| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liangqia Guo, Zhihong Li, Huan Chen, Yarong Wu, Ling Chen, Zhiping Song, Tianran Li. Colorimetric biosensor for the assay of paraoxon in environmental water samples based on the iodine-starch color reaction. Analytica chimica acta. vol 967. 2018-06-15. PMID:28390486. |
in the presence of acetylcholine chloride, acetylcholinesterase (ache) and choline oxidase (cho) catalyzed the formation of h |
2018-06-15 |
2023-08-13 |
Not clear |
| Carlota Saldanha, Teresa Freitas, Ana Santos Silva-Herdad. Timolol effects on erythrocyte deformability and nitric oxide metabolism. Clinical hemorheology and microcirculation. vol 69. issue 1-2. 2018-06-15. PMID:29630536. |
in healthy human red blood cells (rbcs), timolol is an inhibitor of ache and induces no efflux and gsno efflux from that blood component in lower concentration than those obtained in presence of the natural ache substrate, acetylcholine (ach). |
2018-06-15 |
2023-08-13 |
human |
| Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seege. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis. Toxicology letters. vol 293. 2018-06-04. PMID:29191791. |
organophosphorus compounds, including nerve agents and pesticides, exert their toxicity through irreversible inhibition of acetylcholinesterase (ache) resulting in an accumulation of acetylcholine and functional impairment of muscarinic and nicotinic acetylcholine receptors. |
2018-06-04 |
2023-08-13 |
human |
| Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seege. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis. Toxicology letters. vol 293. 2018-06-04. PMID:29191791. |
current therapy comprises oximes to reactivate ache and atropine to antagonize effects induced by muscarinic acetylcholine receptors. |
2018-06-04 |
2023-08-13 |
human |
| Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seege. Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning. Toxicology letters. vol 293. 2018-06-04. PMID:29248576. |
irreversible inhibition of acetylcholinesterase (ache) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (op). |
2018-06-04 |
2023-08-13 |
human |
| Volker Strauss, Maria Cecilia Rey Moreno, Jeanette Vogt, Martina Dammann, Steffen Schneider, Sibylle Gröters, Bennard van Ravenzwaa. Acetylcholinesterase measurement in various brain regions and muscles of juvenile, adolescent, and adult rats. Toxicology mechanisms and methods. vol 27. issue 9. 2018-05-23. PMID:28671028. |
several insecticides, chemicals, and drugs are known to inhibit acetylcholinesterase (ache) activity, responsible for the cleavage of the neurotransmitter acetylcholine. |
2018-05-23 |
2023-08-13 |
rat |
| Nathalie Lécrivain, Vincent Aurenche, Nathalie Cottin, Victor Frossard, Bernard Clémen. Multi-contamination (heavy metals, polychlorinated biphenyls and polycyclic aromatic hydrocarbons) of littoral sediments and the associated ecological risk assessment in a large lake in France (Lake Bourget). The Science of the total environment. vol 619-620. 2018-05-23. PMID:29734631. |
biological analysis including both laboratory (microcosm assays) and in situ (acetylcholine esterase (ache) and glutathione s-transferase (gst) activity measurements) experiments highlighted significant differences among sites both in the field and in laboratory assays suggesting a spatial variation of the biota response to contamination. |
2018-05-23 |
2023-08-13 |
Not clear |
| Hongru Ma, Jianfeng Han, Qinchuan Don. Neuroprotective effect of Annona glabra extract against ethanol-induced apoptotic neurodegeneration in neonatal rats. Journal of photochemistry and photobiology. B, Biology. vol 181. 2018-05-14. PMID:29549803. |
the lipid peroxidation, reduced glutathione (gsh), glutathione peroxidase (gpx), superoxide dismutase (sod), catalase, and acetylcholine esterase (ache) levels were determined. |
2018-05-14 |
2023-08-13 |
rat |
| Samuel Legeay, Nicolas Clere, Grégory Hilairet, Quoc-Tuan Do, Philippe Bernard, Jean-François Quignard, Véronique Apaire-Marchais, Bruno Lapied, Sébastien Faur. The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells. Scientific reports. vol 6. 2018-05-08. PMID:27345502. |
in addition, deet inhibited ache which increased acetylcholine bioavailability and binding to m3 receptors and also strengthened proangiogenic effects by an allosteric modulation. |
2018-05-08 |
2023-08-13 |
Not clear |
| Anders Allgardsson, C David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekströ. An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-08. PMID:28867801. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. |
2018-05-08 |
2023-08-13 |
Not clear |
