| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeong Su Ha, Jong Min Kim, Seon Kyeong Park, Jin Yong Kang, Du Sang Lee, Uk Lee, Dae-Ok Kim, Sung-Gil Choi, Ho Jin He. Anti-amyloidogenic properties of an ethyl acetate fraction from Actinidia arguta in Aβ Food & function. vol 9. issue 6. 2018-10-01. PMID:29786737. |
furthermore, efaa showed the ameliorating effect of cholinergic functions by increasing acetylcholine (ach) levels and decreasing acetylcholinesterase (ache) activity, and protected antioxidant systems by increasing superoxide dismutase (sod) and decreasing the oxidized glutathione (gsh)/total gsh and malondialdehyde (mda) in the brain. |
2018-10-01 |
2023-08-13 |
mouse |
| Dinithi Champika Peiris, Thamali Dhanushk. Low doses of chlorpyrifos interfere with spermatogenesis of rats through reduction of sex hormones. Environmental science and pollution research international. vol 24. issue 26. 2018-09-25. PMID:28721614. |
another two sets of (four groups/set; n = 10) animals were orally treated with the same doses of cpf, control animal groups were treated with distilled water only for 30 days, and fertility indices and blood plasma acetylcholine esterase (ache) were determined on day 31. |
2018-09-25 |
2023-08-13 |
human |
| A Kroth, V Mackedanz, C Matté, A T S Wyse, M F M Ribeiro, W A Partat. Effect of Sciatic Nerve Transection on acetylcholinesterase activity in spinal cord and skeletal muscles of the bullfrog Lithobates catesbeianus. Brazilian journal of biology = Revista brasleira de biologia. vol 78. issue 2. 2018-09-05. PMID:28977043. |
in some vertebrate tissues, this condition decreases acetylcholinesterase (ache) activity, the enzyme responsible for fast hydrolysis of released acetylcholine in cholinergic synapses. |
2018-09-05 |
2023-08-13 |
rat |
| Yongliang Zhang, Qiong Wang, Hailong Chen, Xinmin Liu, Ke Lv, Tingmei Wang, Yanli Wang, Guohua Ji, Hongqing Cao, Guanghan Kan, Yinghui Li, Lina Q. Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats. BioMed research international. vol 2018. 2018-09-04. PMID:29581965. |
besides, acetylcholine esterase (ache) activity, malondialdehyde (mda) level in brain, reactive oxygen species (ros), and 8-hydroxy-2-deoxyguanosine (8-ohdg) concentrations of hu rats were significantly increased. |
2018-09-04 |
2023-08-13 |
rat |
| Qingqing Zhang, Yufang Hu, Di Wu, Shaohua Ma, Jiao Wang, Jiajia Rao, Lihua Xu, Huan Xu, Huili Shao, Zhiyong Guo, Sui Wan. Protein-mimicking nanowire-inspired electro-catalytic biosensor for probing acetylcholinesterase activity and its inhibitors. Talanta. vol 183. 2018-09-03. PMID:29567174. |
this sensing strategy involves the reaction of acetylcholine chloride (ach) with acetylcholinesterase (ache) to form choline that is in turn catalytically oxidized by choline oxidase (chox) to produce hydrogen peroxide (h |
2018-09-03 |
2023-08-13 |
Not clear |
| You-Na Lee, Koichi Okumura, Tomoko Horio, Tatsuya Iwata, Kazuhiro Takahashi, Toshiaki Hattori, Kazuaki Sawad. A bio-image sensor for simultaneous detection of multi-neurotransmitters. Talanta. vol 179. 2018-08-31. PMID:29310276. |
apyrase and acetylcholinesterase (ache), as selective elements, are used to recognize adenosine 5'-triphosphate (atp) and acetylcholine (ach), respectively. |
2018-08-31 |
2023-08-13 |
Not clear |
| Ariana Beste, DeCarlos E Taylor, Tsung-Ming Shih, Thaddeus P Thoma. Mechanisms of acetylcholinesterase protection against sarin and soman by adenosine A Computational biology and chemistry. vol 75. 2018-08-29. PMID:29747078. |
