anxiety, and narcolepsy, all of which are comorbid with asd. |
2019-10-07 |
2023-08-13 |
mouse |
| Robert Josef Nachlinger, Vivien Kauschke, Katja Trinkaus, Thaqif El Khassawna, Christian Heiss, Katrin Susanne Lip. Application of donepezil increased collagen 1 expression in mesenchymal stroma cells of an ovine osteoporosis model. Journal of musculoskeletal & neuronal interactions. vol 18. issue 3. 2019-09-30. PMID:30179213. |
donepezil inhibits the acetylcholine degradation molecule acetylcholinesterase (ache). |
2019-09-30 |
2023-08-13 |
Not clear |
| Julie V Miller, Ryan F LeBouf, Kimberly A Kelly, Lindsay T Michalovicz, Anand Ranpara, Alicia R Locker, Diane B Miller, James P O'Callagha. The Neuroinflammatory Phenotype in a Mouse Model of Gulf War Illness is Unrelated to Brain Regional Levels of Acetylcholine as Measured by Quantitative HILIC-UPLC-MS/MS. Toxicological sciences : an official journal of the Society of Toxicology. vol 165. issue 2. 2019-09-25. PMID:29846716. |
although inhibition of ache leading to accumulation of acetylcholine (ach) will activate the cholinergic anti-inflammatory pathway, the signature symptomatology of gwi has been shown to be associated with neuroinflammation. |
2019-09-25 |
2023-08-13 |
mouse |
| Jia Xu, Xiaotong Hu, Habib Khan, Miaomiao Tian, Li Yan. Converting solution viscosity to distance-readout on paper substrates based on enzyme-mediated alginate hydrogelation: Quantitative determination of organophosphorus pesticides. Analytica chimica acta. vol 1071. 2019-09-16. PMID:31128750. |
the method is accomplished with the aid of the inhibition effect of target samples on the ache enzyme-catalyzed hydrolysis of acetylcholine, which changes the ph value of the solution to release ca |
2019-09-16 |
2023-08-13 |
Not clear |
| Aisa Ozawa, Erina Kadowaki, Tomoyo Horio, Motoharu Sakau. Acetylcholine suppresses the increase of glia fibrillary acidic protein expression via acetylcholine receptors in cAMP-induced astrocytic differentiation of rat C6 glioma cells. Neuroscience letters. vol 698. 2019-09-10. PMID:30639397. |
we previously demonstrated that the inhibition of acetylcholine esterase (ache) suppressed the differentiation of rat glioma c6 cells, an astrocyte differentiation model, and we observed a suppressive effect of ach agonists on astrocyte differentiation. |
2019-09-10 |
2023-08-13 |
rat |
| Aliya R Mukhametgalieva, Aliya R Aglyamova, Sofya V Lushchekina, Marko Goličnik, Patrick Masso. Time-course of human cholinesterases-catalyzed competing substrate kinetics. Chemico-biological interactions. vol 310. 2019-09-09. PMID:31247192. |
for ache, acetylcholine was competing with visible substrates. |
2019-09-09 |
2023-08-13 |
human |
| Zhi-Pu Yu, Yin-Yin Wang, Shu-Juan Yu, Jie Bao, Jin-Hai Yu, Hua Zhan. Absolute structure assignment of an iridoid-monoterpenoid indole alkaloid hybrid from Dipsacus asper. Fitoterapia. vol 135. 2019-09-03. PMID:31051193. |
our biological evaluations showed that compound 2 exhibited moderate inhibition against acetylcholine esterase (ache) with an ic |
2019-09-03 |
2023-08-13 |
Not clear |
| Muhammed Khairujjaman Mazumder, Shuvasish Choudhur. Tea polyphenols as multi-target therapeutics for Alzheimer's disease: An in silico study. Medical hypotheses. vol 125. 2019-08-27. PMID:30902161. |
with neurodegeneration, the level of the neurotransmitter acetylcholine (ach), as well as acetylcholinesterase (ache), decreases in the synaptic cleft, called cholinergic deficiency. |
2019-08-27 |
2023-08-13 |
Not clear |
| Nehad E M Taktak, Mohamed E I Badaw. Potential of hydrocarbon and oxygenated monoterpenes against Culex pipiens larvae: Toxicity, biochemical, pharmacophore modeling and molecular docking studies. Pesticide biochemistry and physiology. vol 158. 2019-08-23. PMID:31378352. |
in addition, in vivo biochemical studies including effects on acetylcholine esterase (ache), acid and alkaline phosphatases (acp and alp), total adenosine triphosphatase (atpase) and gamma-aminobutyric acid transaminase (gaba-t) were investigated. |
2019-08-23 |
2023-08-13 |
Not clear |
| b' Maja D Vitorovi\\xc4\\x87-Todorovi\\xc4\\x87, Franz Worek, Andrej Perdih, Sonja \\xc4\\x90 Bauk, Tamara B Vujatovi\\xc4\\x87, Ilija N Cvijeti\\xc4\\x8. The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents. Chemico-biological interactions. vol 309. 2019-08-19. PMID:31228470.' |
acetylcholinesterase (ache) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. |
2019-08-19 |
2023-08-13 |
human |
| Shaukat Ali, Can Zhang, Zeqing Wang, Xing-Min Wang, Jian-Hui Wu, Andrew G S Cuthbertson, Zhenfang Shao, Bao-Li Qi. Toxicological and biochemical basis of synergism between the entomopathogenic fungus Lecanicillium muscarium and the insecticide matrine against Bemisia tabaci (Gennadius). Scientific reports. vol 7. 2019-08-06. PMID:28425450. |
the strong synergistic effect is possibly related to the disturbance of acetylcholine balance and changes in ache activities of the whitefly as both matrine and l. muscarium target insect acetylcholine (ach) receptors which in turn effects ache production. |