| Paula Rayane de Souza, Kelma Sirleide de Souza, Caio Rodrigo Dias de Assis, Marlyete Chagas de Araújo, Kaline Catiely Campos Silva, Juliett de Fátima Xavier da Silva, Andreia Cybelle Marques Ferreira, Valdir Luna da Silva, Mônica Lúcia Adam, Luiz Bezerra de Carvalho, Ranilson de Souza Bezerr. Acetylcholinesterase of mangrove oyster Crassostrea rhizophorae: A highly thermostable enzyme with promising features for estuarine biomonitoring. Aquatic toxicology (Amsterdam, Netherlands). vol 197. 2018-05-07. PMID:29462762. |
acetylcholinesterase (ache; ec 3.1.1.7) is an enzyme of the group of serine esterases that acts on the hydrolysis of the neurotransmitter acetylcholine allowing the intermittence of the nerve impulses responsible for the neuronal communication. |
2018-05-07 |
2023-08-13 |
Not clear |
| Taibi Ben Hadda, Oualid Talhi, Artur S M Silva, Fatma Sezer Senol, Ilkay Erdogan Orhan, Abdur Rauf, Yahia N Mabkhot, Khaldoun Bachari, Ismail Warad, Thoraya A Farghaly, Ismail I Althagafi, Mohammad S Mubara. Cholinesterase Inhibitory Activity of Some semi-Rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site. Mini reviews in medicinal chemistry. vol 18. issue 8. 2018-05-04. PMID:28714400. |
cholinesterase family consists of two sister enzymes; acetylcholinesterase (ache) and butyrylcholinesterase (bche) which hydrolyze acetylcholine. |
2018-05-04 |
2023-08-13 |
Not clear |
| Irini Doytchinova, Mariyana Atanasova, Iva Valkova, Georgi Stavrakov, Irena Philipova, Zvetanka Zhivkova, Dimitrina Zheleva-Dimitrova, Spiro Konstantinov, Ivan Dimitro. Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-05-01. PMID:29651876. |
the inhibition of the enzyme acetylcholinesterase (ache) increases the levels of the neurotransmitter acetylcholine and symptomatically improves the affected cognitive function. |
2018-05-01 |
2023-08-13 |
Not clear |
| Fen Wang, Zhangbi Wu, Xiaoxue Zha, Yaojun Cai, Bo Wu, Xuemei Jia, Defa Zh. Concurrent administration of thyroxine and donepezil induces plastic changes in the prefrontal cortex of adult hypothyroid rats. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28713915. |
the acetylcholine (ach) content and ache activity was assessed, as well as the expressions of synaptotagmin‑1 (syt‑1) and snap‑25 were analyzed in the rats. |
2018-04-24 |
2023-08-13 |
rat |
| Shi-Jie Zhang, Ting-Ting Xu, Lin Li, Yu-Min Xu, Zi-Ling Qu, Xin-Chen Wang, Shui-Qing Huang, Yi Luo, Na-Chuan Luo, Ping Lu, Ya-Fei Shi, Xin Yang, Qi Wan. Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28521305. |
bsyz decreases the activity of acetylcholinesterase (ache), and increases the activity of choline acetyltransferase (chat) and the concentration of acetylcholine (ach) in both hippocampus and cortex. |
2018-04-23 |
2023-08-13 |
mouse |
| Adam Kostelnik, Alexander Cegan, Miroslav Pohank. Anti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase. BioMed research international. vol 2017. 2018-04-23. PMID:28785576. |
it acts as antagonist of muscarinic receptor activated by acetylcholine while the enzyme acetylcholinesterase (ache) cleaves acetylcholine in synaptic junction into choline and acetic acid. |
2018-04-23 |
2023-08-13 |
Not clear |
| Indresh Kaur, Amit Kumar, Amteshwar S Jaggi, Nirmal Sing. Evidence for the role of histaminergic pathways in neuroprotective mechanism of ischemic postconditioning in mice. Fundamental & clinical pharmacology. vol 31. issue 4. 2018-04-05. PMID:28173624. |
brain acetylcholine esterase (ache) activity, brain myeloperoxidase (mpo) activity, brain thiobarbituric acid-reactive species (tbars), and glutathione level (gsh) were also estimated. |
2018-04-05 |
2023-08-13 |
mouse |
| Cho Rong Kim, Soo Jung Choi, Jae Kyeom Kim, Chan Kyu Park, Min Chul Gim, Youn-Jung Kim, Gwi Gun Park, Dong-Hoon Shi. 2,4-Bis(1,1-dimethylethyl)phenol from Cinnamomum loureirii Improves Cognitive Deficit, Cholinergic Dysfunction, and Oxidative Damage in TMT-Treated Mice. Biological & pharmaceutical bulletin. vol 40. issue 6. 2018-03-06. PMID:28566637. |
moreover, bp reduced ache activity and lipid peroxidation but increased acetylcholine levels in the brain. |
2018-03-06 |
2023-08-13 |
mouse |
| Ruchi Malik, Bhanwar Singh Choudhary, Shubham Srivastava, Pakhuri Mehta, Manish Sharm. Identification of novel acetylcholinesterase inhibitors through e-pharmacophore-based virtual screening and molecular dynamics simulations. Journal of biomolecular structure & dynamics. vol 35. issue 15. 2018-02-23. PMID:27782777. |
to date, the successful therapeutic strategy to treat ad is maintaining the levels of acetylcholine via inhibiting acetylcholinesterase (ache). |
2018-02-23 |
2023-08-13 |
Not clear |
| Sifang Wang, Tianbo Ding, Manlin Xu, Bin Zhan. Bidirectional interactions between beet armyworm and its host in response to different fertilization conditions. PloS one. vol 13. issue 1. 2018-02-21. PMID:29293621. |
higher p likely enhanced acetylcholine esterase (ache) activity at lower degrees of defoliation, but a higher n proportion resulted in higher ache activity at higher degrees of defoliation. |
2018-02-21 |
2023-08-13 |
cat |