mechanisms of acetylcholinesterase protection against sarin and soman by adenosine a organophosphorus nerve agents (nas) irreversibly inhibit acetylcholinesterase (ache), the enzyme responsible for breaking down the neurotransmitter acetylcholine (ach). |
2018-08-29 |
2023-08-13 |
Not clear |
| G A Toledo-Ibarra, E J Rodríguez-Sánchez, H G Ventura-Ramón, K J G Díaz-Resendiz, M I Girón-Pére. Cholinergic alterations by exposure to pesticides used in control vector: Guppies fish (Poecilia reticulta) as biological model. International journal of environmental health research. vol 28. issue 1. 2018-08-27. PMID:29380629. |
subsequently, acetylcholinesterase activity (ache) and acetylcholine concentrations (ach) in muscle tissue were determined. |
2018-08-27 |
2023-08-13 |
Not clear |
| Mark P Gunderson, Brandon T Nguyen, Juan C Cervantes Reyes, Laura L Holden, John M T French, Brandon D Smith, Connor Lineberge. Response of phase I and II detoxification enzymes, glutathione, metallothionein and acetylcholine esterase to mercury and dimethoate in signal crayfish (Pacifastacus leniusculus). Chemosphere. vol 208. 2018-08-22. PMID:29902759. |
we examined the effects of mercury and the organophosphate pesticide dimethoate on erod, mrod, glutathione s-transferase (gst), acetylcholine esterase (ache), metallothionein (mt) and glutathione (gsh) in the signal crayfish (pacifastacus leniusculus). |
2018-08-22 |
2023-08-13 |
Not clear |
| Antonise M Jaguezeski, Gessica Perin, Leandro A Rhoden, Teane M A da Silva, Ricardo E Mendes, Nathieli B Bottari, Matheus D Baldissera, Vera M Morsch, Maria Rosa C Schetinger, Lenita M Stefani, Aleksandro S da Silv. Changes on the activity of cholinesterase's in an immunomodulatory response of cattle infected by Listeria monocytogenes. Microbial pathogenesis. vol 114. 2018-08-13. PMID:29066379. |
the ache activity and acetylcholine (ach) levels were measured in the central nervous system on day 14 pi, and histopathological analyses were also performed. |
2018-08-13 |
2023-08-13 |
cattle |
| Mengshi Wang, Wenchuan Bi, Kaiyue Fan, Tongde Li, Tingxu Yan, Feng Xiao, Bosai He, Kaishun Bi, Ying Ji. Ameliorating effect of Alpinia oxyphylla-Schisandra chinensis herb pair on cognitive impairment in a mouse model of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-03. PMID:29080453. |
finally, the level of acetylcholine (ach) and muscarinic receptor (m1) receptors, the activity of choline acetyltransferase (chat) and acetyl cholinesterase (ache) were measured by commercial assay kits and elisa kit. |
2018-08-03 |
2023-08-13 |
mouse |
| Satpati Abhijit, Muthangi V V Subramanyam, Sambe Asha Dev. Grape Seed Proanthocyanidin and Swimming Exercise Protects Against Cognitive Decline: A Study on M1 Acetylcholine Receptors in Aging Male Rat Brain. Neurochemical research. vol 42. issue 12. 2018-08-02. PMID:28993969. |
the aim of the present study was to assess the influence of grape seed proanthocyanidin extract (gspe) either individually or in combination with swimming training on acetylcholine esterase activity (ache) and m1 acetylcholine receptor (m1achr) on the extent of cognitive decline with aging. |
2018-08-02 |
2023-08-13 |
rat |
| Alsu R Mukhametshina, Svetlana V Fedorenko, Alexey M Petrov, Guzel F Zakyrjanova, Konstantin A Petrov, Leniz F Nurullin, Irek R Nizameev, Asiya R Mustafina, Oleg G Sinyashi. Targeted Nanoparticles for Selective Marking of Neuromuscular Junctions and ex Vivo Monitoring of Endogenous Acetylcholine Hydrolysis. ACS applied materials & interfaces. vol 10. issue 17. 2018-07-31. PMID:29652477. |