2019-08-06 |
2023-08-13 |
cat |
| Géssica Perin, Nathieli B Bottari, Anielen D Silva, Antonise M Jaguezeski, Teane M A Gomes, Thalison F Lopes, Maria Rosa C Schetinger, Vera M Morsch, Aleksandro S Da Silv. Cholinesterase's activities of infected mice by Brucella ovis. Microbial pathogenesis. vol 132. 2019-08-06. PMID:31028864. |
the increase in ache and bche characterized a pro-inflammatory response, since these enzymes regulate levels of acetylcholine (ach) and butyrylcholine (busch), molecules with anti-inflammatory properties. |
2019-08-06 |
2023-08-13 |
mouse |
| Rosa Purgatorio, Modesto de Candia, Marco Catto, Antonio Carrieri, Leonardo Pisani, Annalisa De Palma, Maddalena Toma, Olga A Ivanova, Leonid G Voskressensky, Cosimo D Altomar. Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease. European journal of medicinal chemistry. vol 177. 2019-07-25. PMID:31158754. |
due to the role of butyrylcholinesterase (bche) in acetylcholine hydrolysis in the late stages of the alzheimer's disease (ad), inhibitors of butyrylcholinesterase (bche) have been recently envisaged, besides acetylcholinesterase (ache) inhibitors, as candidates for treating mild-to-moderate ad. |
2019-07-25 |
2023-08-13 |
Not clear |
| Priyapan Posri, Jittra Suthiwong, Pitchayakarn Takomthong, Chatchawan Wongsa, Chindawadee Chuenban, Chantana Boonyarat, Chavi Yenja. A new flavonoid from the leaves of Atalantia monophylla (L.) DC. Natural product research. vol 33. issue 8. 2019-07-22. PMID:29600742. |
focusing on alzheimer's disease, acetylcholine esterase (ache) inhibition and antioxidant activity were evaluated using the modified ellman's method and the abts scavenging assay, respectively. |
2019-07-22 |
2023-08-13 |
Not clear |
| Pengfei Zhang, Shengtao Xu, Zheying Zhu, Jinyi X. Multi-target design strategies for the improved treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 176. 2019-07-22. PMID:31103902. |
herein, we highlight nine major targets associated with ad, which are acetylcholine esterase (ache), beta-site amyloid precursor protein cleaving enzyme 1 (β-secretase, bace-1), glycogen synthase kinase 3 beta (gsk-3β), monoamine oxidases (maos), metal ions in the brain, n-methyl-d-aspartate (nmda) receptor, 5-hydroxytryptamine (5-ht) receptors, the third subtype of histamine receptor (h |
2019-07-22 |
2023-08-13 |
human |
| Miranda L Xu, Wilson K W Luk, Etta Y L Liu, Xiang P Kong, Qi Y Wu, Ying J Xia, Tina T X Dong, Karl W K Tsi. Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31170385. |
acetylcholinesterase (ache) hydrolyzes acetylcholine at cholinergic synapses, and which has various isoforms of ache, i.e. |
2019-07-22 |
2023-08-13 |
Not clear |
| Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Le. Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease. International journal of molecular sciences. vol 20. issue 4. 2019-07-17. PMID:30823604. |
acetylcholinesterase (ache) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. |
2019-07-17 |
2023-08-13 |
human |
| Shibaji Ghosh, Kalyanashis Jana, Bishwajit Gangul. Revealing the mechanistic pathway of cholinergic inhibition of Alzheimer's disease by donepezil: a metadynamics simulation study. Physical chemistry chemical physics : PCCP. vol 21. issue 25. 2019-07-10. PMID:31173012. |
we report for the first time, the inhibition mechanism of ache by the donepezil drug molecule for the hydrolysis of acetylcholine (ach) with docking and well-tempered metadynamics (wtmtd) simulations with a human acetylcholinesterase (hache) crystal structure (). |
2019-07-10 |
2023-08-13 |
human |
| Monica Janeczek, Tamar Gefen, Mehrnoosh Samimi, Garam Kim, Sandra Weintraub, Eileen Bigio, Emily Rogalski, M-Marsel Mesulam, Changiz Geul. Variations in Acetylcholinesterase Activity within Human Cortical Pyramidal Neurons Across Age and Cognitive Trajectories. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 4. 2019-06-26. PMID:28334147. |
conceivably, low levels of ache activity could enhance the impact of acetylcholine on pyramidal neurons to counterbalance other involutional factors that mediate the decline of memory capacity during average aging. |
2019-06-26 |
2023-08-13 |
human |
| Ashok Iyaswamy, Ananth Kumar Kammella, Citarasu Thavasimuthu, Wankhar Wankupar, Wankhar Dapkupar, Sambantham Shanmugam, Ravindran Rajan, Sheeladevi Rathinasam. Oxidative stress evoked damages leading to attenuated memory and inhibition of NMDAR-CaMKII-ERK/CREB signalling on consumption of aspartame in rat model. Journal of food and drug analysis. vol 26. issue 2. 2019-06-26. PMID:29567262. |
the animals showed a marked decrease in learning, spatial working and spatial recognition memory deficit in the morris water maze and y-maze performance task which could have resulted due to reduced hippocampal acetylcholine esterase (ache) activity. |
2019-06-26 |
2023-08-13 |
human |