the present work for the first time introduces nanosensors for luminescent monitoring of acetylcholinesterase (ache)-catalyzed hydrolysis of endogenous acetylcholine (ach) released in neuromuscular junctions of isolated muscles. |
2018-07-31 |
2023-08-13 |
Not clear |
| Terrone L Rosenberry, Xavier Brazzolotto, Ian R Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nacho. Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study. Molecules (Basel, Switzerland). vol 22. issue 12. 2018-07-17. PMID:29186056. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2018-07-17 |
2023-08-13 |
human |
| Yue Wang, Qing Tian, En-Jie Liu, Li Zhao, Jie Song, Xin-An Liu, Qing-Guo Ren, Xia Jiang, Juan Zeng, Yu-Tao Yang, Jian-Zhi Wan. Activation of GSK-3 disrupts cholinergic homoeostasis in nucleus basalis of Meynert and frontal cortex of rats. Journal of cellular and molecular medicine. vol 21. issue 12. 2018-07-11. PMID:28656644. |
we activated gsk-3 by lateral ventricular infusion of wortmannin (wt) and gf-109203x (gfx), the inhibitors of phosphoinositol-3 kinase (pi3-k) and protein kinase c (pkc), respectively, and significantly decreased the acetylcholine (ach) level via inhibiting choline acetyl transferase (chat) rather than regulating acetylcholinesterase (ache). |
2018-07-11 |
2023-08-13 |
rat |
| Carlos Roca, Carlos Requena, Víctor Sebastián-Pérez, Sony Malhotra, Chris Radoux, Concepción Pérez, Ana Martinez, Juan Antonio Páez, Tom L Blundell, Nuria E Campill. Identification of new allosteric sites and modulators of AChE through computational and experimental tools. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-07-05. PMID:29873262. |
acetylcholinesterase (ache), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for amyloidosis in alzheimer's disease through interaction with amyloid β-peptide. |
2018-07-05 |
2023-08-13 |
Not clear |
| Liangqia Guo, Zhihong Li, Huan Chen, Yarong Wu, Ling Chen, Zhiping Song, Tianran Li. Colorimetric biosensor for the assay of paraoxon in environmental water samples based on the iodine-starch color reaction. Analytica chimica acta. vol 967. 2018-06-15. PMID:28390486. |
in the presence of acetylcholine chloride, acetylcholinesterase (ache) and choline oxidase (cho) catalyzed the formation of h |
2018-06-15 |
2023-08-13 |
Not clear |
| Carlota Saldanha, Teresa Freitas, Ana Santos Silva-Herdad. Timolol effects on erythrocyte deformability and nitric oxide metabolism. Clinical hemorheology and microcirculation. vol 69. issue 1-2. 2018-06-15. PMID:29630536. |
in healthy human red blood cells (rbcs), timolol is an inhibitor of ache and induces no efflux and gsno efflux from that blood component in lower concentration than those obtained in presence of the natural ache substrate, acetylcholine (ach). |
2018-06-15 |
2023-08-13 |
human |
| Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seege. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis. Toxicology letters. vol 293. 2018-06-04. PMID:29191791. |
organophosphorus compounds, including nerve agents and pesticides, exert their toxicity through irreversible inhibition of acetylcholinesterase (ache) resulting in an accumulation of acetylcholine and functional impairment of muscarinic and nicotinic acetylcholine receptors. |
2018-06-04 |
2023-08-13 |
human |
| Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seege. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis. Toxicology letters. vol 293. 2018-06-04. PMID:29191791. |
current therapy comprises oximes to reactivate ache and atropine to antagonize effects induced by muscarinic acetylcholine receptors. |
2018-06-04 |
2023-08-13 |
human |